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Volumn 8, Issue 12, 2012, Pages

A Mechanism of Gene Amplification Driven by Small DNA Fragments

Author keywords

[No Author keywords available]

Indexed keywords

DNA FRAGMENT; DOUBLE STRANDED DNA; EXTRACHROMOSOMAL DNA; HELICASE; NUCLEIC ACID BINDING PROTEIN; POL PROTEIN; POL32 PROTEIN; PROTEIN RAD1; RAD10 PROTEIN; RAD51 PROTEIN; RAD52 PROTEIN; RAD59 PROTEIN; SINGLE STRANDED DNA; UNCLASSIFIED DRUG;

EID: 84872021998     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1003119     Document Type: Article
Times cited : (18)

References (81)
  • 1
    • 33746255899 scopus 로고    scopus 로고
    • Gene amplification in cancer
    • Albertson DG, (2006) Gene amplification in cancer. Trends Genet 22: 447-455.
    • (2006) Trends Genet , vol.22 , pp. 447-455
    • Albertson, D.G.1
  • 2
    • 84857397985 scopus 로고    scopus 로고
    • Intratumoral heterogeneity of receptor tyrosine kinases EGFR and PDGFRA amplification in glioblastoma defines subpopulations with distinct growth factor response
    • Szerlip NJ, Pedraza A, Chakravarty D, Azim M, McGuire J, et al. (2012) Intratumoral heterogeneity of receptor tyrosine kinases EGFR and PDGFRA amplification in glioblastoma defines subpopulations with distinct growth factor response. Proc Natl Acad Sci U S A 109: 3041-3046.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 3041-3046
    • Szerlip, N.J.1    Pedraza, A.2    Chakravarty, D.3    Azim, M.4    McGuire, J.5
  • 4
    • 0021363699 scopus 로고
    • Gene amplification, drug resistance, and cancer
    • Schimke RT, (1984) Gene amplification, drug resistance, and cancer. Cancer Res 44: 1735-1742.
    • (1984) Cancer Res , vol.44 , pp. 1735-1742
    • Schimke, R.T.1
  • 5
    • 62149098010 scopus 로고    scopus 로고
    • Mechanisms of gene amplification and evidence of coamplification in drug-resistant human osteosarcoma cell lines
    • Hattinger CM, Stoico G, Michelacci F, Pasello M, Scionti I, et al. (2009) Mechanisms of gene amplification and evidence of coamplification in drug-resistant human osteosarcoma cell lines. Genes Chromosomes Cancer 48: 289-309.
    • (2009) Genes Chromosomes Cancer , vol.48 , pp. 289-309
    • Hattinger, C.M.1    Stoico, G.2    Michelacci, F.3    Pasello, M.4    Scionti, I.5
  • 6
    • 20044377204 scopus 로고    scopus 로고
    • The influence of CCL3L1 gene-containing segmental duplications on HIV-1/AIDS susceptibility
    • Gonzalez E, Kulkarni H, Bolivar H, Mangano A, Sanchez R, et al. (2005) The influence of CCL3L1 gene-containing segmental duplications on HIV-1/AIDS susceptibility. Science 307: 1434-1440.
    • (2005) Science , vol.307 , pp. 1434-1440
    • Gonzalez, E.1    Kulkarni, H.2    Bolivar, H.3    Mangano, A.4    Sanchez, R.5
  • 7
    • 0030239979 scopus 로고    scopus 로고
    • Chromosomal localization of amplified esterase genes in insecticide resistant Culex mosquitoes
    • Tomita T, Kono Y, Shimada T, (1996) Chromosomal localization of amplified esterase genes in insecticide resistant Culex mosquitoes. Insect Biochem Mol Biol 26: 853-857.
    • (1996) Insect Biochem Mol Biol , vol.26 , pp. 853-857
    • Tomita, T.1    Kono, Y.2    Shimada, T.3
  • 9
    • 43049143055 scopus 로고    scopus 로고
    • Mapping and sequencing of structural variation from eight human genomes
    • Kidd JM, Cooper GM, Donahue WF, Hayden HS, Sampas N, et al. (2008) Mapping and sequencing of structural variation from eight human genomes. Nature 453: 56-64.
    • (2008) Nature , vol.453 , pp. 56-64
    • Kidd, J.M.1    Cooper, G.M.2    Donahue, W.F.3    Hayden, H.S.4    Sampas, N.5
  • 10
    • 40849109768 scopus 로고    scopus 로고
    • Phenotypically concordant and discordant monozygotic twins display different DNA copy-number-variation profiles
    • Bruder CE, Piotrowski A, Gijsbers AA, Andersson R, Erickson S, et al. (2008) Phenotypically concordant and discordant monozygotic twins display different DNA copy-number-variation profiles. Am J Hum Genet 82: 763-771.
    • (2008) Am J Hum Genet , vol.82 , pp. 763-771
    • Bruder, C.E.1    Piotrowski, A.2    Gijsbers, A.A.3    Andersson, R.4    Erickson, S.5
  • 11
    • 51549095601 scopus 로고    scopus 로고
    • Somatic mosaicism for copy number variation in differentiated human tissues
    • Piotrowski A, Bruder CE, Andersson R, Diaz de Stahl T, Menzel U, et al. (2008) Somatic mosaicism for copy number variation in differentiated human tissues. Hum Mutat 29: 1118-1124.
    • (2008) Hum Mutat , vol.29 , pp. 1118-1124
    • Piotrowski, A.1    Bruder, C.E.2    Andersson, R.3    Diaz de Stahl, T.4    Menzel, U.5
  • 12
    • 59249105978 scopus 로고    scopus 로고
    • A microhomology-mediated break-induced replication model for the origin of human copy number variation
    • doi:10.1371/journal.pgen.1000327
    • Hastings PJ, Ira G, Lupski JR, (2009) A microhomology-mediated break-induced replication model for the origin of human copy number variation. PLoS Genet 5: e1000327 doi:10.1371/journal.pgen.1000327.
    • (2009) PLoS Genet , vol.5
    • Hastings, P.J.1    Ira, G.2    Lupski, J.R.3
  • 13
    • 80053542924 scopus 로고    scopus 로고
    • Copy number variation analysis in the great apes reveals species-specific patterns of structural variation
    • Gazave E, Darre F, Morcillo-Suarez C, Petit-Marty N, Carreno A, et al. (2011) Copy number variation analysis in the great apes reveals species-specific patterns of structural variation. Genome Res 21: 1626-1639.
    • (2011) Genome Res , vol.21 , pp. 1626-1639
    • Gazave, E.1    Darre, F.2    Morcillo-Suarez, C.3    Petit-Marty, N.4    Carreno, A.5
  • 14
    • 60149083509 scopus 로고    scopus 로고
    • A burst of segmental duplications in the genome of the African great ape ancestor
    • Marques-Bonet T, Kidd JM, Ventura M, Graves TA, Cheng Z, et al. (2009) A burst of segmental duplications in the genome of the African great ape ancestor. Nature 457: 877-881.
    • (2009) Nature , vol.457 , pp. 877-881
    • Marques-Bonet, T.1    Kidd, J.M.2    Ventura, M.3    Graves, T.A.4    Cheng, Z.5
  • 15
    • 0027218485 scopus 로고
    • Regulation and mechanisms of mammalian gene amplification
    • Stark GR, (1993) Regulation and mechanisms of mammalian gene amplification. Adv Cancer Res 61: 87-113.
    • (1993) Adv Cancer Res , vol.61 , pp. 87-113
    • Stark, G.R.1
  • 16
    • 77956277959 scopus 로고    scopus 로고
    • Gene amplification as double minutes or homogeneously staining regions in solid tumors: origin and structure
    • Storlazzi CT, Lonoce A, Guastadisegni MC, Trombetta D, D'Addabbo P, et al. (2010) Gene amplification as double minutes or homogeneously staining regions in solid tumors: origin and structure. Genome Res 20: 1198-1206.
    • (2010) Genome Res , vol.20 , pp. 1198-1206
    • Storlazzi, C.T.1    Lonoce, A.2    Guastadisegni, M.C.3    Trombetta, D.4    D'Addabbo, P.5
  • 17
    • 0025376252 scopus 로고
    • Double minutes arise from circular extrachromosomal DNA intermediates which integrate into chromosomal sites in human HL-60 leukemia cells
    • Von Hoff DD, Forseth B, Clare CN, Hansen KL, VanDevanter D, (1990) Double minutes arise from circular extrachromosomal DNA intermediates which integrate into chromosomal sites in human HL-60 leukemia cells. J Clin Invest 85: 1887-1895.
    • (1990) J Clin Invest , vol.85 , pp. 1887-1895
    • von Hoff, D.D.1    Forseth, B.2    Clare, C.N.3    Hansen, K.L.4    VanDevanter, D.5
  • 18
    • 77951977063 scopus 로고    scopus 로고
    • Gene amplification, radiation sensitivity and DNA double-strand breaks
    • Mondello C, Smirnova A, Giulotto E, (2010) Gene amplification, radiation sensitivity and DNA double-strand breaks. Mutat Res 704: 29-37.
    • (2010) Mutat Res , vol.704 , pp. 29-37
    • Mondello, C.1    Smirnova, A.2    Giulotto, E.3
  • 19
    • 0037206935 scopus 로고    scopus 로고
    • Induction of multiple double-strand breaks within an hsr by meganucleaseI-SceI expression or fragile site activation leads to formation of double minutes and other chromosomal rearrangements
    • Coquelle A, Rozier L, Dutrillaux B, Debatisse M, (2002) Induction of multiple double-strand breaks within an hsr by meganucleaseI-SceI expression or fragile site activation leads to formation of double minutes and other chromosomal rearrangements. Oncogene 21: 7671-7679.
    • (2002) Oncogene , vol.21 , pp. 7671-7679
    • Coquelle, A.1    Rozier, L.2    Dutrillaux, B.3    Debatisse, M.4
  • 20
    • 0032472367 scopus 로고    scopus 로고
    • Interstitial deletions and intrachromosomal amplification initiated from a double-strand break targeted to a mammalian chromosome
    • Pipiras E, Coquelle A, Bieth A, Debatisse M, (1998) Interstitial deletions and intrachromosomal amplification initiated from a double-strand break targeted to a mammalian chromosome. EMBO J 17: 325-333.
    • (1998) EMBO J , vol.17 , pp. 325-333
    • Pipiras, E.1    Coquelle, A.2    Bieth, A.3    Debatisse, M.4
  • 21
    • 33750410484 scopus 로고    scopus 로고
    • The breakage-fusion-bridge (BFB) cycle as a mechanism for generating genetic heterogeneity in osteosarcoma
    • Selvarajah S, Yoshimoto M, Park PC, Maire G, Paderova J, et al. (2006) The breakage-fusion-bridge (BFB) cycle as a mechanism for generating genetic heterogeneity in osteosarcoma. Chromosoma 115: 459-467.
    • (2006) Chromosoma , vol.115 , pp. 459-467
    • Selvarajah, S.1    Yoshimoto, M.2    Park, P.C.3    Maire, G.4    Paderova, J.5
  • 22
    • 0001294157 scopus 로고
    • The Stability of Broken Ends of Chromosomes in Zea Mays
    • McClintock B, (1941) The Stability of Broken Ends of Chromosomes in Zea Mays. Genetics 26: 234-282.
    • (1941) Genetics , vol.26 , pp. 234-282
    • McClintock, B.1
  • 23
    • 15044351972 scopus 로고    scopus 로고
    • Widespread and nonrandom distribution of DNA palindromes in cancer cells provides a structural platform for subsequent gene amplification
    • Tanaka H, Bergstrom DA, Yao MC, Tapscott SJ, (2005) Widespread and nonrandom distribution of DNA palindromes in cancer cells provides a structural platform for subsequent gene amplification. Nat Genet 37: 320-327.
    • (2005) Nat Genet , vol.37 , pp. 320-327
    • Tanaka, H.1    Bergstrom, D.A.2    Yao, M.C.3    Tapscott, S.J.4
  • 24
    • 0025988472 scopus 로고
    • The role of inverted duplication in the generation of gene amplification in mammalian cells
    • Fried M, Feo S, Heard E, (1991) The role of inverted duplication in the generation of gene amplification in mammalian cells. Biochim Biophys Acta 1090: 143-155.
    • (1991) Biochim Biophys Acta , vol.1090 , pp. 143-155
    • Fried, M.1    Feo, S.2    Heard, E.3
  • 25
    • 0035902483 scopus 로고    scopus 로고
    • Repeat expansion by homologous recombination in the mouse germ line at palindromic sequences
    • Zhou ZH, Akgun E, Jasin M, (2001) Repeat expansion by homologous recombination in the mouse germ line at palindromic sequences. Proc Natl Acad Sci U S A 98: 8326-8333.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 8326-8333
    • Zhou, Z.H.1    Akgun, E.2    Jasin, M.3
  • 26
    • 0037169325 scopus 로고    scopus 로고
    • The Mre11 complex is required for repair of hairpin-capped double-strand breaks and prevention of chromosome rearrangements
    • Lobachev KS, Gordenin DA, Resnick MA, (2002) The Mre11 complex is required for repair of hairpin-capped double-strand breaks and prevention of chromosome rearrangements. Cell 108: 183-193.
    • (2002) Cell , vol.108 , pp. 183-193
    • Lobachev, K.S.1    Gordenin, D.A.2    Resnick, M.A.3
  • 27
    • 33745264366 scopus 로고    scopus 로고
    • The pattern of gene amplification is determined by the chromosomal location of hairpin-capped breaks
    • Narayanan V, Mieczkowski PA, Kim HM, Petes TD, Lobachev KS, (2006) The pattern of gene amplification is determined by the chromosomal location of hairpin-capped breaks. Cell 125: 1283-1296.
    • (2006) Cell , vol.125 , pp. 1283-1296
    • Narayanan, V.1    Mieczkowski, P.A.2    Kim, H.M.3    Petes, T.D.4    Lobachev, K.S.5
  • 29
    • 0038799991 scopus 로고    scopus 로고
    • Multiple pathways of recombination induced by double-strand breaks in Saccharomyces cerevisiae
    • Paques F, Haber JE, (1999) Multiple pathways of recombination induced by double-strand breaks in Saccharomyces cerevisiae. Microbiol Mol Biol Rev 63: 349-404.
    • (1999) Microbiol Mol Biol Rev , vol.63 , pp. 349-404
    • Paques, F.1    Haber, J.E.2
  • 30
    • 37349109667 scopus 로고    scopus 로고
    • A DNA replication mechanism for generating nonrecurrent rearrangements associated with genomic disorders
    • Lee JA, Carvalho CM, Lupski JR, (2007) A DNA replication mechanism for generating nonrecurrent rearrangements associated with genomic disorders. Cell 131: 1235-1247.
    • (2007) Cell , vol.131 , pp. 1235-1247
    • Lee, J.A.1    Carvalho, C.M.2    Lupski, J.R.3
  • 31
    • 67649878596 scopus 로고    scopus 로고
    • The DNA replication FoSTeS/MMBIR mechanism can generate genomic, genic and exonic complex rearrangements in humans
    • Zhang F, Khajavi M, Connolly AM, Towne CF, Batish SD, et al. (2009) The DNA replication FoSTeS/MMBIR mechanism can generate genomic, genic and exonic complex rearrangements in humans. Nat Genet 41: 849-853.
    • (2009) Nat Genet , vol.41 , pp. 849-853
    • Zhang, F.1    Khajavi, M.2    Connolly, A.M.3    Towne, C.F.4    Batish, S.D.5
  • 32
    • 3843101398 scopus 로고    scopus 로고
    • Molecular structure of double-minute chromosomes bearing amplified copies of the epidermal growth factor receptor gene in gliomas
    • Vogt N, Lefevre SH, Apiou F, Dutrillaux AM, Cor A, et al. (2004) Molecular structure of double-minute chromosomes bearing amplified copies of the epidermal growth factor receptor gene in gliomas. Proc Natl Acad Sci U S A 101: 11368-11373.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 11368-11373
    • Vogt, N.1    Lefevre, S.H.2    Apiou, F.3    Dutrillaux, A.M.4    Cor, A.5
  • 33
    • 0036245047 scopus 로고    scopus 로고
    • MYCC and MYCN oncogene amplification in medulloblastoma. A fluorescence in situ hybridization study on paraffin sections from the Children's Oncology Group
    • Aldosari N, Bigner SH, Burger PC, Becker L, Kepner JL, et al. (2002) MYCC and MYCN oncogene amplification in medulloblastoma. A fluorescence in situ hybridization study on paraffin sections from the Children's Oncology Group. Arch Pathol Lab Med 126: 540-544.
    • (2002) Arch Pathol Lab Med , vol.126 , pp. 540-544
    • Aldosari, N.1    Bigner, S.H.2    Burger, P.C.3    Becker, L.4    Kepner, J.L.5
  • 34
    • 0024792009 scopus 로고
    • Early dihydrofolate reductase gene amplification events in CHO cells usually occur on the same chromosome arm as the original locus
    • Trask BJ, Hamlin JL, (1989) Early dihydrofolate reductase gene amplification events in CHO cells usually occur on the same chromosome arm as the original locus. Genes Dev 3: 1913-1925.
    • (1989) Genes Dev , vol.3 , pp. 1913-1925
    • Trask, B.J.1    Hamlin, J.L.2
  • 35
    • 0345166826 scopus 로고    scopus 로고
    • Chromosomal site-specific double-strand breaks are efficiently targeted for repair by oligonucleotides in yeast
    • Storici F, Durham CL, Gordenin DA, Resnick MA, (2003) Chromosomal site-specific double-strand breaks are efficiently targeted for repair by oligonucleotides in yeast. Proc Natl Acad Sci U S A 100: 14994-14999.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 14994-14999
    • Storici, F.1    Durham, C.L.2    Gordenin, D.A.3    Resnick, M.A.4
  • 36
    • 2442426243 scopus 로고    scopus 로고
    • Delitto perfetto targeted mutagenesis in yeast with oligonucleotides
    • Storici F, Resnick MA, (2003) Delitto perfetto targeted mutagenesis in yeast with oligonucleotides. Genet Eng (N Y) 25: 189-207.
    • (2003) Genet Eng (N Y) , vol.25 , pp. 189-207
    • Storici, F.1    Resnick, M.A.2
  • 37
    • 80053323743 scopus 로고    scopus 로고
    • In vivo site-specific mutagenesis and gene collage using the delitto perfetto system in yeast Saccharomyces cerevisiae
    • Stuckey S, Mukherjee K, Storici F, (2011) In vivo site-specific mutagenesis and gene collage using the delitto perfetto system in yeast Saccharomyces cerevisiae. Methods Mol Biol 745: 173-191.
    • (2011) Methods Mol Biol , vol.745 , pp. 173-191
    • Stuckey, S.1    Mukherjee, K.2    Storici, F.3
  • 38
    • 0000422658 scopus 로고
    • Yeast recombination: the association between double-strand gap repair and crossing-over
    • Orr-Weaver TL, Szostak JW, (1983) Yeast recombination: the association between double-strand gap repair and crossing-over. Proc Natl Acad Sci U S A 80: 4417-4421.
    • (1983) Proc Natl Acad Sci U S A , vol.80 , pp. 4417-4421
    • Orr-Weaver, T.L.1    Szostak, J.W.2
  • 39
    • 33749590905 scopus 로고    scopus 로고
    • Conservative repair of a chromosomal double-strand break by single-strand DNA through two steps of annealing
    • Storici F, Snipe JR, Chan GK, Gordenin DA, Resnick MA, (2006) Conservative repair of a chromosomal double-strand break by single-strand DNA through two steps of annealing. Mol Cell Biol 26: 7645-7657.
    • (2006) Mol Cell Biol , vol.26 , pp. 7645-7657
    • Storici, F.1    Snipe, J.R.2    Chan, G.K.3    Gordenin, D.A.4    Resnick, M.A.5
  • 40
    • 0036900120 scopus 로고    scopus 로고
    • Role of RAD52 epistasis group genes in homologous recombination and double-strand break repair
    • Symington LS, (2002) Role of RAD52 epistasis group genes in homologous recombination and double-strand break repair. Microbiol Mol Biol Rev 66: 630-670.
    • (2002) Microbiol Mol Biol Rev , vol.66 , pp. 630-670
    • Symington, L.S.1
  • 42
    • 34547927220 scopus 로고    scopus 로고
    • Break-induced replication and telomerase-independent telomere maintenance require Pol32
    • Lydeard JR, Jain S, Yamaguchi M, Haber JE, (2007) Break-induced replication and telomerase-independent telomere maintenance require Pol32. Nature 448: 820-823.
    • (2007) Nature , vol.448 , pp. 820-823
    • Lydeard, J.R.1    Jain, S.2    Yamaguchi, M.3    Haber, J.E.4
  • 43
    • 58149494717 scopus 로고    scopus 로고
    • Yeast Mph1 helicase dissociates Rad51-made D-loops: implications for crossover control in mitotic recombination
    • Prakash R, Satory D, Dray E, Papusha A, Scheller J, et al. (2009) Yeast Mph1 helicase dissociates Rad51-made D-loops: implications for crossover control in mitotic recombination. Genes Dev 23: 67-79.
    • (2009) Genes Dev , vol.23 , pp. 67-79
    • Prakash, R.1    Satory, D.2    Dray, E.3    Papusha, A.4    Scheller, J.5
  • 44
    • 0342546023 scopus 로고    scopus 로고
    • RAD51 is required for the repair of plasmid double-stranded DNA gaps from either plasmid or chromosomal templates
    • Bartsch S, Kang LE, Symington LS, (2000) RAD51 is required for the repair of plasmid double-stranded DNA gaps from either plasmid or chromosomal templates. Mol Cell Biol 20: 1194-1205.
    • (2000) Mol Cell Biol , vol.20 , pp. 1194-1205
    • Bartsch, S.1    Kang, L.E.2    Symington, L.S.3
  • 46
    • 0345447604 scopus 로고    scopus 로고
    • Srs2 and Sgs1-Top3 suppress crossovers during double-strand break repair in yeast
    • Ira G, Malkova A, Liberi G, Foiani M, Haber JE, (2003) Srs2 and Sgs1-Top3 suppress crossovers during double-strand break repair in yeast. Cell 115: 401-411.
    • (2003) Cell , vol.115 , pp. 401-411
    • Ira, G.1    Malkova, A.2    Liberi, G.3    Foiani, M.4    Haber, J.E.5
  • 47
    • 0035158640 scopus 로고    scopus 로고
    • SGS1, the Saccharomyces cerevisiae homologue of BLM and WRN, suppresses genome instability and homeologous recombination
    • Myung K, Datta A, Chen C, Kolodner RD, (2001) SGS1, the Saccharomyces cerevisiae homologue of BLM and WRN, suppresses genome instability and homeologous recombination. Nat Genet 27: 113-116.
    • (2001) Nat Genet , vol.27 , pp. 113-116
    • Myung, K.1    Datta, A.2    Chen, C.3    Kolodner, R.D.4
  • 48
    • 0034724751 scopus 로고    scopus 로고
    • Elevation of sister chromatid exchange in Saccharomyces cerevisiae sgs1 disruptants and the relevance of the disruptants as a system to evaluate mutations in Bloom's syndrome gene
    • Onoda F, Seki M, Miyajima A, Enomoto T, (2000) Elevation of sister chromatid exchange in Saccharomyces cerevisiae sgs1 disruptants and the relevance of the disruptants as a system to evaluate mutations in Bloom's syndrome gene. Mutat Res 459: 203-209.
    • (2000) Mutat Res , vol.459 , pp. 203-209
    • Onoda, F.1    Seki, M.2    Miyajima, A.3    Enomoto, T.4
  • 49
    • 51549095956 scopus 로고    scopus 로고
    • Sgs1 helicase and two nucleases Dna2 and Exo1 resect DNA double-strand break ends
    • Zhu Z, Chung WH, Shim EY, Lee SE, Ira G, (2008) Sgs1 helicase and two nucleases Dna2 and Exo1 resect DNA double-strand break ends. Cell 134: 981-994.
    • (2008) Cell , vol.134 , pp. 981-994
    • Zhu, Z.1    Chung, W.H.2    Shim, E.Y.3    Lee, S.E.4    Ira, G.5
  • 50
    • 0000930196 scopus 로고
    • The origin of chromosome rearrangements at early stages of AMPD2 gene amplification in Chinese hamster cells
    • Toledo F, Buttin G, Debatisse M, (1993) The origin of chromosome rearrangements at early stages of AMPD2 gene amplification in Chinese hamster cells. Curr Biol 3: 255-264.
    • (1993) Curr Biol , vol.3 , pp. 255-264
    • Toledo, F.1    Buttin, G.2    Debatisse, M.3
  • 51
    • 0024347356 scopus 로고
    • Amplified N-myc in human neuroblastoma cells is often arranged as clustered tandem repeats of differently recombined DNA
    • Amler LC, Schwab M, (1989) Amplified N-myc in human neuroblastoma cells is often arranged as clustered tandem repeats of differently recombined DNA. Mol Cell Biol 9: 4903-4913.
    • (1989) Mol Cell Biol , vol.9 , pp. 4903-4913
    • Amler, L.C.1    Schwab, M.2
  • 52
    • 55349107544 scopus 로고    scopus 로고
    • Tandem duplication producing a novel oncogenic BRAF fusion gene defines the majority of pilocytic astrocytomas
    • Jones DT, Kocialkowski S, Liu L, Pearson DM, Backlund LM, et al. (2008) Tandem duplication producing a novel oncogenic BRAF fusion gene defines the majority of pilocytic astrocytomas. Cancer Res 68: 8673-8677.
    • (2008) Cancer Res , vol.68 , pp. 8673-8677
    • Jones, D.T.1    Kocialkowski, S.2    Liu, L.3    Pearson, D.M.4    Backlund, L.M.5
  • 53
  • 54
    • 72949119310 scopus 로고    scopus 로고
    • Complex landscapes of somatic rearrangement in human breast cancer genomes
    • Stephens PJ, McBride DJ, Lin ML, Varela I, Pleasance ED, et al. (2009) Complex landscapes of somatic rearrangement in human breast cancer genomes. Nature 462: 1005-1010.
    • (2009) Nature , vol.462 , pp. 1005-1010
    • Stephens, P.J.1    McBride, D.J.2    Lin, M.L.3    Varela, I.4    Pleasance, E.D.5
  • 55
    • 84863725818 scopus 로고    scopus 로고
    • Tandem duplication of chromosomal segments is common in ovarian and breast cancer genomes
    • McBride DJ, Etemadmoghadam D, Cooke SL, Alsop K, George J, et al. (2012) Tandem duplication of chromosomal segments is common in ovarian and breast cancer genomes. J Pathol 227: 446-455.
    • (2012) J Pathol , vol.227 , pp. 446-455
    • McBride, D.J.1    Etemadmoghadam, D.2    Cooke, S.L.3    Alsop, K.4    George, J.5
  • 56
    • 84857996064 scopus 로고    scopus 로고
    • The role of tandem duplicator phenotype in tumour evolution in high-grade serous ovarian cancer
    • Ng CK, Cooke SL, Howe K, Newman S, Xian J, et al. (2012) The role of tandem duplicator phenotype in tumour evolution in high-grade serous ovarian cancer. J Pathol 226: 703-712.
    • (2012) J Pathol , vol.226 , pp. 703-712
    • Ng, C.K.1    Cooke, S.L.2    Howe, K.3    Newman, S.4    Xian, J.5
  • 57
    • 63249130106 scopus 로고    scopus 로고
    • Polymerase dynamics at the eukaryotic DNA replication fork
    • Burgers PM, (2009) Polymerase dynamics at the eukaryotic DNA replication fork. J Biol Chem 284: 4041-4045.
    • (2009) J Biol Chem , vol.284 , pp. 4041-4045
    • Burgers, P.M.1
  • 58
    • 80755187806 scopus 로고    scopus 로고
    • Double-strand break end resection and repair pathway choice
    • Symington LS, Gautier J, (2011) Double-strand break end resection and repair pathway choice. Annu Rev Genet 45: 247-271.
    • (2011) Annu Rev Genet , vol.45 , pp. 247-271
    • Symington, L.S.1    Gautier, J.2
  • 59
    • 0029970701 scopus 로고    scopus 로고
    • Capture of retrotransposon DNA at the sites of chromosomal double-strand breaks
    • Moore JK, Haber JE, (1996) Capture of retrotransposon DNA at the sites of chromosomal double-strand breaks. Nature 383: 644-646.
    • (1996) Nature , vol.383 , pp. 644-646
    • Moore, J.K.1    Haber, J.E.2
  • 60
    • 84859516414 scopus 로고    scopus 로고
    • Extrachromosomal microDNAs and chromosomal microdeletions in normal tissues
    • Shibata Y, Kumar P, Layer R, Willcox S, Gagan JR, et al. (2012) Extrachromosomal microDNAs and chromosomal microdeletions in normal tissues. Science 336: 82-86.
    • (2012) Science , vol.336 , pp. 82-86
    • Shibata, Y.1    Kumar, P.2    Layer, R.3    Willcox, S.4    Gagan, J.R.5
  • 61
    • 15444374064 scopus 로고    scopus 로고
    • Spontaneous uptake of biologically active recombinant DNA by mammalian cells via a selected DNA segment
    • Lehmann MJ, Sczakiel G, (2005) Spontaneous uptake of biologically active recombinant DNA by mammalian cells via a selected DNA segment. Gene Ther 12: 446-451.
    • (2005) Gene Ther , vol.12 , pp. 446-451
    • Lehmann, M.J.1    Sczakiel, G.2
  • 63
    • 0034630317 scopus 로고    scopus 로고
    • Apoptotic DNA fragmentation
    • Nagata S, (2000) Apoptotic DNA fragmentation. Exp Cell Res 256: 12-18.
    • (2000) Exp Cell Res , vol.256 , pp. 12-18
    • Nagata, S.1
  • 64
    • 0034619794 scopus 로고    scopus 로고
    • A Toll-like receptor recognizes bacterial DNA
    • Hemmi H, Takeuchi O, Kawai T, Kaisho T, Sato S, et al. (2000) A Toll-like receptor recognizes bacterial DNA. Nature 408: 740-745.
    • (2000) Nature , vol.408 , pp. 740-745
    • Hemmi, H.1    Takeuchi, O.2    Kawai, T.3    Kaisho, T.4    Sato, S.5
  • 65
    • 0033152288 scopus 로고    scopus 로고
    • Horizontal transfer of DNA by the uptake of apoptotic bodies
    • Holmgren L, Szeles A, Rajnavolgyi E, Folkman J, Klein G, et al. (1999) Horizontal transfer of DNA by the uptake of apoptotic bodies. Blood 93: 3956-3963.
    • (1999) Blood , vol.93 , pp. 3956-3963
    • Holmgren, L.1    Szeles, A.2    Rajnavolgyi, E.3    Folkman, J.4    Klein, G.5
  • 66
    • 3242657948 scopus 로고    scopus 로고
    • Extracellular nucleic acids in cultures of long-term cultivated eukaryotic cells
    • Morozkin ES, Laktionov PP, Rykova EY, Vlassov VV, (2004) Extracellular nucleic acids in cultures of long-term cultivated eukaryotic cells. Ann N Y Acad Sci 1022: 244-249.
    • (2004) Ann N Y Acad Sci , vol.1022 , pp. 244-249
    • Morozkin, E.S.1    Laktionov, P.P.2    Rykova, E.Y.3    Vlassov, V.V.4
  • 67
    • 33947306107 scopus 로고    scopus 로고
    • Circulating nucleic acids in plasma/serum
    • Tsang JC, Lo YM, (2007) Circulating nucleic acids in plasma/serum. Pathology 39: 197-207.
    • (2007) Pathology , vol.39 , pp. 197-207
    • Tsang, J.C.1    Lo, Y.M.2
  • 68
    • 0035866393 scopus 로고    scopus 로고
    • DNA fragments in the blood plasma of cancer patients: quantitations and evidence for their origin from apoptotic and necrotic cells
    • Jahr S, Hentze H, Englisch S, Hardt D, Fackelmayer FO, et al. (2001) DNA fragments in the blood plasma of cancer patients: quantitations and evidence for their origin from apoptotic and necrotic cells. Cancer Res 61: 1659-1665.
    • (2001) Cancer Res , vol.61 , pp. 1659-1665
    • Jahr, S.1    Hentze, H.2    Englisch, S.3    Hardt, D.4    Fackelmayer, F.O.5
  • 69
    • 0017360626 scopus 로고
    • Free DNA in the serum of cancer patients and the effect of therapy
    • Leon SA, Shapiro B, Sklaroff DM, Yaros MJ, (1977) Free DNA in the serum of cancer patients and the effect of therapy. Cancer Res 37: 646-650.
    • (1977) Cancer Res , vol.37 , pp. 646-650
    • Leon, S.A.1    Shapiro, B.2    Sklaroff, D.M.3    Yaros, M.J.4
  • 70
    • 28544443522 scopus 로고    scopus 로고
    • Diagnostic developments involving cell-free (circulating) nucleic acids
    • Tong YK, Lo YM, (2006) Diagnostic developments involving cell-free (circulating) nucleic acids. Clin Chim Acta 363: 187-196.
    • (2006) Clin Chim Acta , vol.363 , pp. 187-196
    • Tong, Y.K.1    Lo, Y.M.2
  • 71
    • 0033566003 scopus 로고    scopus 로고
    • Functional gene transfer of HIV DNA by an HIV receptor-independent mechanism
    • Spetz AL, Patterson BK, Lore K, Andersson J, Holmgren L, (1999) Functional gene transfer of HIV DNA by an HIV receptor-independent mechanism. J Immunol 163: 736-742.
    • (1999) J Immunol , vol.163 , pp. 736-742
    • Spetz, A.L.1    Patterson, B.K.2    Lore, K.3    Andersson, J.4    Holmgren, L.5
  • 72
    • 84861453626 scopus 로고    scopus 로고
    • Oncogenic transformation induced by cell-free nucleic acids circulating in plasma (genometastasis) remains after the surgical resection of the primary tumor: a pilot study
    • Garcia-Olmo D, Garcia-Olmo DC, Dominguez-Berzosa C, Guadalajara H, Vega L, et al. (2012) Oncogenic transformation induced by cell-free nucleic acids circulating in plasma (genometastasis) remains after the surgical resection of the primary tumor: a pilot study. Expert Opin Biol Ther 12: S61-S68.
    • (2012) Expert Opin Biol Ther , vol.12
    • Garcia-Olmo, D.1    Garcia-Olmo, D.C.2    Dominguez-Berzosa, C.3    Guadalajara, H.4    Vega, L.5
  • 76
    • 57149094856 scopus 로고    scopus 로고
    • Hypermutability of damaged single-strand DNA formed at double-strand breaks and uncapped telomeres in yeast Saccharomyces cerevisiae
    • doi:10.1371/journal.pgen.1000264
    • Yang Y, Sterling J, Storici F, Resnick MA, Gordenin DA, (2008) Hypermutability of damaged single-strand DNA formed at double-strand breaks and uncapped telomeres in yeast Saccharomyces cerevisiae. PLoS Genet 4: e1000264 doi:10.1371/journal.pgen.1000264.
    • (2008) PLoS Genet , vol.4
    • Yang, Y.1    Sterling, J.2    Storici, F.3    Resnick, M.A.4    Gordenin, D.A.5
  • 77
    • 84855551999 scopus 로고    scopus 로고
    • Mobile genetic elements and cancer. From mutations to gene therapy
    • Kozeretska IA, Demydov SV, Ostapchenko LI, (2011) Mobile genetic elements and cancer. From mutations to gene therapy. Exp Oncol 33: 198-205.
    • (2011) Exp Oncol , vol.33 , pp. 198-205
    • Kozeretska, I.A.1    Demydov, S.V.2    Ostapchenko, L.I.3
  • 78
    • 33947257997 scopus 로고    scopus 로고
    • Intrastrand annealing leads to the formation of a large DNA palindrome and determines the boundaries of genomic amplification in human cancer
    • Tanaka H, Cao Y, Bergstrom DA, Kooperberg C, Tapscott SJ, et al. (2007) Intrastrand annealing leads to the formation of a large DNA palindrome and determines the boundaries of genomic amplification in human cancer. Mol Cell Biol 27: 1993-2002.
    • (2007) Mol Cell Biol , vol.27 , pp. 1993-2002
    • Tanaka, H.1    Cao, Y.2    Bergstrom, D.A.3    Kooperberg, C.4    Tapscott, S.J.5
  • 79
    • 0023545322 scopus 로고
    • A Saccharomyces cerevisiae genomic plasmid bank based on a centromere-containing shuttle vector
    • Rose MD, Novick P, Thomas JH, Botstein D, Fink GR, (1987) A Saccharomyces cerevisiae genomic plasmid bank based on a centromere-containing shuttle vector. Gene 60: 237-243.
    • (1987) Gene , vol.60 , pp. 237-243
    • Rose, M.D.1    Novick, P.2    Thomas, J.H.3    Botstein, D.4    Fink, G.R.5


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