Inhibition of DNA helicases with DNA-competitive inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 4, 2006, Pages 923-927

  Dubaele, Sandy ^a   Jahnke, Wolfang ^a   Schoepfer, Joseph ^a   Fuchs, Jean ^a   Chène, Patrick ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

ATPase; Helicase; Inhibitor

Indexed keywords

ADENOSINE TRIPHOSPHATASE; DIBENZOTHIAZEPINE DERIVATIVE; HELICASE;

ARTICLE; DRUG BINDING SITE; DRUG DNA BINDING; DRUG MECHANISM; DRUG POTENCY; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION;

ADENOSINE TRIPHOSPHATASES; BINDING SITES; BINDING, COMPETITIVE; CRYSTALLOGRAPHY, X-RAY; DIBENZOTHIEPINS; DNA; DNA HELICASES; ENZYME INHIBITORS; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 30344445979     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.10.110     Document Type: Article

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