Metformin rescues the myocardium from doxorubicin-induced energy starvation and mitochondrial damage in rats

Oxidative Medicine and Cellular Longevity

Volumn , Issue , 2012, Pages

  Ashour, Abdelkader E ^a   Sayed Ahmed, Mohamed M ^a   Abd Allah, Adel R ^a   Korashy, Hesham M ^a   Maayah, Zaid H ^a   Alkhalidi, Hisham ^b   Mubarak, Mohammed ^b   Alhaider, Abdulqader ^a  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

^b KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDIABETIC DRUG; ANTIOXIDANT ACTIVITIES; BIOCHEMICAL CHANGES; CARDIOTOXICITY; CLINICAL USE; DOXORUBICIN; GLUTATHIONES; IN-VIVO; METFORMINS; MITOCHONDRIAL DAMAGE; MRNA EXPRESSION; RAT MODEL; SERUM LEVELS; SIDE EFFECT; ULTRASTRUCTURAL CHANGES;

ELECTRON MICROSCOPY; PLANTS (BOTANY);

GENE EXPRESSION;

4 NITROQUINOLINE 1 OXIDE; ADENOSINE TRIPHOSPHATE; CATALASE; COENZYME A; COMPLEMENTARY DNA; CREATINE KINASE MB; DOXORUBICIN; GLUTATHIONE; LACTATE DEHYDROGENASE; MESSENGER RNA; METFORMIN; PROTECTIVE AGENT;

ANIMAL EXPERIMENT; ANTIOXIDANT ACTIVITY; ARTICLE; BIOCHEMISTRY; CARDIOTOXICITY; CELL ULTRASTRUCTURE; CONCENTRATION (PARAMETERS); ELECTRON MICROSCOPY; ENERGY STARVATION; HEART INJURY; HEART MUSCLE; HEART PROTECTION; HISTOPATHOLOGY; MALE; MITOCHONDRIAL DAMAGE; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; RAT; RNA EXTRACTION; ANIMAL; CARDIOMEGALY; DRUG EFFECT; ENERGY METABOLISM; GENE EXPRESSION REGULATION; GENETICS; HEART MUSCLE CELL; METABOLISM; MITOCHONDRION; PATHOLOGY; ULTRASTRUCTURE; WISTAR RAT;

ANIMALS; CARDIOMEGALY; COENZYME A; DOXORUBICIN; ENERGY METABOLISM; GENE EXPRESSION REGULATION; GLUTATHIONE; MALE; METFORMIN; MITOCHONDRIA; MYOCARDIUM; MYOCYTES, CARDIAC; OXIDATIVE STRESS; PROTECTIVE AGENTS; RATS; RATS, WISTAR;

EID: 84862301097     PISSN: 19420900     EISSN: 19420994     Source Type: Journal    
DOI: 10.1155/2012/434195     Document Type: Article

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