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Volumn 24, Issue 1, 2013, Pages 77-87

HNF1β is essential for nephron segmentation during nephrogenesis

Author keywords

[No Author keywords available]

Indexed keywords

HEPATOCYTE NUCLEAR FACTOR 1BETA; NOTCH RECEPTOR; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR IRX3B; TRANSCRIPTION FACTOR PAX2; TRANSCRIPTION FACTOR PAX2A; TRANSCRIPTION FACTOR PAX8; UNCLASSIFIED DRUG; WT1 PROTEIN;

EID: 84871894268     PISSN: 10466673     EISSN: 15333450     Source Type: Journal    
DOI: 10.1681/ASN.2012070756     Document Type: Article
Times cited : (75)

References (57)
  • 1
    • 42949130073 scopus 로고    scopus 로고
    • The zebrafish pronephros: A model to study nephron segmentation
    • DOI 10.1038/ki.2008.37, PII KI200837
    • Wingert RA, Davidson AJ: The zebra fish pronephros: A model to study nephron segmentation. Kidney Int 73: 1120-1127, 2008 (Pubitemid 351620435)
    • (2008) Kidney International , vol.73 , Issue.10 , pp. 1120-1127
    • Wingert, R.A.1    Davidson, A.J.2
  • 3
    • 0031966041 scopus 로고    scopus 로고
    • LIM domains: Multiple roles as adapters and functional modifiers in protein interactions
    • DOI 10.1016/S0168-9525(98)01424-3
    • Dawid IB, Breen JJ, Toyama R: LIM domains: Multiple roles as adapters and functional modifiers in protein interactions. Trends Genet 14: 156-162, 1998 (Pubitemid 28206396)
    • (1998) Trends in Genetics , vol.14 , Issue.4 , pp. 156-162
    • Dawid, I.B.1    Breen, J.J.2    Toyama, R.3
  • 4
    • 0031668375 scopus 로고    scopus 로고
    • Characterization of three novel members of the zebrafish Pax2/5/8 family: Dependency of Pax5 and Pax8 expression on the Pax2.1 (noi) function
    • Pfeffer PL, Gerster T, Lun K, Brand M, Busslinger M: Characterization of three novel members of the zebrafish Pax2/5/8 family: Dependency of Pax5 and Pax8 expression on the Pax2.1 (noi) function. Development 125: 3063-3074, 1998 (Pubitemid 28434406)
    • (1998) Development , vol.125 , Issue.16 , pp. 3063-3074
    • Pfeffer, P.L.1    Gerster, T.2    Lun, K.3    Brand, M.4    Busslinger, M.5
  • 5
    • 0032007710 scopus 로고    scopus 로고
    • Expression of LIM-domain binding protein (Ldb) genes during zebrafish embryogenesis
    • DOI 10.1016/S0925-4773(97)00202-5, PII S0925477397002025
    • Toyama R, Kobayashi M, Tomita T, Dawid IB: Expression of LIM-domain binding protein (ldb) genes during zebrafi shembryogenesis. Mech Dev 71: 197-200, 1998 (Pubitemid 28153532)
    • (1998) Mechanisms of Development , vol.71 , Issue.1-2 , pp. 197-200
    • Toyama, R.1    Kobayashi, M.2    Tomita, T.3    Dawid, I.B.4
  • 6
    • 25844519579 scopus 로고    scopus 로고
    • Organization of the pronephric filtration apparatus in zebrafish requires Nephrin, Podocin and the FERM domain protein Mosaic eyes
    • DOI 10.1016/j.ydbio.2005.06.038, PII S0012160605004422
    • Kramer-Zucker AG, Wiessner S, Jensen AM, Drummond IA: Organization of the pronephric fi ltration apparatus in zebrafish requires Nephrin, Podocin and the FERM domain protein Mosaic eyes. Dev Biol 285: 316-329, 2005 (Pubitemid 41394022)
    • (2005) Developmental Biology , vol.285 , Issue.2 , pp. 316-329
    • Kramer-Zucker, A.G.1    Wiessner, S.2    Jensen, A.M.3    Drummond, I.A.4
  • 8
    • 0032900981 scopus 로고    scopus 로고
    • Initial differentiation of the metanephric mesenchyme is independent of WT1 and the ureteric bud
    • DOI 10.1002/(SICI)1520-6408(1999)24:3/4<252::AID-DVG8>3.0.CO;2-K
    • Donovan MJ, Natoli TA, Sainio K, Amstutz A, Jaenisch R, Sariola H, Kreidberg JA: Initial differentiation of the metanephric mesenchyme is independent of WT1 and the ureteric bud. Dev Genet 24: 252-262, 1999 (Pubitemid 29211789)
    • (1999) Developmental Genetics , vol.24 , Issue.3-4 , pp. 252-262
    • Donovan, M.J.1    Natoli, T.A.2    Sainio, K.3    Amstutz, A.4    Jaenisch, R.5    Sariola, H.6    Kreidberg, J.A.7
  • 9
    • 80053107072 scopus 로고    scopus 로고
    • Wt1a, Foxc1a, and the Notch mediator Rbpj physically interact and regulate the formation of podocytes in zebrafi sh
    • O'Brien LL, Grimaldi M, Kostun Z, Wingert RA, Selleck R, Davidson AJ: Wt1a, Foxc1a, and the Notch mediator Rbpj physically interact and regulate the formation of podocytes in zebrafi sh. Dev Biol 358: 318-330, 2011
    • (2011) Dev Biol , vol.358 , pp. 318-330
    • O'Brien, L.L.1    Grimaldi, M.2    Kostun, Z.3    Wingert, R.A.4    Selleck, R.5    Davidson, A.J.6
  • 10
    • 79960342415 scopus 로고    scopus 로고
    • Zebrafi sh nephrogenesis involves dynamic spatiotemporal expression changes in renal progenitors and essential signals from retinoic acid and irx3b
    • Wingert RA, Davidson AJ: Zebrafi sh nephrogenesis involves dynamic spatiotemporal expression changes in renal progenitors and essential signals from retinoic acid and irx3b. Dev Dyn 240: 2011-2027, 2011
    • (2011) Dev Dyn , vol.240 , pp. 2011-2027
    • Wingert, R.A.1    Davidson, A.J.2
  • 12
    • 65549103373 scopus 로고    scopus 로고
    • Transgenic zebra fi sh reporter lines reveal conserved Toll-like receptor signaling potential in embryonic myeloid leukocytes and adult immune cell lineages
    • Hall C, Flores MV, Chien A, Davidson A, Crosier K, Crosier P: Transgenic zebra fi sh reporter lines reveal conserved Toll-like receptor signaling potential in embryonic myeloid leukocytes and adult immune cell lineages. J Leukoc Biol 85: 751-765, 2009
    • (2009) J Leukoc Biol , vol.85 , pp. 751-765
    • Hall, C.1    Flores, M.V.2    Chien, A.3    Davidson, A.4    Crosier, K.5    Crosier, P.6
  • 13
    • 0025775278 scopus 로고
    • vHNF1 is a homeoprotein that activates transcription and forms heterodimers with HNF1
    • Rey-Campos J, Chouard T, Yaniv M, Cereghini S: vHNF1 is a homeoprotein that activates transcription and forms heterodimers with HNF1. EMBO J 10: 1445-1457, 1991 (Pubitemid 21905610)
    • (1991) EMBO Journal , vol.10 , Issue.6 , pp. 1445-1457
    • Rey-Campos, J.1    Chouard, T.2    Yaniv, M.3    Cereghini, S.4
  • 14
    • 4143099433 scopus 로고    scopus 로고
    • Two distinct teleost hepatocyte nuclear factor 1 genes, hnf1alpha/tcf1 and hnf1beta/tcf2, abundantly expressed in liver, pancreas, gut and kidney of zebrafish
    • DOI 10.1016/j.gene.2004.05.003, PII S0378111904002689
    • Gong HY, Lin CJ, Chen MH, Hu MC, Lin GH, Zhou Y, Zon LI, Wu JL: Two distinct teleost hepatocyte nuclear factor 1 genes, hnf1alpha/tcf1 and hnf1beta/tcf2, abundantly expressed in liver, pancreas, gut and kidney of zebrafish. Gene 338: 35-46, 2004 (Pubitemid 39092409)
    • (2004) Gene , vol.338 , Issue.1 , pp. 35-46
    • Gong, H.-Y.1    Lin, C.J.-F.2    Chen, M.H.-C.3    Hu, M.-C.4    Lin, G.-H.5    Zhou, Y.6    Zon, L.I.7    Wu, J.-L.8
  • 17
    • 0035577271 scopus 로고    scopus 로고
    • Vhnf1, the MODY5 and familial GCKD-associated gene, regulates regional specification of the zebrafish gut, pronephros, and hindbrain
    • DOI 10.1101/gad946701
    • Sun Z, Hopkins N: vhnf1, the MODY5 and familial GCKD-associated gene, regulates regional specification of the zebrafish gut, pronephros, and hindbrain. Genes Dev 15: 3217-3229, 2001 (Pubitemid 33115684)
    • (2001) Genes and Development , vol.15 , Issue.23 , pp. 3217-3229
    • Sun, Z.1    Hopkins, N.2
  • 18
    • 0029590072 scopus 로고
    • Pax-2 controls multiple steps of urogenital development
    • Torres M, Gómez-Pardo E, Dressler GR, Gruss P: Pax-2 controls multiple steps of urogenital development. Development 121: 4057-4065, 1995 (Pubitemid 26007357)
    • (1995) Development , vol.121 , Issue.12 , pp. 4057-4065
    • Torres, M.1    Gomez-Pardo, E.2    Dressler, G.R.3    Gruss, P.4
  • 19
    • 0034121744 scopus 로고    scopus 로고
    • Zebrafish no isthmus reveals a role for pax2.1 in tubule differentiation and patterning events in the pronephric primordia
    • Majumdar A, Lun K, Brand M, Drummond IA: Zebrafish no isthmus reveals a role for pax2.1 in tubule differentiation and patterning events in the pronephric primordia. Development 127: 2089-2098, 2000 (Pubitemid 30386673)
    • (2000) Development , vol.127 , Issue.10 , pp. 2089-2098
    • Majumdar, A.1    Lun, K.2    Brand, M.3    Drummond, I.A.4
  • 23
    • 0033215449 scopus 로고    scopus 로고
    • Synergism between Pax-8 and lim-1 in embryonic kidney development
    • DOI 10.1006/dbio.1999.9414
    • Carroll TJ, Vize PD: Synergism between Pax-8 and lim-1 in embryonic kidney development. Dev Biol 214: 46-59, 1999 (Pubitemid 29463355)
    • (1999) Developmental Biology , vol.214 , Issue.1 , pp. 46-59
    • Carroll, T.J.1    Vize, P.D.2
  • 24
    • 21644437758 scopus 로고    scopus 로고
    • Distinct and sequential tissue-specific activitites of the LIM-class homeobox gene Lim1 for tubular morphogenesis during kidney development
    • DOI 10.1242/dev.01858
    • Kobayashi A, Kwan KM, Carroll TJ, McMahon AP, Mendelsohn CL, Behringer RR: Distinct and sequential tissue-specifi c activities of the LIM-class homeobox gene Lim1 for tubular morphogenesis during kidney development. Development 132: 2809-2823, 2005 (Pubitemid 40932870)
    • (2005) Development , vol.132 , Issue.12 , pp. 2809-2823
    • Kobayashi, A.1    Kwan, K.-M.2    Carroll, T.J.3    McMahon, A.P.4    Mendelsohn, C.L.5    Behringer, R.R.6
  • 26
    • 34548127051 scopus 로고    scopus 로고
    • The Wilms tumor genes wt1a and wt1b control different steps during formation of the zebrafish pronephros
    • DOI 10.1016/j.ydbio.2007.06.022, PII S0012160607011608
    • Perner B, Englert C, Bollig F: The Wilms tumor genes wt1a and wt1b control different steps during formation of the zebra fish pronephros. Dev Biol 309: 87-96, 2007 (Pubitemid 47302449)
    • (2007) Developmental Biology , vol.309 , Issue.1 , pp. 87-96
    • Perner, B.1    Englert, C.2    Bollig, F.3
  • 27
    • 0023937876 scopus 로고
    • Inhibition of mouse cytosolic aldehyde dehydrogenase by 4-(diethylamino)benzaldehyde
    • DOI 10.1016/0006-2952(88)90030-5
    • Russo JE, Hauguitz D, Hilton J: Inhibition of mouse cytosolic aldehyde dehydrogenase by 4-(diethylamino)benzaldehyde. Biochem Pharmacol 37: 1639-1642, 1988 (Pubitemid 18093362)
    • (1988) Biochemical Pharmacology , vol.37 , Issue.8 , pp. 1639-1642
    • Russo, J.E.1    Hauquitz, D.2    Hilton, J.3
  • 28
    • 33751161268 scopus 로고    scopus 로고
    • The cellular basis of kidney development
    • Dressler GR: The cellular basis of kidney development. Annu Rev Cell Dev Biol 22: 509-529, 2006
    • (2006) Annu Rev Cell Dev Biol , vol.22 , pp. 509-529
    • Dressler, G.R.1
  • 29
    • 77952946956 scopus 로고    scopus 로고
    • Patterning a complex organ: Branching morphogenesis and nephron segmentation in kidney development
    • Costantini F, Kopan R: Patterning a complex organ: Branching morphogenesis and nephron segmentation in kidney development. Dev Cell 18: 698-712, 2010
    • (2010) Dev Cell , vol.18 , pp. 698-712
    • Costantini, F.1    Kopan, R.2
  • 30
    • 79954572863 scopus 로고    scopus 로고
    • Formation of the spinal network in zebra fi sh determined by domain-specific pax genes
    • Ikenaga T, Urban JM, Gebhart N, Hatta K, Kawakami K, Ono F: Formation of the spinal network in zebra fi sh determined by domain-specific pax genes. J Comp Neurol 519: 1562-1579, 2011
    • (2011) J Comp Neurol , vol.519 , pp. 1562-1579
    • Ikenaga, T.1    Urban, J.M.2    Gebhart, N.3    Hatta, K.4    Kawakami, K.5    Ono, F.6
  • 31
    • 0344771681 scopus 로고    scopus 로고
    • Essential role for the homeoprotein vHNF1/HNF1beta in visceral endoderm differentiation
    • Coffinier C, Thépot D, Babinet C, Yaniv M, Barra J: Essential role for the homeoprotein vHNF1/HNF1beta in visceral endoderm differentiation. Development 126: 4785-4794, 1999
    • (1999) Development , vol.126 , pp. 4785-4794
    • Coffinier, C.1    Thépot, D.2    Babinet, C.3    Yaniv, M.4    Barra, J.5
  • 33
    • 77951222415 scopus 로고    scopus 로고
    • Hepatocyte nuclear factor 1alpha and beta control terminal differentiation and cell fate commitment in the gut epithelium
    • D'Angelo A, Bluteau O, Garcia-Gonzalez MA, Gresh L, Doyen A, Garbay S, Robine S, Pontoglio M: Hepatocyte nuclear factor 1alpha and beta control terminal differentiation and cell fate commitment in the gut epithelium. Development 137: 1573-1582, 2010
    • (2010) Development , vol.137 , pp. 1573-1582
    • D'Angelo, A.1    Bluteau, O.2    Garcia-Gonzalez, M.A.3    Gresh, L.4    Doyen, A.5    Garbay, S.6    Robine, S.7    Pontoglio, M.8
  • 35
    • 0041342009 scopus 로고    scopus 로고
    • Distinct molecular and morphogenetic properties of mutations in the human HNF1beta gene that lead to defective kidney development
    • DOI 10.1097/01.ASN.0000078808.70309.C4
    • Bohn S, Thomas H, Turan G, Ellard S, Bingham C, Hattersley AT, Ryffel GU: Distinct molecular and morphogenetic properties of mutations in the human HNF1beta gene that lead to defective kidney development. J Am Soc Nephrol 14: 2033-2041, 2003 (Pubitemid 36909911)
    • (2003) Journal of the American Society of Nephrology , vol.14 , Issue.8 , pp. 2033-2041
    • Bohn, S.1    Thomas, H.2    Turan, G.3    Ellard, S.4    Bingham, C.5    Hattersley, A.T.6    Ryffel, G.U.7
  • 36
    • 0027978760 scopus 로고
    • Cloning and developmental expression of LFB3/HNF1beta transcription factor in Xenopus laevis
    • DOI 10.1016/0925-4773(94)90092-2
    • Demartis A, Maffei M, Vignali R, Barsacchi G, De Simone V: Cloning and developmental expression of LFB3/HNF1 beta transcription factor in Xenopus laevis. Mech Dev 47: 19-28, 1994 (Pubitemid 24242113)
    • (1994) Mechanisms of Development , vol.47 , Issue.1 , pp. 19-28
    • Dermartis, A.1    Maffei, M.2    Vignali, R.3    Barsacchi, G.4    De Simone, V.5
  • 37
    • 70450203075 scopus 로고    scopus 로고
    • The miR-30 miRNA family regulates Xenopus pronephros development and targets the transcription factor Xlim1/Lhx1
    • Agrawal R, Tran U, Wessely O: The miR-30 miRNA family regulates Xenopus pronephros development and targets the transcription factor Xlim1/Lhx1. Development 136: 3927-3936, 2009
    • (2009) Development , vol.136 , pp. 3927-3936
    • Agrawal, R.1    Tran, U.2    Wessely, O.3
  • 38
    • 0032727268 scopus 로고    scopus 로고
    • Variant hepatocyte nuclear factor 1 is required for visceral endoderm specification
    • Barbacci E, Reber M, Ott MO, Breillat C, Huetz F, Cereghini S: Variant hepatocyte nuclear factor 1 is required for visceral endoderm specification. Development 126: 4795-4805, 1999
    • (1999) Development , vol.126 , pp. 4795-4805
    • Barbacci, E.1    Reber, M.2    Ott, M.O.3    Breillat, C.4    Huetz, F.5    Cereghini, S.6
  • 39
    • 0032585936 scopus 로고    scopus 로고
    • Expression of the vHNF1/HNF1beta homeoprotein gene during mouse organogenesis
    • DOI 10.1016/S0925-4773(99)00221-X, PII S092547739900221X
    • Coffinier C, Barra J, Babinet C, Yaniv M: Expression of the vHNF1/HNF1beta homeoprotein gene during mouse organogenesis. Mech Dev 89: 211-213, 1999 (Pubitemid 29528294)
    • (1999) Mechanisms of Development , vol.89 , Issue.1-2 , pp. 211-213
    • Coffinier, C.1    Barra, J.2    Babinet, C.3    Yaniv, M.4
  • 42
    • 15444375084 scopus 로고    scopus 로고
    • Role of the hepatocyte nuclear factor-1beta (HNF-1beta) C-terminal domain in Pkhd1 (ARPKD) gene transcription and renal cystogenesis
    • DOI 10.1074/jbc.M414121200
    • Hiesberger T, Shao X, Gourley E, Reimann A, Pontoglio M, Igarashi P: Role of the hepatocyte nuclear factor-1beta (HNF-1beta) C-terminal domain in Pkhd1 (ARPKD) gene transcription and renal cystogenesis. J Biol Chem 280: 10578-10586, 2005 (Pubitemid 40395919)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.11 , pp. 10578-10586
    • Hiesberger, T.1    Shao, X.2    Gourley, E.3    Reimann, A.4    Pontoglio, M.5    Igarashi, P.6
  • 44
    • 84858274918 scopus 로고    scopus 로고
    • Heat-shock mediated overexpression of HNF1b mutations has differential effects on gene expression in the Xenopus pronephric kidney
    • Sauert K, Kahnert S, Roose M, Gull M, Brändli AW, Ryffel GU, Waldner C: Heat-shock mediated overexpression of HNF1b mutations has differential effects on gene expression in the Xenopus pronephric kidney. PLoS ONE 7: e33522, 2012
    • (2012) PLoS ONE , vol.7
    • Sauert, K.1    Kahnert, S.2    Roose, M.3    Gull, M.4    Brändli, A.W.5    Ryffel, G.U.6    Waldner, C.7
  • 45
    • 79251551056 scopus 로고    scopus 로고
    • The nephrogenic potential of the transcription factors osr1, osr2, hnf1b, lhx1 and pax8 assessed in Xenopus animal caps
    • Drews C, Senkel S, Ryffel GU: The nephrogenic potential of the transcription factors osr1, osr2, hnf1b, lhx1 and pax8 assessed in Xenopus animal caps. BMC Dev Biol 11: 5, 2011
    • (2011) BMC Dev Biol , vol.11 , pp. 5
    • Drews, C.1    Senkel, S.2    Ryffel, G.U.3
  • 48
    • 84857247515 scopus 로고    scopus 로고
    • Regulation of tissuespecific expression of renal organic anion transporters by hepatocyte nuclear factor 1 α/β and DNA methylation
    • Jin L, Kikuchi R, Saji T, Kusuhara H, Sugiyama Y: Regulation of tissuespecific expression of renal organic anion transporters by hepatocyte nuclear factor 1 α/β and DNA methylation. J Pharmacol Exp Ther 340: 648-655, 2012
    • (2012) J Pharmacol Exp Ther , vol.340 , pp. 648-655
    • Jin, L.1    Kikuchi, R.2    Saji, T.3    Kusuhara, H.4    Sugiyama, Y.5
  • 49
    • 36348965458 scopus 로고    scopus 로고
    • Regulation of tissue-specific expression of the human and mouse urate transporter 1 gene by hepatocyte nuclear factor 1 alpha/beta and DNA methylation
    • DOI 10.1124/mol.107.039701
    • Kikuchi R, Kusuhara H, Hattori N, Kim I, Shiota K, Gonzalez FJ, Sugiyama Y: Regulation of tissue-speci fic expression of the human and mouse urate transporter 1 gene by hepatocyte nuclear factor 1 alpha/beta and DNA methylation. Mol Pharmacol 72: 1619-1625, 2007 (Pubitemid 350146099)
    • (2007) Molecular Pharmacology , vol.72 , Issue.6 , pp. 1619-1625
    • Kikuchi, R.1    Kusuhara, H.2    Hattori, N.3    Kim, I.4    Shiota, K.5    Gonzalez, F.J.6    Sugiyama, Y.7
  • 51
    • 69049108803 scopus 로고    scopus 로고
    • A highly conserved retinoic acid responsive element controls wt1a expression in the zebrafish pronephros
    • Bollig F, Perner B, Besenbeck B, Köthe S, Ebert C, Taudien S, Englert C: A highly conserved retinoic acid responsive element controls wt1a expression in the zebrafish pronephros. Development 136: 2883-2892, 2009
    • (2009) Development , vol.136 , pp. 2883-2892
    • Bollig, F.1    Perner, B.2    Besenbeck, B.3    Köthe, S.4    Ebert, C.5    Taudien, S.6    Englert, C.7
  • 53
    • 0141860124 scopus 로고    scopus 로고
    • The role of Suppressor of Hairless in Notch mediated signalling during zebrafish somitogenesis
    • DOI 10.1016/S0925-4773(03)00154-0
    • Sieger D, Tautz D, Gajewski M: The role of Suppressor of Hairless in Notch mediated signalling during zebrafish somitogenesis. Mech Dev 120: 1083-1094, 2003 (Pubitemid 37205050)
    • (2003) Mechanisms of Development , vol.120 , Issue.9 , pp. 1083-1094
    • Sieger, D.1    Tautz, D.2    Gajewski, M.3
  • 54
    • 58149240682 scopus 로고    scopus 로고
    • Odd skipped related1 reveals a novel role for endodermin regulating kidney versus vascular cell fate
    • Mudumana SP, Hentschel D, Liu Y, Vasilyev A, Drummond IA: odd skipped related1 reveals a novel role for endodermin regulating kidney versus vascular cell fate. Development 135: 3355-3367, 2008
    • (2008) Development , vol.135 , pp. 3355-3367
    • Mudumana, S.P.1    Hentschel, D.2    Liu, Y.3    Vasilyev, A.4    Drummond, I.A.5
  • 57
    • 60749123442 scopus 로고    scopus 로고
    • A Wnt7b-dependent pathway regulates the orientation of epithelial cell division and establishes the cortico-medullary axis of the mammalian kidney
    • Yu J, Carroll TJ, Rajagopal J, Kobayashi A, Ren Q, McMahon AP: A Wnt7b-dependent pathway regulates the orientation of epithelial cell division and establishes the cortico-medullary axis of the mammalian kidney. Development 136: 161-171, 2009
    • (2009) Development , vol.136 , pp. 161-171
    • Yu, J.1    Carroll, T.J.2    Rajagopal, J.3    Kobayashi, A.4    Ren, Q.5    McMahon, A.P.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.