Epigenetic regulation of early osteogenesis and mineralized tissue formation by a HOXA10-PBX1-associated complex

Cells Tissues Organs

Volumn 194, Issue 2-4, 2011, Pages 146-150

  Gordon, Jonathan A R ^a   Hassan, Mohammad Q ^a   Koss, Matthew ^b   Montecino, Martin ^c   Selleri, Licia ^b   Van Wijnen, Andre J ^a   Stein, Janet L ^a   Stein, Gary S ^a   Lian, Jane B ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

^c UNIVERSIDAD ANDRÉS BELLO   (Chile)

Author keywords

Chromatin remodeling during osteogenesis; Osterix histone acetylation; Pbx inhibition of osteoblastogenesis

Indexed keywords

ACETYLATED HISTONE 3 LYSINE 9; ACETYLATED HISTONE 4 LYSINE 16; ALKALINE PHOSPHATASE; BONE SIALOPROTEIN; HISTONE; HISTONE ACETYLTRANSFERASE PCAF; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE 2; HISTONE DEACETYLASE 3; HISTONE H4; MESSENGER RNA; OSTEOCALCIN; TRANSCRIPTION FACTOR HOXA10; TRANSCRIPTION FACTOR OSTERIX; TRANSCRIPTION FACTOR PBX1; UNCLASSIFIED DRUG;

ANIMAL CELL; BIOMINERALIZATION; BONE DEVELOPMENT; BONE MARROW CELL; BONE MARROW STROMAL CELL; CELL DIFFERENTIATION; CELL STRAIN HEK293; CHROMATIN ASSEMBLY AND DISASSEMBLY; CONFERENCE PAPER; CONTROLLED STUDY; ENZYME ACTIVATION; EPIGENETICS; GENE EXPRESSION; GENETIC REGULATION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; OSTEOBLAST; PRIORITY JOURNAL; STROMA CELL; UPREGULATION; VIRAL GENE DELIVERY SYSTEM;

ANIMALS; BONE MARROW CELLS; CALCIFICATION, PHYSIOLOGIC; CELL DIFFERENTIATION; EPIGENESIS, GENETIC; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEK293 CELLS; HOMEODOMAIN PROTEINS; HUMANS; MICE; MULTIPROTEIN COMPLEXES; OSTEOBLASTS; OSTEOGENESIS; PROMOTER REGIONS, GENETIC; RNA, SMALL INTERFERING; STROMAL CELLS; TRANSCRIPTION FACTORS;

EID: 80051787815     PISSN: 14226405     EISSN: 14226421     Source Type: Journal    
DOI: 10.1159/000324790     Document Type: Conference Paper

References (8)

1. Choe, S.K., P. Lu, M. Nakamura, J. Lee, C.G. Sagerstrom (2009) Meis cofactors control HDAC and CBP accessibility at Hox-regulated promoters during zebrafish embryogenesis. Dev Cell 17: 561-567.
2. Gordon, J.A., M.Q. Hassan, S. Saini, M. Montecino, A.J. van Wijnen, G.S. Stein, J.L. Stein, J.B. Lian (2010) Pbx1 represses osteoblastogenesis by blocking Hoxa10-mediated recruitment of chromatin remodeling factors. Mol Cell Biol 30: 3531-3541.
3. Hassan, M.Q., R. Tare, S.H. Lee, M. Mandeville, B. Weiner, M. Montecino, A.J. van Wijnen, J.L. Stein, G.S. Stein, J.B. Lian (2007) HOXA10 controls osteoblastogenesis by directly activating bone regulatory and phenotypic genes. Mol Cell Biol 27: 3337-3352. (Pubitemid 46685212)
4. LaRonde-LeBlanc, N.A., C. Wolberger (2003) Structure of HoxA9 and Pbx1 bound to DNA: Hox hexapeptide and DNA recognition anterior to posterior. Genes Dev 17: 2060-2072. (Pubitemid 36999331)
5. Lu, X., L. Gilbert, X. He, J. Rubin, M.S. Nanes (2006) Transcriptional regulation of the osterix (Osx, Sp7) promoter by tumor necrosis factor identifies disparate effects of mitogen-activated protein kinase and NF kappa B pathways. J Biol Chem 281: 6297-6306. (Pubitemid 43847561)
6. Moens, C.B., L. Selleri (2006) Hox cofactors in vertebrate development. Dev Biol 291: 193-206.
7. Nakashima, K., X. Zhou, G. Kunkel, Z. Zhang, J.M. Deng, R.R. Behringer, B. de Crombrugghe (2002) The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation. Cell 108: 17-29. (Pubitemid 34137009)
8. Selleri, L., M.J. Depew, Y. Jacobs, S.K. Chanda, K.Y. Tsang, K.S. Cheah, J.L. Rubenstein, S. O'Gorman, M.L. Cleary (2001) Requirement for Pbx1 in skeletal patterning and programming chondrocyte proliferation and differentiation. Development 128: 3543-3557. (Pubitemid 32962722)