Sub-anesthetic concentrations of (R,S)-ketamine metabolites inhibit acetylcholine-evoked currents in α7 nicotinic acetylcholine receptors

European Journal of Pharmacology

Volumn 698, Issue 1-3, 2013, Pages 228-234

  Moaddel, Ruin ^a   Abdrakhmanova, Galia ^b   Kozak, Joanna ^c   Jozwiak, Krzysztof ^c   Toll, Lawrence ^d   Jimenez, Lucita ^e   Rosenberg, Avraham ^a   Tran, Thao ^f   Xiao, Yingxian ^f   Zarate, Carlos A ^a   Wainer, Irving W ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^c MEDICAL UNIVERSITY OF LUBLIN   (Poland)

^d TORREY PINES INSTITUTE FOR MOLECULAR STUDIES   (United States)

^e SRI INTERNATIONAL   (United States)

^f GEORGETOWN UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Dehydronorketamine; Depression; Hydroxynorketamine; Negative allosteric modifiers; Neuronal nicotinic acetylcholine receptors; Norketamine; Pain

Indexed keywords

ACETYLCHOLINE; BUNGAROTOXIN RECEPTOR; DEHYDRONORKETAMINE; DRUG METABOLITE; HYDROXYNORKETAMINE; KETAMINE; KETAMINE DERIVATIVE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NICOTINIC RECEPTOR; NICOTINIC RECEPTOR ALPHA3BETA4; NORKETAMINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; EVOKED RESPONSE; IC 50; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RECEPTOR BINDING;

ACETYLCHOLINE; ANESTHETICS; ANIMALS; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHYSIOLOGICAL PROCESSES; KETAMINE; NICOTINIC AGONISTS; RATS; RECEPTORS, N-METHYL-D-ASPARTATE; RECEPTORS, NICOTINIC;

EID: 84871924074     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2012.11.023     Document Type: Article

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