Age specific responses to acute inhalation of diffusion flame soot particles: Cellular injury and the airway antioxidant response

Inhalation Toxicology

Volumn 22, Issue SUPPL. 2, 2010, Pages 70-83

  Van Winkle, Laura S ^a   Chan, Jackie K W ^a   Anderson, Donald S ^a   Kumfer, Benjamin M ^b,c   Kennedy, Ian M ^b   Wexler, Anthony S ^a   Wallis, Christopher ^a   Abid, Aamir D ^b   Sutherland, Katherine M ^a   Fanucchi, Michelle V ^d  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b University of California   (United States)

^c WASHINGTON UNIVERSITY IN ST LOUIS   (United States)

^d UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

Antioxidant; Bronchiolar; Lung development; Particulate matter

Indexed keywords

ATM PROTEIN; BINDING PROTEIN; CATALASE; COPPER ZINC SUPEROXIDE DISMUTASE; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE PEROXIDASE; GLUTATHIONE PEROXIDASE 1; GLUTATHIONE PEROXIDASE 3; GLUTATHIONE PEROXIDASE 6; GLUTATHIONE PEROXIDASE 7; INTERLEUKIN 18; KINESIN; KINESIN 9; LACTATE DEHYDROGENASE; MANGANESE SUPEROXIDE DISMUTASE; MYOGLOBIN; PEROXIREDOXIN 1; PEROXIREDOXIN 2; PEROXIREDOXIN 3; PEROXIREDOXIN 5; POLYCYCLIC AROMATIC HYDROCARBON; PROSTAGLANDIN ENDOPEROXIDE SYNTHASE 1; PROTEASOME; PROTEIN PSMB5; PROTEIN XIRP1; SYNTHETASE; TROPOMODULIN; TROPOMODULIN 1; UNCLASSIFIED DRUG; VIMENTIN; XERODERMA PIGMENTOSUM GROUP A PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; ATMOSPHERE; CELL COMPOSITION; CELL DAMAGE; CYTOTOXICITY; ENZYME ACTIVITY; EPITHELIUM CELL; EXPOSURE; GENE EXPRESSION; LUNG LAVAGE; MALE; NEWBORN; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PARTICLE SIZE; PARTICULATE MATTER; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RESPIRATORY EPITHELIUM;

ADMINISTRATION, INHALATION; AGE FACTORS; ANIMALS; ANIMALS, NEWBORN; ANTIOXIDANTS; BRONCHOALVEOLAR LAVAGE FLUID; CATALASE; GENE EXPRESSION; GLUTAMATE-CYSTEINE LIGASE; INHALATION; LUNG; MALE; PARTICLE SIZE; PARTICULATE MATTER; RATS; RATS, SPRAGUE-DAWLEY; RESPIRATORY SYSTEM; SOOT;

ANIMALIA; RATTUS;

EID: 78650195025     PISSN: 08958378     EISSN: 10917691     Source Type: Journal    
DOI: 10.3109/08958378.2010.513403     Document Type: Article

References (61)

1. ALA. 2009. American Lung Association State of the Air: 2009. American Lung Association, New York, NY.
2. Baker GL, Shultz MA, Fanucchi MV, Morin DM, Buckpitt AR, Plopper CG. 2004. Assessing gene expression in lung subcompartments utilizing in situ RNA preservation. Toxicol Sci 77:135-141.
3. Becker S, Dailey LA, Soukup JM, Grambow SC, Devlin RB, Huang YC. 2005. Seasonal variations in air pollution particle-induced inflammatory mediator release and oxidative stress. Environ Health Perspect 113:1032-1038.
4. Billet S, Garçon G, Dagher Z, Verdin A, Ledoux F, Cazier F, Courcot D, Aboukais A, Shirali P. 2007. Ambient particulate matter (PM2.5): Physicochemical characterization and metabolic activation of the organic fraction in human lung epithelial cells (A549). Environ Res 105:212-223.
5. Branis M, Safranek J, Hytychova A. 2009. Exposure of children to airborne particulate matter of different size fractions during indoor physical education at school. Building and Environment 44:1246-1252.
6. CARB. 2009. Air Quality Data and Statistics for PM2.5 in San Jaoquin Valley air basin for 2009: Days above standard California Air Resources Board (CARB).
7. Carter JM, Corson N, Driscoll KE, Elder A, Finkelstein JN, Harkema JN, Gelein R, Wade-Mercer P, Nguyen K, Oberdorster G. 2006. A comparative dose-related response of several key pro- and antiinflammatory mediators in the lungs of rats, mice, and hamsters after subchronic inhalation of carbon black. J Occup Environ Med 48:1265-1278.
8. Chen Y, Frank L. 1993. Differential gene expression of antioxidant enzymes in the perinatal rat lung. Pediatr Res 34:27-31.
9. Chen Y, Shah N, Braun A, Huggins F, Huffman G. 2005. Electron microscopy investigation of carbonaceous particulate matter generated by combusion of fossil fuels. Energy and Fuels 19:1644-1651.
10. Chomczynski P, Sacchi N. 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156-159.
11. Chung MY, Lazaro RA, Lim D, Jackson J, Lyon J, Rendulic D, Hasson AS. 2006. Aerosol-borne quinones and reactive oxygen species generation by particulate matter extracts. Environ Sci Technol 40:4880-4886.
12. Ciccone G, Forastiere F, Agabiti N, Biggeri A, Bisanti L, Chellini E, Corbo G, Dell'Orco V, Dalmasso P, Volante TF, Galassi C, Piffer S, Renzoni E, Rusconi F, Sestini P, Viegi G. 1998. Road traffic and adverse respiratory effects in children. SIDRIA Collaborative Group. Occup Environ Med 55:771-778.
13. Claiborne A, Yeh JI, Mallett TC, Luba J, Crane EJ 3rd, Charrier V, Parsonage D. 1999. Protein-sulfenic acids: Diverse roles for an unlikely player in enzyme catalysis and redox regulation. Biochemistry 38:15407-15416.
14. Dye JA, Lehmann JR, McGee JK, Winsett DW, Ledbetter AD, Everitt JI, Ghio AJ, Costa DL. 2001. Acute pulmonary toxicity of particulate matter filter extracts in rats: Coherence with epidemiologic studies in Utah Valley residents. Environ Health Perspect 109 Suppl 3:395-403.
15. Fanucchi MV, Buckpitt AR, Murphy ME, Plopper CG. 1997. Naphthalene cytotoxicity of differentiating Clara cells in neonatal mice. Toxicol Appl Pharmacol 144:96-104.
16. Fanucchi MV, Buckpitt AR, Murphy ME, Storms DH, Hammock BD, Plopper CG. 2000. Development of phase II xenobiotic metabolizing enzymes in differentiating murine clara cells. Toxicol Appl Pharmacol 168:253-267.
17. Fanucchi MV, Day KC, Clay CC, Plopper CG. 2004. Increased vulnerability of neonatal rats and mice to 1-nitronaphthalene-induced pulmonary injury. Toxicol Appl Pharmacol 201:53-65.
18. Ghio AJ, Kim C, Devlin RB. 2000. Concentrated ambient air particles induce mild pulmonary inflammation in healthy human volunteers. Am J Respir Crit Care Med 162:981-988.
19. Hammond TG, Mobbs M. 1984. Lung oedema-microscopic detection. J Appl Toxicol 4:219-221.
20. Harding R, PKE, Plopper CG. 2004. The Lung - Development, Aging and the Environment. Elsevier Academic Press, San Diego, CA, pp. 403.
21. Hayes JD, Pulford DJ. 1995. The glutathione S-transferase supergene family: Regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance. Crit Rev Biochem Mol Biol 30:445-600.
22. Heidenfelder BL, Reif DM, Harkema JR, Cohen Hubal EA, Hudgens EE, Bramble LA, Wagner JG, Morishita M, Keeler GJ, Edwards SW, Gallagher JE. 2009. Comparative microarray analysis and pulmonary changes in Brown Norway rats exposed to ovalbumin and concentrated air particulates. Toxicol Sci 108:207-221.
23. Herner JD, Aw J, Gao O, Chang DP, Kleeman MJ. 2005. Size and composition distribution of airborne particulate matter in northern California: I-particulate mass, carbon, and water-soluble ions. J Air Waste Manag Assoc 55:30-51.
24. Hinners RG, Burkart JK, Punte CL. 1968. Animal inhalation exposure chambers. Arch Environ Health 16:194-206.
25. Howard C, Reed M. 1998. Unbiased Stereology. Springer-Verlag, New York, pp. 246.
26. Hu Y, Benya RV, Carroll RE, Diamond AM. 2005. Allelic loss of the gene for the GPX1 selenium-containing protein is a common event in cancer. J Nutr 135:3021S-3024S.
27. Hyde DM, Plopper CG, St., George, JA, Harkema JR. 1990. Morphometric Cell Biology of Air Space Epithelium. In: Schraufnagel, D.E. (Ed.) Electron Microscopy of the Lung, vol. 48. Marcel Dekker, New York, pp. 71-120.
28. Kennedy CH, Catallo WJ, Wilson VL, Mitchell JB. 2009. Combustion products of 1,3-butadiene inhibit catalase activity and induce expression of oxidative DNA damage repair enzymes in human bronchial epithelial cells. Cell Biol Toxicol 25:457-470.
29. Kooter I, Pennings J, Opperhuizen A, Cassee F. 2005. Gene expression pattern in spontaneously hypertensive rats exposed to urban particulate matter (EHC-93). Inhal Toxicol 17:53-65.
30. Livak KJ, Schmittgen TD. 2001. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25:402-408.
31. Madden MC. 2008. Complex issues with examining diesel exhaust toxicity: Is the task getting easier or harder? Exp Toxicol Pathol 60:135-140.
32. Morrow PE, Mercer T.T. 1964. A point-to-plane electrostatic precipitator for particle size sampling. Am Ind Hyg Assoc J 25 8-14.
33. Na K, Cocker DR. 2005. Organic and elemental carbon concentrations in fine particulate matter in residences, schoolrooms, and outdoor air in Mira Loma, California. Atmospheric Environment 39:3325-3333. (Pubitemid 40732805)
34. Oosterlee A, Drijver M, Lebret E, Brunekreef B. 1996. Chronic respiratory symptoms in children and adults living along streets with high traffic density. Occup Environ Med 53:241-247.
35. Pascal LE, True LD, Campbell DS, Deutsch EW, Risk M, Coleman IM, Eichner LJ, Nelson PS, Liu AY. 2008. Correlation of mRNA and protein levels: Cell typespecific gene expression of cluster designation antigens in the prostate. BMC Genomics 9:246.
36. Pey J, Querol X, Alastuey A, Rodriguez S, Putaud JP, Van Dingenen R. 2009. Source apportionment of urban fine and ultra-fine particle number concentration in a Western Mediterranean city. Atmospheric Environment 43:4407-4415.
37. Pinkerton KE, Zhou Y, Zhong C, Smith KR, Teague SV, Kennedy IM, Ménache MG. 2008. Mechanisms of particulate matter toxicity in neonatal and young adult rat lungs. Res Rep Health Eff Inst 3-41; discussion 43.
38. Pinkerton KE, Zhou YM, Teague SV, Peake JL, Walther RC, Kennedy IM, Leppert VJ, Aust AE. 2004. Reduced lung cell proliferation following shortterm exposure to ultrafine soot and iron particles in neonatal rats: Key to impaired lung growth? Inhal Toxicol 16 Suppl 1:73-81.
39. Plopper CG, Macklin J, Nishio SJ, Hyde DM, Buckpitt AR. 1992. Relationship of cytochrome P-450 activity to Clara cell cytotoxicity. III. Morphometric comparison of changes in the epithelial populations of terminal bronchioles and lobar bronchi in mice, hamsters, and rats after parenteral administration of naphthalene. Lab Invest 67:553-565.
40. Plopper CG, Weir AJ, Nishio SJ, Chang A, Voit M, Philpot RM, Buckpitt AR. 1994. Elevated susceptibility to 4-ipomeanol cytotoxicity in immature Clara cells of neonatal rabbits. J Pharmacol Exp Ther 269:867-880.
41. Raaschou-Nielsen O, Sørensen M, Hansen RD, Frederiksen K, Tjønneland A, Overvad K, Vogel U. 2007. GPX1 Pro198Leu polymorphism, interactions with smoking and alcohol consumption, and risk for lung cancer. Cancer Lett 247:293-300.
42. Rengasamy A, Barger MW, Kane E, Ma JK, Castranova V, Ma JY. 2003. Diesel exhaust particle-induced alterations of pulmonary phase I and phase II enzymes of rats. J Toxicol Environ Health Part A 66:153-167.
43. Rhee SG, Yang KS, Kang SW, Woo HA, Chang TS. 2005. Controlled elimination of intracellular H(2)O(2): Regulation of peroxiredoxin, catalase, and glutathione peroxidase via post-translational modification. Antioxid Redox Signal 7:619-626.
44. Robert MA, VanBergen S, Kleeman MJ, Jakober CA. 2007. Size and composition distributions of particulate matter emissions: Part 1-light-duty gasoline vehicles. J Air Waste Manag Assoc 57:1414-1428.
45. Rosenberger A, Illig T, Korb K, Klopp N, Zietemann V, Wölke G, Meese E, Sybrecht G, Kronenberg F, Cebulla M, Degen M, Drings P, Gröschel A, Konietzko N, Kreymborg KG, Häussinger K, Höffken G, Jilge B, Ko YD, Morr H, Schmidt C, Schmidt EW, Täuscher D, Bickeböller H, Wichmann HE. 2008. Do genetic factors protect for early onset lung cancer? A case control study before the age of 50 years. BMC Cancer 8:60.
46. Samet JM, Rappold A, Graff D, Cascio WE, Berntsen JH, Huang YC, Herbst M, Bassett M, Montilla T, Hazucha MJ, Bromberg PA, Devlin RB. 2009. Concentrated ambient ultrafine particle exposure induces cardiac changes in young healthy volunteers. Am J Respir Crit Care Med 179:1034-1042.
47. Sherratt AJ, Culpepper BT, Lubawy WC. 1988. Relative participation of the gas phase and total particulate matter in the imbalance in prostacyclin and thromboxane formation seen following chronic cigarette smoke exposure. Prostaglandins Leukot Essent Fatty Acids 34: 15-18.
48. Smiley-Jewell SM, Liu FJ, Weir AJ, Plopper CG. 2000. Acute injury to differentiating Clara cells in neonatal rabbits results in age-related failure of bronchiolar epithelial repair. Toxicol Pathol 28:267-276.
49. Smiley-Jewell SM, Nishio SJ, Weir AJ, Plopper CG. 1998. Neonatal Clara cell toxicity by 4-ipomeanol alters bronchiolar organization in adult rabbits. Am J Physiol 274:L485-L498.
50. Smiley-Jewell SM, Plopper CG. 2003. Proliferation during early phases of bronchiolar repair in neonatal rabbits following lung injury by 4-ipomeanol. Toxicol Appl Pharmacol 192:69-77.
51. Sundberg BE, Wååg E, Jacobsson JA, Stephansson O, Rumaks J, Svirskis S, Alsiö J, Roman E, Ebendal T, Klusa V, Fredriksson R. 2008. The evolutionary history and tissue mapping of amino acid transporters belonging to solute carrier families SLC32, SLC36, and SLC38. J Mol Neurosci 35: 179-193.
52. Theophilus EH, Keith Shreve W, Ayres PH, Garner CD, Pence DH, Swauger JE. 2007. Comparative 13-week cigarette smoke inhalation study in Sprague- Dawley rats: Evaluation of cigarettes with two banded cigarette paper technologies. Food Chem Toxicol 45:1076-1090.
53. USEPA. 2008. US EPA Green Book - Counties Designated Nonattainment. vol. 2008.
54. USEPA. 2009. US EPA Green Book - Particulate Matter (PM-2.5) Nonattainment Areas (1997 Standard). vol. 2009.
55. van Vliet P, Knape M, de Hartog J, Janssen N, Harssema H, Brunekreef B. 1997. Motor vehicle exhaust and chronic respiratory symptoms in children living near freeways. Environ Res 74:122-132.
56. Van Winkle LS, Isaac JM, Plopper CG. 1996. Repair of naphthalene-injured microdissected airways in vitro. Am J Respir Cell Mol Biol 15:1-8.
57. Weisiger RA, Fridovich I. 1973. Mitochondrial superoxide simutase. Site of synthesis and intramitochondrial localization. J Biol Chem 248:4793-4796.
58. Wilson HH, Chauhan J, Kerry PJ, Evans JG. 2001. Ethanol vapour-fixation of rat lung for immunocytochemistry investigations. J Immunol Methods 247:187-190.
59. Yang G, Teague SV, Pinkerton K, Kennedy I. 2001. Synthesis of an ultrafine iron and soot aerosol for the evaluation of particle toxicity. Aerosol Sci Tehnol 35:759-766.
60. Zhong CY, Zhou YM, Smith KR, Kennedy IM, Chen CY, Aust AE, Pinkerton KE. 2010. Oxidative injury in the lungs of neonatal rats following short-term exposure to ultrafine iron and soot particles. J Toxicol Environ Health Part A 73:837-847.
61. Zhou YM, Zhong CY, Kennedy IM, Leppert VJ, Pinkerton KE. 2003. Oxidative stress and NFkappaB activation in the lungs of rats: A synergistic interaction between soot and iron particles. Toxicol Appl Pharmacol 190:157-169.