The Wilms tumor genes wt1a and wt1b control different steps during formation of the zebrafish pronephros

Developmental Biology

Volumn 309, Issue 1, 2007, Pages 87-96

  Perner, Birgit ^a   Englert, Christoph ^a,b   Bollig, Frank ^a  

^a FRITZ LIPMANN INSTITUTE   (Germany)

^b FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

Duct; Glomerulus; Kidney development; Morpholino; Organogenesis; Podocyte; Tubule

Indexed keywords

UNCLASSIFIED DRUG; WT1 PROTEIN; WT1A PROTEIN; WT1B PROTEIN;

ANIMAL TISSUE; ARTICLE; CYST; EDEMA; EMBRYO; GENE EXPRESSION; GENE FUNCTION; GENE INACTIVATION; GLOMERULUS; KIDNEY DEVELOPMENT; KIDNEY TUBULE; MORPHOGENESIS; NEPHROBLASTOMA; NONHUMAN; PERICARDIUM; PRIORITY JOURNAL; TUMOR GENE; ZEBRA FISH;

DANIO RERIO; MUS;

EID: 34548127051     PISSN: 00121606     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ydbio.2007.06.022     Document Type: Article

References (53)

1. Amemiya C.T., and Zon L.I. Generation of a zebrafish P1 artificial chromosome library. Genomics 58 (1999) 211-213
2. Armstrong J.F., et al. The expression of the Wilms' tumour gene, WT1, in the developing mammalian embryo. Mech. Dev. 40 (1993) 85-97
3. Barbaux S., et al. Donor splice-site mutations in WT1 are responsible for Frasier syndrome. Nat. Genet. 17 (1997) 467-470
4. Bollig F., et al. Identification and comparative expression analysis of a second wt1 gene in zebrafish. Dev. Dyn. 235 (2006) 554-561
5. Boute N., et al. NPHS2, encoding the glomerular protein podocin, is mutated in autosomal recessive steroid-resistant nephrotic syndrome. Nat. Genet. 24 (2000) 349-354
6. Bukanov N.O., et al. Long-lasting arrest of murine polycystic kidney disease with CDK inhibitor roscovitine. Nature 444 (2006) 949-952
7. Call K.M., et al. Isolation and characterization of a zinc finger polypeptide gene at the human chromosome 11 Wilms' tumor locus. Cell 60 (1990) 509-520
8. Carmona R., et al. Localization of the Wilm's tumour protein WT1 in avian embryos. Cell Tissue Res. 303 (2001) 173-186
9. Carroll T.J., and Vize P.D. Wilms' tumor suppressor gene is involved in the development of disparate kidney forms: evidence from expression in the Xenopus pronephros. Dev. Dyn. 206 (1996) 131-138
10. Davies J.A., et al. Development of an siRNA-based method for repressing specific genes in renal organ culture and its use to show that the Wt1 tumour suppressor is required for nephron differentiation. Hum. Mol. Genet. 13 (2004) 235-246
11. Drummond I. Making a zebrafish kidney: a tale of two tubes. Trends Cell Biol. 13 (2003) 357-365
12. Drummond I.A., et al. Early development of the zebrafish pronephros and analysis of mutations affecting pronephric function. Development 125 (1998) 4655-4667
13. Englert C., et al. WT1 suppresses synthesis of the epidermal growth factor receptor and induces apoptosis. EMBO J. 14 (1995) 4662-4675
14. Englert C., et al. Truncated WT1 mutants alter the subnuclear localization of the wild-type protein. Proc. Natl. Acad. Sci. U. S. A. 92 (1995) 11960-11964
15. Gessler M., et al. Homozygous deletion in Wilms tumours of a zinc-finger gene identified by chromosome jumping. Nature 343 (1990) 774-778
16. Guo J.K., et al. WT1 is a key regulator of podocyte function: reduced expression levels cause crescentic glomerulonephritis and mesangial sclerosis. Hum. Mol. Genet. 11 (2002) 651-659
17. Guo G., et al. WT1 activates a glomerular-specific enhancer identified from the human nephrin gene. J. Am. Soc. Nephrol. 15 (2004) 2851-2856
18. Hammes A., et al. Two splice variants of the Wilms' tumor 1 gene have distinct functions during sex determination and nephron formation. Cell 106 (2001) 319-329
19. Hauptmann G., and Gerster T. Two-color whole-mount in situ hybridization to vertebrate and Drosophila embryos. Trends Genet. 10 (1994) 266
20. Holtzinger A., and Evans T. Gata4 regulates the formation of multiple organs. Development 132 (2005) 4005-4014
21. Hosono S., et al. E-cadherin is a WT1 target gene. J. Biol. Chem. 275 (2000) 10943-10953
22. Hsu H.J., et al. Parallel early development of zebrafish interrenal glands and pronephros: differential control by wt1 and ff1b. Development 130 (2003) 2107-2116
23. Huber T.B., et al. Molecular basis of the functional podocin-nephrin complex: mutations in the NPHS2 gene disrupt nephrin targeting to lipid raft microdomains. Hum. Mol. Genet. 12 (2003) 3397-3405
24. Kestila M., et al. Positionally cloned gene for a novel glomerular protein-nephrin-is mutated in congenital nephrotic syndrome. Mol. Cell 1 (1998) 575-582
25. Kimmel C.B., et al. Stages of embryonic development of the zebrafish. Dev. Dyn. 203 (1995) 253-310
26. Klamt B., et al. Frasier syndrome is caused by defective alternative splicing of WT1 leading to an altered ratio of WT1 ± KTS splice isoforms. Hum. Mol. Genet. 7 (1998) 709-714
27. Kramer-Zucker A.G., et al. Cilia-driven fluid flow in the zebrafish pronephros, brain and Kupffer's vesicle is required for normal organogenesis. Development 132 (2005) 1907-1921
28. Kramer-Zucker A.G., et al. Organization of the pronephric filtration apparatus in zebrafish requires Nephrin, Podocin and the FERM domain protein Mosaic eyes. Dev. Biol. 285 (2005) 316-329
29. Kreidberg J.A., et al. WT-1 is required for early kidney development. Cell 74 (1993) 679-691
30. Lahiri D., et al. Nephropathy and defective spermatogenesis in mice transgenic for a single isoform of the Wilms' tumour suppressor protein, WT1-KTS, together with one disrupted Wt1 Allele. Mol. Reprod. Dev. 74 (2007) 300-311
31. Lang M.R., et al. Secretory COPII coat component Sec23a is essential for craniofacial chondrocyte maturation. Nat. Genet. 38 (2006) 1198-1203
32. Livak K.J., and Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(- Delta Delta C(T)) method. Methods 25 (2001) 402-408
33. Maheswaran S., et al. The WT1 gene product stabilizes p53 and inhibits p53-mediated apoptosis. Genes Dev. 9 (1995) 2143-2156
34. Majumdar A., et al. Zebrafish no isthmus reveals a role for pax2.1 in tubule differentiation and patterning events in the pronephric primordia. Development 127 (2000) 2089-2098
35. Mayo M.W., et al. WT1 modulates apoptosis by transcriptionally upregulating the bcl-2 proto-oncogene. EMBO J. 18 (1999) 3990-4003
36. McCune A.R., and Carlson R.L. Twenty ways to lose your bladder: common natural mutants in zebrafish and widespread convergence of swim bladder loss among teleost fishes. Evol. Dev. 6 (2004) 246-259
37. Moffett P., et al. Antagonism of WT1 activity by protein self-association. Proc. Natl. Acad. Sci. U. S. A. 92 (1995) 11105-11109
38. Moore A.W., et al. YAC transgenic analysis reveals Wilms' tumour 1 gene activity in the proliferating coelomic epithelium, developing diaphragm and limb. Mech. Dev. 79 (1998) 169-184
39. Morrison D.J., et al. WT1 induces apoptosis through transcriptional regulation of the proapoptotic Bcl-2 family member Bak. Cancer Res. 65 (2005) 8174-8182
40. Palmer R.E., et al. WT1 regulates the expression of the major glomerular podocyte membrane protein Podocalyxin. Curr. Biol. 11 (2001) 1805-1809
41. Pavenstadt H., et al. Cell biology of the glomerular podocyte. Physiol. Rev. 83 (2003) 253-307
42. Pelletier J., et al. Germline mutations in the Wilms' tumor suppressor gene are associated with abnormal urogenital development in Denys-Drash syndrome. Cell 67 (1991) 437-447
43. Pritchard-Jones K., et al. The candidate Wilms' tumour gene is involved in genitourinary development. Nature 346 (1990) 194-197
44. Rackley R.R., et al. Expression of the Wilms' tumor suppressor gene WT1 during mouse embryogenesis. Cell Growth Differ. 4 (1993) 1023-1031
45. Reddy J.C., et al. WT1-mediated transcriptional activation is inhibited by dominant negative mutant proteins. J. Biol. Chem. 270 (1995) 10878-10884
46. Riccardi V.M., et al. Chromosomal imbalance in the Aniridia-Wilms' tumor association: 11p interstitial deletion. Pediatrics 61 (1978) 604-610
47. Rivera M.N., and Haber D.A. Wilms' tumour: connecting tumorigenesis and organ development in the kidney. Nat. Rev., Cancer 5 (2005) 699-712
48. Roselli S., et al. Plasma membrane targeting of podocin through the classical exocytic pathway: effect of NPHS2 mutations. Traffic 5 (2004) 37-44
49. Sun Z., et al. A genetic screen in zebrafish identifies cilia genes as a principal cause of cystic kidney. Development 131 (2004) 4085-4093
50. Thermes V., et al. I-SceI meganuclease mediates highly efficient transgenesis in fish. Mech. Dev. 118 (2002) 91-98
51. Wagner K.D., et al. The Wilms' tumor gene Wt1 is required for normal development of the retina. EMBO J. 21 (2002) 1398-1405
52. Wagner N., et al. The major podocyte protein nephrin is transcriptionally activated by the Wilms' tumor suppressor WT1. J. Am. Soc. Nephrol. 15 (2004) 3044-3051
53. Wagner N., et al. Coronary vessel development requires activation of the TrkB neurotrophin receptor by the Wilms' tumor transcription factor Wt1. Genes Dev. 19 (2005) 2631-2642