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Volumn 207, Issue 2, 2013, Pages 340-350

Phosphorylation of mitogen-activated protein kinases contributes to interferon γ production in response to mycobacterium tuberculosis

Author keywords

CREB; IFN ; MAPK; signaling; Tuberculosis

Indexed keywords

GAMMA INTERFERON; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; MYCOBACTERIUM ANTIGEN; SMALL INTERFERING RNA; TUBERCULOSTATIC AGENT;

EID: 84871819353     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1093/infdis/jis672     Document Type: Article
Times cited : (24)

References (48)
  • 1
    • 0035877017 scopus 로고    scopus 로고
    • Infection of human macrophages and dendritic cells with Mycobacterium tuberculosis induces a differential cytokine gene expression that modulates T cell response
    • Giacomini E, Iona E, Ferroni L, et al. Infection of human macrophages and dendritic cells with Mycobacterium tuberculosis induces a differential cytokine gene expression that modulates T cell response. J Immunol 2001; 166:7033-41.
    • (2001) J Immunol , vol.166 , pp. 7033-7041
    • Giacomini, E.1    Iona, E.2    Ferroni, L.3
  • 4
    • 0030467174 scopus 로고    scopus 로고
    • A mutation in the interferon-gamma-receptor gene and susceptibility to mycobacterial infection
    • Newport MJ, Huxley CM, Huston S, et al. A mutation in the interferon-gamma-receptor gene and susceptibility to mycobacterial infection. N Engl J Med 1996; 335:1941-9.
    • (1996) N Engl J Med , vol.335 , pp. 1941-1949
    • Newport, M.J.1    Huxley, C.M.2    Huston, S.3
  • 5
    • 0036533614 scopus 로고    scopus 로고
    • Reduced expression of nuclear cyclic adenosine 5'-monophosphate response element-binding proteins and IFN-gamma promoter function in disease due to an intracellular pathogen
    • Samten B, Ghosh P, Yi AK, et al. Reduced expression of nuclear cyclic adenosine 5'-monophosphate response element-binding proteins and IFN-gamma promoter function in disease due to an intracellular pathogen. J Immunol 2002; 168:3520-6.
    • (2002) J Immunol , vol.168 , pp. 3520-3526
    • Samten, B.1    Ghosh, P.2    Yi, A.K.3
  • 6
    • 0030874953 scopus 로고    scopus 로고
    • Clinical correlates of interferon gamma production in patients with tuberculosis
    • Sodhi A, Gong J, Silva C, Qian D, Barnes PF. Clinical correlates of interferon gamma production in patients with tuberculosis. Clin Infect Dis 1997; 25:617-20.
    • (1997) Clin Infect Dis , vol.25 , pp. 617-620
    • Sodhi, A.1    Gong, J.2    Silva, C.3    Qian, D.4    Barnes, P.F.5
  • 7
    • 0036233983 scopus 로고    scopus 로고
    • Transcription: Tantalizing times for T cells
    • Ho IC, Glimcher LH. Transcription: tantalizing times for T cells. Cell 2002; 109 (Suppl):S109-20.
    • (2002) Cell , vol.109 , Issue.SUPPL.
    • Ho, I.C.1    Glimcher, L.H.2
  • 9
    • 34248374256 scopus 로고    scopus 로고
    • Activation of MAP kinase p38 is critical for the cell-cycle-controlled suppressor function of regulatory T cells
    • Adler HS, Kubsch S, Graulich E, Ludwig S, Knop J, Steinbrink K. Activation of MAP kinase p38 is critical for the cell-cycle-controlled suppressor function of regulatory T cells. Blood 2007; 109:4351-9.
    • (2007) Blood , vol.109 , pp. 4351-4359
    • Adler, H.S.1    Kubsch, S.2    Graulich, E.3    Ludwig, S.4    Knop, J.5    Steinbrink, K.6
  • 10
    • 0036716403 scopus 로고    scopus 로고
    • Control of Mycobacterial Replication in Human Macrophages: Roles of Extracellular Signal-Regulated Kinases 1 and 2 and p38 Mitogen-Activated Protein Kinase Pathways
    • Blumenthal A, Ehlers S, Ernst M, Flad H-D, Reiling N. Control of Mycobacterial Replication in Human Macrophages: Roles of Extracellular Signal-Regulated Kinases 1 and 2 and p38 Mitogen-Activated Protein Kinase Pathways. Infection and Immunity 2002; 70:4961-7.
    • (2002) Infection and Immunity , vol.70 , pp. 4961-4967
    • Blumenthal, A.1    Ehlers, S.2    Ernst, M.3    Flad, H.-D.4    Reiling, N.5
  • 11
    • 0036225712 scopus 로고    scopus 로고
    • T-cell antigen receptor signal transduction
    • Cantrell DA. T-cell antigen receptor signal transduction. Immunology 2002; 105:369-74.
    • (2002) Immunology , vol.105 , pp. 369-374
    • Cantrell, D.A.1
  • 12
    • 3142682595 scopus 로고    scopus 로고
    • T cell receptor signaling: Beyond complex complexes
    • Huang Y, Wange RL. T cell receptor signaling: beyond complex complexes. J Biol Chem 2004; 279:28827-30.
    • (2004) J Biol Chem , vol.279 , pp. 28827-28830
    • Huang, Y.1    Wange, R.L.2
  • 13
    • 0037346775 scopus 로고    scopus 로고
    • Macrophage signalling upon mycobacterial infection: The MAP kinases lead the way
    • Schorey JS, Cooper AM. Macrophage signalling upon mycobacterial infection: the MAP kinases lead the way. Cellular Microbiology 2003; 5:133-42.
    • (2003) Cellular Microbiology , vol.5 , pp. 133-142
    • Schorey, J.S.1    Cooper, A.M.2
  • 14
    • 0036036011 scopus 로고    scopus 로고
    • Pharmacological analysis of signal transduction pathways required for Mycobacteri-um tuberculosis-induced IL-8 and MCP-1 production in human peripheral monocytes
    • Fietta AM, Morosini M, Meloni F, Bianco AM, Pozzi E. Pharmacological analysis of signal transduction pathways required for Mycobacteri-um tuberculosis-induced IL-8 and MCP-1 production in human peripheral monocytes. Cytokine 2002; 19:242-9.
    • (2002) Cytokine , vol.19 , pp. 242-249
    • Fietta, A.M.1    Morosini, M.2    Meloni, F.3    Bianco, A.M.4    Pozzi, E.5
  • 15
    • 4344574045 scopus 로고    scopus 로고
    • Evolutionarily conserved sequence elements that positively regulate IFN-gamma expression in T cells
    • Shnyreva M, Weaver WM, Blanchette M, et al. Evolutionarily conserved sequence elements that positively regulate IFN-gamma expression in T cells. Proc Natl Acad Sci U S A 2004; 101:12622-7.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 12622-12627
    • Shnyreva, M.1    Weaver, W.M.2    Blanchette, M.3
  • 16
    • 0029052324 scopus 로고
    • Negative transcriptional regulation of the interferon-gamma promoter by glucocorticoids and dominant negative mutants of c-Jun
    • Cippitelli M, Sica A, Viggiano V, et al. Negative transcriptional regulation of the interferon-gamma promoter by glucocorticoids and dominant negative mutants of c-Jun. J Biol Chem 1995; 270:12548-56.
    • (1995) J Biol Chem , vol.270 , pp. 12548-12556
    • Cippitelli, M.1    Sica, A.2    Viggiano, V.3
  • 17
    • 0029732843 scopus 로고    scopus 로고
    • The proximal regulatory element of the interferon-gamma promoter mediates selective expression in T cells
    • Penix LA, Sweetser MT, Weaver WM, Hoeffler JP, Kerppola TK, Wilson CB. The proximal regulatory element of the interferon-gamma promoter mediates selective expression in T cells. J Biol Chem 1996; 271:31964-72.
    • (1996) J Biol Chem , vol.271 , pp. 31964-31972
    • Penix, L.A.1    Sweetser, M.T.2    Weaver, W.M.3    Hoeffler, J.P.4    Kerppola, T.K.5    Wilson, C.B.6
  • 18
    • 61849092592 scopus 로고    scopus 로고
    • IFN-gamma production during active tuberculosis is regulated by mechanisms that involve IL-17, SLAM, and CREB
    • Pasquinelli V, Townsend JC, Jurado JO, et al. IFN-gamma production during active tuberculosis is regulated by mechanisms that involve IL-17, SLAM, and CREB. J Infect Dis 2009; 199:661-5.
    • (2009) J Infect Dis , vol.199 , pp. 661-665
    • Pasquinelli, V.1    Townsend, J.C.2    Jurado, J.O.3
  • 19
    • 2942530310 scopus 로고    scopus 로고
    • ERK and p38 MAPK-Activated Protein Kinases: A Family of Protein Kinases with Diverse Biological Functions
    • Roux PP, Blenis J. ERK and p38 MAPK-Activated Protein Kinases: a Family of Protein Kinases with Diverse Biological Functions. Microbiology and Molecular Biology Reviews 2004; 68:320-344.
    • (2004) Microbiology and Molecular Biology Reviews , vol.68 , pp. 320-344
    • Roux, P.P.1    Blenis, J.2
  • 20
    • 9144257864 scopus 로고    scopus 로고
    • Expression of signaling lymphocytic activation molecule-associated protein interrupts IFN-gamma production in human tuberculosis
    • Pasquinelli V, Quiroga MF, Martinez GJ, et al. Expression of signaling lymphocytic activation molecule-associated protein interrupts IFN-gamma production in human tuberculosis. J Immunol 2004; 172:1177-85.
    • (2004) J Immunol , vol.172 , pp. 1177-1185
    • Pasquinelli, V.1    Quiroga, M.F.2    Martinez, G.J.3
  • 21
    • 10744226908 scopus 로고    scopus 로고
    • Loss of circulating CD27 + memory B cells and CCR4+ T cells occurring in association with elevated EBV loads in XLP patients surviving primary EBV infection
    • Malbran A, Belmonte L, Ruibal-Ares B, et al. Loss of circulating CD27 + memory B cells and CCR4+ T cells occurring in association with elevated EBV loads in XLP patients surviving primary EBV infection. Blood 2004; 103:1625-31.
    • (2004) Blood , vol.103 , pp. 1625-1631
    • Malbran, A.1    Belmonte, L.2    Ruibal-Ares, B.3
  • 22
    • 0036351317 scopus 로고    scopus 로고
    • Analysis of gene function in somatic mammalian cells using small interfering RNAs
    • Elbashir SM, Harborth J, Weber K, Tuschl T. Analysis of gene function in somatic mammalian cells using small interfering RNAs. Methods 2002; 26:199-213.
    • (2002) Methods , vol.26 , pp. 199-213
    • Elbashir, S.M.1    Harborth, J.2    Weber, K.3    Tuschl, T.4
  • 23
    • 18644370311 scopus 로고    scopus 로고
    • Cyclic AMP response elementbinding protein positively regulates production of IFN-gamma by T cells in response to a microbial pathogen
    • Samten B, Howard ST, Weis SE, et al. Cyclic AMP response elementbinding protein positively regulates production of IFN-gamma by T cells in response to a microbial pathogen. J Immunol 2005; 174:6357-63.
    • (2005) J Immunol , vol.174 , pp. 6357-6363
    • Samten, B.1    Howard, S.T.2    Weis, S.E.3
  • 25
    • 84861926963 scopus 로고    scopus 로고
    • IL-17 and IFN-gamma expression in lymphocytes from patients with active tuberculosis correlates with the severity of the disease
    • Jurado JO, Pasquinelli V, Alvarez IB, et al. IL-17 and IFN-gamma expression in lymphocytes from patients with active tuberculosis correlates with the severity of the disease. J Leukoc Biol 2012; 91:991-1002.
    • (2012) J Leukoc Biol , vol.91 , pp. 991-1002
    • Jurado, J.O.1    Pasquinelli, V.2    Alvarez, I.B.3
  • 26
    • 33645773184 scopus 로고    scopus 로고
    • Selective Requirement of p38a MAPK in Cytokine-Dependent, but Not Antigen Receptor-Dependent, Th1 Responses
    • Berenson LS, Yang J, Sleckman BP, Murphy TL, Murphy KM. Selective Requirement of p38a MAPK in Cytokine-Dependent, but Not Antigen Receptor-Dependent, Th1 Responses. The Journal of Immunology 2006; 176:4616-21.
    • (2006) The Journal of Immunology , vol.176 , pp. 4616-4621
    • Berenson, L.S.1    Yang, J.2    Sleckman, B.P.3    Murphy, T.L.4    Murphy, K.M.5
  • 27
    • 0037125988 scopus 로고    scopus 로고
    • STAT4 serine phosphoryla-tion is critical for IL-12-induced IFN-γ Production but not for cell proliferation
    • Morinobu A, Gadina M, Strober W, et al. STAT4 serine phosphoryla-tion is critical for IL-12-induced IFN-γ production but not for cell proliferation. Proceedings of the National Academy of Sciences 2002; 99:12281-6.
    • (2002) Proceedings of the National Academy of Sciences , vol.99 , pp. 12281-12286
    • Morinobu, A.1    Gadina, M.2    Strober, W.3
  • 28
    • 0034284088 scopus 로고    scopus 로고
    • Importance of the MKK6/p38 pathway for interleukin- 12â€"induced STAT4 serine phosphoryla-tion and transcriptional activity
    • Visconti R, Gadina M, Chiariello M, et al. Importance of the MKK6/p38 pathway for interleukin-12â€"induced STAT4 serine phosphoryla-tion and transcriptional activity. Blood 2000; 96:1844-52.
    • (2000) Blood , vol.96 , pp. 1844-1852
    • Visconti, R.1    Gadina, M.2    Chiariello, M.3
  • 29
    • 79952180387 scopus 로고    scopus 로고
    • T-cell receptor ligation induces distinct signaling pathways in naive vs. antigen-experienced t cells
    • Adachi K, Davis MM. T-cell receptor ligation induces distinct signaling pathways in naive vs. antigen-experienced T cells. Proceedings of the National Academy of Sciences 2010; 108:1549-54.
    • (2010) Proceedings of the National Academy of Sciences , vol.108 , pp. 1549-1554
    • Adachi, K.1    Davis, M.M.2
  • 30
    • 78649986122 scopus 로고    scopus 로고
    • Activation of p38 mitogen-activated protein kinase is critical step for acquisition of effector function in cytokine-activated t cells but acts as a negative regulator in t cells activated through the t-cell receptor
    • Li C, Beavis P, Palfreeman AC, Amjadi P, Kennedy A, Brennan FM. Activation of p38 mitogen-activated protein kinase is critical step for acquisition of effector function in cytokine-activated T cells, but acts as a negative regulator in T cells activated through the T-cell receptor. Immunology 2011; 132:104-10.
    • (2011) Immunology , vol.132 , pp. 104-110
    • Li, C.1    Beavis, P.2    Palfreeman, A.C.3    Amjadi, P.4    Kennedy, A.5    Brennan, F.M.6
  • 31
    • 0028220266 scopus 로고
    • Interleukin 12 at the site of disease in tuberculosis
    • Zhang M, Gately MK, Wang E, et al. Interleukin 12 at the site of disease in tuberculosis. J Clin Invest 1994; 93:1733-9.
    • (1994) J Clin Invest , vol.93 , pp. 1733-1739
    • Zhang, M.1    Gately, M.K.2    Wang, E.3
  • 32
    • 70349303968 scopus 로고    scopus 로고
    • ERK and not p38 pathway is required for IL-12 restoration of T cell IL-2 and IFN-gamma in a rodent model of alcohol intoxication and burn injury
    • Li X, Chaudry IH, Choudhry MA. ERK and not p38 pathway is required for IL-12 restoration of T cell IL-2 and IFN-gamma in a rodent model of alcohol intoxication and burn injury. J Immunol 2009; 183:3955-62.
    • (2009) J Immunol , vol.183 , pp. 3955-3962
    • Li, X.1    Chaudry, I.H.2    Choudhry, M.A.3
  • 33
    • 80054810826 scopus 로고    scopus 로고
    • Mycobacterium tuberculosis lip-omannan blocks tnf biosynthesis by regulating macrophage mapk-activated protein kinase 2 (mk2) and microrna mir-125b
    • Rajaram MV, Ni B, Morris JD, et al. Mycobacterium tuberculosis lip-omannan blocks TNF biosynthesis by regulating macrophage MAPK-activated protein kinase 2 (MK2) and microRNA miR-125b. Proc Natl Acad Sci U S A 2011; 108:17408-13.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 17408-17413
    • Rajaram, M.V.1    Ni, B.2    Morris, J.D.3
  • 34
    • 59449106444 scopus 로고    scopus 로고
    • Roles of reactive oxygen species in CXCL8 and CCL2 expression in response to the 30-kDa antigen of Mycobacterium tuberculosis
    • Lee HM, Shin DM, Kim KK, Lee JS, Paik TH, Jo EK. Roles of reactive oxygen species in CXCL8 and CCL2 expression in response to the 30-kDa antigen of Mycobacterium tuberculosis. J Clin Immunol 2009; 29:46-56.
    • (2009) J Clin Immunol , vol.29 , pp. 46-56
    • Lee, H.M.1    Shin, D.M.2    Kim, K.K.3    Lee, J.S.4    Paik, T.H.5    Jo, E.K.6
  • 35
    • 33846186744 scopus 로고    scopus 로고
    • Protein kinase C zeta plays an essential role for Mycobacterium tuberculosis-induced extracellular signalregulated kinase 1/2 activation in monocytes/macrophages via Tolllike receptor 2
    • Yang CS, Lee JS, Song CH, et al. Protein kinase C zeta plays an essential role for Mycobacterium tuberculosis-induced extracellular signalregulated kinase 1/2 activation in monocytes/macrophages via Tolllike receptor 2. Cell Microbiol 2007; 9:382-96.
    • (2007) Cell Microbiol , vol.9 , pp. 382-396
    • Yang, C.S.1    Lee, J.S.2    Song, C.H.3
  • 36
    • 31344442826 scopus 로고    scopus 로고
    • Activation of ERK1/2 and TNF-alpha production are mediated by calcium/calmodulin, and PKA signaling pathways during Mycobacterium bovis infection
    • Mendez-Samperio P, Trejo A, Miranda E. Activation of ERK1/2 and TNF-alpha production are mediated by calcium/calmodulin, and PKA signaling pathways during Mycobacterium bovis infection. J Infect 2006; 52:147-53.
    • (2006) J Infect , vol.52 , pp. 147-153
    • Mendez-Samperio, P.1    Trejo, A.2    Miranda, E.3
  • 37
    • 77954230361 scopus 로고    scopus 로고
    • The PPE18 of Mycobacterium tuberculosis interacts with TLR2 and activates IL-10 induction in macrophage
    • Nair S, Ramaswamy PA, Ghosh S, et al. The PPE18 of Mycobacterium tuberculosis interacts with TLR2 and activates IL-10 induction in macrophage. J Immunol 2009; 183:6269-81.
    • (2009) J Immunol , vol.183 , pp. 6269-6281
    • Nair, S.1    Ramaswamy, P.A.2    Ghosh, S.3
  • 38
    • 0345306608 scopus 로고    scopus 로고
    • Induction of p38 Mitogen-activated Protein Kinase Reduces Early Endosome Autoantigen 1 (EEA1) Recruitment to Phagosomal Membranes
    • Fratti RA, Chua J, Deretic V. Induction of p38 Mitogen-activated Protein Kinase Reduces Early Endosome Autoantigen 1 (EEA1) Recruitment to Phagosomal Membranes. Journal of Biological Chemistry 2003; 278:46961-7.
    • (2003) Journal of Biological Chemistry , vol.278 , pp. 46961-46967
    • Fratti, R.A.1    Chua, J.2    Deretic, V.3
  • 39
    • 0035160822 scopus 로고    scopus 로고
    • P38 Mitogen-Activated Protein Kinase Inhibition Increases Cytokine Release by Macrophages in Vitro and during Infection in Vivo
    • van den Blink B, Juffermans NP, ten Hove T, et al. p38 Mitogen-Activated Protein Kinase Inhibition Increases Cytokine Release by Macrophages In Vitro and During Infection In Vivo. The Journal of Immunology 2001; 166:582-7.
    • (2001) The Journal of Immunology , vol.166 , pp. 582-587
    • Van Den Blink, B.1    Juffermans, N.P.2    Ten Hove, T.3
  • 40
    • 0036437048 scopus 로고    scopus 로고
    • Loss of RD1 contributed to the attenuation of the live tuberculosis vaccines Mycobac-terium bovis BCG and Mycobacterium microti
    • Pym AS, Brodin P, Brosch R, Huerre M, Cole ST. Loss of RD1 contributed to the attenuation of the live tuberculosis vaccines Mycobac-terium bovis BCG and Mycobacterium microti. Molecular Microbiology 2002; 46:709-17.
    • (2002) Molecular Microbiology , vol.46 , pp. 709-717
    • Pym, A.S.1    Brodin, P.2    Brosch, R.3    Huerre, M.4    Cole, S.T.5
  • 41
    • 0037219942 scopus 로고    scopus 로고
    • Deletion of RD1 from Mycobacte-rium tuberculosis Mimics Bacille Calmette-Guérin Attenuation
    • Lewis KN, Liao R, Guinn KM, et al. Deletion of RD1 from Mycobacte-rium tuberculosis Mimics Bacille Calmette-Guérin Attenuation. Journal of Infectious Diseases 2003; 187:117-23.
    • (2003) Journal of Infectious Diseases , vol.187 , pp. 117-123
    • Lewis, K.N.1    Liao, R.2    Guinn, K.M.3
  • 42
    • 79959911673 scopus 로고    scopus 로고
    • The Mycobacterium tuberculosis Early Secreted Antigenic Target of 6 kDa Inhibits T Cell Interferon-γ Production through the p38 Mitogen-activated Protein Kinase Pathway
    • Peng H, Wang X, Barnes PF, Tang H, Townsend JC, Samten B. The Mycobacterium tuberculosis Early Secreted Antigenic Target of 6 kDa Inhibits T Cell Interferon-γ Production through the p38 Mitogen-activated Protein Kinase Pathway. Journal of Biological Chemistry 2011; 286:24508-18.
    • (2011) Journal of Biological Chemistry , vol.286 , pp. 24508-24518
    • Peng, H.1    Wang, X.2    Barnes, P.F.3    Tang, H.4    Townsend, J.C.5    Samten, B.6
  • 43
    • 78650666211 scopus 로고    scopus 로고
    • The role of the transcription factor CREB in immune function
    • Wen AY, Sakamoto KM, Miller LS. The role of the transcription factor CREB in immune function. J Immunol 2010; 185: 6413-9.
    • (2010) J Immunol , vol.185 , pp. 6413-6419
    • Wen, A.Y.1    Sakamoto, K.M.2    Miller, L.S.3
  • 44
    • 3242799552 scopus 로고    scopus 로고
    • Cyclic adenosine 5'-monophosphate response element binding protein plays a central role in mediating proliferation and differentiation downstream of the pre-TCR complex in developing thymocytes
    • Grady GC, Mason SM, Stephen J, Zuniga-Pflucker JC, Michie AM. Cyclic adenosine 5'-monophosphate response element binding protein plays a central role in mediating proliferation and differentiation downstream of the pre-TCR complex in developing thymocytes. J Immunol 2004; 173:1802-10.
    • (2004) J Immunol , vol.173 , pp. 1802-1810
    • Grady, G.C.1    Mason, S.M.2    Stephen, J.3    Zuniga-Pflucker, J.C.4    Michie, A.M.5
  • 45
    • 0032575574 scopus 로고    scopus 로고
    • A protein kinase C-, Ras-, and RSK2-dependent signal transduction pathway activates the cAMP-responsive element-binding protein transcription factor following T cell receptor engagement
    • Muthusamy N, Leiden JM. A protein kinase C-, Ras-, and RSK2-dependent signal transduction pathway activates the cAMP-responsive element-binding protein transcription factor following T cell receptor engagement. J Biol Chem 1998; 273:22841-7.
    • (1998) J Biol Chem , vol.273 , pp. 22841-22847
    • Muthusamy, N.1    Leiden, J.M.2
  • 47
    • 34548749896 scopus 로고    scopus 로고
    • MSK regulate TCR-induced CREB phosphorylation but not immediate early gene transcription
    • Kaiser M, Wiggin GR, Lightfoot K, Arthur JS, Macdonald A. MSK regulate TCR-induced CREB phosphorylation but not immediate early gene transcription. Eur J Immunol 2007; 37:2583-95.
    • (2007) Eur J Immunol , vol.37 , pp. 2583-2595
    • Kaiser, M.1    Wiggin, G.R.2    Lightfoot, K.3    Arthur, J.S.4    MacDonald, A.5
  • 48
    • 0031884839 scopus 로고    scopus 로고
    • The duration of antigenic stimulation determines the fate of naive and effector T cells
    • Iezzi G, Karjalainen K, Lanzavecchia A. The duration of antigenic stimulation determines the fate of naive and effector T cells. Immunity 1998; 8:89-95.
    • (1998) Immunity , vol.8 , pp. 89-95
    • Iezzi, G.1    Karjalainen, K.2    Lanzavecchia, A.3


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