Rosmarinic acid treatment alleviates fibrotic changes in the myocardium induced in a rat model of insulin resistance

Asian Pacific Journal of Tropical Disease

Volumn 2, Issue SUPPL2, 2012, Pages

  Karthik, Dhanapalan ^a   Arunkumar, Elumalai ^a   Viswanathan, Periasamy ^b   Anuradha, Carani Venkatraman ^a  

^a Department of Biochemistry and Biotechnology ^*  (India)

^b ANNAMALAI UNIVERSITY   (India)

Author keywords

Angiotensin II; Cardiac fibrosis; Fructose; ROS; Rosmarinic acid

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; ANGIOTENSIN 2 RECEPTOR; ANGIOTENSIN II; COLLAGEN; FIBRONECTIN; GELATINASE A; GELATINASE B; MESSENGER RNA; REACTIVE OXYGEN METABOLITE; ROSMARINIC ACID; SUPEROXIDE; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; ELECTROCARDIOGRAPHY; HEART FUNCTION; HEART MUSCLE FIBROSIS; HEART PROTECTION; HEART RATE; HISTOPATHOLOGY; INSULIN RESISTANCE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT;

EID: 84871741694     PISSN: 22221808     EISSN: None     Source Type: Journal    
DOI: 10.1016/S2222-1808(12)60292-8     Document Type: Article

References (26)

1. Miller A, Adeli K Dietary fructose and the metabolic syndrome. Curr Opin Gastroenterol 2008, 24(2):204-209.
2. Patel J, Matnor NA, Iyer A, Brown L A Regenerative Antioxidant Protocol of Vitamin E and α-Lipoic Acid Ameliorates Cardiovascular and Metabolic Changes in Fructose-Fed Rats. Evid Based Complement Alternat Med 2011, 2011:120801.
3. Mellor KM, Bell JR, Young MJ, Ritchie RH, Delbridge LM Myocardial autophagy activation and suppressed survival signaling is associated with insulin resistance in fructose-fed mice. J Mol Cell Cardiol 2011, 50(6):1035-1043.
4. Panchal SK, Brown L Rodent models for metabolic syndrome research. J Biomed Biotechnol 2011, 2011:351982.
5. Ashour AE, Sayed-Ahmed MM, Abd-Allah AR, Korashy HM, Maayah ZH, Alkhalidi H, Mubarak M, Alhaider A Metformin rescues the myocardium from Doxorubicin-induced energy starvation and mitochondrial damage in rats. Oxid Med Cell Longev 2012, 2012:434195.
6. Porter KE, Turner NA Cardiac fibroblasts: at the heart of myocardial remodeling. Pharmacol Ther 2009, 123(2):255-278.
7. Ban CR, Twigg SM Fibrosis in diabetes complications: pathogenic mechanisms and circulating and urinary markers. Vasc Health Risk Manag 2008, 4(3):575-596.
8. Fadel O, El Kirat K, Morandat S The natural antioxidant rosmarinic acid spontaneously penetrates membranes to inhibit lipid peroxidation in situ. Biochim Biophys Acta 2011, 1808(12):2973-2980.
9. Ersoy S, Orhan I, Turan NN, Sahan G, Ark M, Tosun F Endothelium-dependent induction of vasorelaxation by Melissa officinalis L. ssp. officinalis in rat isolated thoracic aorta. Phytomedicine 2008, 15(12):1087-1092.
10. Bulgakov VP, Inyushkina YV, Fedoreyev SA Rosmarinic acid and its derivatives: biotechnology and applications. Crit Rev Biotechnol 2008, 7(25):4959-4965.
11. Karthik D, Viswanathan P, Anuradha CV Administration of Rosmarinic Acid Reduces Cardiopathology and Blood Pressure Through Inhibition of p22phox NADPH Oxidase in Fructose-Fed Hypertensive Rats. J Cardiovasc Pharmacol 2011, 58(5):514-521.
12. Li GS, Jiang WL, Tian JW, Qu GW, Zhu HB, Fu FH In vitro and in vivo antifibrotic effects of rosmarinic acid on experimental liver fibrosis. Phytomedicine 2010, 17(3-4):282-288.
13. Shen Y, Shen HM, Shi CY, Ong CN Benzene metabolites enhance reactive oxygen species generation in HL60 human leukemia cells. Hum Exp Toxicol 1996, 15(5):422-427.
14. Woessner JF The determination of hydroxyproline in tissue and protein samples containing small proportions of this imino acid. Arch Biochem Biophys 1961, 93(2):440-447.
15. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ Protein measurement with the Folin phenol reagent. J Biol Chem 1951, 193(1):265-275.
16. Wang L, Sweet DH Active Hydrophilic Components of the Medicinal Herb Salvia miltiorrhiza (Danshen) Potently Inhibit Organic Anion Transporters 1 (Slc22a6) and 3 (Slc22a8). Evid Based Complement Alternat Med 2012, 2012:872458.
17. Elrashidy RA, Asker ME, Mohamed HE Pioglitazone attenuates cardiac fibrosis and hypertrophy in a rat model of diabetic nephropathy. J Cardiovasc Pharmacol Ther 2012, 17(3):324-333.
18. Challa AA, Vukmirovic M, Blackmon J, Stefanovic B Withaferin-A Reduces Type I Collagen Expression In Vitro and Inhibits Development of Myocardial Fibrosis In Vivo. PLoS ONE 2012, 7(8):e42989.
19. Li J, Zhu H, Shen E, Wan L, Arnold JM, Peng T Deficiency of rac1 blocks NADPH oxidase activation, inhibits endoplasmic reticulum stress, and reduces myocardial remodeling in a mouse model of type 1 diabetes. Diabetes 2010, 59(8):2033-2042.
20. Giacco F, Brownlee M Oxidative stress and diabetic complicationstrix remodeling and the matrix metalloproteinases: influence on cardiac form and function. Physiol Rev 2007, 87(4):1285-1342.
21. Ruiz-Ortega M, Rodríguez-Vita J, Sanchez-Lopez E, Carvajal G, Egido J TGF-beta signaling in vascular fibrosis. Cardiovasc Res 2007, 74(2):196-206.
22. Huang XR, Chung AC, Yang F, Yue W, Deng C, Lau CP, Tse HF, Lan HY Smad3 mediates cardiac inflammation and fibrosis in angiotensin II-induced hypertensive cardiac remodeling. Hypertension 2010, 55(5):1165-1171.
23. Yoo KH, Thornhill BA, Wolstenholme JT, Chevalier RL Tissue-specific regulation of growth factors and clusterin by angiotensin II. Am J Hypertens 1998, 11:715-722.
24. Toblli JE, Cao G, DeRosa G, Forcada P Reduced cardiac expression of plasminogen activator inhibitor 1 and transforming growth factor beta1 in obese Zucker rats by perindopril. Heart 2005, 91(1):80-86.
25. Kim DS, Kim HR, Woo ER, Hong ST, Chae HJ, Chae SW Inhibitory effects of rosmarinic acid on adriamycin-induced apoptosis in H9c2 cardiac muscle cells by inhibiting reactive oxygen species and the activations of c-Jun N-terminal kinase and extracellular signal-regulated kinase. Biochem Pharmacol 2005, 70(7):1066-1078.
26. Baba S, Osakabe N, Natsume M, Terao J Orally administered rosmarinic acid is present as the conjugated and/or methylated forms in plasma, and is degraded and metabolized to conjugated forms of caffeic acid, ferulic acid and m-coumaric acid. Life Sci 2004, 75(2):165-178.