Distinct expression profiles of MSI2 and NUMB genes in myelodysplastic syndromes and acute myeloid leukemia patients

Leukemia Research

Volumn 36, Issue 10, 2012, Pages 1300-1303

  Pereira, João Kleber Novais ^a   Traina, Fabiola ^a   Machado Neto, João Agostinho ^a   Duarte, Adriana da Silva Santos ^a   Lopes, Matheus Rodrigues ^a   Saad, Sara Teresinha Olalla ^a   Favaro, Patricia ^a,b  

^a UNIVERSITY OF CAMPINAS   (Brazil)

^b FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Acute myeloid leukemia; Differentiation; Musashi 2; Myelodysplastic syndromes; NUMB

Indexed keywords

CD34 ANTIGEN;

ACUTE GRANULOCYTIC LEUKEMIA; ADOLESCENT; ADULT; ARTICLE; BONE MARROW CELL; CANCER GROWTH; CANCER PATIENT; CD34 SELECTION; CELL DIFFERENTIATION; CELL LINEAGE; CONTROLLED STUDY; DOWN REGULATION; ERYTHROID CELL; ERYTHROPOIESIS; FEMALE; GENE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HIGH RISK POPULATION; HUMAN; HUMAN CELL; IMMUNOPHENOTYPING; MAJOR CLINICAL STUDY; MALE; MOLECULAR PATHOLOGY; MUSASHI 2 GENE; MYELODYSPLASTIC SYNDROME; NUMB GENE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; TUMOR DIFFERENTIATION; UPREGULATION;

ADOLESCENT; ADULT; AGED; ANTIGENS, CD34; CASE-CONTROL STUDIES; CELL DIFFERENTIATION; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION PROFILING; HUMANS; LEUKEMIA, MYELOID, ACUTE; MALE; MEMBRANE PROTEINS; MIDDLE AGED; MYELODYSPLASTIC SYNDROMES; NERVE TISSUE PROTEINS; PROGNOSIS; REAL-TIME POLYMERASE CHAIN REACTION; RISK FACTORS; RNA, MESSENGER; RNA-BINDING PROTEINS; YOUNG ADULT;

EID: 84865166248     PISSN: 01452126     EISSN: 18735835     Source Type: Journal    
DOI: 10.1016/j.leukres.2012.06.010     Document Type: Article

References (11)

1. Ito T., Kwon H.Y., Zimdahl B., et al. Regulation of myeloid leukaemia by the cell-fate determinant Musashi. Nature 2010, 466:765-768.
2. Kharas M.G., Lengner C.J., Al-Shahrour F., et al. Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia. Nat Med 2010, 16:903-908.
3. Pece S.S., Confalonieri R.R.P., et al. NUMB-ing down cancer by more than just a NOTCH. Biochim Biophys Acta 2011, 1815:26-43.
4. Byers R.J., Currie T., Tholouli E., et al. MSI2 protein expression predicts unfavorable outcome in acute myeloid leukemia. Blood 2011, 118:2857-2867.
5. Takahashi S. Downstream molecular pathways of FLT3 in the pathogenesis of acute myeloid leukemia: biology and therapeutic implications. J Hematol Oncol 2011, 4:13.
6. Takahashi S. Current findings for recurring mutations in acute myeloid leukemia. J Hematol Oncol 2011, 4:36.
7. Benites B.D., Traina F., Duarte Ada S., et al. Increased expression of APAF-1 in low-risk myelodysplastic syndrome: a possible role in the pathophysiology of myelodysplasia. Eur J Haematol 2010, 84:525-530.
8. Livak K.J., Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 2001, 25:402-408.
9. Cheng X., Huber T.L., Chen V.C., et al. Numb mediates the interaction between Wnt and Notch to modulate primitive erythropoietic specification from the hemangioblast. Development 2008, 135:3447-3458.
10. Bresciani E., Confalonieri S., Cermenati S., et al. Zebrafish numb and numblike are involved in primitive erythrocyte differentiation. PLoS One 2010, 5:e14296.
11. Aggarwal S., van de Loosdrecht A.A., Alhan C., et al. Role of immune responses in the pathogenesis of low-risk MDS and high-risk MDS: implications for immunotherapy. Br J Haematol 2011, 153:568-581.