Epithelial-mesenchymal transition contributes to SWCNT-induced pulmonary fibrosis

Nanotoxicology

Volumn 6, Issue 6, 2012, Pages 600-610

  Chang, Chih Ching ^a   Tsai, Mei Ling ^b   Huang, Hui Chun ^a   Chen, Chin Yu ^a   Dai, Shi Xun ^a  

^a NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^b NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

Author keywords

catenin; Epithelial mesenchymal transition; Flow cytometry; Pulmonary fibrosis; SWCNT; TGF

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; BETA CATENIN; COLLAGEN TYPE 1; DESMOSINE; GELATINASE A; GELATINASE B; HYDROXYPROLINE; LACTATE DEHYDROGENASE; NERVE CELL ADHESION MOLECULE; PHOSPHOPROTEIN; SINGLE WALLED NANOTUBE; SMAD2 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; CARBON NANOTUBE; MATRIX METALLOPROTEINASE; SMAD2 PROTEIN, MOUSE; SURFACTANT ASSOCIATED PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL HYPERPLASIA; CONTROLLED STUDY; EPITHELIAL MESENCHYMAL TRANSITION; FEMALE; FLOW CYTOMETRY; FLUORESCENCE ACTIVATED CELL SORTING; IMMUNOFLUORESCENCE MICROSCOPY; LUNG ALVEOLUS EPITHELIUM; LUNG ALVEOLUS MACROPHAGE; LUNG FIBROBLAST; LUNG FIBROSIS; LUNG GRANULOMATOSIS; MOUSE; NEUTROPHIL; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION; ANIMAL; C57BL MOUSE; CHEMICALLY INDUCED DISORDER; CHEMISTRY; DRUG EFFECT; LUNG; METABOLISM; PATHOLOGY;

ANIMALS; BETA CATENIN; EPITHELIAL-MESENCHYMAL TRANSITION; FEMALE; FLOW CYTOMETRY; LUNG; MATRIX METALLOPROTEINASES, SECRETED; MICE; MICE, INBRED C57BL; NANOTUBES, CARBON; PULMONARY FIBROSIS; PULMONARY SURFACTANT-ASSOCIATED PROTEINS; SMAD2 PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

EID: 84871869249     PISSN: 17435390     EISSN: 17435404     Source Type: Journal    
DOI: 10.3109/17435390.2011.594913     Document Type: Article

References (36)

1. Aimes RT, Quigley JP. 1995. Matrix metalloproteinase-2 is an interstitial collagenase. J Biol Chem 270:5872-5876
2. Andersson-Sjoland A, de Alba CG, Nihlberg K, Becerril C, Ramirez R, Pardo A, Westergren-Thorsson G, Selman M. 2008. Fibrocytes are a potential source of lung fibroblasts in idiopathic pulmonary fibrosis. Int J Biochem Cell Biol 40:2129-2140
3. Chilosi M, Poletti V, Zamo A, Lestani M, Montagna L, Piccoli P, Pedron S, Bertaso M, Scarpa A, Murer B, et al. 2003. Aberrant Wnt/b-catenin pathway activation in idiopathic pulmonary fibrosis. Am J Pathol 162:1495-1502 (Pubitemid 36512831)
4. Crouch E. 1990. Pathology of pulmonary fibrosis. Am J Physiol 259: L159-L184
5. Devarajan P, Johnston JJ, Ginsberg SS, Van Wart HE, Berliner N. 1992. Structure and expression of Neutrophil gelatinase cDNA. J Biol Chem 267:25228-25232
6. Epperly MW, Guo HL, Gretton JE, Greenberger JS. 2003. Bone marrow origin of myofibroblasts in irradiation pulmonary fibrosis. Am J Respir Cell Mol Biol 29:213-224 (Pubitemid 36936649)
7. Hamilton RF Jr, Buford MC, Wood MB, Arnone B, Morandi M, Holian A. 2007. Engineered carbon nanoparticles alter macrophage immune function and initiate airway hyper-responsiveness in the BALB/c mouse model. Nanotoxicol 1:104-117 (Pubitemid 47344132)
8. Hashimoto N, Jin H, Liu T, Chensue SW, Phan SH. 2004. Bone marrow-derived progenitor cells in pulmonary fibrosis. J Clin Invest 113:243-252 (Pubitemid 38544209)
9. Higashiyama H, Yoshimoto D, Okamoto Y, Kikkawa H, Asano S, Kinoshita M. 2007. Receptor-activated Smad localisation in bleomycin-induced pulmonary fibrosis. J Clin Pathol 60:283-289 (Pubitemid 46447744)
10. Iwano M, Plieth D, Danoff TM, Xue CS, Okada H, Neilson EG. 2002. Evidence that fibroblasts derive from epithelium during tissue fibrosis. J Clin Invest 110:341-350 (Pubitemid 34847966)
11. Jain AK, Mehra NK, Lodhi N, Dubey V, Mishra DK, Jain PK, Jain NK. 2007. Carbon nanotubes and their toxicity. Nanotoxicology 1:167-197 (Pubitemid 350179073)
12. Kalluri R, Neilson EG. 2003. Epithelial-mesenchymal transition and its implications for fibrosis. J Clin Invest 112:1776-1784 (Pubitemid 38063698)
13. Kasai H, Allen JT, Mason RM, Kamimura T, Zhang Z. 2005. TGF-b1 induces human alveolar epithelial to mesenchymal cell transition (EMT). Respir Res 6:56
14. Kim K, Lu ZF, Hay ED. 2002. Direct evidence for a role of b-catenin/ LEF-1 signaling pathway in induction of EMT. Cell Biol Int 26:463-476 (Pubitemid 34762099)
15. Kim KK, Kugler MC, Wolters PJ, Robillard L, Galvez MG, Brumwell AN, Sheppard D, Chapman HA. 2006. Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix. PNAS 103:13180-13185 (Pubitemid 44338936)
16. Kim KK, Wei Y, Szekeres C, Kugler MC, Wolters PJ, Hill ML, Frank JA, Brumwell AN, Wheeler SE, Kreidberg JA, Chapman HA. 2009. Epithelial cell 3ab1 integrin links b-catenin and Smad signaling to promote myofibroblast formation and pulmonary fibrosis. J Clin Invest 119:213-224
17. Konigshoff M, Balsara N, Pfaff E-M, Kramer M, Chrobak I, Seeger W, Eickelberg O. 2008. Functional Wnt signaling is increased in idiopathic pulmonary fibrosis. PLoS ONE 3:e2142
18. Lam CW, James JT, McCluskey R, Hunter RL. 2004. Pulmonary toxicity of single-wall carbon nanotubes in mice 7 and 90 days after intratracheal instillation. Toxicol Sci 77:126-134 (Pubitemid 38128652)
19. Lam CW, James JT, McCluskey R, Arepalli S, Hunter RL. 2006. A review of carbon nanotube toxicity and assessment of potential occupational and environmental health risks. Crit Rev Toxicol 36:189-217
20. Mehrad B, Burdick MD, Zisman DA, Keane MP, Belperio JA, Strieter RM. 2007. Circulating peripheral blood fibrocytes in human fibrotic interstitial lung disease. Biochem Biophys Res Commun 353:104-108 (Pubitemid 44958347)
21. Moore BB, Hogaboam CM. 2008. Murine models of pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol 294:L152-160 (Pubitemid 351253350)
22. Nelson WJ, Nussee R. 2004. Convergence of Wnt, b-catenin, and cadherin pathways. Science 303:1483-1487 (Pubitemid 38314410)
23. Phillips RJ, Burdick MD, Hong K, Lutz MA, Murray LA, Xue YY, Belperio JA Keane MP, Strieter RM. 2004. Circulating fibrocytes traffic to the lungs in responses to CXCL12 and mediate fibrosis. J Clin Invest 114:438-446 (Pubitemid 39071616)
24. Selman M, Pardo A, Kaminski N. 2008. Idiopathic pulmonary fibrosis: Aberrant recapitulation of developmental programs? PLoS Med 5: E62
25. Shintani Y, Maeda M, Chaika N, Johnson KR, Wheelock MJ. 2008. Collagen I promotes epithelial-to-mesenchymal transition in lung cancer cells via transforming growth factor-b signaling. Am J Respir Cell Mol Biol 38:95-104
26. ShvedovaAA, Kisin ER, Mercer R,MurrayAR,Johnson VJ, Potapovich AI, Tyurina YY, Gorelik O, Aprepalli S, Schwegler-Berry D, et al. 2005 Unusual inflammatory and fibrogenic pulmonary response to single-walled carbon nanotubes in mice. Am J Physiol Lung Cell Mol Physiol 289:L698-L708 (Pubitemid 41504399)
27. Shvedova AA, Kisin E, Murray AR, Johnson VJ, Gorelik O, Aprepalli S, Hubbs AF, Mercer RR, Keohavong P, Sussman N, et al. 2008 Inhalation vs. aspiration of single-walled carbon nanotubes in C57BL/6 mice: Inflammation, fibrosis, oxidative stress, and mutagenesis. Am J Physiol Lung Cell Mol Physiol 295:L552-L565
28. Swiderski RE, Dencoff JE, Floerchinger CS, Shapiro SD, Hunninghake GW. 1998. Differential expression of extracellular matrix remodeling genes in a murine model of bleomycin-induced pulmonary fibrosis. Am J Pathol 152:821-828 (Pubitemid 28110729)
29. Tan RJ, Fattman CL, Niehouse LM, Tobolewski JM, Hanford LE, Li Q, Monzon FA, Parks WC, Oury TD. 2006. Matrix metalloproteinases promote inflammation and fibrosis in asbestos-induced lung injury in mice. Am J Respir Cell Mol Biol 35:289-297 (Pubitemid 44353396)
30. Tanjore H, Xu XC, Polosukhin VV, Degryse AL, Li B, Han W, Sherrill TP, Plieth D, Neilson EG, Blackwell TS, Lawson WE. 2009 Contribution of epithelial-derived fibroblasts to bleomycin-induced lung fibrosis. Am J Respir Crit Care Med 180:657-665
31. Warheit DB, Laurence BR, Reed KL, Roach DH, Reynold GAM, Webb TR. 2004. Comparative pulmonary toxicity assessment of single-wall carbon nanotubes in rats. Toxicol Sci 77:117-125 (Pubitemid 38128651)
32. Willis BC, Liebler JM, Luby-Phelps K, Nicholson AG, Crandall ED, du Bois RM, Borok Z. 2005. Induction of epithelial-mesenchymal transition in alveolar epithelial cells by transforming growth factor-b1. Am J Pathol 166:1321-1332
33. Yang J, Shultz RW, Mars WM, Wegner RE, Li YJ, Dai C, Nejak K, Liu Y. 2002. Disruption of tissue-type plasminogen activator gene in mice reduces renal interstitial fibrosis in obstructive nephropathy. J Clin Invest 110:1525-1538 (Pubitemid 35396923)
34. Yang JW, Liu YH. 2001. Dissection of key events in tubular epithelial to myofibroblast transition and its implications in renal interstitial fibrosis. Am J Pathol 159:1465-1475
35. Zeisberg M, Bonner G, Maeshima Y, Colorado P, Muller GA, Strutz F, Kalluri R. 2001. Collagen composition and assembly regulates epithelial-mesenchymal transdifferentiation. Am J Pathol 159:1313-1321 (Pubitemid 32947961)
36. Zhao J, Shi W, Wang YL, Chen H, Bringas P Jr, Datto MB, Frederick JP, Wang X-F, Warburton D. 2002. Smad3 deficiency attenuates bleomycin-induced pulmonary fibrosis in mice. Am J Physiol Lung Cell Mol Physiol 282:L585-L593 (Pubitemid 34654664)