Discovery, characterization and comparison of inhibitors of Bacillus anthracis and Staphylococcus aureus replicative DNA helicases

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 13, 2009, Pages 4466-4476

  Aiello, Daniel ^a   Barnes, Marjorie H ^a   Biswas, Esther E ^b   Biswas, Subhasis B ^b   Gu, Shen ^a   Williams, John D ^a   Bowlin, Terry L ^a   Moir, Donald T ^a  

^a MICROBIOTIX INC   (United States)

^b UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY   (United States)

Author keywords

Aminocoumarin; Bacillus anthracis; Helicase; High throughput screen; Staphylococcus aureus

Indexed keywords

AMINOCOUMARIN DERIVATIVE; ANTIINFECTIVE AGENT; BENZOTHIAZOLE DERIVATIVE; CLOROBIOCIN; COUMAMYCIN A1; DNA; ENZYME INHIBITOR; HELICASE; HELICASE INHIBITOR; NOVOBIOCIN; PYRROLE DERIVATIVE; RHODANINE; TRIAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BACILLUS ANTHRACIS; BACTERICIDAL ACTIVITY; BACTERIUM CULTURE; COMPETITIVE INHIBITION; DNA REPLICATION; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG STRUCTURE; ENZYME ASSAY; ENZYME INHIBITION; ENZYME SUBSTRATE; FLUORESCENCE RESONANCE ENERGY TRANSFER; HELA CELL; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; STAPHYLOCOCCUS AUREUS; STRUCTURE ACTIVITY RELATION;

AMINOCOUMARINS; ANTI-BACTERIAL AGENTS; BACILLUS ANTHRACIS; BACTERIA; BACTERIAL PROTEINS; BASE SEQUENCE; CLONING, MOLECULAR; DNA HELICASES; DNA REPLICATION; DNA, BACTERIAL; MICROBIAL VIABILITY; MOLECULAR SEQUENCE DATA; SMALL MOLECULE LIBRARIES; STAPHYLOCOCCUS AUREUS; STRUCTURE-ACTIVITY RELATIONSHIP;

BACILLI (CLASS); BACILLUS ANTHRACIS; BACTERIA (MICROORGANISMS); MAMMALIA; POSIBACTERIA; STAPHYLOCOCCUS; STAPHYLOCOCCUS AUREUS;

EID: 66449129371     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.05.014     Document Type: Article

References (44)

1. Payne D.J., Gwynn M.N., Holmes D.J., and Pompliano D.L. Nat. Rev. Drug Discovery 6 (2007) 29
2. Appelbaum P.C., and Hunter P.A. Int. J. Antimicrob. Agents 16 (2000) 5
3. Zhi C., Long Z.Y., Gambino J., Xu W.C., Brown N.C., Barnes M., Butler M., LaMarr W., and Wright G.E. J. Med. Chem. 46 (2003) 2731
4. Bailey S., Eliason W.K., and Steitz T.A. Science 318 (2007) 459
5. Griep M.A., Blood S., Larson M.A., Koepsell S.A., and Hinrichs S.H. Bioorg. Med. Chem. 15 (2007) 7203
6. McKay G.A., Reddy R., Arhin F., Belley A., Lehoux D., Moeck G., Sarmiento I., Parr T.R., Gros P., Pelletier J., and Far A.R. Bioorg. Med. Chem. Lett. 16 (2006) 1286
7. Seefeld M.A., Miller W.H., Newlander K.A., Burgess W.J., Payne D.J., Rittenhouse S.F., Moore T.D., DeWolf Jr. W.E., Keller P.M., Qiu X., Janson C.A., Vaidya K., Fosberry A.P., Smyth M.G., Jaworski D.D., Slater-Radosti C., and Huffman W.F. Bioorg. Med. Chem. Lett. 11 (2001) 2241
8. Hackbarth, C. J.; Lopez, S.; Lewis, J. G.; Wu, C.; Wang, W.; Withers, G.; Chen, D.; Jacobs, J.; Patel, D. V.; White, R.; Trias, J.; Yuan, Z. In In vitro Profile of N-Alkyl Urea Hydroxamic Acids that Inhibit Bacterial Peptide Deformylase, 41st Interscience Conference on Antimicrobial Agents and Chemotyerapy (ICAAC), Chicago, IL, 2001; American Society for Microbiology: Chicago, IL, 2001; p 2135.
9. Hooper D.C., Wolfson J.S., McHugh G.L., Winters M.B., and Swartz M.N. Antimicrob. Agents Chemother. 22 (1982) 662
10. Boger D.L., Fink B.E., Brunette S.R., Tse W.C., and Hedrick M.P. J. Am. Chem. Soc. 123 (2001) 5878
11. Feng B.Y., and Shoichet B.K. Nat. Protoc. 1 (2006) 550
12. Schepetkin I.A., Khlebnikov A.I., Kirpotina L.N., and Quinn M.T. J. Med. Chem. 49 (2006) 5232
13. Jiang S., Lu H., Liu S., Zhao Q., He Y., and Debnath A.K. Antimicrob. Agents Chemother. 48 (2004) 4349
14. Sugino A., Higgins N.P., Brown P.O., Peebles C.L., and Cozzarelli N.R. Proc. Natl. Acad. Sci. U.S.A. 75 (1978) 4838
15. Pi N., Meyers C.L., Pacholec M., Walsh C.T., and Leary J.A. Proc. Natl. Acad. Sci. U.S.A. 101 (2004) 10036
16. Daly J.S., Giehl T.J., Brown N.C., Zhi C., Wright G.E., and Ellison III R.T. Antimicrob. Agents Chemother. 44 (2000) 2217
17. Hooper D.C. Clin. Infect. Dis. 32 (2001) S9
18. Zhang L., Schwartz G., O'Donnell M., and Harrison R.K. Anal. Biochem. 293 (2001) 31
19. Zhang Y., Yang F., Kao Y.C., Kurilla M.G., Pompliano D.L., and Dicker I.B. Anal. Biochem. 304 (2002) 174
20. Earnshaw D.L., Moore K.J., Greenwood C.J., Djaballah H., Jurewicz A.J., Murray K.J., and Pope A.J. J. Biomol. Screen. 4 (1999) 239
21. Earnshaw D.L., and Pope A.J. J. Biomol. Screen. 6 (2001) 39
22. Dubaele S., Jahnke W., Schoepfer J., Fuchs J., and Chene P. Bioorg. Med. Chem. Lett. 16 (2006) 923
23. Xu H., Ziegelin G., Schroder W., Frank J., Ayora S., Alonso J.C., Lanka E., and Saenger W. Nucleic Acids Res. 29 (2001) 5058
24. Zhang B., Zhang A.H., Chen L., and Xi X.G. J. Biochem. 143 (2008) 773
25. Walsh C.W. Antibiotics: Actions, Origins, Resistance (2003), ASM Press, Washington, DC p 335
26. Vickers A.A., Chopra I., and O'Neill A.J. Antimicrob. Agents. Chemother. 51 (2007) 4484
27. Nichols R.L., and Finland M. Antibiot. Med. Clin. Ther. 2 (1956) 241
28. Murren J.R., DiStasio S.A., Lorico A., McKeon A., Zuhowski E.G., Egorin M.J., Sartorelli A.C., and Rappa G. Cancer J. 6 (2000) 256
29. Biswas E.E., Barnes M.H., Moir D.T., and Biswas S.B. J. Bacteriol. 191 (2009) 249
30. Arai K., Yasuda S., and Kornberg A. J. Biol. Chem. 256 (1981) 5247
31. Biswas E.E., and Biswas S.B. Biochemistry 38 (1999) 10919
32. Biswas E.E., Fricke W.M., Chen P.H., and Biswas S.B. Biochemistry 36 (1997) 13277
33. Zhang J.H., Chung T.D., and Oldenburg K.R. J. Biomol. Screen. 4 (1999) 67
34. Barnes M.H., and Brown N.C. Nucleic Acids Res. 6 (1979) 1203
35. Saiki A.Y., Shen L.L., Chen C.M., Baranowski J., and Lerner C.G. Antimicrob. Agents Chemother. 43 (1999) 1574
36. Wei M., Wynn R., Hollis G., Liao B., Margulis A., Reid B.G., Klabe R., Liu P.C., Becker-Pasha M., Rupar M., Burn T.C., McCall D.E., and Li Y. J. Biomol. Screen. 12 (2007) 220
37. Brown N.C., Wisseman III C.L., and Matsushita T. Nat. New. Biol. 237 (1972) 72
38. Anonymous. NCCLS Approved Standard Procedures, 4th Ed. 1997, 17, #22, M11.
39. NCCLS, Methods for Determining Bactericidal Activity of Antimicrobial Agents; Approved Guideline (M26-A). National Committee for Clinical Laboratory Standards: Wayne, PA, 1999.
40. Marshall N.J., Goodwin C.J., and Holt S.J. Growth Regulat. 5 (1995) 69
41. Shatalin K.Y., and Neyfakh A.A. FEMS Microbiol. Lett. 245 (2005) 315
42. Green B.D., Battisti L., Koehler T.M., Thorne C.B., and Ivins B.E. Infect. Immun. 49 (1985) 291
43. Love E., D'Ambrosio D., and Brown N.C. Mol. Gen. Genet. 144 (1976) 313
44. Ghosh S., and Lowenstein J.M. Gene 176 (1996) 249