메뉴 건너뛰기




Volumn 14, Issue 9, 2012, Pages 520-526

Addressing the medicinal chemistry bottleneck: A lean approach to centralized purification

Author keywords

drug discovery; lean sigma; preparative LCMS; productivity; purification

Indexed keywords

DRUG;

EID: 84866081663     PISSN: 21568952     EISSN: None     Source Type: Journal    
DOI: 10.1021/co300075g     Document Type: Article
Times cited : (13)

References (18)
  • 2
    • 58149260010 scopus 로고    scopus 로고
    • Implementing Lean Sigma in pharmaceutical research and development: A review by practitioners
    • Carleysmith, S. W.; Dufton, A. M.; Altria, K. D. Implementing Lean Sigma in pharmaceutical research and development: A review by practitioners R&D Manage. 2009, 39, 95-106
    • (2009) R&D Manage. , vol.39 , pp. 95-106
    • Carleysmith, S.W.1    Dufton, A.M.2    Altria, K.D.3
  • 3
    • 34249905210 scopus 로고    scopus 로고
    • At 3M, A Struggle between Efficiency and Creativity
    • June 11
    • Hindo, B. At 3M, A Struggle Between Efficiency and Creativity. Business Week, June 11, 2007.
    • (2007) Business Week
    • Hindo, B.1
  • 4
    • 78651365936 scopus 로고    scopus 로고
    • Creativity, innovation and lean sigma: A controversial combination?
    • Johnstone, C.; Pairaudeau, G.; Pettersson, J. A. Creativity, innovation and lean sigma: A controversial combination? Drug Discovery Today 2011, 16, 50-57
    • (2011) Drug Discovery Today , vol.16 , pp. 50-57
    • Johnstone, C.1    Pairaudeau, G.2    Pettersson, J.A.3
  • 6
    • 84863420874 scopus 로고    scopus 로고
    • From crude samples to highly pure isolated solids in 4 h: Delivery of pure, dry, free flowing solids by a customer focused, medicinal chemistry purification service, using a Lean Sigma approach
    • Barton, P.; Boyd, S.; Chapman, S.; Green, C.; Groombridge, S.; Loynes, A.; Whittamore, Paul. From crude samples to highly pure isolated solids in 4 h: Delivery of pure, dry, free flowing solids by a customer focused, medicinal chemistry purification service, using a Lean Sigma approach Chromatogr. Today 2010, 3, 26-29
    • (2010) Chromatogr. Today , vol.3 , pp. 26-29
    • Barton, P.1    Boyd, S.2    Chapman, S.3    Green, C.4    Groombridge, S.5    Loynes, A.6    Whittamore, P.7
  • 10
    • 38849140851 scopus 로고    scopus 로고
    • Fully automated open access platform for rapid, combined serial evaporation and sample reformatting
    • Benali, O.; Davies, G.; Deal, M.; Farrant, E.; Guthrie, D.; Holden, J.; Wheeler, R. Fully automated open access platform for rapid, combined serial evaporation and sample reformatting J. Comb. Chem. 2008, 10, 52-55
    • (2008) J. Comb. Chem. , vol.10 , pp. 52-55
    • Benali, O.1    Davies, G.2    Deal, M.3    Farrant, E.4    Guthrie, D.5    Holden, J.6    Wheeler, R.7
  • 11
    • 84866116299 scopus 로고    scopus 로고
    • Biotage A. B. Uppsala Sweden. (accessed April 16
    • Biotage A. B., Uppsala Sweden. http://www.biotage.com/DynPage.aspx?id= 30804 (accessed April 16, 2012).
    • (2012)
  • 13
    • 84866141139 scopus 로고    scopus 로고
    • version 11; PerkinElmer Informatics (Formerly CambridgeSoft Corporation): Cambridge, MA, U.S.A. accessed August 24, 2012
    • E-Notebook, version 11; PerkinElmer Informatics (Formerly CambridgeSoft Corporation): Cambridge, MA, U.S.A., 2011; http://www.cambridgesoft.com/ Ensemble-for-Chemistry/ENotebookforChemistry/Default.aspx, accessed August 24, 2012.
    • (2011) E-Notebook
  • 15
    • 0141795449 scopus 로고    scopus 로고
    • Optimizing preparative LC/MS configurations and methods for parallel synthesis purification
    • DOI 10.1021/cc020086n
    • Blom, K. F.; Sparks, R.; Doughty, J.; Everlof, J. G.; Haque, T.; Combs, A. P. Optimizing preparative LC-MS configurations and methods for parallel synthesis purification J. Comb. Chem. 2003, 5, 670-683 (Pubitemid 37206173)
    • (2003) Journal of Combinatorial Chemistry , vol.5 , Issue.5 , pp. 670-683
    • Blom, K.F.1    Sparks, R.2    Doughty, J.3    Everlof, J.G.4    Haque, T.5    Combs, A.P.6
  • 16
    • 19544379199 scopus 로고    scopus 로고
    • Peak capacity in gradient ultra performance liquid chromatography (UPLC)
    • DOI 10.1016/j.jpba.2004.12.028, PII S0731708505000142
    • Wren, S. A. C. Peak capacity in gradient ultra performance liquid chromatography (UPLC) J. Pharm. Biomed. Anal. 2005, 38, 337-343 equation 2 (Pubitemid 40733163)
    • (2005) Journal of Pharmaceutical and Biomedical Analysis , vol.38 , Issue.2 , pp. 337-343
    • Wren, S.A.C.1
  • 17
    • 84866116297 scopus 로고    scopus 로고
    • Genevac LTD: Ipswich, United Kingdom; accessed August 24, 2012
    • Genevac model HT-12 or HT-24; Genevac LTD: Ipswich, United Kingdom; http://genevac.com/en/ProductDetail2.asp?S=3&V=1&G=2&Product=5, accessed August 24, 2012.
    • Genevac Model HT-12 or HT-24


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.