Pharmacological inhibition of GSK3 attenuates DNA damage-induced apoptosis via reduction of p53 mitochondrial translocation and Bax oligomerization in neuroblastoma SH-SY5Y CELLS

Cellular and Molecular Biology Letters

Volumn 18, Issue 1, 2013, Pages 58-74

  Ngok Ngam, Patchara ^a   Watcharasit, Piyajit ^a,b   Thiantanawat, Apinya ^a,b   Satayavivad, Jutamaad ^a,b  

^a Research and Innovation   (Thailand)

^b Chulabhorn Research Institute   (Thailand)

Author keywords

Apoptosis; Bax oligomerization; Camptothecin; Cytochrome C; Doxorubicin; Etoposide; GSK3; Mitochondrial translocation; p53; Phosphorylation

Indexed keywords

2 (2,4 DICHLOROPHENYL) 3 (1 METHYL 3 INDOLYL)MALEIMIDE; CAMPTOTHECIN; CASPASE 3; CYTOCHROME C; DOXORUBICIN; ETOPOSIDE; GLYCOGEN SYNTHASE KINASE 3; LITHIUM; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53;

APOPTOSIS; ARTICLE; BIOACCUMULATION; CONTROLLED STUDY; DNA DAMAGE; ENZYME ACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; MITOCHONDRION; NEUROBLASTOMA CELL; OLIGOMERIZATION; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN SECRETION; REGULATORY MECHANISM; WILD TYPE;

EID: 84871715443     PISSN: 14258153     EISSN: 16891392     Source Type: Journal    
DOI: 10.2478/s11658-012-0039-y     Document Type: Article

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