Solvent- and chromatography-free amination of π-deficient nitrogen heterocycles under microwave irradiation. A fast, efficient and green route to 9-aminoacridines, 4-aminoquinolines and 4-aminoquinazolines and its application to the synthesis of the drugs amsacrine and bistacrine

Tetrahedron

Volumn 69, Issue 3, 2013, Pages 1024-1030

  Staderini, Matteo ^a   Cabezas, Nieves ^a   Bolognesi, Maria Laura ^b   Menéndez, J Carlos ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^b UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

Green chemistry; Heterocyclic amination; Heterocyclic libraries; Microwave assisted synthesis; Solvent free synthesis

Indexed keywords

1,4 BIS(6 CHLORO 2 METHOXYACRIDIN 9 YL)PIPERAZINE; 4 (6 CHLORO 2 METHOXYACRIDIN 9 YL)MORPHOLINE; 4 AMINOQUINAZOLINE DERIVATIVE; 4 AMINOQUINOLINE DERIVATIVE; 6 CHLORO 2 METHOXY N (4 METHOXYPHENYL)ACRIDIN 9 AMINE; 6 CHLORO 2 METHOXY N (4 MORPHOLINOPHENYL)ACRIDIN 9 AMINE; 6 CHLORO 2 METHOXY N [4 (PIPERIDIN 1 YL)METHOXYPHENYL]ACRIDIN 9 AMINE; 6 CHLORO 2 METHOXY N PHENYLACRIDIN 9 AMINE; 6 CHLORO 9 (1H IMIDAZOL 1 YL) 2 METHOXY ACRIDINE; 6 CHLORO N HEXYL 2 METHOXYACRIDIN 9 AMINE; 7 CHLORO N(4 METHOXYPHENYL)QUINOLIN 4 AMINE; 9 (1H BENZO[D]IMIDAZOL 1 YL) 6 CHLORO 2 METHOXYACRIDINE; ACRIDINE; AMINE; AMINOACRIDINE DERIVATIVE; AMSACRINE; BISTACRINE; DIAMINE DERIVATIVE; N 1 (6 CHLORO 2 METHOXYACRIDIN 9 YL)ETHANE 1,2 DIAMINE; N 1 (6 CHLORO 2 METHOXYACRIDIN 9 YL)N 4,N 4 DIMETHYLBENZENE 1,4 AMINE; N BENZYL 6 CHLORO 2 METHOXYACRIDIN 9 AMINE; N(1 BENZYLPIPERIDIN 4 YL) 6 CHLORO 2 METHOXYACRIDIN 9 AMINE; NITROGEN; ORGANIC SOLVENT; PHENOL; QUINAZOLINE; QUINAZOLINE DERIVATIVE; QUINOLINE; SOLVENT; UNCLASSIFIED DRUG; WATER;

AMINATION; ARTICLE; CHROMATOGRAPHY; CRYSTALLIZATION; DRUG SYNTHESIS; ENERGY CONSERVATION; EXTRACTION; MICROWAVE IRRADIATION; NITROGEN CONCENTRATION; PRIORITY JOURNAL; PURIFICATION; REACTION TIME;

EID: 84871630833     PISSN: 00404020     EISSN: 14645416     Source Type: Journal    
DOI: 10.1016/j.tet.2012.11.083     Document Type: Article

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