Hypermutability of damaged single-strand DNA formed at double-strand breaks and uncapped telomeres in yeast Saccharomyces cerevisiae

PLoS Genetics

Volumn 4, Issue 11, 2008, Pages

  Yang, Yong ^a   Sterling, Joan ^a   Storici, Francesca ^a,b   Resnick, Michael A ^a   Gordenin, Dmitry A ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MESYLIC ACID; SINGLE STRANDED DNA; FUNGAL DNA;

ALLELE; ARTICLE; CARCINOGENESIS; DNA DAMAGE; DNA SYNTHESIS; DOUBLE STRANDED DNA BREAK; MOLECULAR EVOLUTION; NONHUMAN; NUCLEOTIDE SEQUENCE; SACCHAROMYCES CEREVISIAE; TELOMERE; UBIQUITINATION; ULTRAVIOLET RADIATION; BIOLOGICAL MODEL; CHEMISTRY; DNA REPAIR; FUNGAL GENOME; GENETICS; METABOLISM; MUTAGENESIS; MUTATION; RADIATION EXPOSURE;

SACCHAROMYCES CEREVISIAE; SACCHAROMYCETALES;

DNA BREAKS, DOUBLE-STRANDED; DNA REPAIR; DNA, FUNGAL; DNA, SINGLE-STRANDED; GENOME, FUNGAL; MODELS, GENETIC; MUTAGENESIS; MUTATION; SACCHAROMYCES CEREVISIAE; TELOMERE; ULTRAVIOLET RAYS;

EID: 57149094856     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1000264     Document Type: Article

References (43)

1. Loeb LA (1991) Mutator phenotype may be required for multistage carcinogenesis. Cancer Res 51: 3075-3079.
2. Giraud A, Radman M, Matic I, Taddei F (2001) The rise and fall of mutator bacteria. Curr Opin Microbiol 4: 582-585.
3. Ninio J (1991) Transient mutators: a semiquantitative analysis of the influence of translation and transcription errors on mutation rates. Genetics 129: 957-962.
4. Drake JW (2007) Too many mutants with multiple mutations. Crit Rev Biochem Mol Biol 42: 247-258.
5. Odegard VH, Schatz DG (2006) Targeting of somatic hypermutation. Nat Rev Immunol 6: 573-583.
6. Wang J, Gonzalez KD, Scaringe WA, Tsai K, Liu N, et al. (2007) Evidence for mutation showers. Proc Natl Acad Sci U S A 104: 8403-8408.
7. He AS, Rohatgi PR, Hersh MN, Rosenberg SM (2006) Roles of E. coli double-strand-break-repair proteins in stress-induced mutation. DNA Repair (Amst) 5: 258-273.
8. Magni GE (1963) The Origin of Spontaneous Mutations During Meiosis. Proc Natl Acad Sci U S A 50: 975-980.
9. Strathern JN, Shafer BK, McGill CB (1995) DNA synthesis errors associated with double-strand-break repair. Genetics 140: 965-972.
10. Meyer DH, Bailis AM (2007) Telomere dysfunction drives increased mutation by error-prone polymerases Rev1 and zeta in Saccharomyces cerevisiae. Genetics 175: 1533-1537.
11. Harrison JC, Haber JE (2006) Surviving the breakup: the DNA damage checkpoint. Annu Rev Genet 40: 209-235.
12. Lydall D (2003) Hiding at the ends of yeast chromosomes: telomeres, nucleases and checkpoint pathways. J Cell Sci 116: 4057-4065.
13. Friedberg EC (2005) Suffering in silence: the tolerance of DNA damage. Nat Rev Mol Cell Biol 6: 943-953.
14. Harper JW, Elledge SJ (2007) The DNA damage response: ten years after. Mol Cell 28: 739-745.
15. Longhese MP (2008) DNA damage response at functional and dysfunctional telomeres. Genes Dev 22: 125-140.
16. Storici F, Snipe JR, Chan GK, Gordenin DA, Resnick MA (2006) Conservative repair of a chromosomal double-strand break by single-strand DNA through two steps of annealing. Mol Cell Biol 26: 7645-7657.
17. Rattray AJ, Shafer BK, McGill CB, Strathern JN (2002) The roles of REV3 and RAD57 in double-strand-break-repair-induced mutagenesis of Saccharomyces cerevisiae. Genetics 162: 1063-1077.
18. Gao H, Cervantes RB, Mandell EK, Otero JH, Lundblad V (2007) RPA-like proteins mediate yeast telomere function. Nat Struct Mol Biol 14: 208-214.
19. Booth C, Griffith E, Brady G, Lydall D (2001) Quantitative amplification of single-stranded DNA (QAOS) demonstrates that cdc13-1 mutants generate ssDNA in a telomere to centromere direction. Nucleic Acids Res 29: 4414-4422.
20. Louis EJ (1995) The chromosome ends of Saccharomyces cerevisiae. Yeast 11: 1553-1573.
21. Bhattacharjee JK (1985) alpha-Aminoadipate pathway for the biosynthesis of lysine in lower eukaryotes. Crit Rev Microbiol 12: 131-151.
22. Schmidt KH, Pennaneach V, Putnam CD, Kolodner RD (2006) Analysis of gross-chromosomal rearrangements in Saccharomyces cerevisiae. Methods Enzymol 409: 462-476.
23. Kozmin SG, Pavlov YI, Kunkel TA, Sage E (2003) Roles of Saccharomyces cerevisiae DNA polymerases Pol eta and Pol zeta in response to irradiation by simulated sunlight. Nucleic Acids Res 31: 4541-4552.
24. Sakamoto AN, Stone JE, Kissling GE, McCulloch SD, Pavlov YI, et al. (2007) Mutator alleles of yeast DNA polymerase zeta. DNA Repair (Amst) 6: 1829-1838.
25. Drake JW, Bebenek A, Kissling GE, Peddada S (2005) Clusters of mutations from transient hypermutability. Proc Natl Acad Sci U S A 102: 12849-12854.
26. Pfeifer GP (1997) Formation and processing of UV photoproducts: effects of DNA sequence and chromatin environment. Photochem Photobiol 65: 270-283.
27. Lawrence CW (2002) Cellular roles of DNA polymerase zeta and Rev1 protein. DNA Repair (Amst) 1: 425-435.
28. Ulrich HD (2007) Conservation of DNA damage tolerance pathways from yeast to humans. Biochem Soc Trans 35: 1334-1337.
29. Storici F, Lewis LK, Resnick MA (2001) In vivo site-directed mutagenesis using oligonucleotides. Nat Biotechnol 19: 773-776.
30. Wheatcroft R, Cox BS, Haynes RH (1975) Repair of UV-induced DNA damage and survival in yeast. I. Dimer excision. Mutat Res 30: 209-218.
31. Resnick MA, Setlow JK (1972) Repair of pyrimidine dimer damage induced in yeast by ultraviolet light. J Bacteriol 109: 979-986.
32. Bekker-Jensen S, Lukas C, Kitagawa R, Melander F, Kastan MB, et al. (2006) Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks. J Cell Biol 173: 195-206.
33. Sartori AA, Lukas C, Coates J, Mistrik M, Fu S, et al. (2007) Human CtIP promotes DNA end resection. Nature 450: 509-514.
34. Bjursell G, Gussander E, Lindahl T (1979) Long regions of single-stranded DNA in human cells. Nature 280: 420-423.
35. Cordeiro-Stone M, Makhov AM, Zaritskaya LS, Griffith JD (1999) Analysis of DNA replication forks encountering a pyrimidine dimer in the template to the leading strand. J Mol Biol 289: 1207-1218.
36. Lopes M, Foiani M, Sogo JM (2006) Multiple mechanisms control chromosome integrity after replication fork uncoupling and restart at irreparable UV lesions. Mol Cell 21: 15-27.
37. Colgin LM, Hackmann AF, Emond MJ, Monnat RJ Jr (2002) The unexpected landscape of in vivo somatic mutation in a human epithelial cell lineage. Proc Natl Acad Sci U S A 99: 1437-1442.
38. Camps M, Herman A, Loh E, Loeb LA (2007) Genetic constraints on protein evolution. Crit Rev Biochem Mol Biol 42: 313-326.
39. Jin YH, Clark AB, Slebos RJ, Al-Refai H, Taylor JA, et al. (2003) Cadmium is a mutagen that acts by inhibiting mismatch repair. Nat Genet 34: 326-329.
40. Storici F, Durham CL, Gordenin DA, Resnick MA (2003) Chromosomal site-specific double-strand breaks are efficiently targeted for repair by oligonucleotides in yeast. Proc Natl Acad Sci U S A 100: 14994-14999.
41. Storici F, Resnick MA (2006) The delitto perfetto approach to in vivo site-directed mutagenesis and chromosome rearrangements with synthetic oligonucleotides in yeast. Methods Enzymol 409: 329-345.
42. Goldstein AL, McCusker JH (1999) Three new dominant drug resistance cassettes for gene disruption in Saccharomyces cerevisiae. Yeast 15: 1541-1553.
43. Northam MR, Garg P, Baitin DM, Burgers PM, Shcherbakova PV (2006) A novel function of DNA polymerase zeta regulated by PCNA. EMBO J 25: 4316-4325.