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Volumn 8, Issue 1, 2013, Pages

ERG Transcriptional Networks in Primary Acute Leukemia Cells Implicate a Role for ERG in Deregulated Kinase Signaling

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; DOVITINIB; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN P53; SORAFENIB; TRANSCRIPTION FACTOR ERG; WNT PROTEIN;

EID: 84871878659     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0052872     Document Type: Article
Times cited : (12)

References (39)
  • 1
    • 45549102935 scopus 로고    scopus 로고
    • The transcription factor Erg is essential for definitive hematopoiesis and the function of adult hematopoietic stem cells
    • Loughran SJ, Kruse EA, Hacking DF, de Graaf CA, Hyland CD, et al. (2008) The transcription factor Erg is essential for definitive hematopoiesis and the function of adult hematopoietic stem cells. Nat Immunol 9(7): 810-819.
    • (2008) Nat Immunol , vol.9 , Issue.7 , pp. 810-819
    • Loughran, S.J.1    Kruse, E.A.2    Hacking, D.F.3    de Graaf, C.A.4    Hyland, C.D.5
  • 2
    • 79551585898 scopus 로고    scopus 로고
    • ERG dependence distinguishes developmental control of hematopoietic stem cell maintenance from hematopoietic specification
    • Taoudi S, Bee T, Hilton A, Knezevic K, Scott J, et al. (2011) ERG dependence distinguishes developmental control of hematopoietic stem cell maintenance from hematopoietic specification. Genes Dev. 25(3): 251-262.
    • (2011) Genes Dev , vol.25 , Issue.3 , pp. 251-262
    • Taoudi, S.1    Bee, T.2    Hilton, A.3    Knezevic, K.4    Scott, J.5
  • 3
    • 41149097040 scopus 로고    scopus 로고
    • A causal role for ERG in neoplastic transformation of prostate epithelium
    • Klezovitch O, Risk M, Coleman I, Lucas JM, Null M, et al. (2008) A causal role for ERG in neoplastic transformation of prostate epithelium. PNAS 105(6): 2105-2110.
    • (2008) PNAS , vol.105 , Issue.6 , pp. 2105-2110
    • Klezovitch, O.1    Risk, M.2    Coleman, I.3    Lucas, J.M.4    Null, M.5
  • 4
    • 27344451557 scopus 로고    scopus 로고
    • Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer
    • Tomlins SA, Rhodes DR, Perner S, Dhanasekaran SM, Mehra R, et al. (2005) Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer. Science 310(5748): 644-648.
    • (2005) Science , vol.310 , Issue.5748 , pp. 644-648
    • Tomlins, S.A.1    Rhodes, D.R.2    Perner, S.3    Dhanasekaran, S.M.4    Mehra, R.5
  • 5
    • 0028307384 scopus 로고
    • A second Ewing's sarcoma translocation, t(21;22), fuses the EWS gene to another ETS-family transcription factor, ERG
    • Sorensen PH, Lessnick SL, Lopez-Terrada D, Liu XF, Triche TJ, et al. (1994) A second Ewing's sarcoma translocation, t(21;22), fuses the EWS gene to another ETS-family transcription factor, ERG. Nature Genetics 6(2): 146-151.
    • (1994) Nature Genetics , vol.6 , Issue.2 , pp. 146-151
    • Sorensen, P.H.1    Lessnick, S.L.2    Lopez-Terrada, D.3    Liu, X.F.4    Triche, T.J.5
  • 6
    • 0030871371 scopus 로고    scopus 로고
    • Consistent detection of TLS/FUS-ERG chimeric transcripts in acute myeloid leukemia with t(16; 21)(p11; q22) and identification of a novel transcript
    • Kong XT, Ida K, Ichikawa H, Shimizu K, Ohki M, et al. (1997) Consistent detection of TLS/FUS-ERG chimeric transcripts in acute myeloid leukemia with t(16; 21)(p11; q22) and identification of a novel transcript. Blood 90(3): 1192-1199.
    • (1997) Blood , vol.90 , Issue.3 , pp. 1192-1199
    • Kong, X.T.1    Ida, K.2    Ichikawa, H.3    Shimizu, K.4    Ohki, M.5
  • 8
    • 33644830601 scopus 로고    scopus 로고
    • Overexpression of the ETS-Related Gene, ERG, predicts a worse outcome in acute myeloid leukemia with normal karyotype: a Cancer and Leukemia Group B Study
    • Marcucci G, Baldus CD, Ruppert AS, Radmacher MD, Mrozek K, et al. (2005) Overexpression of the ETS-Related Gene, ERG, predicts a worse outcome in acute myeloid leukemia with normal karyotype: a Cancer and Leukemia Group B Study. Journal of Clinical Oncology 23(36): 9234-9242.
    • (2005) Journal of Clinical Oncology , vol.23 , Issue.36 , pp. 9234-9242
    • Marcucci, G.1    Baldus, C.D.2    Ruppert, A.S.3    Radmacher, M.D.4    Mrozek, K.5
  • 9
    • 77649096189 scopus 로고    scopus 로고
    • ERG expression is an independent prognostic factor and allows refined risk stratification in cytogenetically normal acute myeloid leukemia: a comprehensive analysis of ERG, MN1, and BAALC transcript levels using oligonucleotide microarrays
    • Metzeler KH, Dufour A, Benthaus T, Hummel M, Sauerland MC, et al. (2009) ERG expression is an independent prognostic factor and allows refined risk stratification in cytogenetically normal acute myeloid leukemia: a comprehensive analysis of ERG, MN1, and BAALC transcript levels using oligonucleotide microarrays. Journal of Clinical Oncology 27(30): 5031-5038.
    • (2009) Journal of Clinical Oncology , vol.27 , Issue.30 , pp. 5031-5038
    • Metzeler, K.H.1    Dufour, A.2    Benthaus, T.3    Hummel, M.4    Sauerland, M.C.5
  • 10
    • 33750590923 scopus 로고    scopus 로고
    • High expression of the ETS transcription factor ERG predicts adverse outcome in acute T-lymphoblastic leukemia in adults
    • Baldus CD, Burmeister T, Martus P, Schwartz S, Gökbuget N, et al. (2006) High expression of the ETS transcription factor ERG predicts adverse outcome in acute T-lymphoblastic leukemia in adults. Journal of Clinical Oncology 24(29): 4714-20.
    • (2006) Journal of Clinical Oncology , vol.24 , Issue.29 , pp. 4714-4720
    • Baldus, C.D.1    Burmeister, T.2    Martus, P.3    Schwartz, S.4    Gökbuget, N.5
  • 12
    • 79959825899 scopus 로고    scopus 로고
    • ERG promotes T-acute lymphoblastic leukemia and is transcriptionally regulated in leukemic cells by a stem cell enhancer
    • Thoms JA, Birger Y, Foster S, Knezevic K, Kirschenbaum Y, et al. (2011) ERG promotes T-acute lymphoblastic leukemia and is transcriptionally regulated in leukemic cells by a stem cell enhancer. Blood 117(26): 7079-7089.
    • (2011) Blood , vol.117 , Issue.26 , pp. 7079-7089
    • Thoms, J.A.1    Birger, Y.2    Foster, S.3    Knezevic, K.4    Kirschenbaum, Y.5
  • 13
    • 84871854370 scopus 로고    scopus 로고
    • Promotion and maintenance of leukemia by ERG
    • Tsuzuki S, Taguchi O, Seto M, (2012) Promotion and maintenance of leukemia by ERG. Blood 117(26): 7079-89.
    • (2012) Blood , vol.117 , Issue.26 , pp. 7079-7089
    • Tsuzuki, S.1    Taguchi, O.2    Seto, M.3
  • 14
    • 79955477519 scopus 로고    scopus 로고
    • Genome-wide screen reveals WNT11, a non-canonical WNT gene, as a direct target of ETS transcription factor ERG
    • Mochmann LH, Bock J, Ortiz-Tanchez J, Schlee C, Bohne A, et al. (2011) Genome-wide screen reveals WNT11, a non-canonical WNT gene, as a direct target of ETS transcription factor ERG. Oncogene 30(17): 2044-2056.
    • (2011) Oncogene , vol.30 , Issue.17 , pp. 2044-2056
    • Mochmann, L.H.1    Bock, J.2    Ortiz-Tanchez, J.3    Schlee, C.4    Bohne, A.5
  • 16
    • 78149356747 scopus 로고    scopus 로고
    • Profiling of histone H3 lysine 9 trimethylation levels predicts transcription factor activity and survival in acute myeloid leukemia
    • Müller-Tidow C, Klein H, Hascher A, Isken F, Tickenbrock L, et al. (2010) Profiling of histone H3 lysine 9 trimethylation levels predicts transcription factor activity and survival in acute myeloid leukemia. Blood 116(18): 3564-3571.
    • (2010) Blood , vol.116 , Issue.18 , pp. 3564-3571
    • Müller-Tidow, C.1    Klein, H.2    Hascher, A.3    Isken, F.4    Tickenbrock, L.5
  • 17
    • 41949133411 scopus 로고    scopus 로고
    • Chromatin modifications induced by PML-RAR α repress critical targets in leukemogenesis as analyzed by ChIP-Chip
    • Hoemme C, Peerzada A, Behre G, Wang Y, McClelland M, et al. (2008) Chromatin modifications induced by PML-RAR α repress critical targets in leukemogenesis as analyzed by ChIP-Chip. Blood 111(5): 2887-2895.
    • (2008) Blood , vol.111 , Issue.5 , pp. 2887-2895
    • Hoemme, C.1    Peerzada, A.2    Behre, G.3    Wang, Y.4    McClelland, M.5
  • 18
    • 58549112996 scopus 로고    scopus 로고
    • Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists
    • Huang DW, Sherman BT, Lempicki RA, (2009) Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists. Nucleic Acids Research 37(1): 1-13.
    • (2009) Nucleic Acids Research , vol.37 , Issue.1 , pp. 1-13
    • Huang, D.W.1    Sherman, B.T.2    Lempicki, R.A.3
  • 19
    • 67849114236 scopus 로고    scopus 로고
    • Pscan: finding over-represented transcription factor binding site motifs in sequences from co-regulated or co-expressed genes
    • Zambelli F, Pesole G, Pavesi G (2009) Pscan: finding over-represented transcription factor binding site motifs in sequences from co-regulated or co-expressed genes. Nucleic Acids Research 37, 247-252.
    • (2009) Nucleic Acids Research , vol.37 , pp. 247-252
    • Zambelli, F.1    Pesole, G.2    Pavesi, G.3
  • 20
    • 77956290679 scopus 로고    scopus 로고
    • FZD4 as a mediator of ERG oncogene-induced WNT signaling and epithelial-to-mesenchymal transition in human prostate cancer cells
    • Gupta S, Iljin K, Sara H, Mpindi JP, Mirtti T, et al. (2010) FZD4 as a mediator of ERG oncogene-induced WNT signaling and epithelial-to-mesenchymal transition in human prostate cancer cells. Cancer Research 70(17): 6735-6745.
    • (2010) Cancer Research , vol.70 , Issue.17 , pp. 6735-6745
    • Gupta, S.1    Iljin, K.2    Sara, H.3    Mpindi, J.P.4    Mirtti, T.5
  • 21
    • 43549123588 scopus 로고    scopus 로고
    • Transcription factor Erg regulates angiogenesis and endothelial apoptosis through VE-cadherin
    • Birdsey GM, Dryden NH, Amsellem V, Gebhardt F, Sahnan K, et al. (2008) Transcription factor Erg regulates angiogenesis and endothelial apoptosis through VE-cadherin. Blood 111(7): 3498-3506.
    • (2008) Blood , vol.111 , Issue.7 , pp. 3498-3506
    • Birdsey, G.M.1    Dryden, N.H.2    Amsellem, V.3    Gebhardt, F.4    Sahnan, K.5
  • 22
    • 33646739524 scopus 로고    scopus 로고
    • Progression of prostate cancer by synergy of AKT with genotropic and nongenotropic actions of the androgen receptor
    • Xin L, Teitell MA, Lawson DA, Kwon A, Mellinghoff IK, et al. (2006) Progression of prostate cancer by synergy of AKT with genotropic and nongenotropic actions of the androgen receptor. PNAS 103(20): 7789-7794.
    • (2006) PNAS , vol.103 , Issue.20 , pp. 7789-7794
    • Xin, L.1    Teitell, M.A.2    Lawson, D.A.3    Kwon, A.4    Mellinghoff, I.K.5
  • 24
    • 69449087581 scopus 로고    scopus 로고
    • Functional RET G691S Polymorphism in Cutaneous Malignant Melanoma
    • Narita N, Tanemura A, Murali R, Scolyer RA, Huang S, et al. (2009) Functional RET G691S Polymorphism in Cutaneous Malignant Melanoma. Oncogene 28(34): 3058-3068.
    • (2009) Oncogene , vol.28 , Issue.34 , pp. 3058-3068
    • Narita, N.1    Tanemura, A.2    Murali, R.3    Scolyer, R.A.4    Huang, S.5
  • 25
    • 80054863376 scopus 로고    scopus 로고
    • A chemical-genetic screen reveals a mechanism of resistance to PI3K inhibitors in cancer
    • Muellner MK, Uras IZ, Gapp BV, Kerzendorfer C, Smida M, et al. (2011) A chemical-genetic screen reveals a mechanism of resistance to PI3K inhibitors in cancer. Nat Chem Biol. 7(11): 787-793.
    • (2011) Nat Chem Biol , vol.7 , Issue.11 , pp. 787-793
    • Muellner, M.K.1    Uras, I.Z.2    Gapp, B.V.3    Kerzendorfer, C.4    Smida, M.5
  • 26
    • 84864340439 scopus 로고    scopus 로고
    • Neuregulin 1-ErbB4-PI3K signaling in schizophrenia and phosphoinositide 3-kinase-p110δ inhibition as a potential therapeutic strategy
    • 4
    • Law AJ, Wang Y, Sei Y, Donnell PO, Piantadosi P, et al. (2012) Neuregulin 1-ErbB4-PI3K signaling in schizophrenia and phosphoinositide 3-kinase-p110δ inhibition as a potential therapeutic strategy. PNAS 109(30): 12165-12170 4.
    • (2012) PNAS , vol.109 , Issue.30 , pp. 12165-12170
    • Law, A.J.1    Wang, Y.2    Sei, Y.3    Donnell, P.O.4    Piantadosi, P.5
  • 27
    • 26244464326 scopus 로고    scopus 로고
    • PKB/Akt induces transcription of enzymes involved in cholesterol and fatty acid biosynthesis via activation of SREBP
    • Porstmann T, Griffiths B, Chung Y, Delpuech O, Griffiths JR, et al. (2005) PKB/Akt induces transcription of enzymes involved in cholesterol and fatty acid biosynthesis via activation of SREBP. Oncogene 24(43): 6465-6481.
    • (2005) Oncogene , vol.24 , Issue.43 , pp. 6465-6481
    • Porstmann, T.1    Griffiths, B.2    Chung, Y.3    Delpuech, O.4    Griffiths, J.R.5
  • 28
    • 84861576558 scopus 로고    scopus 로고
    • Regulation of neuroendocrine differentiation by AKT/hnRNPK/AR/β-catenin signaling in prostate cancer cells
    • Ciarlo M, Benelli R, Barbieri O, Minghelli S, Barboro P, et al. (2012) Regulation of neuroendocrine differentiation by AKT/hnRNPK/AR/β-catenin signaling in prostate cancer cells. International Journal of Cancer 131(3): 582-590.
    • (2012) International Journal of Cancer , vol.131 , Issue.3 , pp. 582-590
    • Ciarlo, M.1    Benelli, R.2    Barbieri, O.3    Minghelli, S.4    Barboro, P.5
  • 29
    • 68149159298 scopus 로고    scopus 로고
    • ETS family transcription factors collaborate with alternative signaling pathways to induce carcinoma from adult murine prostate cells
    • Zong Y, Xin L, Goldstein AS, Lawson DA, Teitell MA, et al. (2009) ETS family transcription factors collaborate with alternative signaling pathways to induce carcinoma from adult murine prostate cells. PNAS 106(30): 12465-12470.
    • (2009) PNAS , vol.106 , Issue.30 , pp. 12465-12470
    • Zong, Y.1    Xin, L.2    Goldstein, A.S.3    Lawson, D.A.4    Teitell, M.A.5
  • 30
    • 66749188650 scopus 로고    scopus 로고
    • Aberrant ERG expression cooperates with loss of PTEN to promote cancer progression in the prostate
    • Carver BS, Tran J, Gopalan A, Chen Z, Shaikh S, et al. (2009) Aberrant ERG expression cooperates with loss of PTEN to promote cancer progression in the prostate. Nature Genetics 41(5): 619-624.
    • (2009) Nature Genetics , vol.41 , Issue.5 , pp. 619-624
    • Carver, B.S.1    Tran, J.2    Gopalan, A.3    Chen, Z.4    Shaikh, S.5
  • 31
  • 32
    • 77951645227 scopus 로고    scopus 로고
    • Phase I/II study of combination therapy with sorafenib, idarubicin, and cytarabine in younger patients with acute myeloid leukemia
    • Ravandi F, Cortes JE, Jones D, Faderl S, Garcia-Manero G, et al. (2010) Phase I/II study of combination therapy with sorafenib, idarubicin, and cytarabine in younger patients with acute myeloid leukemia. Journal of Clinical Oncology 28(11): 1856-1862.
    • (2010) Journal of Clinical Oncology , vol.28 , Issue.11 , pp. 1856-1862
    • Ravandi, F.1    Cortes, J.E.2    Jones, D.3    Faderl, S.4    Garcia-Manero, G.5
  • 33
    • 82555173128 scopus 로고    scopus 로고
    • Phase I/II and pharmacodynamic study of dovitinib (TKI258), an inhibitor of fibroblast growth factor receptors and VEGF receptors, in patients with advanced melanoma
    • Kim KB, Chesney J, Robinson D, Gardner H, Shi MM, et al. (2011) Phase I/II and pharmacodynamic study of dovitinib (TKI258), an inhibitor of fibroblast growth factor receptors and VEGF receptors, in patients with advanced melanoma. Clinical Cancer Research 17(23): 7451-7461.
    • (2011) Clinical Cancer Research , vol.17 , Issue.23 , pp. 7451-7461
    • Kim, K.B.1    Chesney, J.2    Robinson, D.3    Gardner, H.4    Shi, M.M.5
  • 34
    • 0034684613 scopus 로고    scopus 로고
    • Genetic analysis of ETS genes in C. elegans
    • Hart AH, Reventar R, Bernstein A, (2000) Genetic analysis of ETS genes in C. elegans. Oncogene 19(55): 6400-6408.
    • (2000) Oncogene , vol.19 , Issue.55 , pp. 6400-6408
    • Hart, A.H.1    Reventar, R.2    Bernstein, A.3
  • 35
    • 4544268945 scopus 로고    scopus 로고
    • ETS transcription factors: possible targets for cancer therapy
    • Oikawa T, (2004) ETS transcription factors: possible targets for cancer therapy. Cancer Science (8): 626-633.
    • (2004) Cancer Science , vol.8 , pp. 626-633
    • Oikawa, T.1
  • 36
    • 84865166248 scopus 로고    scopus 로고
    • Distinct expression profiles of MSI2 and NUMB genes in myelodysplastic syndromes and acute myeloid leukemia patients
    • Pereira JK, Traina F, Machado-Neto JA, Duarte Ada S, Lopes MR, et al. (2012) Distinct expression profiles of MSI2 and NUMB genes in myelodysplastic syndromes and acute myeloid leukemia patients. Leukemia Research 36(10): 1300-1303.
    • (2012) Leukemia Research , vol.36 , Issue.10 , pp. 1300-1303
    • Pereira, J.K.1    Traina, F.2    Machado-Neto, J.A.3    Duarte, A.S.4    Lopes, M.R.5
  • 37
    • 33746257209 scopus 로고    scopus 로고
    • The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
    • Engelman JA, Luo J, Cantley LC, (2006) The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism. Nature Reviews (8): 606-619.
    • (2006) Nature Reviews , vol.8 , pp. 606-619
    • Engelman, J.A.1    Luo, J.2    Cantley, L.C.3
  • 38
    • 78349277366 scopus 로고    scopus 로고
    • Target of rapamycin signaling in leukemia and lymphoma
    • Vu C, Fruman DA, (2010) Target of rapamycin signaling in leukemia and lymphoma. Clinical Cancer Research 16(22): 5374-5380.
    • (2010) Clinical Cancer Research , vol.16 , Issue.22 , pp. 5374-5380
    • Vu, C.1    Fruman, D.A.2
  • 39
    • 79956042920 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors, valproic acid and trichostatin-A induce apoptosis and affect acetylation status of p53 in ERG-positive prostate cancer cells
    • Fortson WS, Kayarthodi S, Fujimura Y, Xu H, Mathews R, et al. (2011) Histone deacetylase inhibitors, valproic acid and trichostatin-A induce apoptosis and affect acetylation status of p53 in ERG-positive prostate cancer cells. International Journal of Oncology 39(1): 111-119.
    • (2011) International Journal of Oncology , vol.39 , Issue.1 , pp. 111-119
    • Fortson, W.S.1    Kayarthodi, S.2    Fujimura, Y.3    Xu, H.4    Mathews, R.5


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