Local changes in lipid environment of TCR microclusters regulate membrane binding by the CD3ε cytoplasmic domain

Journal of Experimental Medicine

Volumn 209, Issue 13, 2012, Pages 2423-2439

  Gagnon, Etienne ^a,b   Schubert, David A ^a   Gordo, Susana ^a   Chu, Hamlet H ^a   Wucherpfennig, Kai W ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b INSTITUTE FOR RESEARCH IN IMMUNOLOGY AND CANCER   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINO 7 TERT BUTYL 5 (4 CHLOROPHENYL)PYRAZOLO[3,4 D]PYRIMIDINE; ANION; CD3 EPSILON; LIPID; LYMPHOCYTE RECEPTOR; PEPTIDE; PROTEIN KINASE LCK; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; CELL MEMBRANE; CYTOPLASM; DENSITY; DIFFUSION; DISSOCIATION; HUMAN; INHIBITION KINETICS; LIPID COMPOSITION; MAJOR HISTOCOMPATIBILITY COMPLEX; MEMBRANE BINDING; MICROENVIRONMENT; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SYNAPSE; T LYMPHOCYTE ACTIVATION;

ANTIGENS, CD3; CELLS, CULTURED; FLUORESCENCE RESONANCE ENERGY TRANSFER; HEK293 CELLS; HLA-DR4 ANTIGEN; HUMANS; IMMUNOLOGICAL SYNAPSES; INTERCELLULAR ADHESION MOLECULE-1; LYMPHOCYTE ACTIVATION; LYMPHOCYTE SPECIFIC PROTEIN TYROSINE KINASE P56(LCK); MEMBRANE LIPIDS; PHOSPHATIDYLSERINES; PROTEIN INTERACTION DOMAINS AND MOTIFS; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION; STATIC ELECTRICITY; T-LYMPHOCYTES;

EID: 84871909015     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.20120790     Document Type: Article

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