Small molecule inhibitors of E. coli primase, a novel bacterial target

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 10, 2007, Pages 2807-2810

  Agarwal, Atul ^a   Louise May, Shirley ^a   Thanassi, Jane A ^a   Podos, Steven D ^a   Cheng, Jijun ^a   Thoma, Christy ^a   Liu, Cuixian ^a   Wiles, Jason A ^a   Nelson, David M ^a   Phadke, Avinash S ^a   Bradbury, Barton J ^a   Deshpande, Milind S ^a   Pucci, Michael J ^a  

^a Achillion Pharmaceuticals   (United States)

Author keywords

Antibacterial; DNA primase; DnaG; Gram negative; Gram positive; In silico screening; MIC; Pharmacophore; Virtual screening

Indexed keywords

ALIPHATIC AMINE; BENZO[D]PYRIMIDO[5,4 B]FURAN; DNA PRIMASE; ENZYME INHIBITOR; FURAN DERIVATIVE; IMIDAZOLE DERIVATIVE; PRIMASE INHIBITOR; PYRIDO[3',2':4,5]THIENO[3,2 D]PYRIMIDINE; PYRIMIDINE DERIVATIVE; QUINAZOLINE DERIVATIVE; THIOPHENE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DNA REPLICATION; DRUG SCREENING; ENZYME INHIBITION; ESCHERICHIA COLI; IN VITRO STUDY; NONHUMAN; PHARMACOPHORE; THREE DIMENSIONAL IMAGING;

ANTI-BACTERIAL AGENTS; DNA PRIMASE; DNA REPLICATION; DRUG DESIGN; ENZYME INHIBITORS; ESCHERICHIA COLI; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MOLECULAR WEIGHT;

BACTERIA (MICROORGANISMS); EUKARYOTA; NEGIBACTERIA; POSIBACTERIA;

EID: 34247332706     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.02.056     Document Type: Article

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