Oleoylethanolamide dose-dependently attenuates cocaine-induced behaviours through a PPARα receptor-independent mechanism

Addiction Biology

Volumn 18, Issue 1, 2013, Pages 78-87

  Bilbao, Ainhoa ^a   Blanco, Eduardo ^b,c   Luque Rojas, María Jesús ^b   Suárez, Juan ^b   Palomino, Ana ^b   Vida, Margarita ^b   Araos, Pedro ^b   Bermúdez Silva, Francisco J ^b   Fernández Espejo, Emilio ^d   Spanagel, Rainer ^a   Rodríguez De Fonseca, Fernando ^b  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b IBIMA Hospital   (Spain)

^c UNIVERSITY OF MÁLAGA   (Spain)

^d UNIVERSITY OF SEVILLE   (Spain)

Author keywords

cocaine; knockout; motor sensitization; oleoylethanolamide; PPAR ; reinforcement

Indexed keywords

COCAINE; N OLEOYLETHANOLAMINE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BEHAVIOR; CONTROLLED STUDY; DRUG SEEKING BEHAVIOR; GENE DELETION; LOCOMOTION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PSYCHOMOTOR ACTIVITY; REWARD; SENSITIZATION;

ANALYSIS OF VARIANCE; ANIMALS; BEHAVIOR, ADDICTIVE; COCAINE; CONDITIONING, OPERANT; DOPAMINE UPTAKE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG-SEEKING BEHAVIOR; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MOTOR ACTIVITY; OLEIC ACIDS; PPAR ALPHA; REINFORCEMENT (PSYCHOLOGY); REWARD;

EID: 84871754544     PISSN: 13556215     EISSN: 13691600     Source Type: Journal    
DOI: 10.1111/adb.12006     Document Type: Article

References (39)

1. Adamczyk P, Miszkiel J, McCreary AC, Filip M, Papp M, PrzegaliÅski E, (2012) The effects of cannabinoid CB1, CB2 and vanilloid TRPV1 receptor antagonists on cocaine addictive behavior in rats. Brain Res 1444: 45-54.
2. Almasi R, Szoke E, Bolcskei K, Varga A, Riedl Z, Sandor Z, Szolcsányi J, Petho G, (2008) Actions of 3-methyl-N-oleoyldopamine, 4-methyl-N-oleoyldopamine and N-oleoylethanolamide on the rat TRPV1 receptor in vitro and in vivo. Life Sci 82: 644-651.
3. Baker D, Pryce G, Davies WL, Hiley CR, (2006) In silico patent searching reveals a new cannabinoid receptor. Trends Pharmacol Sci 27: 1-4.
4. Berger JP, Akiyama TE, Meinke PT, (2005) PPARs: therapeutic targets for metabolic disease. Trends Pharmacol Sci 26: 244-251.
5. Bilbao A, Parkitna JR, Engblom D, Perreau-Lenz S, Sanchis-Segura C, Schneider M, Konopka W, Westphal M, Breen G, Desrivieres S, Klugmann M, Guindalini C, Vallada H, Laranjeira R, de, Fonseca FR, Schumann G, Schütz G, Spanagel R, (2008) Loss of the Ca2+/calmodulin-dependent protein kinase type IV in dopaminoceptive neurons enhances behavioral effects of cocaine. Proc Natl Acad Sci U S A 105: 17549-17554.
6. Blanco E, Bilbao A, Luque-Rojas MJ, Palomino A, Bermúdez-Silva FJ, Suárez J, Santín LJ, Estivill-Torrús G, Gutiérrez A, Campos-Sandoval JA, Alonso-Carriõn FJ, Márquez J, de, Fonseca FR, (2012) Attenuation of cocaine-induced conditioned locomotion is associated with altered expression of hippocampal glutamate receptors in mice lacking LPA1 receptors. Psychopharmacology (Berl) 220: 27-42.
7. Campolongo P, Roozendaal B, Trezza V, Cuomo V, Astarita G, Fu J, McGaugh JL, Piomelli D, (2009) Fat-induced satiety factor oleoylethanolamide enhances memory consolidation. Proc Natl Acad Sci U S A 106: 8027-8031.
8. Cluny NL, Keenan CM, Lutz B, Piomelli D, Sharkey KA, (2009) The identification of peroxisome proliferator-activated receptor alpha-independent effects of oleoylethanolamide on intestinal transit in mice. Neurogastroenterol Motil 21: 420-429.
9. Di Marzo V, Bifulco M, De Petrocellis L, (2004) The endocannabinoid system and its therapeutic exploitation. Nat Rev Drug Discov 3: 771-784.
10. Escher P, Wahli W, (2000) Peroxisome proliferator-activated receptors: insight into multiple cellular functions. Mutat Res 448: 121-138.
11. Fernandez-Espejo E, Ramiro-Fuentes S, Rodriguez de Fonseca F, (2009) The absence of a functional peroxisome proliferator-activated receptor-alpha gene in mice enhances motor sensitizing effects of morphine, but not cocaine. Neuroscience 164: 667-675.
12. Fu J, Gaetani S, Oveisi F, Lo Verme J, Serrano A, Rodriguez de Fonseca F, Rosengarth A, Luecke H, Di Giacomo B, Tarzia G, Piomelli D, (2003) Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-alpha. Nature 425: 90-93.
13. Fu J, Oveisi F, Gaetani S, Lin E, Piomelli D, (2005) Oleoylethanolamide, an endogenous PPAR-alpha agonist, lowers body weight and hyperlipidemia in obese rats. Neuropharmacology 48: 1147-1153.
14. Gaetani S, Fu J, Cassano T, Dipasquale P, Romano A, Righetti L, Cianci S, Laconca L, Giannini E, Scaccianoce S, Mairesse J, Cuomo V, Piomelli D, (2010) The fat-induced satiety factor oleoylethanolamide suppresses feeding through central release of oxytocin. J Neurosci 30: 8096-8101.
15. Galan-Rodriguez B, Suarez J, Gonzalez-Aparicio R, Bermudez-Silva FJ, Maldonado R, Robledo P, Rodriguez de Fonseca F, Fernandez-Espejo E, (2009) Oleoylethanolamide exerts partial and dose-dependent neuroprotection of substantia nigra dopamine neurons. Neuropharmacology 56: 653-664.
16. González-Yanes C, Serrano A, Bermúdez-Silva FJ, Hernández-Dominguez M, Páez-Ochoa MA, Rodríguez de Fonseca F, Sánchez-Margalet V, (2005) Oleylethanolamide impairs glucose tolerance and inhibits insulin-stimulated glucose uptake in rat adipocytes through p38 and JNK MAPK pathways. Am J Physiol Endocrinol Metab 289: E923-E929.
17. Guzman M, Lo Verme J, Fu J, Oveisi F, Blazquez C, Piomelli D, (2004) Oleoylethanolamide stimulates lipolysis by activating the nuclear receptor peroxisome proliferator-activated receptor alpha (PPAR-alpha). J Biol Chem 279: 27849-27854.
18. Howlett AC, (2002) The cannabinoid receptors. Prostaglandins Other Lipid Mediat 68-69: 619-631.
19. Itzhak Y, Martin JL, (2002) Cocaine-induced conditioned place preference in mice: induction, extinction and reinstatement by related psychostimulants. Neuropsychopharmacology 26: 130-134.
20. Lo Verme J, Fu J, Astarita G, La Rana G, Russo R, Calignano A, Piomelli D, (2005a) The nuclear receptor peroxisome proliferator-activated receptor-alpha mediates the anti-inflammatory actions of palmitoylethanolamide. Mol Pharmacol 67: 15-19.
21. Lo Verme J, Gaetani S, Fu J, Oveisi F, Burton K, Piomelli D, (2005b) Regulation of food intake by oleoylethanolamide. Cell Mol Life Sci 62: 708-716.
22. Luchicchi A, Lecca S, Carta S, Pillolla G, Muntoni AL, Yasar S, Goldberg SR, Pistis M, (2010) Effects of fatty acid amide hydrolase inhibition on neuronal responses to nicotine, cocaine and morphine in the nucleus accumbens shell and ventral tegmental area: involvement of PPAR-alpha nuclear receptors. Addict Biol 15: 277-288.
23. Maldonado R, Valverde O, Berrendero F, (2006) Involvement of the endocannabinoid system in drug addiction. Trends Neurosci 29: 225-232.
24. Martín AB, Fernandez-Espejo E, Ferrer B, Gorriti MA, Bilbao A, Navarro M, Rodriguez de Fonseca F, Moratalla R, (2008) Expression and function of CB1 receptor in the rat striatum: localization and effects on D1 and D2 dopamine receptor-mediated motor behaviors. Neuropsychopharmacology 33: 1667-1679.
25. Mascia P, Pistis M, Justinova Z, Panlilio LV, Luchicchi A, Lecca S, Scherma M, Fratta W, Fadda P, Barnes C, Redhi GH, Yasar S, Le Foll B, Tanda G, Piomelli D, Goldberg SR, (2011) Blockade of nicotine reward and reinstatement by activation of alpha-type peroxisome proliferator-activated receptors. Biol Psychiatry 69: 633-641.
26. Mazzola C, Medalie J, Scherma M, Panlilio LV, Solinas M, Tanda G, Drago F, Cadet JL, Goldberg SR, Yasar S, (2009) Fatty acid amide hydrolase (FAAH) inhibition enhances memory acquisition through activation of PPAR-alpha nuclear receptors. Learn Mem 16: 332-337.
27. Melis M, Carta S, Fattore L, Tolu S, Yasar S, Goldberg SR, Fratta W, Maskos U, Pistis M, (2010) Peroxisome proliferator-activated receptors-alpha modulate dopamine cell activity through nicotinic receptors. Biol Psychiatry 68: 256-264.
28. Overton HA, Babbs AJ, Doel SM, Fyfe MC, Gardner LS, Griffin G, Jackson HC, Procter MJ, Rasamison CM, Tang-Christensen M, Widdowson PS, Williams GM, Reynet C, (2006) Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents. Cell Metab 3: 167-175.
29. Rodriguez de Fonseca F, Navarro M, Gomez R, Escuredo L, Nava F, Fu J, Murillo-Rodríguez E, Giuffrida A, LoVerme J, Gaetani S, Kathuria S, Gall C, Piomelli D, (2001) An anorexic lipid mediator regulated by feeding. Nature 414: 209-212.
30. Ropero AB, Juan-Picõ P, Rafacho A, Fuentes E, Bermúdez-Silva FJ, Roche E, Quesada I, de, Fonseca FR, Nadal A, (2009) Rapid non-genomic regulation of Ca2+ signals and insulin secretion by PPAR alpha ligands in mouse pancreatic islets of Langerhans. J Endocrinol 200: 127-138.
31. Sanchis-Segura C, Spanagel R, (2006) Behavioural assessment of drug reinforcement and addictive features in rodents: an overview. Addict Biol 11: 2-38.
32. Scherma M, Justinová Z, Zanettini C, Panlilio LV, Mascia P, Fadda P, Fratta W, Makriyannis A, Vadivel SK, Gamaleddin I, Le Foll B, Goldberg SR, (2012) The anandamide transport inhibitor AM404 reduces the rewarding effects of nicotine and nicotine-induced dopamine elevations in the nucleus accumbens shell in rats. Br J Pharmacol 165: 2539-2548.
33. Serrano A, Pavõn FJ, Tovar S, Casanueva F, Señarís R, Diéguez C, de, Fonseca FR, (2011) Oleoylethanolamide: effects on hypothalamic transmitters and gut peptides regulating food intake. Neuropharmacology 60: 593-601.
34. Solinas M, Goldberg SR, Piomelli D, (2008) The endocannabinoid system in brain reward processes. Br J Pharmacol 154: 369-383.
35. Stone VM, Dhayal S, Smith DM, Lenaghan C, Brocklehurst KJ, Morgan NG, (2012) The cytoprotective effects of oleoylethanolamide in insulin-secreting cells do not require activation of GPR119. Br J Pharmacol 165: 2758-2770.
36. Suardíaz M, Estivill-Torrús G, Goicoechea C, Bilbao A, Rodríguez de Fonseca F, (2007) Analgesic properties of oleoylethanolamide (OEA) in visceral and inflammatory pain. Pain 133: 99-110.
37. Sun Y, Alexander SP, Garle MJ, Gibson CL, Hewitt K, Murphy SP, Kendall DA, Bennett AJ, (2007) Cannabinoid activation of PPAR alpha; a novel neuroprotective mechanism. Br J Pharmacol 152: 734-743.
38. Tzschentke TM, (2007) Measuring reward with the conditioned place preference (CPP) paradigm: update of the last decade. Addict Biol 12: 227-462.
39. Wiskerke J, Pattij T, Schoffelmeer AN, De Vries TJ, (2008) The role of CB1 receptors in psychostimulant addiction. Addict Biol 13: 225-238. Review.