Gonadal hormones do not account for sexual dimorphism in vagal modulation of nociception in the rat

Journal of Pain

Volumn 4, Issue 4, 2003, Pages 190-196

  Khasar, Sachia G ^b   Green, Paul G ^b   Gear, Robert W ^b   Isenberg, William ^b   Levine, Jon D ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Hyperalgesia; Nociception; Sex hormones; Vagotomy

Indexed keywords

ANDROSTANOLONE; BRADYKININ; ESTRADIOL; PROSTAGLANDIN E2; SEX HORMONE; TESTOSTERONE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; FEMALE; FUNCTION TEST; GONADECTOMY; HORMONE SUBSTITUTION; HYPERALGESIA; MALE; NEUROMODULATION; NOCICEPTION; NONHUMAN; PAIN THRESHOLD; PAW WITHDRAWAL TEST; RAT; SEX DIFFERENCE; SEXUAL MATURATION; VAGOTOMY; VAGUS NERVE; WITHDRAWAL REFLEX;

EID: 0037642241     PISSN: 15265900     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1526-5900(03)00560-1     Document Type: Article

References (15)

1. Aley KO, McCarter G, Levine JD: Nitric oxide signaling in pain and nociceptor sensitization in the rat. J Neurosci 18: 7008-7014, 1998
2. Bradshaw H, Miller J, Ling Q, Malsnee K, Ruda MA: Sex differences and phases of the estrous cycle alter the response of spinal cord dynorphin neurons to peripheral inflammation and hyperalgesia. Pain 85:93-99, 2000
3. Dina OA, Aley KO, Isenberg W, Messing RO, Levine JD: Sex hormones regulate the contribution of PKCepsilon and PKA signalling in inflammatory pain in the rat. Eur J Neurosci 13:2227-2233, 2001
4. Khasar SG, Miao FJ-P, Gear RW, Green PG, Isenberg WM, Levine JD: Sympathetic-independent bradykinin mechanical hyperalgesia induced by subdiaphragmatic vagotomy in the rat. J Pain 3:369-376, 2002
5. Khasar SG, Miao FJ-P, Jänig W, Levine JD: Modulation of bradykinin-induced mechanical hyperalgesia in the rat by activity in abdominal vagal afferents. Eur J Neurosci 10:435-444, 1998
6. Levine JD, Taiwo YO, Collins SD, Tam JK: Noradrenaline hyperalgesia is mediated through interaction with sympathetic postganglionic neurone terminals rather than activation of primary afferent nociceptors. Nature 323:158-160, 1986
7. Papka RE, Srinivasan B, Miller KE, Hayashi S: Localization of estrogen receptor protein and estrogen receptor messenger RNA in peripheral autonomic and sensory neurons. Neuroscience 79:1153-1163, 1997
8. Papka RE, Storey-Workley M, Shughrue PJ, Merchenthaler I, Collins JJ, Usip S, Saunders PT, Shupnik M: Estrogen receptor-alpha and beta-immunoreactivity and mRNA in neurons of sensory and autonomic ganglia and spinal cord. Cell Tissue Res 304:193-214, 2001
9. Smith ER, Damassa DA, Davidson JM. Hormone administration: peripheral and intracranial implants. In Myers RD (ed): Methods in Psychobiology. Academic Press, New York, NY, 1977, pp 259-279
10. Sun YT, Irby DC, Robertson DM, de Kretser DM: The effects of exogenously administered testosterone on spermatogenesis in intact and hypophysectomized rats. Endocrinology 125:1000-1010, 1989
11. Taiwo YO, Coderre TJ, Levine JD: The contribution of training to sensitivity in the nociceptive paw-withdrawal test. Brain Res 487:148-151, 1989
12. Taiwo YO, Goetzl EJ, Levine JD: Hyperalgesia onset latency suggests a hierarchy of action. Brain Res 423:333-337, 1987
13. Taiwo YO, Levine JD: Prostaglandin effects after elimination of indirect hyperalgesic mechanisms in the skin of the rat. Brain Res 492:397-399, 1989
14. Tall JM, Stuesse SL, Cruce WL, Crisp T: Gender and the behavioral manifestations of neuropathic pain. Pharmacol Biochem Behav 68:99-104, 2001
15. Waynforth HB and Flecknell PA. Experimental and surgical technique in the rat. Academic Press, London, UK, 1992