Sex differences in the brain: The not so inconvenient truth

Journal of Neuroscience

Volumn 32, Issue 7, 2012, Pages 2241-2247

  McCarthy, Margaret M ^a   Arnold, Arthur P ^b   Ball, Gregory F ^c   Blaustein, Jeffrey D ^d   de Vries, Geert J ^d  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c JOHNS HOPKINS UNIVERSITY   (United States)

^d UNIVERSITY OF MASSACHUSETTS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SEX HORMONE;

ANXIETY; ARTICLE; BRAIN; ESTRUS CYCLE; GENOTYPE; GONADECTOMY; HORMONE ACTION; HUMAN; LEARNING TEST; MENSTRUAL CYCLE; MENTAL STRESS; MOOD DISORDER; PHYSICAL STRESS; PRIORITY JOURNAL; REPRODUCTION; SEX CHROMOSOME; SEX DIFFERENCE; SEXUAL DEVELOPMENT;

ANIMALS; BRAIN; CLINICAL TRIALS AS TOPIC; FEMALE; HUMANS; MALE; SEX CHARACTERISTICS;

EID: 84857069883     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.5372-11.2012     Document Type: Article

References (41)

1. Abel KM, Drake R, Goldstein JM (2010) Sex differences in schizophrenia. Int Rev Psychiatry 22:417-428.
2. Amateau SK, McCarthy MM (2004) Induction of PGE(2) by estradiol mediates developmental masculinization of sex behavior. Nat Neurosci 7:643-650.
3. Arnold AP, Wade J, Grisham W, Jacobs EC, Campagnoni AT (1996) Sexual differentiation of the brain in songbirds. Dev Neurosci 18:124-136.
4. Arnold AP, Burgoyne PS (2004) Are XX and XY brain cells intrinsically different? Trends Endocrinol Metab 15:6-11.
5. Arnold AP, Chen X (2009) What does the "four core genotypes" mouse model tell us about sex differences in the brain and other tissues? Front Neuroendocrinol 30:1-9.
6. Baron-Cohen S, Knickmeyer RC, Belmonte MK (2005) Sex differences in the brain: implications for explaining autism. Science 310:819-823.
7. Becker JB, Breedlove SM, Crews D, McCarthy MM (2002) Behavioral endocrinology, Ed 2. Cambridge, MA: MIT.
8. Becker JB, Arnold AP, Berkley KJ, Blaustein JD, Eckel LA, Hampson E, Herman JP, Marts S, Sadee W, Steiner M, Taylor J, Young E (2005) Strategies and methods for research on sex differences in brain and behavior. Endocrinology 146:1650-1673.
9. Beery AK, Zucker I (2011) Sex bias in neuroscience and biomedical research. Neurosci Biobehav Rev 35:565-572.
10. Beiko J, Lander R, Hampson E, Boon F, Cain DP (2004) Contribution of sex differences in the acute stress response to sex differences in water maze performance. Behav Brain Res 151:239-253.
11. Breedlove SM (2010) Minireview: Organizational hypothesis: instances of the fingerpost. Endocrinology 151:4116-4122.
12. Büdefeld T, Grgurevic N, Tobet SA, Majdic G (2008) Sex differences in brain developing in the presence or absence of gonads. Dev Neurobiol 68:981-995.
13. Cahill L (2006) Why sex matters for neuroscience. Nat Rev Neurosci 7:477-484.
14. Carruth LL, Reisert I, Arnold AP (2002) Sex chromosome genes directly affect brain sexual differentiation. Nat Neurosci 5:933-934.
15. Dao DT, Mahon PB, Cai X, Kovacsics CE, Blackwell RA, Arad M, Shi J, Zandi PP, O'Donnell P, Knowles JA, Weissman MM, Coryell W, Scheftner WA, Lawson WB, Levinson DF, Thompson SM, Potash JB, Gould TD (2010) Mood disorder susceptibility gene CACNA1C modifies mood-related behaviors in mice and interacts with sex to influence behavior in mice and diagnosis in humans. Biol Psychiatry 68:801-810.
16. De Vries GJ (2004) Minireview: Sex differences in adult and developing brains: compensation, compensation, compensation. Endocrinology 145:1063-1068.
17. De Vries GJ, Simerly RB (2002) Anatomy, development and function of sexually dimorphic neural circuits in the mammalian brain. In: Hormones, brain and behavior, Vol 4 (Pfaff DW, Arnold AP, Etgen AM, Fahrbach SE, Rubin RT, eds), pp 137-192. New York: Academic.
18. De Vries GJ, Rissman EF, Simerly RB, Yang LY, Scordalakes EM, Auger CJ, Swain A, Lovell- Badge R, Burgoyne PS, Arnold AP (2002) A model system for study of sex chromosome effects on sexually dimorphic neural and behavioral traits. J Neurosci 22:9005-9014.
19. Dewing P, Chiang CW, Sinchak K, Sim H, Fernagut PO, Kelly S, Chesselet MF, Micevych PE, Albrecht KH, Harley VR, Vilain E (2006) Direct regulation of adult brain function by the male-specific factor SRY. Curr Biol 16:415-420.
20. Forger NG (2009) The organizational hypothesis and final common pathways: Sexual differentiation of the spinal cord and peripheral nervous system. Horm Behav 55:605-610.
21. Gregg C, Zhang J, Butler JE, Haig D, Dulac C (2010) Sex-specific parent-of-origin allelic expression in the mouse brain. Science 329: 682-685.
22. Hines M (2010) Sex-related variation in human behavior and the brain. Trends Cogn Sci 14:448-456.
23. Jazin E, Cahill L (2010) Sex differences in molecular neuroscience: from fruit flies to humans. Nat Rev Neurosci 11:9-17.
24. McCarthy M, De Vries G, Forger N (2009) Sexual differentiation of the brain: Mode, mechanisms and meaning. In: Hormones, brain and behavior, Vol 3 (Pfaff D, Arnold AP, Etgen AM, Fahrbach SE, Rubin RT, eds), pp 1707-1744. San Diego: Academic.
25. McCarthy MM, Arnold AP (2011) Reframing sexual differentiation of the brain. Nat Neurosci 14:677-683.
26. McCarthy MM, Konkle AT (2005) When is a sex difference not a sex difference? Front Neuroendocrinol 26:85-102.
27. Mogil JS, Chanda ML (2005) The case for the inclusion of female subjects in basic science studies of pain. Pain 117:1-5.
28. Morris JA, Jordan CL, Breedlove SM (2004) Sexual differentiation of the vertebrate nervous system. Nat Neurosci 7:1034-1039.
29. Naftolin F, Ryan KJ, Davies IJ, Reddy VV, Flores F, Petro Z, Kuhn M, White RJ, Takaoka Y, Wolin L (1975) The formation of estrogens by central neuroendocrine tissues. Recent Prog Horm Res 31:295-319.
30. National Institute of Mental Health (2011) Sex differences in brain, behavior, mental health and mental disorders. Workshop. Bethesda, MD, February. http://www.nimh.nih.gov/research-funding/scientific-meetings/2011/sexdifferences- in-brain-behavior-mental-healthand- mental-disorders/index.shtml.
31. Nordeen EJ, Nordeen KW, Sengelaub DR, Arnold AP (1985) Androgens prevent normally occurring cell death in a sexually dimorphic spinal nucleus. Science 229:671-673.
32. Nottebohm F, Liu WC (2010) The origins of vocal learning: new sounds, new circuits, new cells. Brain Lang 115:3-17.
33. Nuñez JL, McCarthy MM (2009) Resting intracellular calcium concentration, depolarizing GABA and possible role of local estradiol synthesis in the developing male and female hippocampus. Neuroscience 158:623-634.
34. Perrot-Sinal TS, Kostenuik MA, Ossenkopp KP, Kavaliers M (1996) Sex differences in performance intheMorriswatermazeandthe effects of initial nonstationary hidden platform training. Behav Neurosci 110:1309-1320.
35. Pfaff DW, Arnold AP, Etgen AM, Fahrback SE, Rubin RT (2002) Hormones, brain and behavior. San Diego: Academic.
36. Shors TJ, Chua C, Falduto J (2001) Sex differences and opposite effects of stress on dendritic spine density in the male versus female hippocampus. J Neurosci 21:6292-6297.
37. Simerly RB (2002) Wired for reproduction: Organization and development of sexually dimorphic circuits in the mammalian forebrain. Annu Rev Neurosci 25:507-536.
38. Sisk CL, Zehr JL (2005) Pubertal hormones organize the adolescent brain and behavior. Front Neuroendocrinol 26:163-174.
39. Wade J, Arnold AP (2004) Sexual differentiation of the zebra finch song system. Ann N Y Acad Sci 1016:540-559.
40. Wizemann TM, Pardu ML (2001) Exploring the biological contributions to human health. Does sex matter? Washington DC: National Academies.
41. Zucker I, Beery AK (2010) Males still dominate animal studies. Nature 465:690.