메뉴 건너뛰기




Volumn 71, Issue 3, 2012, Pages 200-204

Genetics and epigenetics of osteoarthritis

Author keywords

Epigenetics; GDF5; Genetics; MCF2L; Methylation; Susceptibility

Indexed keywords

GROWTH DIFFERENTIATION FACTOR 5; MCF2L PROTEIN; PROTEIN; UNCLASSIFIED DRUG; UNTRANSLATED RNA;

EID: 84856952418     PISSN: 03785122     EISSN: 18734111     Source Type: Journal    
DOI: 10.1016/j.maturitas.2011.12.001     Document Type: Review
Times cited : (99)

References (53)
  • 2
    • 84881264653 scopus 로고    scopus 로고
    • All cause and disease specific mortality in patients with knee or hip osteoarthritis: Population based cohort study
    • E. Nüesch, P. Dieppe, and S. Reichenbach All cause and disease specific mortality in patients with knee or hip osteoarthritis: population based cohort study Br Med J 342 2011 d1165
    • (2011) Br Med J , vol.342 , pp. 1165
    • Nüesch, E.1    Dieppe, P.2    Reichenbach, S.3
  • 3
    • 17044392213 scopus 로고    scopus 로고
    • Recent advances in the genetic investigation of osteoarthritis
    • C.A. Peach, A.J. Carr, and J. Loughlin Recent advances in the genetic investigation of osteoarthritis Trends Mol Med 11 2005 186 191
    • (2005) Trends Mol Med , vol.11 , pp. 186-191
    • Peach, C.A.1    Carr, A.J.2    Loughlin, J.3
  • 9
    • 66449089103 scopus 로고    scopus 로고
    • Large-scale analysis of association between GDF5 and FRZB variants and osteoarthritis of the hip, knee and hand
    • E. Evangelou, K. Chapman, and I. Meulenbelt Large-scale analysis of association between GDF5 and FRZB variants and osteoarthritis of the hip, knee and hand Arthritis Rheum 60 2009 1710 1721
    • (2009) Arthritis Rheum , vol.60 , pp. 1710-1721
    • Evangelou, E.1    Chapman, K.2    Meulenbelt, I.3
  • 10
    • 78650988509 scopus 로고    scopus 로고
    • The GDF5 rs143383 polymorphism is associated with osteoarthritis of the knee with genome-wide statistical significance
    • A.M. Valdes, E. Evangelou, and H.J. Kerkhof The GDF5 rs143383 polymorphism is associated with osteoarthritis of the knee with genome-wide statistical significance Ann Rheum Dis 70 2011 873 875
    • (2011) Ann Rheum Dis , vol.70 , pp. 873-875
    • Valdes, A.M.1    Evangelou, E.2    Kerkhof, H.J.3
  • 11
    • 67650074525 scopus 로고    scopus 로고
    • Functional analysis of the osteoarthritis susceptibility-associated GDF5 regulatory polymorphism
    • R. Egli, L. Southam, and J.M. Wilkins Functional analysis of the osteoarthritis susceptibility-associated GDF5 regulatory polymorphism Arthritis Rheum 60 2009 2055 2064
    • (2009) Arthritis Rheum , vol.60 , pp. 2055-2064
    • Egli, R.1    Southam, L.2    Wilkins, J.M.3
  • 12
    • 78650666914 scopus 로고    scopus 로고
    • GDF5 deficiency in mice is associated with instability-driven joint damage, gait and subchondral bone changes
    • M. Daans, F.P. Luyten, and R.J. Lories GDF5 deficiency in mice is associated with instability-driven joint damage, gait and subchondral bone changes Ann Rheum Dis 70 2011 208 213
    • (2011) Ann Rheum Dis , vol.70 , pp. 208-213
    • Daans, M.1    Luyten, F.P.2    Lories, R.J.3
  • 13
    • 84969213492 scopus 로고    scopus 로고
    • Wellcome, and Trust Case Control Consortium Genome-wide association study of 14,000 cases of seven common diseases and 3000 shared controls
    • Wellcome, and Trust Case Control Consortium Genome-wide association study of 14,000 cases of seven common diseases and 3000 shared controls Nature 447 2007 661 678
    • (2007) Nature , vol.447 , pp. 661-678
  • 14
    • 75749110202 scopus 로고    scopus 로고
    • A genome-wide association study identifies an osteoarthritis susceptibility locus on chromosome 7q22
    • H.J.M. Kerkhof, R.J. Lories, and I. Meulenbelt A genome-wide association study identifies an osteoarthritis susceptibility locus on chromosome 7q22 Arthritis Rheum 62 2010 499 510
    • (2010) Arthritis Rheum , vol.62 , pp. 499-510
    • Kerkhof, H.J.M.1    Lories, R.J.2    Meulenbelt, I.3
  • 15
    • 78751703383 scopus 로고    scopus 로고
    • Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22
    • E. Evangelou, A.M. Valdes, and H.J. Kerkhof Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22 Ann Rheum Dis 70 2011 349 355
    • (2011) Ann Rheum Dis , vol.70 , pp. 349-355
    • Evangelou, E.1    Valdes, A.M.2    Kerkhof, H.J.3
  • 16
    • 79953309875 scopus 로고    scopus 로고
    • Insights into the genetic architecture of osteoarthritis from stage 1 of the arcOGEN study
    • K. Panoutsopoulou, L. Southam, and K.S. Elliott Insights into the genetic architecture of osteoarthritis from stage 1 of the arcOGEN study Ann Rheum Dis 70 2011 864 867
    • (2011) Ann Rheum Dis , vol.70 , pp. 864-867
    • Panoutsopoulou, K.1    Southam, L.2    Elliott, K.S.3
  • 17
    • 77952716339 scopus 로고    scopus 로고
    • Stickler syndrome and the vitreous phenotype: Mutations in COL2A1 and COL11A1
    • A.J. Richards, A. McNinch, and H. Martin Stickler syndrome and the vitreous phenotype: mutations in COL2A1 and COL11A1 Hum Mutat 31 2010 E1461 E1471
    • (2010) Hum Mutat , vol.31
    • Richards, A.J.1    McNinch, A.2    Martin, H.3
  • 19
    • 79960556965 scopus 로고    scopus 로고
    • Epigenome-wide association studies for common human diseases
    • V.K. Rakyan, T.A. Down, D.J. Balding, and S. Beck Epigenome-wide association studies for common human diseases Nat Rev Genet 12 2011 529 541
    • (2011) Nat Rev Genet , vol.12 , pp. 529-541
    • Rakyan, V.K.1    Down, T.A.2    Balding, D.J.3    Beck, S.4
  • 20
    • 3242663659 scopus 로고    scopus 로고
    • An integrated epigenetic and genetic approach to common human disease
    • DOI 10.1016/j.tig.2004.06.009, PII S016895250400160X
    • H.T. Bjornsson, M. Daniele Fallin, and A.P. Feinberg An integrated epigenetic and genetic approach to common human disease Trends Genet 20 2004 350 358 (Pubitemid 38943025)
    • (2004) Trends in Genetics , vol.20 , Issue.8 , pp. 350-358
    • Bjornsson, H.T.1    Daniele Fallin, M.2    Feinberg, A.P.3
  • 21
    • 61549140408 scopus 로고    scopus 로고
    • DNA methylation is not responsible for p21WAF1/CIP1 down-regulation in osteoarthritic chondrocytes
    • S. Sesselmann, S. Söder, and R. Voigt DNA methylation is not responsible for p21WAF1/CIP1 down-regulation in osteoarthritic chondrocytes Osteoarthritis Cartilage 17 2009 507 512
    • (2009) Osteoarthritis Cartilage , vol.17 , pp. 507-512
    • Sesselmann, S.1    Söder, S.2    Voigt, R.3
  • 22
    • 61449135868 scopus 로고    scopus 로고
    • Expression of ADAMTS-4 by chondrocytes in the surface zone of human osteoarthritic cartilage is regulated by epigenetic DNA de-methylation
    • K.S. Cheung, K. Hashimoto, N. Yamada, and H.I. Roach Expression of ADAMTS-4 by chondrocytes in the surface zone of human osteoarthritic cartilage is regulated by epigenetic DNA de-methylation Rheumatol Int 29 2009 525 534
    • (2009) Rheumatol Int , vol.29 , pp. 525-534
    • Cheung, K.S.1    Hashimoto, K.2    Yamada, N.3    Roach, H.I.4
  • 23
    • 65249106542 scopus 로고    scopus 로고
    • Cellular and epigenetic features of a young healthy and a young osteoarthritic cartilage compared with aged control and OA cartilage
    • M.A. da Silva, N. Yamada, N.M. Clarke, and H.I. Roach Cellular and epigenetic features of a young healthy and a young osteoarthritic cartilage compared with aged control and OA cartilage J Orthop Res 27 2009 593 601
    • (2009) J Orthop Res , vol.27 , pp. 593-601
    • Da Silva, M.A.1    Yamada, N.2    Clarke, N.M.3    Roach, H.I.4
  • 24
    • 26844518429 scopus 로고    scopus 로고
    • Association between the abnormal expression of matrix-degrading enzymes by human osteoarthritic chondrocytes and demethylation of specific CpG sites in the promoter regions
    • DOI 10.1002/art.21300
    • H.I. Roach, N. Yamada, and K.S. Cheung Association between the abnormal expression of matrix-degrading enzymes by human osteoarthritic chondrocytes and demethylation of specific CpG sites in the promoter regions Arthritis Rheum 52 2005 3110 3124 (Pubitemid 41447092)
    • (2005) Arthritis and Rheumatism , vol.52 , Issue.10 , pp. 3110-3124
    • Roach, H.I.1    Yamada, N.2    Cheung, K.S.C.3    Tilley, S.4    Clarke, N.M.P.5    Oreffo, R.O.C.6    Kokubun, S.7    Bronner, F.8
  • 25
    • 77955436218 scopus 로고    scopus 로고
    • Superoxide dismutase downregulation in osteoarthritis progression and end-stage disease
    • J.L. Scott, C. Gabrielides, and R.K. Davidson Superoxide dismutase downregulation in osteoarthritis progression and end-stage disease Ann Rheum Dis 69 2010 1502 1510
    • (2010) Ann Rheum Dis , vol.69 , pp. 1502-1510
    • Scott, J.L.1    Gabrielides, C.2    Davidson, R.K.3
  • 26
    • 61549102182 scopus 로고    scopus 로고
    • Methylation of the OP-1 promoter: Potential role in the age-related decline in OP-1 expression in cartilage
    • R.F. Loeser, H.J. Im, and B. Richardson Methylation of the OP-1 promoter: potential role in the age-related decline in OP-1 expression in cartilage Osteoarthritis Cartilage 17 2009 513 517
    • (2009) Osteoarthritis Cartilage , vol.17 , pp. 513-517
    • Loeser, R.F.1    Im, H.J.2    Richardson, B.3
  • 27
    • 79952534189 scopus 로고    scopus 로고
    • Regulation of chromatin by histone modifications
    • A.J. Bannister, and T. Kouzarides Regulation of chromatin by histone modifications Cell Res 21 2011 381 395
    • (2011) Cell Res , vol.21 , pp. 381-395
    • Bannister, A.J.1    Kouzarides, T.2
  • 28
    • 33847076849 scopus 로고    scopus 로고
    • Chromatin Modifications and Their Function
    • DOI 10.1016/j.cell.2007.02.005, PII S0092867407001845
    • T. Kouzarides Chromatin modifications and their function Cell 128 2007 693 705 (Pubitemid 46273577)
    • (2007) Cell , vol.128 , Issue.4 , pp. 693-705
    • Kouzarides, T.1
  • 29
    • 78650783194 scopus 로고    scopus 로고
    • Contribution of H3K4 methylation by SET-1A to interleukin-1-induced cyclooxygenase 2 and inducible nitric oxide synthase expression in human osteoarthritis chondrocytes
    • F.E. El Mansouri, N. Chabane, and N. Zayed Contribution of H3K4 methylation by SET-1A to interleukin-1-induced cyclooxygenase 2 and inducible nitric oxide synthase expression in human osteoarthritis chondrocytes Arthritis Rheum 63 2011 168 179
    • (2011) Arthritis Rheum , vol.63 , pp. 168-179
    • El Mansouri, F.E.1    Chabane, N.2    Zayed, N.3
  • 30
    • 70349670585 scopus 로고    scopus 로고
    • A novel domain in histone deacetylase 1 and 2 mediates repression of cartilage-specific genes in human chondrocytes
    • S. Hong, A. Derfoul, L. Pereira-Mouries, and D.J. Hall A novel domain in histone deacetylase 1 and 2 mediates repression of cartilage-specific genes in human chondrocytes FASEB J 23 2009 3539 3552
    • (2009) FASEB J , vol.23 , pp. 3539-3552
    • Hong, S.1    Derfoul, A.2    Pereira-Mouries, L.3    Hall, D.J.4
  • 31
    • 76649099170 scopus 로고    scopus 로고
    • Correlation between MMP-13 and HDAC7 expression in human knee osteoarthritis
    • R. Higashiyama, S. Miyaki, and S. Yamashita Correlation between MMP-13 and HDAC7 expression in human knee osteoarthritis Mod Rheumatol 20 2010 11 17
    • (2010) Mod Rheumatol , vol.20 , pp. 11-17
    • Higashiyama, R.1    Miyaki, S.2    Yamashita, S.3
  • 32
    • 51149086596 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors suppress interleukin-1beta-induced nitric oxide and prostaglandin E2 production in human chondrocytes
    • N. Chabane, N. Zayed, and H. Afif Histone deacetylase inhibitors suppress interleukin-1beta-induced nitric oxide and prostaglandin E2 production in human chondrocytes Osteoarthritis Cartilage 16 2008 1267 1274
    • (2008) Osteoarthritis Cartilage , vol.16 , pp. 1267-1274
    • Chabane, N.1    Zayed, N.2    Afif, H.3
  • 33
    • 21644471962 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors modulate metalloproteinase gene expression in chondrocytes and block cartilage resorption
    • D.A. Young, R.L. Lakey, and C.J. Pennington Histone deacetylase inhibitors modulate metalloproteinase gene expression in chondrocytes and block cartilage resorption Arthritis Res Ther 7 2005 R503 R512
    • (2005) Arthritis Res Ther , vol.7
    • Young, D.A.1    Lakey, R.L.2    Pennington, C.J.3
  • 34
    • 78149460199 scopus 로고    scopus 로고
    • Alleviation of osteoarthritis by Trichostatin A, a histone deacetylase inhibitor, in experimental osteoarthritis
    • W.P. Chen, J.P. Bao, P.F. Hu, and L.D. Wu Alleviation of osteoarthritis by Trichostatin A, a histone deacetylase inhibitor, in experimental osteoarthritis Mol Biol Rep 37 2010 3967 3972
    • (2010) Mol Biol Rep , vol.37 , pp. 3967-3972
    • Chen, W.P.1    Bao, J.P.2    Hu, P.F.3    Wu, L.D.4
  • 35
    • 0347444723 scopus 로고    scopus 로고
    • MicroRNAs: Genomics, biogenesis, mechanism, and function
    • D.P. Bartel MicroRNAs: genomics, biogenesis, mechanism, and function Cell 116 2004 281 297
    • (2004) Cell , vol.116 , pp. 281-297
    • Bartel, D.P.1
  • 39
    • 61849173539 scopus 로고    scopus 로고
    • The identification of differentially expressed microRNA in osteoarthritic tissue that modulate the production of TNF-α and MMP13
    • S.W. Jones, G. Watkins, and N. Le Good The identification of differentially expressed microRNA in osteoarthritic tissue that modulate the production of TNF-α and MMP13 Osteoarthritis Cartilage 17 2009 464 472
    • (2009) Osteoarthritis Cartilage , vol.17 , pp. 464-472
    • Jones, S.W.1    Watkins, G.2    Le Good, N.3
  • 40
    • 65249191384 scopus 로고    scopus 로고
    • Expression of MicroRNA-146a in osteoarthritis cartilage
    • K. Yamasaki, T. Nakasa, and S. Miyaki Expression of MicroRNA-146a in osteoarthritis cartilage Arthritis Rheum 60 2009 1035 1041
    • (2009) Arthritis Rheum , vol.60 , pp. 1035-1041
    • Yamasaki, K.1    Nakasa, T.2    Miyaki, S.3
  • 41
    • 77951743715 scopus 로고    scopus 로고
    • MicroRNA-27b regulates the expression of matrix metalloproteinase 13 in human osteoarthritis chondrocytes
    • N. Akhtar, Z. Rasheed, and S. Ramamurthy MicroRNA-27b regulates the expression of matrix metalloproteinase 13 in human osteoarthritis chondrocytes Arthritis Rheum 62 2010 1361 1371
    • (2010) Arthritis Rheum , vol.62 , pp. 1361-1371
    • Akhtar, N.1    Rasheed, Z.2    Ramamurthy, S.3
  • 42
    • 69449103973 scopus 로고    scopus 로고
    • MicroRNA-140 is expressed in differentiated human articular chondrocytes and modulates interleukin-1 responses
    • S. Miyaki, T. Nakasa, and S. Otsuki MicroRNA-140 is expressed in differentiated human articular chondrocytes and modulates interleukin-1 responses Arthritis Rheum 60 2009 2723 2730
    • (2009) Arthritis Rheum , vol.60 , pp. 2723-2730
    • Miyaki, S.1    Nakasa, T.2    Otsuki, S.3
  • 43
    • 73649139221 scopus 로고    scopus 로고
    • Regulation of the IGFBP-5 and MMP-13 genes by the microRNAs miR-140 and miR-27a in human osteoarthritic chondrocytes
    • G. Tardif, D. Hum, and J.P. Pelletier Regulation of the IGFBP-5 and MMP-13 genes by the microRNAs miR-140 and miR-27a in human osteoarthritic chondrocytes BMC Musculoskelet Disord 10 2009 148
    • (2009) BMC Musculoskelet Disord , vol.10 , pp. 148
    • Tardif, G.1    Hum, D.2    Pelletier, J.P.3
  • 44
    • 77953067173 scopus 로고    scopus 로고
    • MicroRNA-140 plays dual roles in both cartilage development and homeostasis
    • S. Miyaki, T. Sato, and A. Inoue MicroRNA-140 plays dual roles in both cartilage development and homeostasis Genes Dev 24 2010 1173 1185
    • (2010) Genes Dev , vol.24 , pp. 1173-1185
    • Miyaki, S.1    Sato, T.2    Inoue, A.3
  • 45
    • 78649506925 scopus 로고    scopus 로고
    • Integrated genetic and epigenetic analysis identifies haptotype-specific methylation in the FTO type 2 diabetes and obesity susceptibility locus
    • C.G. Bell, C.M. Lindgren, and G.A. Wilson Integrated genetic and epigenetic analysis identifies haptotype-specific methylation in the FTO type 2 diabetes and obesity susceptibility locus PLoS One 5 2010 e14040
    • (2010) PLoS One , vol.5 , pp. 14040
    • Bell, C.G.1    Lindgren, C.M.2    Wilson, G.A.3
  • 46
    • 80051693596 scopus 로고    scopus 로고
    • Expression of the osteoarthritis-associated gene GDF5 is modulated epigenetically by DNA methylation
    • L.N. Reynard, C. Bui, and E.G. Canty-Laid Expression of the osteoarthritis-associated gene GDF5 is modulated epigenetically by DNA methylation Hum Mol Genet 20 2011 3450 3460
    • (2011) Hum Mol Genet , vol.20 , pp. 3450-3460
    • Reynard, L.N.1    Bui, C.2    Canty-Laid, E.G.3
  • 47
    • 34249275353 scopus 로고    scopus 로고
    • Phenotypic plasticity and the epigenetics of human disease
    • DOI 10.1038/nature05919, PII NATURE05919
    • A.P. Feinberg Phenotypic plasticity and the epigenetics of human disease Nature 447 2007 433 440 (Pubitemid 46816750)
    • (2007) Nature , vol.447 , Issue.7143 , pp. 433-440
    • Feinberg, A.P.1
  • 48
    • 77957965145 scopus 로고    scopus 로고
    • Epigenomics reveals a functional genome anatomy and a new approach to common disease
    • A.P. Feinberg Epigenomics reveals a functional genome anatomy and a new approach to common disease Nat Biotechnol 28 2010 1049 1052
    • (2010) Nat Biotechnol , vol.28 , pp. 1049-1052
    • Feinberg, A.P.1
  • 49
    • 77954189998 scopus 로고    scopus 로고
    • Extensive sequence-influenced DNA methylation polymorphism in the human genome
    • A. Hellman, and A. Chess Extensive sequence-influenced DNA methylation polymorphism in the human genome Epigenetics Chromatin 3 2010 11
    • (2010) Epigenetics Chromatin , vol.3 , pp. 11
    • Hellman, A.1    Chess, A.2
  • 50
    • 77953223693 scopus 로고    scopus 로고
    • Abundant quantitative trait loci exist for DNA methylation and gene expression in human brain
    • J.R. Gibbs, M.P. van der Brug, and D.G. Hernandez Abundant quantitative trait loci exist for DNA methylation and gene expression in human brain PLoS Genet 6 2010 e1000952
    • (2010) PLoS Genet , vol.6 , pp. 1000952
    • Gibbs, J.R.1    Van Der Brug, M.P.2    Hernandez, D.G.3
  • 51
    • 77649204292 scopus 로고    scopus 로고
    • Genetic control of individual differences in gene-specific methylation in human brain
    • D. Zhang, L. Cheng, and J.A. Badner Genetic control of individual differences in gene-specific methylation in human brain Am J Hum Gen 86 2010 411 419
    • (2010) Am J Hum Gen , vol.86 , pp. 411-419
    • Zhang, D.1    Cheng, L.2    Badner, J.A.3
  • 52
    • 79960688508 scopus 로고    scopus 로고
    • DNA methylation patterns associate with genetic and gene expression variation in HapMap cell lines
    • J.T. Bell, A.A. Pai, and J.K. Pickrell DNA methylation patterns associate with genetic and gene expression variation in HapMap cell lines Genome Biol 12 2011 R10
    • (2011) Genome Biol , vol.12 , pp. 10
    • Bell, J.T.1    Pai, A.A.2    Pickrell, J.K.3
  • 53
    • 77957947562 scopus 로고    scopus 로고
    • Hundreds of variants clustered in genomic loci and biological pathways affect human height
    • H. Lango Allen, K. Estrada, and G. Lettre Hundreds of variants clustered in genomic loci and biological pathways affect human height Nature 467 2010 832 838
    • (2010) Nature , vol.467 , pp. 832-838
    • Lango Allen, H.1    Estrada, K.2    Lettre, G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.