Variant alleles of the Wnt antagonist FRZB are determinants of hip shape and modify the relationship between hip shape and osteoarthritis

Arthritis and Rheumatism

Volumn 64, Issue 5, 2012, Pages 1457-1465

  Baker LePain, Julie C ^a   Lynch, John A ^a   Parimi, Neeta ^b   McCulloch, Charles E ^a   Nevitt, Michael C ^a   Corr, Maripat ^c   Lane, Nancy E ^d  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b CALIFORNIA PACIFIC MEDICAL CENTER   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ESTROGEN; VITAMIN D;

ACETABULUM; AGED; ARTICLE; BODY HEIGHT; BODY MASS; BODY WEIGHT; BONE CHARACTERISTICS AND FUNCTIONS; BONE DENSITY; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMUR; FEMUR NECK; FRZB GENE; GENE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HEALTH STATUS; HIP OSTEOARTHRITIS; HIP RADIOGRAPHY; HIP SHAPE; HOMOZYGOSITY; HUMAN; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; VITAMIN SUPPLEMENTATION;

AGED; CASE-CONTROL STUDIES; FEMALE; FEMUR; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GLYCOPROTEINS; HIP; HIP JOINT; HUMANS; OSTEOARTHRITIS, HIP; POLYMORPHISM, SINGLE NUCLEOTIDE; SOMATOTYPES;

EID: 84860464634     PISSN: 00043591     EISSN: 15290131     Source Type: Journal    
DOI: 10.1002/art.34526     Document Type: Article

References (50)

1. Reginster JY. The prevalence and burden of arthritis. Rheumatology (Oxford) 2002;41 Supp 1:3-6.
2. Reginster JY, Khaltaev NG. Introduction and WHO perspective on the global burden of musculoskeletal conditions. Rheumatology (Oxford) 2002;41 Supp 1:1-2.
3. Lawrence RC, Helmick CG, Arnett FC, Deyo RA, Felson DT, Giannini EH, et al. Estimates of the prevalence of arthritis and selected musculoskeletal disorders in the United States. Arthritis Rheum 1998;41:778-99.
4. Felson DT, Naimark A, Anderson J, Kazis L, Castelli W, Meenan RF. The prevalence of knee osteoarthritis in the elderly: the Framingham Osteoarthritis Study. Arthritis Rheum 1987;30: 914-8.
5. Maurer K. Basic data on arthritis knee, hip, and sacroiliac joints in adults ages 25-74 years. Vital Health Stat 11 1979;(213):1-31.
6. Hunter DJ. Pharmacologic therapy for osteoarthritis-the era of disease modification. Nat Rev Rheumatol 2011;7:13-22.
7. MacGregor AJ, Antoniades L, Matson M, Andrew T, Spector TD. The genetic contribution to radiographic hip osteoarthritis in women: results of a classic twin study. Arthritis Rheum 2000;43: 2410-6.
8. Baker-LePain JC, Lane NE. Relationship between joint shape and the development of osteoarthritis. Curr Opin Rheumatol. 2010;22:538-43.
9. Lories RJ, Peeters J, Bakker A, Tylzanowski P, Derese I, Schrooten J, et al. Articular cartilage and biomechanical properties of the long bones in Frzb-knockout mice. Arthritis Rheum 2007;56:4095-103.
10. Enomoto-Iwamoto M, Kitagaki J, Koyama E, Tamamura Y, Wu C, Kanatani N, et al. The Wnt antagonist Frzb-1 regulates chondrocyte maturation and long bone development during limb skeletogenesis. Dev Biol 2002;251:142-56.
11. Dong Y, Drissi H, Chen M, Chen D, Zuscik MJ, Schwarz EM, et al. Wnt-mediated regulation of chondrocyte maturation: modulation by TGF-β. J Cell Biochem 2005;95:1057-68.
12. Yuasa T, Otani T, Koike T, Iwamoto M, Enomoto-Iwamoto M. Wnt/β-catenin signaling stimulates matrix catabolic genes and activity in articular chondrocytes: its possible role in joint degeneration. Lab Invest 2008;88:264-74.
13. DellAccio F, De Bari C, Eltawil NM, Vanhummelen P, Pitzalis C. Identification of the molecular response of articular cartilage to injury, by microarray screening: Wnt-16 expression and signaling after injury and in osteoarthritis. Arthritis Rheum 2008;58:1410-21.
14. Beyer C, Schett G. Pharmacotherapy: concepts of pathogenesis and emerging treatments. Novel targets in bone and cartilage. Best Pract Res Clin Rheumatol 2010;24:489-96.
15. Lane NE, Lian K, Nevitt MC, Zmuda JM, Lui L, Li J, et al. Frizzled-related protein variants are risk factors for hip osteoarthritis. Arthritis Rheum 2006;54:1246-54.
16. Loughlin J, Dowling B, Chapman K, Marcelline L, Mustafa Z, Southam L, et al. Functional variants within the secreted frizzledrelated protein 3 gene are associated with hip osteoarthritis in females. Proc Natl Acad Sci U S A 2004;101:9757-62.
17. Waarsing JH, Kloppenburg M, Slagboom PE, Kroon HM, Houwing-Duistermaat JJ, Weinans H, et al. Osteoarthritis susceptibility genes influence the association between hip morphology and osteoarthritis. Arthritis Rheum 2011;63:1349-54.
18. Evangelou E, Chapman K, Meulenbelt I, Karassa FB, Loughlin J, Carr A, et al. Large-scale analysis of association between GDF5 and FRZB variants and osteoarthritis of the hip, knee, and hand. Arthritis Rheum 2009;60:1710-21.
19. Robinson JA, Chatterjee-Kishore M, Yaworsky PJ, Cullen DM, Zhao W, Li C, et al. Wnt/β-catenin signaling is a normal physiological response to mechanical loading in bone. J Biol Chem 2006;281:31720-8.
20. Doherty M, Courtney P, Doherty S, Jenkins W, Maciewicz RA, Muir K, et al. Nonspherical femoral head shape (pistol grip deformity), neck shaft angle, and risk of hip osteoarthritis: a case-control study. Arthritis Rheum 2008;58:3172-82.
21. Lynch JA, Parimi N, Chaganti RK, Nevitt MC, Lane NE. The association of proximal femoral shape and incident radiographic hip OA in elderly women. Osteoarthritis Cartilage 2009;17: 1313-8.
22. McWilliams DF, Doherty SA, Jenkins WD, Maciewicz RA, Muir KR, Zhang W, et al. Mild acetabular dysplasia and risk of osteoarthritis of the hip: a case-control study. Ann Rheum Dis 2010;69:1774-8.
23. Wagner S, Hofstetter W, Chiquet M, Mainil-Varlet P, Stauffer E, Ganz R, et al. Early osteoarthritic changes of human femoral head cartilage subsequent to femoro-acetabular impingement. Osteoarthritis Cartilage 2003;11:508-18.
24. Cummings SR, Black DM, Nevitt MC, Browner WS, Cauley JA, Genant HK, et al, the Study of Osteoporotic Fractures Research Group. Appendicular bone density and age predict hip fracture in women. JAMA 1990;263:665-8.
25. Paffenbarger RS Jr, Hyde RT, Wing AL, Hsieh CC. Physical activity, all-cause mortality, and longevity of college alumni. N Engl J Med 1986;314:605-13.
26. Black DM, Steinbuch M, Palermo L, Dargent-Molina P, Lindsay R, Hoseyni MS, et al. An assessment tool for predicting fracture risk in postmenopausal women. Osteoporos Int 2001;12:519-28.
27. Lane NE, Nevitt MC, Hochberg MC, Hung YY, Palermo L. Progression of radiographic hip osteoarthritis over eight years in a community sample of elderly white women. Arthritis Rheum 2004;50:1477-86.
28. Lian K, Zmuda JM, Nevitt MC, Lui L, Hochberg MC, Greene D, et al. Type I collagen α1 Sp1 transcription factor binding site polymorphism is associated with reduced risk of hip osteoarthritis defined by severe joint space narrowing in elderly women. Arthritis Rheum 2005;52:1431-6.
29. Lin K, Wang S, Julius MA, Kitajewski J, Moos M Jr, Luyten FP. The cysteine-rich frizzled domain of Frzb-1 is required and sufficient for modulation of Wnt signaling. Proc Natl Acad Sci U S A 1997;94:11196-200.
30. Buckland-Wright C. Protocols for precise radio-anatomical positioning of the tibiofemoral and patellofemoral compartments of the knee. Osteoarthritis Cartilage 1995;3 Suppl A:71-80.
31. Cootes TF, Taylor CJ, Cooper DH, Graham J. Active shape models-their training and application. Computer Vision and Image Understanding 1995;61:38-59.
32. Beymer D, Syeda-Mahmood T. Cardiac disease recognition in echocardiograms using spatio-temporal statistical models. Conf Proc IEEE Eng Med Biol Soc 2008;2008:4784-8.
33. Cosio FA. Automatic initialization of an active shape model of the prostate. Med Image Anal 2008;12:469-83.
34. Heimann T, Wolf I, Meinzer HP. Active shape models for a fully automated 3D segmentation of the liver-an evaluation on clinical data. Med Image Comput Comput Assist Interv 2006;9:41-8.
35. Li H, Lim JH, Liu J, Wong TY. Towards automatic grading of nuclear cataract. Conf Proc IEEE Eng Med Biol Soc 2007;2007: 4961-4.
36. Shi Y, Shen D. Hierarchical shape statistical model for segmentation of lung fields in chest radiographs. Med Image Comput Comput Assist Interv 2008;11:417-24.
37. Spiegel M, Hahn DA, Daum V, Wasza J, Hornegger J. Segmentation of kidneys using a new active shape model generation technique based on non-rigid image registration. Comput Med Imaging Graph 2009;33:29-39.
38. Gregory JS, Testi D, Stewart A, Undrill PE, Reid DM, Aspden RM. A method for assessment of the shape of the proximal femur and its relationship to osteoporotic hip fracture. Osteoporos Int 2004;15:5-11.
39. Baker-LePain JC, Luker KR, Lynch JA, Parimi N, Nevitt MC, Lane NE. Active shape modeling of the hip in prediction of incident hip fracture. J Bone Miner Res 2011;26:468-74.
40. Wiberg G. A measuring method for distinguishing between a normal and a maldevelopmental acetabulum. Acta Chir Scand 1939;83:28-38.
41. Murray RO. The aetiology of primary osteoarthritis of the hip. Br J Radiol 1965;38:810-24.
42. Hoang BH, Thomas JT, Abdul-Karim FW, Correia KM, Conlon RA, Luyten FP, et al. Expression pattern of two Frizzled-related genes, Frzb-1 and Sfrp-1, during mouse embryogenesis suggests a role for modulating action of Wnt family members. Dev Dyn 1998;212:364-72.
43. Chimal-Monroy J, Montero JA, Ganan Y, Macias D, Garcia-Porrero JA, Hurle JM. Comparative analysis of the expression and regulation of Wnt5a, Fz4, and Frzb1 during digit formation and in micromass cultures. Dev Dyn 2002;224:314-20.
44. Duprez D, Leyns L, Bonnin MA, Lapointe F, Etchevers H, De Robertis EM, et al. Expression of Frzb-1 during chick development. Mech Dev 1999;89:179-83.
45. Lenaerts G, Bartels W, Gelaude F, Mulier M, Spaepen A, Van der Perre G, et al. Subject-specific hip geometry and hip joint centre location affects calculated contact forces at the hip during gait. J Biomech 2009;42:1246-51.
46. Min JL, Meulenbelt I, Riyazi N, Kloppenburg M, Houwing-Duistermaat JJ, Seymour AB, et al. Association of the Frizzledrelated protein gene with symptomatic osteoarthritis at multiple sites. Arthritis Rheum 2005;52:1077-80.
47. Lories RJ, Boonen S, Peeters J, de Vlam K, Luyten FP. Evidence for a differential association of the Arg200Trp single-nucleotide polymorphism in FRZB with hip osteoarthritis and osteoporosis. Rheumatology (Oxford) 2006;45:113-4.
48. Rodriguez-Lopez J, Pombo-Suarez M, Liz M, Gomez-Reino JJ, Gonzalez A. Further evidence of the role of frizzled-related protein gene polymorphisms in osteoarthritis. Ann Rheum Dis 2007;66:1052-5.
49. Kerkhof JM, Uitterlinden AG, Valdes AM, Hart DJ, Rivadeneira F, Jhamai M, et al. Radiographic osteoarthritis at three joint sites and FRZB, LRP5, and LRP6 polymorphisms in two populationbased cohorts. Osteoarthritis Cartilage 2008;16:1141-9.
50. Kerkhof HJ, Meulenbelt I, Akune T, Arden NK, Aromaa A, Bierma-Zeinstra SM, et al. Recommendations for standardization and phenotype definitions in genetic studies of osteoarthritis: the TREAT-OA consortium. Osteoarthritis Cartilage 2011;19:254-64.