Inhibition of methylation decreases osteoblast differentiation via a non-DNA-dependent methylation mechanism

Bone

Volumn 46, Issue 2, 2010, Pages 514-523

  Vaes, Bart L T ^a   Lute, Carolien ^a   van der Woning, Sebastian P ^b   Piek, Ester ^b   Vermeer, Jenny ^a   Blom, Henk J ^c   Mathers, John C ^d   Müller, Michael ^a   de Groot, Lisette C P G M ^a   Steegenga, Wilma T ^a  

^a WAGENINGEN UNIVERSITY   (Netherlands)

^b RADBOUD UNIVERSITY NIJMEGEN   (Netherlands)

^c VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^d NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

5 Aza 2 deoxycytidine; Methylation; Osteoblast; Periodate oxidized adenosine; Runx2

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; ALKALINE PHOSPHATASE; BONE MORPHOGENETIC PROTEIN 2; HYDROLASE INHIBITOR; OSTEOCALCIN; PERIODATE OXIDIZED ADENOSINE; S ADENOSYLHOMOCYSTEINE; S ADENOSYLMETHIONINE; TRANSCRIPTION FACTOR DLX5; TRANSCRIPTION FACTOR MSX2; TRANSCRIPTION FACTOR OSTERIX; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BIOMINERALIZATION; CELL DIFFERENTIATION; CONTROLLED STUDY; DNA METHYLATION; EXTRACELLULAR MATRIX; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; MESENCHYMAL STEM CELL; MOUSE; NONHUMAN; OSTEOBLAST;

ADENOSINE; ALKALINE PHOSPHATASE; ANIMALS; AZACITIDINE; CELL DIFFERENTIATION; CELL LINE; CORE BINDING FACTOR ALPHA 1 SUBUNIT; DNA METHYLATION; HUMANS; MICE; ORGAN SPECIFICITY; OSTEOBLASTS; OSTEOGENESIS; TRANSCRIPTIONAL ACTIVATION;

EID: 74249117826     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2009.09.033     Document Type: Article

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