Ketamine: New uses for an old drug?

British Journal of Anaesthesia

Volumn 107, Issue 2, 2011, Pages 123-126

  Hirota, K ^a   Lambert, D G ^b  

^a HIROSAKI UNIVERSITY   (Japan)

^b UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANALGESIC AGENT; ANTIINFLAMMATORY AGENT; ANTINEOPLASTIC AGENT; DIZOCILPINE; KETAMINE; MORPHINE; N METHYL DEXTRO ASPARTIC ACID; NEUROPROTECTIVE AGENT; OPIATE RECEPTOR;

ANALGESIA; ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTINOCICEPTION; BRAIN ISCHEMIA; CANCER PAIN; DRUG TOLERANCE; GENERAL ANESTHESIA; INTRAOPERATIVE AWARENESS; LUNG ADENOCARCINOMA; NEUROPROTECTION; NONHUMAN; PAIN ASSESSMENT; POSTOPERATIVE PAIN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW;

EID: 79960509361     PISSN: 00070912     EISSN: 14716771     Source Type: Journal    
DOI: 10.1093/bja/aer221     Document Type: Editorial

References (35)

1. Hirota K, Lambert DG. Ketamine: its mechanism(s) of action and unusual clinical uses. Br J Anaesth 1996; 77: 441-4 (Pubitemid 26341027)
2. Hughes AM, Rhodes J, Fisher G, Sellers M, Growcott JW. Assess-ment of the effect of dextromethorphan and ketamine on the acute nociceptive threshold and wind-up of the second pain response in healthy volunteers. Br J Clin Pharmacol 2002; 53: 604-12 (Pubitemid 34621786)
3. Campos AR, Santos FA, Rao VS. Ketamine-induced potentiation of morphine analgesia in rat tail-flick test: role of opioid-, alpha2-adrenoceptors and ATP-sensitive potassium channels. Biol Pharm Bull 2006; 29: 86-9 (Pubitemid 43036700)
4. Bell RF, Dahl JB, Moore RA, Kalso E. Perioperative ketamine for acute postoperative pain. Cochrane Database Syst Rev 2006; CD004603
5. Carstensen M, Møller AM. Adding ketamine to morphine for intra-venous patient-controlled analgesia for acute postoperative pain: a qualitative review ofrandomized trials. Br J Anaesth 2010; 104: 401-6
6. Chazan S, Ekstein MP, Marouani N, Weinbroum AA. Ketamine for acute and subacute pain in opioid-tolerant patients. J Opioid Manag 2008; 4: 173-80
7. Lossignol DA, Obiols-Portis M, Body JJ. Successful use of ketamine for intractable cancer pain. Support Care Cancer 2005; 13:188-93 (Pubitemid 40468966)
8. Christie MJ. Cellular neuroadaptations to chronic opioids: toler-ance, withdrawal and addiction. Br J Pharmacol 2008; 154: 384-96 (Pubitemid 351670590)
9. Whistler JL, von Zastrow M. Morphine-activated opioid receptors elude desensitization by ß-arrestin. Proc Natl Acad Sci USA 1998; 95: 9914-9 (Pubitemid 28415269)
10. Patierno S, Zellalem W, Ho A, et al. N-Methyl-D-aspartate recep-tors mediate endogenous opioid release in enteric neurons after abdominal surgery. Gastroenterology 2005; 128: 2009-19 (Pubitemid 40824709)
11. Laulin JP, Maurette P, CorcuffJB, Rivat C, Chauvin M, Simonnet G. The role ofketamine in preventing fentanyl-induced hyperalgesia and subsequent acute morphine tolerance. Anesth Analg 2002; 94: 1263-9 (Pubitemid 34441848)
12. Holtman JR Jr, Crooks PA, Johnson-Hardy J, Wala EP. Interaction between morphine and norketamine enantiomers in rodent models of nociception. Pharmacol Biochem Behav 2008; 90: 769-77
13. Hirota K, Okawa H, Appadu BL, Grandy DK, Devi LA, Lambert DG. Stereoselective interaction of ketamine with recombinant μ , κ, and σ opioid receptors expressed in Chinese hamster ovary cells. Anesthesiology 1999; 90: 174-82
14. Hirota K, Ishihara H, Matsuki A. Ketamine and the inhibition of albumin extravasation in chemical peritonitis in rat. Eur J Anaesthesiol 2002; 19: 173-6 (Pubitemid 34984214)
15. Welters ID, Hafer G, Menzebach A, et al. Ketamine inhibits tran-scription factors activator protein 1 and nuclear factor-kappaB, interleukin-8 production, as well as CD11b and CD16 expression: studies in human leukocytes and leukocytic cell lines. Anesth Analg 2010; 110: 934-41
16. MazarJ, Rogachev B, ShakedG, etal. Involvement of adenosinein the anti-inflammatory action of ketamine. Anesthesiology 2005; 102: 1174-81 (Pubitemid 40745836)
17. Suliburk JW, Helmer KS, Gonzalez EA, Robinson EK, Mercer DW. Ketamine attenuates liver injury attributed to endotoxemia: role of cyclooxygenase-2. Surgery 2005; 138: 134-40 (Pubitemid 41253793)
18. Roytblat L, Talmor D, Rachinsky M, et al. Ketamine attenuates the interleukin-6 response after cardiopulmonary bypass. Anesth Analg 1998; 87: 266-71 (Pubitemid 28369075)
19. Zilberstein G, Levy R, Rachinsky M, et al. Ketamine attenuates neutrophil activation after cardiopulmonary bypass. Anesth Analg 2002; 95: 531-6 (Pubitemid 35006835)
20. Bartoc C, Frumento RJ, Jalbout M, Bennett-Guerrero E, Du E, Nishanian E. A randomized, double-blind, placebo-controlled study assessing the anti-inflammatory effects of ketamine in cardiac surgical patients. J Cardiothorac Vasc Anesth 2006; 20: 217-22
21. Cho JE, Shim JK, Choi YS, Kim DH, Hong SW, Kwak YL. Effect of low-dose ketamine on inflammatory response in off-pump coronary artery bypass graft surgery. Br J Anaesth 2009; 102: 23-8
22. Errando CL, Sigl JC, Robles M, et al. Awareness with recall during general anaesthesia: a prospective observational evaluation of 4001 patients. Br J Anaesth 2008; 101: 178-85 (Pubitemid 351989666)
23. Lynch MA. Long-term potentiation and memory. Physiol Rev 2004; 84: 87-136 (Pubitemid 38049877)
24. Gonano C, Meitner E, Kettner SC, Chiari A, Marhofer P. Effect of earplugs on propofol requirement and awareness with recall during spinal anesthesia. Minerva Anestesiol 2010; 76: 504-8
25. Desmond NL, Colbert CM, Zhang DX, Levy WB. NMDA receptor antagonists block the induction of long-term depression in the hippocampal dentate gyrus of the anesthetized rat. Brain Res 1991; 552: 93-8
26. Rowland LM, Astur RS, Jung RE, Bustillo JR, Lauriello J, Yeo RA. Selective cognitive impairments associated with NMDA receptor blockade in humans. Neuropsychopharmacology 2005; 30: 633-9 (Pubitemid 40271165)
27. Hwang J, Jeon Y, Park HP, Lim YJ, Oh YS. Comparison of alfentanil and ketamine in combination with propofol for patient-controlled sedation during fiberoptic bronchoscopy. Acta Anaesthesiol Scand 2005; 49: 1334-8 (Pubitemid 41375060)
28. Stepulak A, Luksch H, Gebhardt C, et al. Expression of glutamate receptor subunits in human cancers. Histochem Cell Biol 2009; 132: 435-45
29. Rzeski W, Turski L, Ikonomidou C. Glutamate antagonists limit tumor growth. Proc Natl Acad Sci USA 2001; 98: 6372-7 (Pubitemid 32488244)
30. Stepulak A, Sifringer M, Rzeski W, et al. NMDA antagonist inhibits the extracellular signal-regulated kinase pathway and suppresses cancer growth. Proc Natl Acad Sci USA 2005; 102: 15605-10 (Pubitemid 41528103)
31. Watanabe K, Kanno T, Oshima T, Miwa H, Tashiro C, Nishizaki T. The NMDA receptor NR2A subunit regulates proliferation of MKN45 human gastric cancer cells. Biochem Biophys Res Commun 2008; 367: 487-90
32. North WG, Gao G, Memoli VA, Pang RH, Lynch L. Breast cancer express functional NMDA receptors. Brest Cancer Res Tract 2010; 122: 307-14
33. Hudetz JA, Pagel PS. Neuroprotection by ketamine: a review of the experimental and clinical evidence. J Cardiothorac Vasc Anesth 2010; 24: 131-42
34. Kakinohana M, Kakinohana O, Jun JH, Marsala M, Davison KJ, Sugahara K. The activation of spinal N-methyl-D-aspartate recep-tors may contribute to degeneration of spinal motor neurons induced by neuraxial morphine after a noninjurious interval of spinal cord ischemia. Anesth Analg 2005; 100: 327-34 (Pubitemid 40170518)
35. Kakinohana M, Nakamura S, Fuchigami T, Davison KJ, Marsala M, Sugahara K. Mu and delta, but not kappa, opioid agonists induce spastic paraparesis after a short period of spinal cord ischaemia in rats. Br J Anaesth 2006; 96: 88-94 (Pubitemid 43124537)