Age-specific effects on rat lung glutathione and antioxidant enzymes after inhaling ultrafine soot

American Journal of Respiratory Cell and Molecular Biology

Volumn 48, Issue 1, 2013, Pages 114-124

  Chan, Jackie K W ^a   Kodani, Sean D ^a   Charrier, Jessie G ^a   Morin, Dexter ^a   Edwards, Patricia C ^a   Anderson, Donald S ^a   Anastasio, Cort ^a   Van Winkle, Laura S ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Glutathione peroxidase; Glutathione S transferases; Lung development; Oxidative stress; Ultrafine particulate matter

Indexed keywords

GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; GLUTATHIONE TRANSFERASE;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME INDUCTION; ENZYME METABOLISM; GENE EXPRESSION; IN VIVO STUDY; INHALATION; MALE; NEWBORN; NONHUMAN; PROTEIN EXPRESSION; RAT; SOOT;

ADMINISTRATION, INHALATION; AGE FACTORS; ANIMALS; ANIMALS, NEWBORN; ANTIOXIDANTS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLUTAMATE-CYSTEINE LIGASE; GLUTATHIONE; GLUTATHIONE DISULFIDE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; GLUTATHIONE TRANSFERASE; HUMANS; LUNG; MALE; OXIDATIVE STRESS; PARTICULATE MATTER; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; VEHICLE EMISSIONS;

RATTUS;

EID: 84871864454     PISSN: 10441549     EISSN: 15354989     Source Type: Journal    
DOI: 10.1165/rcmb.2012-0108OC     Document Type: Article

References (61)

1. Dockery DW. Health effects of particulate air pollution. Ann Epidemiol 2009;19:257-263.
2. Mills NL, Donaldson K, Hadoke PW, Boon NA, MacNee W, Cassee FR, Sandstrom T, Blomberg A, Newby DE. Adverse cardiovascular effects of air pollution. Nat Clin Pract Cardiovasc Med 2009;6:36-44.
3. Bearer CF. How are children different from adults. Environ Health Perspect 1995;103:7-12.
4. Finkelstein JN, Johnston CJ. Enhanced sensitivity of the postnatal lung to environmental insults and oxidant stress. Pediatrics 2004;113(Suppl) 1092-1096. (Pubitemid 38437363)
5. Langston C. Normal and abnormal structural development of the human lung. Prog Clin Biol Res 1983;140:75-91.
6. Pey J, Querol X, Alastuey A, Rodriguez S, Putaud JP, Van Dingenen R. Source apportionment of urban fine and ultra-fine particle number concentration in a western Mediterranean city. Atmos Environ 2009;43:4407-4415.
7. Rengasamy A, Barger MW, Kane E, Ma JK, Castranova V, Ma JY. Diesel exhaust particle-induced alterations of pulmonary phase I and phase II enzymes of rats. J Toxicol Environ Health A 2003;66:153-167. (Pubitemid 36135676)
8. Baulig A, Garlatti M, Bonvallot V, Marchand A, Barouki R, Marano F, Baeza-Squiban A. Involvement of reactive oxygen species in the metabolic pathways triggered by diesel exhaust particles in human airway epithelial cells. Am J Physiol Lung Cell Mol Physiol 2003;285:L671-L679. (Pubitemid 37022869)
9. Dellinger B, Pryor WA, Cueto R, Squadrito GL, Hegde V, Deutsch WA. Role of free radicals in the toxicity of airborne fine particulate matter. Chem Res Toxicol 2001;14:1371-1377. (Pubitemid 32988407)
10. Brunekreef B, Janssen NA, de Hartog J, Harssema H, Knape M, van Vliet P. Air pollution from truck traffic and lung function in children living near motorways. Epidemiology 1997;8:298-303. (Pubitemid 27183696)
11. Norris G, Young Pong SN, Koenig JQ, Larson TV, Sheppard L, Stout JW. An association between fine particles and asthma emergency department visits for children in seattle. Environ Health Perspect 1999;107:489-493. (Pubitemid 29341374)
12. Ibald-Mulli A, Wichmann HE, Kreyling W, Peters A. Epidemiological evidence on health effects of ultrafine particles. J Aerosol Med 2002;15:189-201. (Pubitemid 34827532)
13. Wichmann HE, Peters A. Epidemiological evidence of the effects of ultrafine particle exposure. Philos T Roy Soc A 1775;2000:2751-2768.
14. Meister A. Glutathione, metabolism and function via the gamma-glutamyl cycle. Life Sci 1974;15:177-190.
15. Krzywanski DM, Dickinson DA, Iles KE, Wigley AF, Franklin CC, Liu RM, Kavanagh TJ, Forman HJ. Variable regulation of glutamate cysteine ligase subunit proteins affects glutathione biosynthesis in response to oxidative stress. Arch Biochem Biophys 2004;423:116-125. (Pubitemid 38198221)
16. Sutherland KM, Edwards PC, Combs TJ, Van Winkle LS. Sex differences in the development of airway epithelial tolerance to naphthalene. Am J Physiol Lung Cell Mol Physiol 2012;302:L68-L81.
17. Lee D,Wallis C, Wexler AS, Schelegle ES, VanWinkle LS, Plopper CG, Fanucchi MV, Kumfer B, Kennedy IM, Chan JK. Small particles disrupt postnatal airway development. J Appl Physiol 2010;109:1115-1124.
18. Chan JK, Fanucchi MV, Anderson DS, Abid AD, Wallis CD, Dickinson DA, Kumfer BM, Kennedy IM, Wexler AS, Van Winkle LS. Susceptibility to inhaled flame-generated ultrafine soot in neonatal and adult rat lungs. Toxicol Sci 2011;124:472-486.
19. Moller W, Felten K, Sommerer K, Scheuch G, Meyer G, Meyer P, Haussinger K, Kreyling WG. Deposition, retention, and translocation of ultrafine particles from the central airways and lung periphery. Am J Respir Crit Care Med 2008;177:426-432. (Pubitemid 351317586)
20. Lakritz J, Plopper CG, Buckpitt AR. Validated high-performance liquid chromatography-electrochemical method for determination of glutathione and glutathione disulfide in small tissue samples. Anal Biochem 1997;247:63-68. (Pubitemid 27161494)
21. Baker GL, Shultz MA, Fanucchi MV, Morin DM, Buckpitt AR, Plopper CG. Assessing gene expression in lung subcompartments utilizing in situ RNA preservation. Toxicol Sci 2004;77:135-141. (Pubitemid 38128653)
22. Stelck RL, Baker GL, Sutherland KM, Van Winkle LS. Estrous cycle alters naphthalene metabolism in female mouse airways. Drug Metab Dispos 2005;33:1597-1602. (Pubitemid 41539955)
23. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta delta C(t)) method. Methods 2001;25:402-408. (Pubitemid 34164012)
24. Schmittgen TD, Livak KJ. Analyzing real-time PCR data by the comparative c(t) method. Nat Protoc 2008;3:1101-1108. (Pubitemid 351818697)
25. Van Winkle LS, Chan JK, Anderson DS, Kumfer BM, Kennedy IM, Wexler AS, Wallis C, Abid AD, Sutherland KM, Fanucchi MV. Age specific responses to acute inhalation of diffusion flame soot particles: cellular injury and the airway antioxidant response. Inhal Toxicol 2010;22:70-83.
26. Wilson HH, Chauhan J, Kerry PJ, Evans JG. Ethanol vapour-fixation of rat lung for immunocytochemistry investigations. J Immunol Methods 2001;247:187-190. (Pubitemid 32057055)
27. Hammond TG, Mobbs M. Lung oedema-microscopic detection. J Appl Toxicol 1984;4:219-221.
28. Van Winkle LS, Isaac JM, Plopper CG. Repair of naphthalene-injured microdissected airways in vitro. Am J Respir Cell Mol Biol 1996;15:1-8. (Pubitemid 126439850)
29. Charrier JG, Anastasio C. Impacts of antioxidants on hydroxyl radical production from individual and mixed transition metals in a surrogate lung fluid. Atmos Environ 2011;45:7555-7562.
30. Kok GL, McLaren SE, Staffelbach TA. HPLC determination of atmospheric organic hydroperoxides. J Atmos Ocean Technol 1995;12:282-289.
31. Helsel DR. More than obvious: better methods for interpreting non-detect data. Environ Sci Technol 2005;39:419a-423a. (Pubitemid 41476571)
32. Shumway RH, Azari RS, Kayhanian M. Statistical approaches to estimating mean water quality concentrations with detection limits. Environ Sci Technol 2002;36:3345-3353. (Pubitemid 34847605)
33. Arthur JR. The glutathione peroxidases. Cell Mol Life Sci 2000;57:1825-1835. (Pubitemid 32102578)
34. Armstrong RN. Glutathione S-transferases: reaction mechanism, structure, and function. Chem Res Toxicol 1991;4:131-140.
35. Zhong CY, Zhou YM, Smith KR, Kennedy IM, Chen CY, Aust AE, Pinkerton KE. Oxidative injury in the lungs of neonatal rats following short-term exposure to ultrafine iron and soot particles. J Toxicol Environ Health A 2010;73:837-847.
36. Pinkerton KE, Zhou Y, Zhong C, Smith KR, Teague SV, Kennedy IM, Menache MG. Mechanisms of particulate matter toxicity in neonatal and young adult rat lungs. Res Rep Health Eff Inst 2008;135:3-41, discussion 43-52.
37. Balakrishna S, Saravia J, Thevenot P, Ahlert T, Lominiki S, Dellinger B, Cormier SA. Environmentally persistent free radicals induce airway hyperresponsiveness in neonatal rat lungs. Part Fibre Toxicol 2011;8:11.
38. Zhu Y, Hinds WC, Kim S, Sioutas C. Concentration and size distribution of ultrafine particles near a major highway. J Air Waste Manag Assoc 2002;52:1032-1042. (Pubitemid 35025845)
39. Martensson J, Jain A, Stole E, Frayer W, Auld PA, Meister A. Inhibition of glutathione synthesis in the newborn rat: a model for endogenously produced oxidative stress. Proc Natl Acad Sci USA 1991;88:9360-9364. (Pubitemid 21915631)
40. Scott RB, Reddy KS, Husain K, Schlorff EC, Rybak LP, Somani SM. Dose response of ethanol on antioxidant defense system of liver, lung, and kidney in rat. Pathophysiology 2000;7:25-32. (Pubitemid 30312995)
41. Perez R, Lopez M, Barja de Quiroga G. Aging and lung antioxidant enzymes, glutathione, and lipid peroxidation in the rat. Free Radic Biol Med 1991;10:35-39. (Pubitemid 121003209)
42. Jenkinson SG, Spence TH Jr, Lawrence RA, Hill KE, Duncan CA, Johnson KH. Rat lung glutathione release: response to oxidative stress and selenium deficiency. J Appl Physiol 1987;62:55-60. (Pubitemid 17060596)
43. Buckpitt A, Chang AM, Weir A, Van Winkle L, Duan X, Philpot R, Plopper C. Relationship of cytochrome P450 activity to clara cell cytotoxicity: IV.Metabolism of naphthalene and naphthalene oxide in microdissected airways from mice, rats, and hamsters. Mol Pharmacol 1995;47:74-81.
44. Duan X, Buckpitt AR, Pinkerton KE, Ji C, Plopper CG. Ozone-induced alterations in glutathione in lung subcompartments of rats and monkeys. Am J Respir Cell Mol Biol 1996;14:70-75. (Pubitemid 126443092)
45. Al-Humadi NH, Siegel PD, Lewis DM, Barger MW, Ma JY, Weissman DN, Ma JK. Alteration of intracellular cysteine and glutathione levels in alveolar macrophages and lymphocytes by diesel exhaust particle exposure. Environ Health Perspect 2002;110:349-353. (Pubitemid 34308598)
46. Plopper CG, Van Winkle LS, Fanucchi MV, Malburg SR, Nishio SJ, Chang A, Buckpitt AR. Early events in naphthalene-induced acute clara cell toxicity: II. Comparison of glutathione depletion and histopathology by airway location. Am J Respir Cell Mol Biol 2001;24:272-281. (Pubitemid 32228375)
47. Phimister AJ, Lee MG, Morin D, Buckpitt AR, Plopper CG. Glutathione depletion is a major determinant of inhaled naphthalene respiratory toxicity and naphthalene metabolism in mice. Toxicol Sci 2004;82:268-278. (Pubitemid 39485340)
48. Li N, Nel AE. Role of the NRF2-mediated signaling pathway as a negative regulator of inflammation: implications for the impact of particulate pollutants on asthma. Antioxid Redox Signal 2006;8:88-98. (Pubitemid 43324534)
49. Rouse RL, Murphy G, Boudreaux MJ, Paulsen DB, Penn AL. Soot nanoparticles promote biotransformation, oxidative stress, and inflammation in murine lungs. Am J Respir Cell Mol Biol 2008;39:198-207.
50. Li YJ, Takizawa H, Azuma A, Kohyama T, Yamauchi Y, Takahashi S, Yamamoto M, Kawada T, Kudoh S, Sugawara I. Disruption of NRF2 enhances susceptibility to airway inflammatory responses induced by low-dose diesel exhaust particles in mice. Clin Immunol 2008;128:366-373.
51. Zhang H, Liu H, Davies KJ, Sioutas C, Finch CE, Morgan TE, Forman HJ. Nrf2-regulated phase ii enzymes are induced by chronic ambient nanoparticle exposure in young mice with age-related impairments. Free Radic Biol Med 2012;52:2038-2046.
52. Kumagai Y, Arimoto T, Shinyashiki M, Shimojo N, Nakai Y, Yoshikawa T, Sagai M. Generation of reactive oxygen species during interaction of diesel exhaust particle components with NADPH-Cytochrome p450 reductase and involvement of the bioactivation in the DNA damage. Free Radic Biol Med 1997;22:479-487. (Pubitemid 27020122)
53. Michiels C, Raes M, Toussaint O, Remacle J. Importance of Se-glutathione peroxidase, catalase, and Cu/Zn-sod for cell-survival against oxidative stress. Free Radic Biol Med 1994;17:235-248.
54. Gilks CB, Price K, Wright JL, Churg A. Antioxidant gene expression in rat lung after exposure to cigarette smoke. Am J Pathol 1998;152:269-278. (Pubitemid 28028067)
55. Fujii T, Endo T, Fujii J, Taniguchi N. Differential expression of glutathione reductase and cytosolic glutathione peroxidase, GPX1, in developing rat lungs and kidneys. Free Radic Res 2002;36:1041-1049.
56. Strange RC, Spiteri MA, Ramachandran S, Fryer AA. Glutathione-s- transferase family of enzymes. Mutat Res 2001;482:21-26. (Pubitemid 32787078)
57. Gilliland FD, Li YF, Saxon A, Diaz-Sanchez D. Effect of glutathione-s-transferase M1 and P1 genotypes on xenobiotic enhancement of allergic responses: randomised, placebo-controlled crossover study. Lancet 2004;363:119-125. (Pubitemid 38068328)
58. Forkert PG, D'Costa D, El-Mestrah M. Expression and inducibility of alpha, pi, and mu glutathione S-transferase protein and mRna in murine lung. Am J Respir Cell Mol Biol 1999;20:143-152. (Pubitemid 129504853)
59. Kabesch M, Hoefler C, Carr D, Leupold W, Weiland SK, von Mutius E. Glutathione S transferase deficiency and passive smoking increase childhood asthma. Thorax 2004;59:569-573. (Pubitemid 38901514)
60. Ritchie KJ, Henderson CJ, Wang XJ, Vassieva O, Carrie D, Farmer PB, Gaskell M, Park K, Wolf CR. Glutathione transferase Pi plays a critical role in the development of lung carcinogenesis following exposure to tobacco-related carcinogens and urethane. Cancer Res 2007;67:9248-9257. (Pubitemid 47535913)
61. Fanucchi MV, Buckpitt AR, Murphy ME, Storms DH, Hammock BD, Plopper CG. Development of phase II xenobiotic metabolizing enzymes in differentiating murine clara cells. Toxicol Appl Pharmacol 2000;168:253-267.