메뉴 건너뛰기




Volumn 16, Issue 1, 2013, Pages 2-8

Combined treatment of betulinic acid, a PTP1B inhibitor, with orthosiphon stamineus extract decreases body weight in high-fat-fed mice

Author keywords

betulinic acid; leptin resistance; obesity; Orthosiphon stamineus

Indexed keywords

ALCOHOL; BETULIC ACID; LEPTIN; ORTHOSIPHON STAMINEUS EXTRACT; PLANT EXTRACT; PROTEIN TYROSINE PHOSPHATASE 1B; UNCLASSIFIED DRUG;

EID: 84872098697     PISSN: 1096620X     EISSN: 15577600     Source Type: Journal    
DOI: 10.1089/jmf.2012.2384     Document Type: Article
Times cited : (21)

References (37)
  • 3
    • 72249092928 scopus 로고    scopus 로고
    • Recent advances in understanding leptin signaling and leptin resistance
    • Morris DL, Rui L: Recent advances in understanding leptin signaling and leptin resistance. Am J Physiol Endocrinol Metab 2009;297:E1247-E1259.
    • (2009) Am J Physiol Endocrinol Metab , vol.297
    • Morris, D.L.1    Rui, L.2
  • 4
    • 60849120123 scopus 로고    scopus 로고
    • HF diets increase hypothalamic PTP1B and induce leptin resistance through both leptin-dependent and -independent mech-anisms
    • White CL, Whittington A, Barnes MJ, Wang Z, Bray GA, Morrison CD: HF diets increase hypothalamic PTP1B and induce leptin resistance through both leptin-dependent and -independent mech-anisms. Am J Physiol Endocrinol Metab 2009;296:E291-E299.
    • (2009) Am J Physiol Endocrinol Metab , vol.296
    • White, C.L.1    Whittington, A.2    Barnes, M.J.3    Wang, Z.4    Bray, G.A.5    Morrison, C.D.6
  • 6
    • 45849148856 scopus 로고    scopus 로고
    • Tannins present in cichorium intybus enhance glucose uptake and inhibit adipogenesis in 3T3-L1 adipocytes through PTP1B inhibition
    • Muthusamy VS, Anand S, Sangeetha KN, Sujatha S, Arun B, Lakshmi BS: Tannins present in cichorium intybus enhance glucose uptake and inhibit adipogenesis in 3T3-L1 adipocytes through PTP1B inhibition. Chem Biol Interact 2008;174:69-78.
    • (2008) Chem Biol Interact , vol.174 , pp. 69-78
    • Muthusamy, V.S.1    Anand, S.2    Sangeetha, K.N.3    Sujatha, S.4    Arun, B.5    Lakshmi, B.S.6
  • 7
    • 59149104496 scopus 로고    scopus 로고
    • Isolation of betulinic acid, its methyl ester and guaiane sesqui-terpenoids with protein tyrosine phosphatase 1B inhibitory ac-tivity from the roots of Saussurea lappa C.B Clarke
    • Choi JY, Na MH, Hwang IH, Lee SH, Bae EY, Kim BY, Ahn JS: Isolation of betulinic acid, its methyl ester and guaiane sesqui-terpenoids with protein tyrosine phosphatase 1B inhibitory ac-tivity from the roots of Saussurea lappa C.B. Clarke. Molecules 2009;14:266-272.
    • (2009) Molecules , vol.14 , pp. 266-272
    • Choi, J.Y.1    Na, M.H.2    Hwang, I.H.3    Lee, S.H.4    Bae, E.Y.5    Kim, B.Y.6    Ahn, J.S.7
  • 8
    • 79955603767 scopus 로고    scopus 로고
    • Antidiabetic activity of some pentacyclic acid triterpenoids, role of PTP-1B: In vitro, in silico, and in vivo approaches
    • Ramírez-Espinosa JJ, Rios MY, López-Martínez S, López-Vallejo F, Medina-Franco JL, Paoli P, Camici G, Navarrete-Vázquez G, Ortiz-Andrade R, Estrada-Soto S: Antidiabetic activity of some pentacyclic acid triterpenoids, role of PTP-1B: in vitro, in silico, and in vivo approaches. Eur J Med Chem 2011;46:2243-2251.
    • (2011) Eur J Med Chem , vol.46 , pp. 2243-2251
    • Ramirez-Espinosa, J.J.1
  • 9
    • 77953898920 scopus 로고    scopus 로고
    • Antihepatotoxic activity of Saussurea lappa extract on D-galactosamine and lipopolysac-charide-induced hepatitis in mice
    • Yaeesh S, Jamal Q, Shah AJ, Gilani AH Antihepatotoxic activity of Saussurea lappa extract on D-galactosamine and lipopolysac-charide-induced hepatitis in mice. Phytother Res 2010;2:S229-S232.
    • (2010) Phytother Res , vol.2
    • Yaeesh, S.1    Jamal, Q.2    Shah, A.J.3    Gilani, A.H.4
  • 10
    • 0037331375 scopus 로고    scopus 로고
    • Nitric oxide inhibitory isopimarane-type diterpenes from Orthosiphon stamineus of Indonesia
    • DOI 10.1021/np020455x
    • Awale S, Tezuka Y, Banskota AH, Adnyana IK, Kadota S: Nitric oxide inhibitory isopimarane-type diterpense from Orthosiphon stamineus of Indonesia. J Nat Prod 2003;66:255-258. (Pubitemid 36278240)
    • (2003) Journal of Natural Products , vol.66 , Issue.2 , pp. 255-258
    • Awale, S.1    Tezuka, Y.2    Banskota, A.H.3    Adnyana, I.K.4    Kadota, S.5
  • 11
    • 46749111110 scopus 로고    scopus 로고
    • An investigation of the anti-inflammatory and analgesic effects of Orthosiphon stamineus leaf extract
    • DOI 10.1089/jmf.2006.065
    • Yam MF, Asmawi MZ, Basir R: An investigation of the anti-inflammatory and analgesic effects of Orthosiphon stamineus leaf extract. J Med Food 2008;11:362-368. (Pubitemid 351948161)
    • (2008) Journal of Medicinal Food , vol.11 , Issue.2 , pp. 362-368
    • Yam, M.F.1    Asmawi, Mohd.Z.2    Basir, R.3
  • 13
    • 84863988727 scopus 로고    scopus 로고
    • Antiproliferative and antiangiogenic effects of fla-vone eupatorin, an active constituent of chloroform extract of Orthosiphon stamineus leaves
    • Dolecková I, Rárová L, Grúz J, Vondrusová M, Strnad M, Krystof V: Antiproliferative and antiangiogenic effects of fla-vone eupatorin, an active constituent of chloroform extract of Orthosiphon stamineus leaves. Fitoterapia 2012;83:1000-1007.
    • (2012) Fitoterapia , vol.83 , pp. 1000-1007
    • Dolecková, I.1    Rárová, L.2    Grúz, J.3    Vondrusová, M.4    Strnad, M.5    Krystof, V.6
  • 17
    • 77955279589 scopus 로고    scopus 로고
    • PTP1B: A double agent in metab-olism and oncogenesis
    • Yip SC, Saha S, Chernoff J: PTP1B: a double agent in metab-olism and oncogenesis. Trends Biochem Sci 2010;35:442-449.
    • (2010) Trends Biochem Sci , vol.35 , pp. 442-449
    • Yip, S.C.1    Saha, S.2    Chernoff, J.3
  • 20
    • 77955052291 scopus 로고    scopus 로고
    • Inhibition of PTP1B by trodusquemine (MSI-1436) causes fat-specific weight loss in diet-induced obese mice
    • Lantz KA, Hart SG, Planey SL, Roitman MF, Ruiz-White IA, Wolfe HR, McLane MP: Inhibition of PTP1B by trodusquemine (MSI-1436) causes fat-specific weight loss in diet-induced obese mice. Obesity 2010;18:1516-1523.
    • (2010) Obesity , vol.18 , pp. 1516-1523
    • Lantz, K.A.1    Hart, S.G.2    Planey, S.L.3    Roitman, M.F.4    Ruiz-White, I.A.5    Wolfe, H.R.6    McLane, M.P.7
  • 22
    • 79960073235 scopus 로고    scopus 로고
    • Novel protein tyrosine phosphatase 1B inhibitors: In-teraction requirements for improved intracellular efficacy in type 2 diabetes mellitus and obesity control
    • Popov D: Novel protein tyrosine phosphatase 1B inhibitors: in-teraction requirements for improved intracellular efficacy in type 2 diabetes mellitus and obesity control. Biochem Biophys Res Commun 2011;410:377-381.
    • (2011) Biochem Biophys Res Commun , vol.410 , pp. 377-381
    • Popov, D.1
  • 25
    • 0031668175 scopus 로고    scopus 로고
    • Aging and fasting regulation of leptin and hypothalamic neuropeptide y gene ex-pression
    • Li H, Matheny M, Tümer N, Scarpace PJ: Aging and fasting regulation of leptin and hypothalamic neuropeptide Y gene ex-pression. Am J Physiol 1998;275:E405-E411.
    • (1998) Am J Physiol , vol.275
    • Li, H.1    Matheny, M.2    Tümer, N.3    Scarpace, P.J.4
  • 26
    • 33745197808 scopus 로고    scopus 로고
    • The role of leptin in leptin resistance and obesity
    • Zhang Y, Scarpace PJ: The role of leptin in leptin resistance and obesity. Physiol Behav 2006;88:249-256.
    • (2006) Physiol Behav , vol.88 , pp. 249-256
    • Zhang, Y.1    Scarpace, P.J.2
  • 27
    • 84856036647 scopus 로고    scopus 로고
    • Over-expression of leptin receptors in hypothalamic POMC neurons increases susceptibility to diet-induced obesity
    • Gamber KM, Huo L, Ha S, Hairston JE, Greeley S, Bjørbæk C: Over-expression of leptin receptors in hypothalamic POMC neurons increases susceptibility to diet-induced obesity. PLoS One 2012;7:e30485.
    • (2012) PLoS One , vol.7
    • Gamber, K.M.1    Huo, L.2    Ha, S.3    Hairston, J.E.4    Greeley, S.5    Bjørbæk, C.6
  • 29
    • 33845980223 scopus 로고    scopus 로고
    • Effects of Orthosiphon stamineus aqueous extract on plasma glucose concentration and lipid profile in normal and streptozotocin-induced diabetic rats
    • DOI 10.1016/j.jep.2006.08.027, PII S0378874106004259
    • Sriplang K, Adisakwattana S, Rungsipipat A, Yibchok-Anun S: Effects of Orthosiphon stamineus aqueous extract on plasma glucose concentration and lipid profile in normal and streptozo-tocin-induced diabetic rats. J Ethnopharmacol 2007;109:510-514. (Pubitemid 46054384)
    • (2007) Journal of Ethnopharmacology , vol.109 , Issue.3 , pp. 510-514
    • Sriplang, K.1    Adisakwattana, S.2    Rungsipipat, A.3    Yibchok-anun, S.4
  • 30
    • 70149123252 scopus 로고    scopus 로고
    • Toxicity study of Orthosiphon stamineus Benth (Misai Kucing) on Sprague Dawley rats
    • Chin JH, Abas HH, Sabariah I: Toxicity study of Orthosiphon stamineus Benth (Misai Kucing) on Sprague Dawley rats. Trop Biomed 2008;25:9-16.
    • (2008) Trop Biomed , vol.25 , pp. 9-16
    • Chin, J.H.1    Abas, H.H.2    Sabariah, I.3
  • 31
    • 59649119488 scopus 로고    scopus 로고
    • Acute toxicity of Orthosiphon stamineus Benth standardized extract in Sprague Dawley rats
    • Abdullah NR, Ismail Z, Ismail Z: Acute toxicity of Orthosiphon stamineus Benth standardized extract in Sprague Dawley rats. Phytomedicine 2009;16:222-226.
    • (2009) Phytomedicine , vol.16 , pp. 222-226
    • Abdullah, N.R.1    Ismail, Z.2    Ismail, Z.3
  • 32
    • 80052624987 scopus 로고    scopus 로고
    • Anti-inflammatory effects of Scoparia dulcis L. and betulinic acid
    • Tsai JC, Peng WH, Chiu TH, Lai SC, Lee CY: Anti-inflammatory effects of Scoparia dulcis L. and betulinic acid. Am J Chin Med 2011;39:943-956.
    • (2011) Am J Chin Med , vol.39 , pp. 943-956
    • Tsai, J.C.1    Peng, W.H.2    Chiu, T.H.3    Lai, S.C.4    Lee, C.Y.5
  • 34
    • 84863720978 scopus 로고    scopus 로고
    • Betulinic acid has an inhibitory effect on pancreatic lipase and induces adipocyte lipolysis
    • Kim J, Lee YS, Kim CS, Kim JS: Betulinic acid has an inhibitory effect on pancreatic lipase and induces adipocyte lipolysis. Phytother Res 2011;26:1103-1106.
    • (2011) Phytother Res , vol.26 , pp. 1103-1106
    • Kim, J.1    Lee, Y.S.2    Kim, C.S.3    Kim, J.S.4
  • 35
  • 36
    • 0034705758 scopus 로고    scopus 로고
    • In vitro anti-inflammatory effects of cynaropicrin, a sesquiterpene lactone, from Saussurea lappa
    • DOI 10.1016/S0014-2999(00)00337-X, PII S001429990000337X
    • Cho JY, Baik KU, Jung JH, Park MH: In vitro anti-inflammatory effects of cynaropicrin, a sesquiterpene lactone, from Saussurea lappa. Eur J Pharmacol 2000;398:399-407. (Pubitemid 30349105)
    • (2000) European Journal of Pharmacology , vol.398 , Issue.3 , pp. 399-407
    • Cho, J.Y.1    Baik, K.U.2    Jung, J.H.3    Park, M.H.4
  • 37
    • 84862786824 scopus 로고    scopus 로고
    • The hexane extract of Saussurea lappa and its active principle, dehydrocostus lactone, inhibit prostate cancer cell migration
    • Kim EJ, Hong JE, Lim SS, Kwon GT, Kim J, Kim JS, Lee KW, Yoon-Park JH: The hexane extract of Saussurea lappa and its active principle, dehydrocostus lactone, inhibit prostate cancer cell migration. J Med Food 2012;15:24-32.
    • (2012) J Med Food , vol.15 , pp. 24-32
    • Kim, E.J.1    Hong, J.E.2    Lim, S.S.3    Kwon, G.T.4    Kim, J.5    Kim, J.S.6    Lee, K.W.7    Yoon-Park, J.H.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.