Genetic polymorphisms of the Wnt receptor LRP5 are differentially associated with trochanteric and cervical hip fractures

Calcified Tissue International

Volumn 90, Issue 2, 2012, Pages 137-143

  Riancho, Javier ^a   García Ibarbia, Carmen ^a   Pérez Núñez, María I ^a   Alonso, María A ^a   Díaz, Teresa ^a   Pérez Castrillón, José L ^b   Riancho, José A ^a  

^a UNIVERSITY OF CANTABRIA   (Spain)

^b UNIVERSITY OF VALLADOLID   (Spain)

Author keywords

Aromatase; Collagen; Estrogen; Lipoprotein receptor related protein; Osteoporosis; Polymorphism

Indexed keywords

FRIZZLED PROTEIN;

ADULT; AGED; ARTICLE; BINDING SITE; CERVICAL HIP FRACTURE; COL1A1 GENE; CONTROLLED STUDY; CYP19A1 GENE; ESR1 GENE; FEMALE; FRAGILITY FRACTURE; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENE PRODUCT; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC LINKAGE; GENETIC VARIABILITY; GENOTYPE; HIP FRACTURE; HOMEOSTASIS; HOMOZYGOSITY; HUMAN; LRP5 GENE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN BINDING; SINGLE NUCLEOTIDE POLYMORPHISM; TROCHANTERIC HIP FRACTURE;

AGED; AGED, 80 AND OVER; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HIP FRACTURES; HUMANS; LOW DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN-5; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 84857046709     PISSN: 0171967X     EISSN: 14320827     Source Type: Journal    
DOI: 10.1007/s00223-011-9557-2     Document Type: Article

References (41)

1. ME Armstrong EA Spencer BJ Cairns E Banks K Pirie J Green FL Wright GK Reeves V Beral 2011 Body mass index and physical activity in relation to the incidence of hip fracture in postmenopausal women J Bone Miner Res 26 1330 1338 21611971 10.1002/jbmr.315
2. DH Solomon H Mogun K Garneau MA Fischer 2011 Risk of fractures in older adults using antihypertensive medications J Bone Miner Res 26 1561 1567 21312268 10.1002/jbmr.356 1:CAS:528:DC%2BC3MXptFWgu74%3D
3. M Peacock CH Turner MJ Econs T Foroud 2002 Genetics of osteoporosis Endocr Rev 23 303 326 12050122 10.1210/er.23.3.303 1:CAS:528: DC%2BD38XltlWjtrg%3D (Pubitemid 34651949)
4. SR Cummings MC Nevitt WS Browner K Stone KM Fox KE Ensrud J Cauley D Black TM Vogt 1995 Risk factors for hip fracture in white women N Engl J Med 332 767 773 7862179 10.1056/NEJM199503233321202 1:STN:280:DyaK2M7ms1aktw%3D%3D
5. K Michaelsson H Melhus H Ferm A Ahlbom NL Pedersen 2005 Genetic liability to fractures in the elderly Arch Intern Med 165 1825 1830 16157825 10.1001/archinte.165.16.1825 (Pubitemid 41352076)
6. JT Wang Y Guo TL Yang XH Xu SS Dong M Li TQ Li Y Chen HW Deng 2008 Polymorphisms in the estrogen receptor genes are associated with hip fractures in Chinese Bone 43 910 914 18678289 10.1016/j.bone.2008.07.001 1:CAS:528:DC%2BD1cXht1ejtLnF
7. J Velasco JL Hernandez JL Perez-Castrillon MT Zarrabeitia MA Alonso J Gonzalez-Macias JA Riancho 2010 Haplotypes of intron 4 of the estrogen receptor alpha gene and hip fractures: a replication study in Caucasians BMC Med Genet 11 16 20109228 10.1186/1471-2350-11-16
8. YP Zhang YZ Liu Y Guo XG Liu XH Xu YF Guo Y Chen F Zhang F Pan XZ Zhu HW Deng 2011 Pathway-based association analyses identified TRAIL pathway for osteoporotic fractures PLoS ONE 6 e21835 21760914 10.1371/journal.pone.0021835 1:CAS:528:DC%2BC3MXps1Chu7k%3D
9. J Dragojevic B Ostanek S Mencej-Bedrac R Komadina J Prezelj J Marc 2011 PPARG gene promoter polymorphism is associated with non-traumatic hip fracture risk in the elderly Slovenian population: a pilot study Clin Biochem 44 1085 1089 21756892 10.1016/j.clinbiochem.2011.06.981 1:CAS:528:DC%2BC3MXhtVCntrzO
10. P Pulkkinen J Partanen P Jalovaara T Jamsa 2010 BMD T-score discriminates trochanteric fractures from unfractured controls, whereas geometry discriminates cervical fracture cases from unfractured controls of similar BMD Osteoporos Int 21 1269 1276 19784537 10.1007/s00198-009-1070-3 1:STN:280:DC%2BC3cnotV2rtQ%3D%3D
11. C Valero JL Perez-Castrillon MT Zarrabeitia JL Hernandez MA Alonso J Pino-Montes JM Olmos J Gonzalez-Macias JA Riancho 2008 Association of aromatase and estrogen receptor gene polymorphisms with hip fractures Osteoporos Int 19 787 792 17962916 10.1007/s00198-007-0491-0 1:CAS:528:DC%2BD1cXltFyjtbk%3D (Pubitemid 351652522)
12. JA Riancho JM Olmos B Pineda C Garcia-Ibarbia MI Perez-Nunez DN Nan J Velasco A Cano MA Garcia-Perez MT Zarrabeitia J Gonzalez-Macias 2011 Wnt receptors, bone mass, and fractures: gene-wide association analysis of LRP5 and LRP6 polymorphisms with replication Eur J Endocrinol 164 123 131 20926594 10.1530/EJE-10-0582 1:CAS:528:DC%2BC3MXnslKgug%3D%3D
13. JA Riancho C Valero A Naranjo DJ Morales C Sanudo MT Zarrabeitia 2007 Identification of an aromatase haplotype that is associated with gene expression and postmenopausal osteoporosis J Clin Endocrinol Metab 92 660 665 17118999 10.1210/jc.2006-1616 1:CAS:528:DC%2BD2sXitVakt7w%3D
14. SH Ralston AG Uitterlinden ML Brandi S Balcells BL Langdahl P Lips R Lorenc B Obermayer-Pietsch S Scollen M Bustamante LB Husted AH Carey A Diez-Perez AM Dunning A Falchetti E Karczmarewicz M Kruk JP van Leeuwen JB van Meurs J Mangion FE McGuigan L Mellibovsky F Del Monte HA Pols J Reeve DM Reid W Renner F Rivadeneira NM van Schoor RE Sherlock JP Ioannidis 2006 Large-scale evidence for the effect of the COLIA1 Sp1 polymorphism on osteoporosis outcomes: the GENOMOS study PLoS Med 3 e90 16475872 10.1371/journal.pmed.0030090
15. H Jin E Evangelou JP Ioannidis SH Ralston 2011 Polymorphisms in the 5 flank of COL1A1 gene and osteoporosis: meta-analysis of published studies Osteoporos Int 22 911 921 20798928 10.1007/s00198-010-1364-5 1:CAS:528:DC%2BC3MXhs1GjsLs%3D
16. S Purcell B Neale K Todd-Brown L Thomas MA Ferreira D Bender J Maller P Sklar PI de Bakker MJ Daly PC Sham 2007 PLINK: a tool set for whole-genome association and population-based linkage analyses Am J Hum Genet 81 559 575 17701901 10.1086/519795 1:CAS:528:DC%2BD2sXhtVSqurrL (Pubitemid 47330214)
17. J Li L Ji 2005 Adjusting multiple testing in multilocus analyses using the eigenvalues of a correlation matrix Heredity 95 221 227 16077740 10.1038/sj.hdy.6800717 1:CAS:528:DC%2BD2MXovVOns7w%3D (Pubitemid 43093236)
18. DR Nyholt 2004 A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other Am J Hum Genet 74 765 769 14997420 10.1086/383251 1:CAS:528:DC%2BD2cXivFCntL0%3D (Pubitemid 38420107)
19. K Michaelsson E Weiderpass BY Farahmand JA Baron PG Persson L Ziden C Zetterberg S Ljunghall 1999 Differences in risk factor patterns between cervical and trochanteric hip fractures. Swedish Hip Fracture Study Group Osteoporos Int 10 487 494 10663350 10.1007/s001980050259 1:STN:280:DC%2BD3c7ltlaqug%3D%3D (Pubitemid 30029016)
20. KM Fox SR Cummings E Williams K Stone 2000 Femoral neck and intertrochanteric fractures have different risk factors: a prospective study Osteoporos Int 11 1018 1023 11256892 10.1007/s001980070022 1:STN:280: DC%2BD3M7osVKjtg%3D%3D (Pubitemid 32144593)
21. MR Karagas GL Lu-Yao JA Barrett ML Beach JA Baron 1996 Heterogeneity of hip fracture: age, race, sex, and geographic patterns of femoral neck and trochanteric fractures among the US elderly Am J Epidemiol 143 677 682 8651229 1:STN:280:DyaK283mvVCqsg%3D%3D
22. DA Tanner M Kloseck RG Crilly B Chesworth J Gilliland 2010 Hip fracture types in men and women change differently with age BMC Geriatr 10 12 20214771 10.1186/1471-2318-10-12
23. AM Schott D Hans F Duboeuf P Dargent-Molina T Hajri G Breart PJ Meunier 2005 Quantitative ultrasound parameters as well as bone mineral density are better predictors of trochanteric than cervical hip fractures in elderly women. Results from the EPIDOS study Bone 37 858 863 16226929 10.1016/j.bone.2005.06. 024 1:STN:280:DC%2BD28%2FpvV2gtg%3D%3D (Pubitemid 41773496)
24. P Szulc F Duboeuf AM Schott P Dargent-Molina PJ Meunier PD Delmas 2006 Structural determinants of hip fracture in elderly women: re-analysis of the data from the EPIDOS study Osteoporos Int 17 231 236 15983728 10.1007/s00198-005-1980-7 1:STN:280:DC%2BD287islWrug%3D%3D (Pubitemid 43053586)
25. M Di Monaco R Di Monaco F Mautino A Cavanna 2002 Femur bone mineral density, age and fracture type in 300 hip-fractured women Aging Clin Exp Res 14 47 51 12027152 1:STN:280:DC%2BD383os1SmtQ%3D%3D (Pubitemid 34413795)
26. Y Maeda N Sugano M Saito K Yonenobu 2011 Comparison of femoral morphology and bone mineral density between femoral neck fractures and trochanteric fractures Clin Orthop Relat Res 469 884 889 20725817 10.1007/s11999-010-1529-8
27. J Partanen T Jamsa P Jalovaara 2001 Influence of the upper femur and pelvic geometry on the risk and type of hip fractures J Bone Miner Res 16 1540 1546 11499877 10.1359/jbmr.2001.16.8.1540 1:STN:280:DC%2BD3Mvltlejtw%3D%3D (Pubitemid 32675206)
28. F Duboeuf D Hans AM Schott PO Kotzki F Favier C Marcelli PJ Meunier PD Delmas 1997 Different morphometric and densitometric parameters predict cervical and trochanteric hip fracture: the EPIDOS study J Bone Miner Res 12 1895 1902 9383694 10.1359/jbmr.1997.12.11.1895 1:STN:280:DyaK1c%2FksV2msw%3D%3D (Pubitemid 27500201)
29. S Gnudi C Ripamonti L Lisi M Fini R Giardino G Giavaresi 2002 Proximal femur geometry to detect and distinguish femoral neck fractures from trochanteric fractures in postmenopausal women Osteoporos Int 13 69 73 11878458 10.1007/s198-002-8340-2 1:STN:280:DC%2BD387ksVGlsQ%3D%3D (Pubitemid 34157833)
30. S Gnudi C Ripamonti G Gualtieri N Malavolta 1999 Geometry of proximal femur in the prediction of hip fracture in osteoporotic women Br J Radiol 72 729 733 10624337 1:STN:280:DC%2BD3c%2FovFClsQ%3D%3D (Pubitemid 29387029)
31. J Panula M Savela PT Jaatinen P Aarnio SL Kivela 2008 The impact of proximal femur geometry on fracture type-a comparison between cervical and trochanteric fractures with two parameters Scand J Surg 97 266 271 18812278 1:STN:280:DC%2BD1cnitlCjsQ%3D%3D
32. BL Riggs S Khosla LJ Melton III 2002 Sex steroids and the construction and conservation of adult skeleton Endocr Rev 23 279 302 12050121 10.1210/er.23.3.279 1:CAS:528:DC%2BD38XltlWjtrs%3D (Pubitemid 34651948)
33. W Balemans W Van Hul 2007 The genetics of low-density lipoprotein receptor-related protein 5 in bone: a story of extremes Endocrinology 148 2622 2629 17395706 10.1210/en.2006-1352 1:CAS:528:DC%2BD2sXmt1ajtrg%3D (Pubitemid 46984773)
34. JB van Meurs TA Trikalinos SH Ralston S Balcells ML Brandi K Brixen DP Kiel BL Langdahl P Lips O Ljunggren R Lorenc B Obermayer-Pietsch C Ohlsson U Pettersson DM Reid F Rousseau S Scollen W Van Hul L Agueda K Akesson LI Benevolenskaya SL Ferrari G Hallmans A Hofman LB Husted M Kruk S Kaptoge D Karasik MK Karlsson M Lorentzon L Masi FE McGuigan D Mellstrom L Mosekilde X Nogues HA Pols J Reeve W Renner F Rivadeneira NM van Schoor K Weber JP Ioannidis AG Uitterlinden 2008 Large-scale analysis of association between LRP5 and LRP6 variants and osteoporosis JAMA 299 1277 1290 18349089 10.1001/jama.299.11.1277 (Pubitemid 351439074)
35. JB Richards F Rivadeneira M Inouye TM Pastinen N Soranzo SG Wilson T Andrew M Falchi R Gwilliam KR Ahmadi AM Valdes P Arp P Whittaker DJ Verlaan M Jhamai V Kumanduri M Moorhouse JB van Meurs A Hofman HA Pols D Hart G Zhai BS Kato BH Mullin F Zhang P Deloukas AG Uitterlinden TD Spector 2008 Bone mineral density, osteoporosis, and osteoporotic fractures: a genome-wide association study Lancet 371 1505 1512 18455228 10.1016/S0140-6736(08)60599-1 1:CAS:528:DC%2BD1cXlsFGisr0%3D
36. L Agueda M Bustamante S Jurado N Garcia-Giralt M Ciria G Salo R Carreras X Nogues L Mellibovsky A Diez-Perez D Grinberg S Balcells 2008 A haplotype-based analysis of the LRP5 gene in relation to osteoporosis phenotypes in Spanish postmenopausal women J Bone Miner Res 23 1954 1963 18684085 10.1359/jbmr.080806 1:CAS:528:DC%2BD1MXosVylsbY%3D
37. J Bollerslev SG Wilson IM Dick FM Islam T Ueland L Palmer A Devine RL Prince 2005 LRP5 gene polymorphisms predict bone mass and incident fractures in elderly Australian women Bone 36 599 606 15777745 10.1016/j.bone.2005.01.006 1:CAS:528:DC%2BD2MXjs1KrtLw%3D (Pubitemid 40602253)
38. K Brixen S Beckers A Peeters E Piters W Balemans TL Nielsen K Wraae L Bathum C Brasen C Hagen M Andersen W Van Hul B Abrahamsen 2007 Polymorphisms in the low-density lipoprotein receptor-related protein 5 (LRP5) gene are associated with peak bone mass in non-sedentary men: results from the Odense Androgen Study Calcif Tissue Int 81 421 429 18058054 10.1007/s00223-007-9088-z 1:CAS:528:DC%2BD2sXhsVKrt7zF
39. MA Koay PY Woon Y Zhang LJ Miles EL Duncan SH Ralston JE Compston C Cooper R Keen BL Langdahl A MacLelland J O'Riordan HA Pols DM Reid AG Uitterlinden JA Wass MA Brown 2004 Influence of LRP5 polymorphisms on normal variation in BMD J Bone Miner Res 19 1619 1627 15355556 10.1359/JBMR.040704 1:CAS:528:DC%2BD2cXovFWmsbk%3D (Pubitemid 41094324)
40. MA Koay JH Tobias SD Leary CD Steer C Vilarino-Guell MA Brown 2007 The effect of LRP5 polymorphisms on bone mineral density is apparent in childhood Calcif Tissue Int 81 1 9 17505772 10.1007/s00223-007-9024-2 1:CAS:528: DC%2BD2sXntlWmtrk%3D (Pubitemid 47030202)
41. E Piters W Balemans TL Nielsen M Andersen E Boudin K Brixen W Van Hul 2010 Common genetic variation in the DKK1 gene is associated with hip axis length but not with bone mineral density and bone turnover markers in young adult men: results from the odense androgen study Calcif Tissue Int 86 271 281 20101398 10.1007/s00223-010-9334-7 1:CAS:528:DC%2BC3cXjvVGns7o%3D