Diet-induced obesity causes innate airway hyperresponsiveness to methacholine and enhances ozone-induced pulmonary inflammation

Journal of Applied Physiology

Volumn 104, Issue 6, 2008, Pages 1727-1735

  Johnston, Richard A ^a,c   Theman, Todd A ^a   Lu, Frank L ^a,b   Terry, Raya D ^a   Williams, Erin S ^a   Shore, Stephanie A ^a  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^c University of Texas Medical Branch School of Medicine   (United States)

Author keywords

Bronchoalveolar lavage fluid; Chemokine; Leptin; Lung elastance; Resistance

Indexed keywords

CHEMOKINE; EOTAXIN; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERLEUKIN 6; MACROPHAGE INFLAMMATORY PROTEIN 2; METHACHOLINE; OZONE; PROTEIN KINASE C; AUTACOID; BRONCHOCONSTRICTING AGENT; LARD; METHACHOLINE CHLORIDE;

AIRWAY RESISTANCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY MASS; CONTROLLED STUDY; CYTOKINE PRODUCTION; DIET; FEMALE; LUNG LAVAGE; LUNG RESISTANCE; MALE; MOUSE; NONHUMAN; OBESITY; PNEUMONIA; PRIORITY JOURNAL; ANIMAL; BODY WEIGHT; BREATHING MECHANICS; BRONCHUS HYPERREACTIVITY; C57BL MOUSE; CHEMICALLY INDUCED DISORDER; CHEMISTRY; CYTOLOGY; DISEASE MODEL; DOSE RESPONSE; DRUG EFFECT; FAT INTAKE; INHALATION TEST; INTRAVENOUS DRUG ADMINISTRATION; LUNG COMPLIANCE; LUNG EDEMA; METABOLISM; PATHOPHYSIOLOGY; PHENOTYPE;

AIRWAY RESISTANCE; ANIMALS; BODY WEIGHT; BRONCHIAL HYPERREACTIVITY; BRONCHIAL PROVOCATION TESTS; BRONCHOALVEOLAR LAVAGE FLUID; BRONCHOCONSTRICTOR AGENTS; DIETARY FATS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; INFLAMMATION MEDIATORS; INJECTIONS, INTRAVENOUS; LUNG COMPLIANCE; MALE; METHACHOLINE CHLORIDE; MICE; MICE, INBRED C57BL; OBESITY; OZONE; PHENOTYPE; PNEUMONIA; PULMONARY EDEMA; RESPIRATORY MECHANICS;

EID: 49649113435     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.00075.2008     Document Type: Article

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