IFN-γ production during active tuberculosis is regulated by mechanisms that involve IL-17, SLAM, and CREB

Journal of Infectious Diseases

Volumn 199, Issue 5, 2009, Pages 661-665

  Pasquinelli, Virginia ^a   Townsend, James C ^b   Jurado, Javier O ^a   Alvarez, Ivana B ^a   Quiroga, María F ^a   Barnes, Peter F ^b,c   Samten, Buka ^b   García, Verónica E ^a  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^b UNIVERSITY OF TEXAS HEALTH CENTER   (United States)

^c Health Science Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD150 ANTIGEN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; GAMMA INTERFERON; INTERLEUKIN 17;

ARTICLE; CELL ACTIVATION; CLINICAL ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; T LYMPHOCYTE; TUBERCULOSIS;

ANTIGENS, CD; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; GENE EXPRESSION REGULATION, BACTERIAL; HUMANS; INTERFERON-GAMMA; INTERLEUKIN-17; PHOSPHORYLATION; RECEPTORS, CELL SURFACE; TUBERCULOSIS;

EID: 61849092592     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/596742     Document Type: Article

References (15)

1. Cooper AM, Dalton DK, Stewart TA, Griffin JP, Russell DG, Orme IM. Disseminated tuberculosis in interferon gamma gene-disrupted mice. J Exp Med 1993; 178:2243-7.
2. Sodhi A, Gong J, Silva C, Qian D, Barnes PF. Clinical correlates of interferon gamma production in patients with tuberculosis. Clin Infect Dis 1997; 25:617-20.
3. Ho IC, Glimcher LH. Transcription: tantalizing times for T cells. Cell 2002; 109(Suppl):S109-20.
4. Samten B, Howard ST, Weis SE, et al. Cyclic AMP response element-binding protein positively regulates production of IFN-γ by T cells in response to a microbial pathogen. J Immunol 2005; 174:6357-63.
5. Pasquinelli V, Quiroga MF, Martinez GJ, et al. Expression of signaling lymphocytic activation molecule-associated protein interrupts IFN-γ production in human tuberculosis. J Immunol 2004; 172:1177-85.
6. Steinman L. A brief history of T(H)17, the first major revision in the T(H)1/T(H)2 hypothesis of T cell-mediated tissue damage. Nat Med 2007; 13:139-45.
7. Elbashir SM, Harborth J, Weber K, Tuschl T. Analysis of gene function in somatic mammalian cells using small interfering RNAs. Methods 2002; 26:199-213.
8. Zhang M, Gong J, Iyer DV, Jones BE, Modlin RL, Barnes PF. T cell cytokine responses in persons with tuberculosis and human immunodeficiency virus infection. J Clin Invest 1994; 94:2435-42.
9. + T cell responses after vaccination and during Mycobacterium tuberculosis challenge. Nat Immunol 2007; 8:369-77.
10. + T cell subsets contribute to the human antimycobacterial immune response. J Immunol 2008; 180:1962-70.
11. Ottenhoff TH, Kumararatne D, Casanova JL. Novel human immunodeficiencies reveal the essential role of type-I cytokines in immunity to intracellular bacteria. Immunol Today 1998; 19:491-4.
12. Samten B, Townsend JC, Weis SE, et al. CREB, ATF, and AP-1 transcription factors regulate IFN-γ secretion by human T cells in response to mycobacterial antigen. J Immunol 2008; 181:2056-64.
13. + T lymphocytes. J Immunol 1998; 160:3642-7.
14. Quiroga MF, Martinez GJ, Pasquinelli V, et al. Activation of signaling lymphocytic activation molecule triggers a signaling cascade that enhances Th1 responses in human intracellular infection. J Immunol 2004; 173:4120-9.
15. Umemura M, Yahagi A, Hamada S, et al. IL-17-mediated regulation of innate and acquired immune response against pulmonary Mycobacterium bovis bacille Calmette-Guerin infection. J Immunol 2007; 178:3786-96.