Rapid non-genomic regulation of Ca2+ signals and insulin secretion by PPARα ligands in mouse pancreatic islets of Langerhans

Journal of Endocrinology

Volumn 200, Issue 2, 2009, Pages 127-138

  Ropero, Ana B ^a   Juan Picó, Pablo ^a   Rafacho, Alex ^a,c   Fuentes, Esther ^a   Bernmúdez Silva, F Javier ^b   Roche, Enrique ^a   Quesada, Ivan ^a   de Fonseca, Fernando Rodríquez ^b   Nadal, Angel ^a  

^a MIGUEL HERNÁNDEZ UNIVERSITY   (Spain)

^b HOSPITAL REGIONAL UNIVERSITARIO DE MÁLAGA   (Spain)

^c UNIVERSITY OF CAMPINAS   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

2 [4 [2 [3 CYCLOHEXYL 1 (4 CYCLOHEXYLBUTYL)UREIDO]ETHYL]PHENYLTHIO] 2 METHYLPROPIONIC ACID; CALCIUM ION; CYCLOHEXIMIDE; DACTINOMYCIN; GPR 119; INSULIN; LIGAND; N OLEOYLETHANOLAMINE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA AGONIST; PIRINIXIC ACID; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CALCIUM SIGNALING; CELL MEMBRANE; CELL NUCLEUS; CONTROLLED STUDY; CYTOSOL; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DRUG TARGETING; GENETIC TRANSCRIPTION; GLUCOSE METABOLISM; INSULIN RELEASE; MALE; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PANCREAS ISLET BETA CELL; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; QUANTITATIVE STUDY; REAL TIME POLYMERASE CHAIN REACTION; RNA SYNTHESIS; SIGNAL TRANSDUCTION;

ANIMALS; ANTICHOLESTEREMIC AGENTS; BUTYRIC ACIDS; CALCIUM; INSULIN; INSULIN-SECRETING CELLS; MALE; MICE; MITOCHONDRIA; OLEIC ACIDS; PHENYLUREA COMPOUNDS; PYRIMIDINES; REACTIVE OXYGEN SPECIES; TRANSCRIPTION FACTORS;

EID: 67449139093     PISSN: 00220795     EISSN: 14796805     Source Type: Journal    
DOI: 10.1677/JOE-08-0397     Document Type: Article

References (43)

1. Ashcroft FM & Rorsman P 1989 Electrophysiology of the pancreatic beta-cell. Progress in Biophysics and Molecular Biology 54 87-143.
2. Barbosa RM, Silva AM, Tome AR, Stamford JA, Santos RM & Rosario LM 1996 Real time electrochemical detection of 5-HT/insulin secretion from single pancreatic islets: effect of glucose and K+ depolarization. Biochemical and Biophysical Research Communications 228 100-104.
3. Detimary P, Gilon P, Nenquin M & Henquin JC 1994 Two sites of glucose control of insulin release with distinct dependence on the energy state in pancreatic B-cells. Biochemical Journal 297 455-461.
4. Fernandez J & Valdeolmillos M 2000 Synchronous glucose-dependent [Ca(2+)](i) oscillations in mouse pancreatic islets of Langerhans recorded in vivo. FEBS Letters 477 33-36.
5. Freeman H, Shimomura K, Horner E, Cox RD & Ashcroft FM 2006 Nicotinamide nucleotide transhydrogenase: a key role in insulin secretion. Cell Metabolism 3 35-45.
6. Fu J, Gaetani S, Oveisi F, Lo VJ, Serrano A, Rodriguez DF, Rosengarth A, Luecke H, D iGiacomo B, Tarzia G et al. 2003 Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPARalpha. Nature 425 90-93.
7. Gardner OS, Dewar BJ, Earp HS, Samet JM & Graves LM 2003 Dependence of peroxisome proliferator-activated receptor ligand-induced mitogen-activated protein kinase signaling on epidermal growth factor receptor transactivation. Journal of Biological Chemistry 278 46261-46269.
8. Gardner OS, Dewar BJ & Graves LM 2005a Activation of mitogen-activated protein kinases by peroxisome proliferator-activated receptor ligands: an example of nongenomic signaling. Molecular Pharmacology 68 933-941.
9. Gardner OS, Shiau CW, Chen CS & Graves LM 2005b Peroxisome proliferator-activated receptor γ-independent activation of p38 MAPK by thiazolidinediones involves calcium/calmodulin-dependent protein kinase II and protein kinase R: correlation with endoplasmic reticulum stress. Journal of Biological Chemistry 280 10109-10118.
10. 2+ as evidences in single pancreatic islets. Journal of Biological Chemistry 268 22265-22268.
11. Gonzalez-Yanes C, Serrano A, Bermudez-Silva FJ, Hernandez-Dominguez M, Paez-Ochoa MA, Rodriguez DF & Sanchez-Margalet V 2005 Oleylethanolamide impairs glucose tolerance and inhibits insulin-stimulated glucose uptake in rat adipocytes through p38 and JNK MAPK pathways. American Journal of Physiology. Endocrinology and Metabolism 289 E923-E929.
12. Krauss S, Zhang CY, Scorrano L, Dalgaard LT, St-Pierre J, Grey ST & Lowell BB 2003 Superoxide-mediated activation of uncoupling protein 2 causes pancreatic beta cell dysfunction. Journal of Clinical Investigation 112 1831-1842.
13. Lee SS, Pineau T, Drago J, Lee EJ, Owens JW, Kroetz DL, Fernandez-Salguero PM, Westphal H & Gonzalez FJ 1995 Targeted disruption of the alpha isoform of the peroxisome proliferator- activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators. Molecular and Cellular Biology 15 3012-3022.
14. Losel RM, Falkenstein E, Feuring M, Schultz A, Tillmann HC, Rossol-Haseroth K & Wehling M 2003 Nongenomic steroid action: controversies, questions, and answers. Physiological Reviews 83 965-1016.
15. Madiraju SR & Poitout V 2007 G protein-coupled receptors and insulin secretion: 119 and counting. Endocrinology 148 2598-2600.
16. Migliaccio S, Bernardini S, Wetsel WC, Korach KS, Faraggiana T & Teti A 1998 Protein kinase C modulates estrogen receptors in differentiated osteoblastic cells in vitro. Steroids 63 352-354.
17. Nadal A, Rovira JM, Laribi O, Leon-quinto T, Andreu E, Ripoll C & Soria B 1998 Rapid insulinotropic effect of 17beta-estradiol via a plasma membrane receptor. FASEB Journal 12 1341-1348.
18. Nadal A, Quesada I & Soria B 1999 Homologous and heterologous asynchronicity between identified alpha-, beta- and delta-cells within intact islets of Langerhans in the mouse. Journal of Physiology 517 85-93.
19. Nadal A, Diaz M & Valverde MA 2001 The estrogen trinity: membrane, cytosolic, and nuclear effects. News in Physiological Sciences 16 251-255.
20. Naranjo JR & Mellstrom B 2007 Split personality of transcription factors inside and outside the nuclear border. Science's STKE 2007 e5.
21. Newsholme P, Haber EP, Hirabara SM, Rebelato EL, Procopio J, Morgan D, Oliveira-Emilio HC, Carpinelli AR & Curi R 2007 Diabetes associated cell stress and dysfunction: role of mitochondrial and non-mitochondrial ROS production and activity. Journal of Physiology 583 9-24.
22. Overton HA, Babbs AJ, Doel SM, Fyfe MC, Gardner LS, Griffin G, Jackson HC, Procter MJ, Rasamison CM, Tang-Christensen M et al. 2006 Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents. Cell Metabolism 3 167-175.
23. Pauley CJ, Ledwith BJ & Kaplanski C 2002 Peroxisome proliferators activate growth regulatory pathways largely via peroxisome proliferator-activated receptor alpha-independent mechanisms. Cell Signalling 14 351-358.
24. Perez-Ortiz JM, Tranque P, Vaquero CF, Domingo B, Molina F, Calvo S, Jordan J, Cena V & Llopis J 2004 Glitazones differentially regulate primary astrocyte and glioma cell survival. Involvement of reactive oxygen species and peroxisome proliferator-activated receptor-gamma. Journal of Biological Chemistry 279 8976-8985.
25. Perez-Ortiz JM, Tranque P, Burgos M, Vaquero CF & Llopis J 2007 Glitazones induce astroglioma cell death by releasing reactive oxygen species from mitochondria: modulation of cytotoxicity by nitric oxide. Molecular Pharmacology 72 407-417.
26. Pertusa JA, Nesher R, Kaiser N, Cerasi E, Henquin JC & Jonas JC 2002 Increased glucose sensitivity of stimulus-secretion coupling in islets from Psammomys obesus after diet induction of diabetes. Diabetes 51 2552-2560.
27. Pessin JE & Saltiel AR 2000 Signaling pathways in insulin action: molecular targets of insulin resistance. Journal of Clinical Investigation 106 165-169.
28. Quesada I, Todorova MG & Soria B 2006 Different metabolic responses in alpha-, beta-, and delta-cells of the islet of Langerhans monitored by redox confocal microscopy. Biophysical Journal 90 2641-2650.
29. Quesada I, Villalobos C, Núñez L, Chamero P, Alonso MT, Nadal A & García-Sancho J 2008 Glucose induces synchronous mitochondrial calcium oscillations in intact pancreatic islets. Cell Calcium 43 39-47.
30. Ravnskjaer K, Boergesen M, Rubi B, Larsen JK, Nielsen T, Fridriksson J, Maechler P & Mandrup S 2005 Peroxisome proliferator-activated receptor alpha (PPARalpha) potentiates, whereas PPARgamma attenuates, glucose-stimulated insulin secretion in pancreatic beta-cells. Endocrinology 146 3266-3276.
31. Robinson-Rechavi M, Escriva GH & Laudet V 2003 The nuclear receptor superfamily. Journal of Cell Science 116 585-586.
32. Rodriguez DF, Navarro M, Gomez R, Escuredo L, Nava F, Fu J, Murillo-Rodriguez E, Giuffrida A, LoVerme J, Gaetani S et al. 2001 An anorexic lipid mediator regulated by feeding. Nature 414 209-212.
33. Roduit R, Morin J, Masse F, Segall L, Roche E, Newgard CB, Assimacopoulos-Jeannet F & Prentki M 2000 Glucose down-regulates the expression of the peroxisome proliferator-activated receptor-alpha gene in the pancreatic beta -cell. Journal of Biological Chemistry 275 35799-35806.
34. Rokos CL & Ledwith BJ 1997 Peroxisome proliferators activate extracellular signal-regulated kinases in immortalized mouse liver cells. Journal of Biological Chemistry 272 13452-13457.
35. Rorsman P, Eliasson L, Renstrom E, Gromada J, Barg S & Gopel S 2000 The cell physiology of biphasic insulin secretion. News in Physiological Sciences 15 72-77.
36. Rose ML, Rivera CA, Bradford BU, Graves LM, Cattley RC, Schoonhoven R, Swenberg JA & Thurman RG 1999 Kupffer cell oxidant production is central to the mechanism of peroxisome proliferators. Carcinogenesis 20 27-33.
37. Santos RM, Rosario LM, Nadal A, Garcia-Sancho J, Soria B & Valdeolmillos M 1991 Widespread synchronous [Ca2C] oscillations due to bursting electrical activity in single pancreatic islets. Pflügers Archiv: European Journal of Physiology 418 417-422.
38. Scatena R, Bottoni P, Martorana GE, Ferrari F, De Sole P, Rossi C & Giardina B 2004 Mitochondrial respiratory chain dysfunction, a non-receptor-mediated effect of synthetic PPAR-ligands: biochemical and pharmacological implications. Biochemical and Biophysical Research Communications 319 967-973.
39. Scatena R, Bottoni P, Martorana GE, Vincenzoni F, Botta G, Pastore P & Giardina B 2007 Mitochondria, ciglitazone and liver: a neglected interaction in biochemical pharmacology. European Journal of Pharmacology 567 50-58.
40. Suardiaz M, Estivill-Torrus G, Goicoechea C, Bilbao A & Rodriguez DF 2007 Analgesic properties of oleoylethanolamide (OEA) in visceral and inflammatory pain. Pain 133 99-110.
41. Tordjman K, Standley KN, Bernal-Mizrachi C, Leone TC, Coleman T, Kelly DP & Semenkovich CF 2002 PPARalpha suppresses insulin secretion and induces UCP2 in insulinoma cells. Journal of Lipid Research 43 936-943.
42. Valdeolmillos M, Nadal A, Soria B & Garcia-Sancho J 1993 Fluorescence digital image analysis of glucose-induced [Ca2+] oscillations in mouse pancreatic islets of Langerhans. Diabetes 42 1210-1214.
43. Zhou YT, Shimabukuro M, Wang MY, Lee Y, Higa M, Milburn JL, Newgard CB & Unger RH 1998 Role of peroxisome proliferator-activated receptor alpha in disease of pancreatic beta cells. PNAS 95 8898-8903.