Loss of the Ca2+/calmodulin-dependent protein kinase type IV in dopaminoceptive neurons enhances behavioral effects of cocaine

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 45, 2008, Pages 17549-17554

  Bilbao, Ainhoa ^a   Parkitna, Jan Rodriguez ^b   Engblom, David ^b   Perreau Lenz, Stéphanie ^a   Sanchis Segura, Carles ^a   Schneider, Miriam ^a   Konopka, Witold ^b   Westphal, Magdalena ^b   Breen, Gerome ^c   Desrivieres, Sylvane ^c   Klugmann, Matthias ^d   Guindalini, Camila ^e   Vallada, Homero ^f   Laranjeira, Ronaldo ^e   De Fonseca, Fernando Rodriguez ^g   Schumann, Gunter ^c   Schütz, Günther ^b   Spanagel, Rainer ^a  

^a CENTRAL INSTITUTE OF MENTAL HEALTH   (Germany)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^c KING'S COLLEGE LONDON   (United Kingdom)

^d JOHANNES GUTENBERG UNIVERSITY   (Germany)

^e FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^f UNIVERSITY OF SÃO PAULO   (Brazil)

^g HOSPITAL REGIONAL UNIVERSITARIO DE MÁLAGA   (Spain)

Author keywords

Addiction; CaMKIV; CREB; Striatum

Indexed keywords

COCAINE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; PROTEIN KINASE (CALCIUM,CALMODULIN); PROTEIN KINASE (CALCIUM,CALMODULIN) IV; UNCLASSIFIED DRUG; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE IV; CAMK4 PROTEIN, MOUSE; CREB1 PROTEIN, MOUSE;

ADULT; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; COCAINE DEPENDENCE; CONTROLLED STUDY; CORPUS STRIATUM; DOPAMINERGIC NERVE CELL; DRUG ABUSE; DRUG SENSITIVITY; FEMALE; FOREBRAIN; GENE ACTIVITY; GENE EXPRESSION; GENETIC ASSOCIATION; GENETIC TRANSCRIPTION; HUMAN; MALE; MOUSE; NONHUMAN; PLACE PREFERENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DEPLETION; PROTEIN POLYMORPHISM; SINGLE NUCLEOTIDE POLYMORPHISM; ANALYSIS OF VARIANCE; ANIMAL; BRAZIL; COMPARATIVE STUDY; GENE DELETION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; IMMUNOHISTOCHEMISTRY; METABOLISM; NERVE CELL; NERVE CELL PLASTICITY; TRANSGENIC MOUSE;

MUS;

ADULT; ANALYSIS OF VARIANCE; ANIMALS; BRAZIL; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 4; COCAINE-RELATED DISORDERS; CORPUS STRIATUM; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; FEMALE; GENE DELETION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MICE; MICE, TRANSGENIC; NEURONAL PLASTICITY; NEURONS; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 56249096914     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0803959105     Document Type: Article

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