Use of human microsomes and deuterated substrates: An alternative approach for the identification of novel metabolites of ketamine by mass spectrometry

Drug Metabolism and Disposition

Volumn 37, Issue 8, 2009, Pages 1769-1778

  Turfus, Sophie C ^a   Parkin, Mark C ^a   Cowan, David A ^a   Halket, John M ^a   Smith, Norman W ^a   Braithwaite, Robin A ^a   Elliot, Simon P ^b   Steventon, Glyn B ^a   Kicman, Andrew T ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b CITY HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL DERIVATIVE; DEHYDRONORKETAMINE; DEUTERIUM; DRUG METABOLITE; GLUCURONIDE; HYDROXYKETAMINE; HYDROXYNORKETAMINE; KETAMINE; PHENOL DERIVATIVE; STABLE ISOTOPE; UNCLASSIFIED DRUG;

ARTICLE; BIOSYNTHESIS; CHEMICAL COMPOSITION; CONTROLLED STUDY; DRUG CONJUGATION; DRUG ELIMINATION; DRUG IDENTIFICATION; DRUG STRUCTURE; DRUG URINE LEVEL; FEMALE; HUMAN; HUMAN EXPERIMENT; ION CYCLOTRON RESONANCE MASS SPECTROMETRY; LIQUID CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; MALE; MASS SPECTROMETRY; MICROSOME; PRIORITY JOURNAL; TANDEM MASS SPECTROMETRY; URINARY EXCRETION;

ADMINISTRATION, ORAL; ANESTHETICS, DISSOCIATIVE; BIOTRANSFORMATION; CHROMATOGRAPHY, LIQUID; CONSCIOUSNESS; CYCLOTRONS; DEUTERIUM; FEMALE; FOURIER ANALYSIS; GLUCURONIDES; HUMANS; HYDROGEN-ION CONCENTRATION; ISOMERISM; KETAMINE; MALE; METABOLOMICS; MICROSOMES, LIVER; MOLECULAR STRUCTURE; PHENOLS; REPRODUCIBILITY OF RESULTS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SUBSTANCE ABUSE DETECTION; TANDEM MASS SPECTROMETRY;

TETRA;

EID: 67650783182     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.108.026328     Document Type: Article

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