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Volumn 14, Issue 3, 2007, Pages 148-156

Supportive evidence for the anticancerous potential of alternative medicine against hepatocarcinogenesis in mice

Author keywords

Anticarcinogenesis; CAM; Homeopathy; Lycopodium clavatum; Physicochemical parameters; Toxicity biomarkers

Indexed keywords

4 DIMETHYLAMINOAZOBENZENE; ALANINE; ALCOHOL; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; CARCINOGEN; CATALASE; CHOLESTEROL; ESTRADIOL; GLUCOSE; GLUTATHIONE; GLUTATHIONE REDUCTASE; HEMOGLOBIN; HERBACEOUS AGENT; HYDROCORTISONE; PHENOBARBITAL; SUCCINATE DEHYDROGENASE; TESTOSTERONE;

EID: 34347333414     PISSN: 16614119     EISSN: 16614127     Source Type: Journal    
DOI: 10.1159/000103280     Document Type: Article
Times cited : (27)

References (66)
  • 2
    • 0141817894 scopus 로고    scopus 로고
    • The current position of complementary/alternative medicine in cancer
    • Ernst E: The current position of complementary/alternative medicine in cancer. Eur J Cancer 2003;39: 2273-2277.
    • (2003) Eur J Cancer , vol.39 , pp. 2273-2277
    • Ernst, E.1
  • 3
    • 0032209571 scopus 로고    scopus 로고
    • A trial method for assessing the adequacy of acupuncture treatments
    • White AR, Ernst E: A trial method for assessing the adequacy of acupuncture treatments. Altern Ther Health Med 1998;4:66-71.
    • (1998) Altern Ther Health Med , vol.4 , pp. 66-71
    • White, A.R.1    Ernst, E.2
  • 4
    • 23944509001 scopus 로고    scopus 로고
    • Are the clinical effects of homeopathy placebo effects? Comparative study of placebo controlled trials of homeopathy and allopathy
    • Shang A, Huwiler-Muntener K, Nartey L, Juni P, Dorig S, Sterne JA, Pewsner D, Egger M: Are the clinical effects of homeopathy placebo effects? Comparative study of placebo controlled trials of homeopathy and allopathy. Lancet 2005;366: 726-732.
    • (2005) Lancet , vol.366 , pp. 726-732
    • Shang, A.1    Huwiler-Muntener, K.2    Nartey, L.3    Juni, P.4    Dorig, S.5    Sterne, J.A.6    Pewsner, D.7    Egger, M.8
  • 5
    • 34347334711 scopus 로고
    • Research in Homeopathy - a Bibliography
    • Fisher P ed, ed 8
    • Fisher P (ed): Research in Homeopathy - a Bibliography, ed 8. Royal London Homeopathic Hospital, 1992.
    • (1992) Royal London Homeopathic Hospital
  • 6
    • 0028359243 scopus 로고
    • Critical review and meta-analysis of serial agitated dilutions in experimental toxicology
    • Linde K, Jonas WB, Worke DMF, Wagner H, Eifel F: Critical review and meta-analysis of serial agitated dilutions in experimental toxicology. Hum Exp Toxicol 1994;13:481-492.
    • (1994) Hum Exp Toxicol , vol.13 , pp. 481-492
    • Linde, K.1    Jonas, W.B.2    Worke, D.M.F.3    Wagner, H.4    Eifel, F.5
  • 7
    • 28444450816 scopus 로고    scopus 로고
    • Efficacy of the potentized homeopathic drug, Carcinosin-200, fed alone and in combination with another drug, Chelidonium 200, in amelioration of p-DAB induced hepatocarcinogenesis in mice
    • Biswas SJ, Pathak S, Bhattacharjee N, Das JK, Khuda-Bukhsh AR: Efficacy of the potentized homeopathic drug, Carcinosin-200, fed alone and in combination with another drug, Chelidonium 200, in amelioration of p-DAB induced hepatocarcinogenesis in mice. J Altern Complement Med 2005; 11:839-854.
    • (2005) J Altern Complement Med , vol.11 , pp. 839-854
    • Biswas, S.J.1    Pathak, S.2    Bhattacharjee, N.3    Das, J.K.4    Khuda-Bukhsh, A.R.5
  • 8
    • 2442672276 scopus 로고    scopus 로고
    • Effect of homeopathic drug, Chelidonium, in amelioration of p-DAB induced hepatocarcinogenesis in mice
    • Biswas SJ, Khuda-Bukhsh AR: Effect of homeopathic drug, Chelidonium, in amelioration of p-DAB induced hepatocarcinogenesis in mice. BMC Complement Altern Med 2002;2:1-12.
    • (2002) BMC Complement Altern Med , vol.2 , pp. 1-12
    • Biswas, S.J.1    Khuda-Bukhsh, A.R.2
  • 9
    • 21444460724 scopus 로고    scopus 로고
    • Hahnemann's legacy in a new light - a systematic approach to the Organon of Medicine
    • Schmidt JM: Hahnemann's legacy in a new light - a systematic approach to the Organon of Medicine. Homoepathy 2005;94:202-206.
    • (2005) Homoepathy , vol.94 , pp. 202-206
    • Schmidt, J.M.1
  • 11
    • 33646191834 scopus 로고    scopus 로고
    • Protective potentials of a potentized homeopathic drug, Lycopodium-30, in ameliorating azo dye induced hepatocarcinogenesis in mice
    • Pathak S, Das JK, Biswas SJ, Khuda-Bukhsh AR: Protective potentials of a potentized homeopathic drug, Lycopodium-30, in ameliorating azo dye induced hepatocarcinogenesis in mice. Mol Cell Biochem 2006;285:121-131.
    • (2006) Mol Cell Biochem , vol.285 , pp. 121-131
    • Pathak, S.1    Das, J.K.2    Biswas, S.J.3    Khuda-Bukhsh, A.R.4
  • 12
    • 0028024703 scopus 로고
    • Inhibitory effect of sialoadenectomy on hepatocellular tumorigenesis in male mice induced by 3'-methyl-4-dimethylaminoazobenzene
    • Yamamoto R, Iishi H, Tatsuta M, Tsuji M, Terada N: Inhibitory effect of sialoadenectomy on hepatocellular tumorigenesis in male mice induced by 3'-methyl-4-dimethylaminoazobenzene. Virchows Arch 1994;425:79-82.
    • (1994) Virchows Arch , vol.425 , pp. 79-82
    • Yamamoto, R.1    Iishi, H.2    Tatsuta, M.3    Tsuji, M.4    Terada, N.5
  • 13
    • 0029006946 scopus 로고
    • Correlation between serum prolactin levels and hepatocellular tumorigenesis induced by 3'-methyl-4-imethylaminoazobenzene in mice
    • Yamamoto R, Iishi H, Tatsuta M, Yamamoto T, Koike K, Kanda Y, Miyaki A, Tsuji M, Terada N: Correlation between serum prolactin levels and hepatocellular tumorigenesis induced by 3'-methyl-4-imethylaminoazobenzene in mice. Br J Cancer 1995;72:17-21.
    • (1995) Br J Cancer , vol.72 , pp. 17-21
    • Yamamoto, R.1    Iishi, H.2    Tatsuta, M.3    Yamamoto, T.4    Koike, K.5    Kanda, Y.6    Miyaki, A.7    Tsuji, M.8    Terada, N.9
  • 14
    • 0017373204 scopus 로고
    • Enhancement of azo-dye hepatocarcinogenesis with dietary phenobarbital in rats
    • Kitagawa T, Sugano H: Enhancement of azo-dye hepatocarcinogenesis with dietary phenobarbital in rats. Gann 1977;68:255-256.
    • (1977) Gann , vol.68 , pp. 255-256
    • Kitagawa, T.1    Sugano, H.2
  • 15
    • 8644283540 scopus 로고    scopus 로고
    • Assessment of the genotoxic and cytotoxic potential of an antiepileptic drug Phenobarbital, in mice: A time course study
    • Biswas SJ, Pathak S, Khuda-Bukhsh AR: Assessment of the genotoxic and cytotoxic potential of an antiepileptic drug Phenobarbital, in mice: A time course study. Mutation Res 2004;563:1-11.
    • (2004) Mutation Res , vol.563 , pp. 1-11
    • Biswas, S.J.1    Pathak, S.2    Khuda-Bukhsh, A.R.3
  • 16
    • 0001979310 scopus 로고
    • The micronucleus test for cytogenetic analysis
    • Hollaender AE ed, New York, Plenum
    • Schmid W: The micronucleus test for cytogenetic analysis; in Hollaender AE (ed): Chemical Mutagens: Principles and Methods of Detection. New York, Plenum, 1976, p 31.
    • (1976) Chemical Mutagens: Principles and Methods of Detection , pp. 31
    • Schmid, W.1
  • 17
    • 0009522517 scopus 로고
    • Handbook of mutagenecity testing protocols
    • Kilbey BJ, Legator M, Nichols W, Ramel C eds, Amsterdam, Elsevier
    • Wyrobek AJ, Watchmaker G, Gordon L: Handbook of mutagenecity testing protocols; in Kilbey BJ, Legator M, Nichols W, Ramel C (eds): Handbook of Mutagenicity Test Procedures Amsterdam, Elsevier, 1984, pp 733-750.
    • (1984) Handbook of Mutagenicity Test Procedures , pp. 733-750
    • Wyrobek, A.J.1    Watchmaker, G.2    Gordon, L.3
  • 19
    • 34347340845 scopus 로고    scopus 로고
    • Beutler E: Red Cell Metabolism - Manual of Biochemical Methods. New York, Grune and Stratton, 1975, pp 69-70
    • Beutler E: Red Cell Metabolism - Manual of Biochemical Methods. New York, Grune and Stratton, 1975, pp 69-70
  • 20
    • 84958688743 scopus 로고
    • The effect of fluoride on succinic oxidase system
    • Slater EC, Bonner WD: The effect of fluoride on succinic oxidase system. Biochem J 1952;52: 185-196.
    • (1952) Biochem J , vol.52 , pp. 185-196
    • Slater, E.C.1    Bonner, W.D.2
  • 21
    • 77957006400 scopus 로고
    • Assay of catalase and peroxidase
    • Chance B, Maehly AC: Assay of catalase and peroxidase. Methods Enzymol 1955;2:764-775.
    • (1955) Methods Enzymol , vol.2 , pp. 764-775
    • Chance, B.1    Maehly, A.C.2
  • 22
    • 34249735959 scopus 로고    scopus 로고
    • Assessment of hepatocellular damage and hematological alterations in mice chronically fed p-dimethylaminoazobenzene and phenobarbital
    • doi:10.1016/j. yexmp.2006.10.003
    • Pathak S, Khuda-Bukhsh AR: Assessment of hepatocellular damage and hematological alterations in mice chronically fed p-dimethylaminoazobenzene and phenobarbital. Exp Mol Pathol doi:10.1016/j. yexmp.2006.10.003.
    • Exp Mol Pathol
    • Pathak, S.1    Khuda-Bukhsh, A.R.2
  • 24
    • 0026039082 scopus 로고
    • Human fibroblasts contain a proteolytic activity, which is inhibited by the Bowman-Birk protease inhibitor
    • Billings PC, Habres JM, Liao DC, Tuttle SW: Human fibroblasts contain a proteolytic activity, which is inhibited by the Bowman-Birk protease inhibitor. Cancer Res 1991;51:5539-5543.
    • (1991) Cancer Res , vol.51 , pp. 5539-5543
    • Billings, P.C.1    Habres, J.M.2    Liao, D.C.3    Tuttle, S.W.4
  • 26
    • 0027931826 scopus 로고
    • Non-random distribution of mutagen induced chromosome breaks in lymphocytes of patients with different malignancies
    • Dave BJ, Hsu TC, Hong WK, Pathak S: Non-random distribution of mutagen induced chromosome breaks in lymphocytes of patients with different malignancies. Int J Oncol 1994;5:733-740.
    • (1994) Int J Oncol , vol.5 , pp. 733-740
    • Dave, B.J.1    Hsu, T.C.2    Hong, W.K.3    Pathak, S.4
  • 29
    • 0029135252 scopus 로고
    • Effect of administering cyclophosphamide and vitamin E on the levels of tumor-marker enzymes in rats with experimentally induced fibrosarcoma
    • Vinitha R, Thangaraju M, Sachdanandam P: Effect of administering cyclophosphamide and vitamin E on the levels of tumor-marker enzymes in rats with experimentally induced fibrosarcoma. Jap J Med Sci Biol 1995;48:145-156.
    • (1995) Jap J Med Sci Biol , vol.48 , pp. 145-156
    • Vinitha, R.1    Thangaraju, M.2    Sachdanandam, P.3
  • 31
    • 0025425377 scopus 로고
    • Increased serum alanine aminotransferase activity associated with muscle necrosis in the dog
    • Valentine BA, Blue JT, Shelley SM, Cooper BJ: Increased serum alanine aminotransferase activity associated with muscle necrosis in the dog. J Vet Intern Med 1990;4:140-143.
    • (1990) J Vet Intern Med , vol.4 , pp. 140-143
    • Valentine, B.A.1    Blue, J.T.2    Shelley, S.M.3    Cooper, B.J.4
  • 33
    • 3042805454 scopus 로고    scopus 로고
    • Evaluation of protective potentials of a potentized homeopathic drug, Chelidonium majus, during azo dye induced hepatocarcinogenesis in mice
    • Biswas SJ, Khuda-Bukhsh AR: Evaluation of protective potentials of a potentized homeopathic drug, Chelidonium majus, during azo dye induced hepatocarcinogenesis in mice. Ind J Exp Biol 2004; 42:698-714.
    • (2004) Ind J Exp Biol , vol.42 , pp. 698-714
    • Biswas, S.J.1    Khuda-Bukhsh, A.R.2
  • 34
    • 33646205797 scopus 로고    scopus 로고
    • Evaluation of protective potential of a crude plant extract (Chelidonium majus) against p-dimethylaminoazobenzene induced hepatocarcinogenesis in mice
    • Nice, France, Feb. 7-10
    • Biswas SJ, Khuda-Bukhsh AR: Evaluation of protective potential of a crude plant extract (Chelidonium majus) against p-dimethylaminoazobenzene induced hepatocarcinogenesis in mice. 7th Int Symp Predict Oncol Intervent Strat, Nice, France, Feb. 7-10, 2004.
    • (2004) 7th Int Symp Predict Oncol Intervent Strat
    • Biswas, S.J.1    Khuda-Bukhsh, A.R.2
  • 35
    • 0016665355 scopus 로고
    • Cell proliferation and sub cellular localization of alkaline phosphatase activity in rat liver parenchyma during azo dye carcinogenesis
    • Karasaki S: Cell proliferation and sub cellular localization of alkaline phosphatase activity in rat liver parenchyma during azo dye carcinogenesis. Cancer Res 1975;35:482-491.
    • (1975) Cancer Res , vol.35 , pp. 482-491
    • Karasaki, S.1
  • 36
    • 0028008362 scopus 로고
    • Drought-stress-induced change in activities of superoxide dismutase, catalase, and peroxidase in wheat species
    • Zhang JX, Kirkham MB: Drought-stress-induced change in activities of superoxide dismutase, catalase, and peroxidase in wheat species. Plant Cell Physiol 1994;35:785-791.
    • (1994) Plant Cell Physiol , vol.35 , pp. 785-791
    • Zhang, J.X.1    Kirkham, M.B.2
  • 37
    • 0019819815 scopus 로고
    • Succinate dehydrogenase - a comparative review
    • Hederstedt L, Rutberg L: Succinate dehydrogenase - a comparative review. Microbiol Rev 1981;45: 542-555.
    • (1981) Microbiol Rev , vol.45 , pp. 542-555
    • Hederstedt, L.1    Rutberg, L.2
  • 38
    • 0017289014 scopus 로고
    • An optimized semi-automatic method for serum glutathione reductase activity and its application to patients with malignant disease
    • Delides A, Richard JS, David MG, Frank EN: An optimized semi-automatic method for serum glutathione reductase activity and its application to patients with malignant disease. J Clin Pathol 1976; 29:73-77.
    • (1976) J Clin Pathol , vol.29 , pp. 73-77
    • Delides, A.1    Richard, J.S.2    David, M.G.3    Frank, E.N.4
  • 40
    • 33646372714 scopus 로고    scopus 로고
    • Jiang J, Nilsson-Ehle P, Xu N: Influence of liver cancer on lipid and lipoprotein metabolism. Review. Lipids Health Dis 2006, doi: 10.1186/1476-511X-5-4.
    • Jiang J, Nilsson-Ehle P, Xu N: Influence of liver cancer on lipid and lipoprotein metabolism. Review. Lipids Health Dis 2006, doi: 10.1186/1476-511X-5-4.
  • 42
    • 0027969252 scopus 로고
    • Di(2-ethylhexyl)phthalate-induced changes in liver estrogen metabolism and hyperplasia
    • Eagon PK, Chandar N, Epley MJ, Elm MS, Brady EP, Rao KN: Di(2-ethylhexyl)phthalate-induced changes in liver estrogen metabolism and hyperplasia. Int J Cancer 1994;58(5):736-743.
    • (1994) Int J Cancer , vol.58 , Issue.5 , pp. 736-743
    • Eagon, P.K.1    Chandar, N.2    Epley, M.J.3    Elm, M.S.4    Brady, E.P.5    Rao, K.N.6
  • 43
    • 0027380018 scopus 로고
    • Suppressive effect of estrogen on hepatocellular tumorigenesis induced in mice by 3'-methyl-4- dimethylaminoazobenzene
    • Yamamoto R, Iishi H, Tatsuta M, Tsuji M, Terada N: Suppressive effect of estrogen on hepatocellular tumorigenesis induced in mice by 3'-methyl-4- dimethylaminoazobenzene. Exp Toxicol Pathol 1993;45:325-328.
    • (1993) Exp Toxicol Pathol , vol.45 , pp. 325-328
    • Yamamoto, R.1    Iishi, H.2    Tatsuta, M.3    Tsuji, M.4    Terada, N.5
  • 44
    • 0025788510 scopus 로고
    • Roles of ovaries and testes in hepatocellular tumorigenesis induced in mice by 3'-methyl-4- dimethylaminoazobenzene
    • Yamamoto R, Iishi H, Tatsuta M, Tsuji M, Terada N: Roles of ovaries and testes in hepatocellular tumorigenesis induced in mice by 3'-methyl-4- dimethylaminoazobenzene. Int J Cancer 1991;49: 83-88.
    • (1991) Int J Cancer , vol.49 , pp. 83-88
    • Yamamoto, R.1    Iishi, H.2    Tatsuta, M.3    Tsuji, M.4    Terada, N.5
  • 45
    • 0026663161 scopus 로고
    • Promoting effect of ovariectomy on hepatocellular tumorigenesis induced in mice by 3'-methyl-4-dimethylaminoazobenzene
    • Tsutsui S, Yamamoto R, Iishi H, Tatsuta M, Tsuji M, Terada N: Promoting effect of ovariectomy on hepatocellular tumorigenesis induced in mice by 3'-methyl-4-dimethylaminoazobenzene. Virchows Arch. B Cell Pathol 1992;62:371-375.
    • (1992) Virchows Arch. B Cell Pathol , vol.62 , pp. 371-375
    • Tsutsui, S.1    Yamamoto, R.2    Iishi, H.3    Tatsuta, M.4    Tsuji, M.5    Terada, N.6
  • 47
    • 0030941458 scopus 로고    scopus 로고
    • p53, the cellular gatekeeper for growth and division
    • Levine AJ: p53, the cellular gatekeeper for growth and division. Cell 1997;88:323-331.
    • (1997) Cell , vol.88 , pp. 323-331
    • Levine, A.J.1
  • 48
    • 0032931517 scopus 로고    scopus 로고
    • The p53 pathway
    • Prives C, Hall PA: The p53 pathway. J Pathol 1999; 187:112-126.
    • (1999) J Pathol , vol.187 , pp. 112-126
    • Prives, C.1    Hall, P.A.2
  • 49
    • 0036674617 scopus 로고    scopus 로고
    • Live or let die: The cell's response to p53
    • Vousden KH, Lu X: Live or let die: the cell's response to p53. Nat Rev Cancer 2002;2:594-604.
    • (2002) Nat Rev Cancer , vol.2 , pp. 594-604
    • Vousden, K.H.1    Lu, X.2
  • 50
    • 0033552640 scopus 로고    scopus 로고
    • Mechanism of switching on p53: A role of covalent modification
    • Meek DW: Mechanism of switching on p53: a role of covalent modification. Oncogene 1999;18: 7666-7675.
    • (1999) Oncogene , vol.18 , pp. 7666-7675
    • Meek, D.W.1
  • 51
    • 0034818446 scopus 로고    scopus 로고
    • Post-transcriptional modifications and activation of p53 by genotoxic stresses
    • Appella E, Anderson AW: Post-transcriptional modifications and activation of p53 by genotoxic stresses. Eur J Biochem 2001;268:2764-2772.
    • (2001) Eur J Biochem , vol.268 , pp. 2764-2772
    • Appella, E.1    Anderson, A.W.2
  • 52
    • 0037737758 scopus 로고    scopus 로고
    • Regulation of p53 responses post-transcriptional modifications
    • Xu Y: Regulation of p53 responses post-transcriptional modifications. Cell Death Differ 2003;10: 400-403.
    • (2003) Cell Death Differ , vol.10 , pp. 400-403
    • Xu, Y.1
  • 53
    • 34347324287 scopus 로고    scopus 로고
    • Biswas SJ: On the efficacy and mechanisms of action of certain potentized homeopathic drugs: An interdisciplinary experimental approach through induced hepatocarcinogenesis and ultrasonication in mice. University of Kalyani, India, unpublished PhD thesis, 2002.
    • Biswas SJ: On the efficacy and mechanisms of action of certain potentized homeopathic drugs: An interdisciplinary experimental approach through induced hepatocarcinogenesis and ultrasonication in mice. University of Kalyani, India, unpublished PhD thesis, 2002.
  • 55
    • 34347338957 scopus 로고    scopus 로고
    • Datta S, Biswas SJ, Khuda-Bukhsh AR: Comparative efficacy of pre-, post- and combined pre- and post feeding of two microdoses of a potentized homeopathic drug, Mercurius solubilis, in ameliorating genotoxic effects produced by mercuric chloride in mice. eCAM 2004;1:291-300.
    • Datta S, Biswas SJ, Khuda-Bukhsh AR: Comparative efficacy of pre-, post- and combined pre- and post feeding of two microdoses of a potentized homeopathic drug, Mercurius solubilis, in ameliorating genotoxic effects produced by mercuric chloride in mice. eCAM 2004;1:291-300.
  • 59
    • 0002273999 scopus 로고
    • NMR-features that relate to homeopathic sulphur potencies
    • Weingartner O: NMR-features that relate to homeopathic sulphur potencies. Berlin J Res Hom 1990; 1:61-68.
    • (1990) Berlin J Res Hom , vol.1 , pp. 61-68
    • Weingartner, O.1
  • 60
    • 0141565084 scopus 로고    scopus 로고
    • Entanglement model of homeopathy as an example of generalized entanglement predicted by weak quantum theory
    • Walach H: Entanglement model of homeopathy as an example of generalized entanglement predicted by weak quantum theory. Forsch Komplementärmed Klass Naturheilkd 2003;10:192-200.
    • (2003) Forsch Komplementärmed Klass Naturheilkd , vol.10 , pp. 192-200
    • Walach, H.1
  • 64
    • 33750861301 scopus 로고    scopus 로고
    • Laboratory research in homeopathy: Pro
    • Khuda-Bukhsh AR: Laboratory research in homeopathy: Pro. Integr Cancer Ther 2006;5:320-332.
    • (2006) Integr Cancer Ther , vol.5 , pp. 320-332
    • Khuda-Bukhsh, A.R.1
  • 65
    • 0030970288 scopus 로고    scopus 로고
    • Potentized homeopathic drugs act through regulation of gene-expression: A hypothesis to explain their mechanism and pathways of action in vivo
    • Khuda-Bukhsh AR: Potentized homeopathic drugs act through regulation of gene-expression: a hypothesis to explain their mechanism and pathways of action in vivo. Complement Ther Med 1997;5: 43-46.
    • (1997) Complement Ther Med , vol.5 , pp. 43-46
    • Khuda-Bukhsh, A.R.1
  • 66
    • 0142243234 scopus 로고    scopus 로고
    • Towards understanding molecular mechanisms of action of homeopathic drugs: An overview
    • Khuda-Bukhsh AR: Towards understanding molecular mechanisms of action of homeopathic drugs: An overview. Mol Cell Biochem 2003;253:339-345.
    • (2003) Mol Cell Biochem , vol.253 , pp. 339-345
    • Khuda-Bukhsh, A.R.1


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