Vhnf1, the MODY5 and familial GCKD-associated gene, regulates regional specification of the zebrafish gut, pronephros, and hindbrain

Genes and Development

Volumn 15, Issue 23, 2001, Pages 3217-3229

  Sun, Zhaoxia ^a   Hopkins, Nancy ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Hindbrain; Kidney; Liver; Pancreas; Regional specification; Vhnf1

Indexed keywords

SONIC HEDGEHOG PROTEIN;

ANIMAL TISSUE; ARTICLE; GENE CONTROL; GENE EXPRESSION; GLOMERULOPATHY; KIDNEY CYST; MATURITY ONSET DIABETES MELLITUS; MUTAGENESIS; NONHUMAN; ORGANOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DOMAIN; RHOMBENCEPHALON; ZEBRA FISH;

AMINO ACID SEQUENCE; ANIMALS; BODY PATTERNING; CLONING, MOLECULAR; DIABETES MELLITUS, TYPE 2; DIGESTIVE SYSTEM; DNA-BINDING PROTEINS; ENDODERM; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEPATOCYTE NUCLEAR FACTOR 1-BETA; HUMANS; IN SITU HYBRIDIZATION; KIDNEY; KIDNEY DISEASES, CYSTIC; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; MUTATION; NUCLEAR PROTEINS; PHENOTYPE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RHOMBENCEPHALON; RNA, MESSENGER; SEQUENCE HOMOLOGY, AMINO ACID; TRANSCRIPTION FACTORS; ZEBRAFISH;

ANIMALIA; DANIO RERIO; ERINACEIDAE;

EID: 0035577271     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad946701     Document Type: Article

References (59)

1. The formation and maintenance of the definitive endoderm lineage in the mouse: Involvement of HNF3/forkhead proteins
2. Sonic hedgehog directs specialised mesoderm differentiation in the intestine and pancreas
3. Early appearance of pancreatic hormone-expressing cells in the zebrafish embryo
4. The expression of the Wilms' tumour gene, WT1, in the developing mammalian embryo
5. Variant hepatocyte nuclear factor 1 is required for visceral endoderm specification
6. A pancreatic beta-Cell-specific enhancer in the human PDX-1 gene is regulated by hepatocyte nuclear factor 3beta (HNF-3beta), HNF-1alpha, and SPs transcription factors
7. Mutations in the hepatocyte nuclear factor-1β gene are associated with familial hypoplastic glomerulocystic kidney disease
8. The excision of intervening sequences from Salmonella 23S ribosomal RNA
9. Expression patterns of vHNF1 and HNF1 homeoproteins in early postimplantation embryos suggest distinct and sequential developmental roles
10. Essential role for the homeoprotein vHNF1/HNF1 beta in visceral endoderm differentiation
11. Transcription factors in renal development: The WT1 and Pax-2 story
12. The zebrafish pronephros: A genetic system for studies of kidney development
13. Early development of the zebrafish pronephros and analysis of mutations affecting pronephric function
14. Renal-coloboma syndrome: A multi-system developmental disorder caused by PAX2 mutations
15. Krox-20: A candidate gene for the regulation of pattern formation in the hindbrain
16. Endoderm development: From patterning to organogenesis
17. Key events of pancreas formation are triggered in gut endoderm by ectopic expression of pancreatic regulatory genes
18. Expression of murine STF-1, a putative insulin gene transcription factor, in beta cells of pancreas, duodenal epithelium and pancreatic exocrine and endocrine progenitors during ontogeny
19. Two-color whole-mount in situ hybridization to vertebrate and Drosophila embryos
20. Notochord repression of endodermal Sonic hedgehog permits pancreas development
21. Mutation in hepatocyte nuclear factor-1 beta gene (TCF2) associated with MODY
22. A simple methylene blue-azure II-basic fuchsin stain for epoxy-embedded tissue sections
23. Pancreas development is promoted by cyclopamine, a hedgehog signaling inhibitor
24. Stages of embryonic development of the zebrafish
25. Expression of the zebrafish paired box gene pax[zf-b] during early neurogenesis
26. A functionally conserved homolog of the Drosophila segment polarity gene hh is expressed in tissues with polarizing activity in zebrafish embryos
27. WT-1 is required for early kidney development
28. LFB1 and LFB3 homeoproteins are sequentially expressed during kidney development
29. Hhex and scl function in parallel to regulate early endothelial and blood differentiation in zebrafish
30. A novel syndrome of diabetes mellitus, renal dysfunction and genital malformation associated with a partial deletion of the pseudo-POU domain of hepatocyte nuclear factor-1 beta
31. Zebrafish no isthmus reveals a role for pax2.1 in tubule differentiation and patterning events in the pronephric primordia
32. The homeobox gene Hex is required in definitive endodermal tissues for normal forebrain, liver and thyroid formation
33. Equivalence in the genetic control of hindbrain segmentation in fish and mouse
34. Frameshift mutation, A263fsinsGG, in the hepatocyte nuclear factor-1beta gene associated with diabetes and renal dysfunction
35. PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum
36. Human insulin gene is a target gene of hepatocyte nuclear factor-1alpha (HNF-1alpha) and HNF-1beta
37. vHNF1 is expressed in epithelial cells of distinct embryonic origin during development and precedes HNF1 expression
38. Cloning of the zebrafish krox-20 gene (krx-20) and its expression during hindbrain development
39. A zinc finger truncation of murine WT1 results in the characteristic urogenital abnormalities of Denys-Drash syndrome
40. WT1 mutations contribute to abnormal genital system development and hereditary Wilms' tumour
41. Zebrafish fgf3 and fgf8 encode redundant functions required for otic placode induction
42. Hepatocyte nuclear factor 1 inactivation results in hepatic dysfunction, phenylketonuria, and renal Fanconi syndrome
43. Zebrafish hox genes: Expression in the hindbrain region of wild-type and mutants of the segmentation gene, valentino
44. The candidate Wilms' tumour gene is involved in genitourinary development
45. Expression of the Wilms' tumor suppressor gene WT1 during mouse embryogenesis
46. vHNF1 is a homeoprotein that activates transcription and forms heterodimers with HNF1
47. Familial hypoplastic glomerulocystic kidney. A new entity?
48. Pax-2 is required for mesenchyme-to-epithelium conversion during kidney development
49. Hedgehog signaling pathway is essential for pancreas specification in the zebrafish embryo
50. Pre-pattern in the pronephric kidney field of zebrafish
51. Hepatocyte nuclear factorlalpha is an essential regulator of bile acid and plasma cholesterol metabolism
52. Early-onset type-II diabetes mellitus (MODY4) linked to IPF1
53. Expression of axial and sonic hedgehog in wildtype and midline defective zebrafish embryos
54. Pax-2 controls multiple steps of urogenital development
55. HNF1, a homeoprotein member of the hepatic transcription regulatory network
56. The winged-helix transcription factor HNF-3 beta is required for notochord development in the mouse embryo
57. Mutations in the hepatocyte nuclear factor-1alpha gene in maturity-onset diabetes of the young (MODY3)
58. Expression of the homebox gene Hex during early stages of chick embryo development