The fat-mass and obesity-associated gene (FTO) predicts mortality in chronic kidney disease of various severity

Nephrology Dialysis Transplantation

Volumn 27, Issue SUPPL.4, 2012, Pages

  Spoto, Belinda ^a   Mattace Raso, Francesco ^b   Sijbrands, Eric ^b   Mallamaci, Francesca ^a   Leonardis, Daniela ^a   Aucella, Filippo ^c   Testa, Alessandra ^a   Gesuete, Antonio ^c   Sanguedolce, Maria C ^a   D'Arrigo, Graziella ^a   Parlongo, Rosa M ^a   Pisano, Anna ^a   Torino, Claudia ^a   Enia, Giuseppe ^a   Tripepi, Giovanni ^a   Postorino, Maurizio ^a   Zoccali, Carmine ^a  

^a CNR   (Italy)

^b ERASMUS MEDICAL CENTER   (Netherlands)

^c CASA SOLLIEVO DELLA SOFFERENZA HOSPITAL   (Italy)

Author keywords

chronic kidney disease; dialysis; FTO gene; meta analysis; mortality

Indexed keywords

ADULT; ALLELE; ARTICLE; CHRONIC KIDNEY DISEASE; COHORT ANALYSIS; CONFIDENCE INTERVAL; CONTROLLED STUDY; DISEASE SEVERITY; FAT MASS AND OBESITY ASSOCIATED GENE; FEMALE; GENE; GENETIC RISK; HAZARD RATIO; HEMODIALYSIS PATIENT; HUMAN; MAJOR CLINICAL STUDY; MALE; META ANALYSIS (TOPIC); MORTALITY; PREDICTION; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM;

FEMALE; HUMANS; MALE; MIDDLE AGED; PROGNOSIS; PROTEINS; RENAL INSUFFICIENCY, CHRONIC; SEVERITY OF ILLNESS INDEX;

EID: 84871828304     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfs550     Document Type: Article

References (27)

1. Christakis NA, Fowler JH. The spread of obesity in a large social network over 32 Years. N Engl J Med 2007; 357: 370-379
2. Segal NL, Feng R, McGuire SA et al. Genetic and environmental contributions to body mass index: comparative analysis of monozygotic twins, dizygotic twins and same-age unrelated siblings. Int J Obes 2009; 33: 37-41
3. O'Rahilly S, Farooqi IS. Genetics of obesity. Philos Trans R Soc B 2006; 361: 1095-1105
4. Zimmermann E, Kring S, II, Berentzen TL et al. Fatness-associated FTO gene variant increases mortality independent of fatness in cohorts of Danish men. PLoS ONE 2009; 4: e4428
5. Kaklamani V, Yi N, Sadim M et al. The role of the fat mass and obesity associated gene (FTO) in breast cancer risk. BMC Med Genet 2011; 12: 52-62
6. Lewis SJ, Murad A, Chen L et al. Associations between an obesity related genetic variant (FTO rs9939609) and prostate cancer risk. PLoS ONE 2010; 5: e13485
7. Brennan P, McKay J, Moore L et al. Obesity and cancer: Mendelian randomization approach utilizing the FTO genotype. Int J Epidemiol 2009; 38: 971-975
8. Frayling TM, Timpson NJ, Weedon MN et al. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 2007; 316: 889-894
9. Zeggini E, Weedon MN, Lindgren CM et al. Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science 2007; 316: 1336-1341
10. Scott LJ, Mohlke KL, Bonnycastle LL et al. A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science 2007; 316: 1341-1345
11. Pausova Z, Syme C, Abrahamowicz M et al. A common variant of the FTO gene is associated with not only increased adiposity but also elevated blood pressure in French Canadians. Circ Cardiovasc Genet 2009; 2: 260-269
12. Stenvinkel P. Chronic kidney disease: a public health priority and harbinger of premature cardiovascular disease. J Intern Med 2010; 268: 456-467
13. Elsayed EF, Tighiouart H, Weiner DE et al. Waist-to-hip ratio and body mass index as risk factors for cardiovascular events in CKD. Am J Kidney Dis 2008; 52: 49-57
14. Kalantar-Zadeh K, Abbott KC, Salahudeen AK et al. Survival advantages of obesity in dialysis patients. Am J Clin Nutr 2005; 81: 543-554
15. Zoccali C, Bode-Böger S, Mallamaci F et al. Plasma concentration of asymmetrical dimethylarginine and mortality in patients with endstage renal disease: a prospective study. Lancet 2001; 358: 2113-2117
16. Aucella F, Maas R, Vigilante M et al. Methylarginines and mortality in patients with end stage renal disease: a prospective cohort study. Atherosclerosis 2009; 207: 541-545
17. Scuteri A, Sanna S, Chen W-M et al. Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. PLoS ONE 2007; 3: e115
18. Dina C, Meyre D, Gallina S et al. Variation in FTO contributes to childhood obesity and severe adult obesity. Nat Genet 2007; 39: 724-726
19. Peng S, Zhu Y, Xu F et al. FTO gene polymorphisms and obesity risk: a meta-analysis. BMC Med 2011; 9: 71
20. Miller SA, Dykes DD, Polesky HF. A simple salting out procedure for extracting DNA from human nucleated cells. Nucl Acids Res 1988; 16: 1215
21. van Stralen KJ, Dekker FW, Zoccali C et al. Confounding. Nephron Clin Pract 2010; 116: c143-c147
22. Churcill GA, Doerge RW. Empirical threshold values for quantitative trait mapping. Genetics 1994; 138: 963-971
23. Higgins JPT, Thompson SG. Quantifying heterogeneity in a metaanalysis. Stat Med 2002; 21: 1539-1558
24. Yang J, Loos RJ, Powell JE et al. FTO genotype is associated with phenotypic variability of body mass index. Nature 2012; 490: 267-272
25. Gerken T, Girard CA, Tung Y-C L et al. The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. Science 2007; 318: 1469-1472
26. Keller L, Xu W, Wang HX et al. The obesity related gene, FTO, interacts with APOE, and is associated with Alzheimer's disease risk: a prospective cohort study. J Alzheimers Dis 2011; 23: 461-469
27. Hubacek JA, Viklicky O, Dlouha D et al. The FTO gene polymorphism is associated with end-stage renal disease: two large independent case-control studies in a general population. Nephrol Dial Transplant 2012; 27: 1030-1035