Antiprion activity of functionalized 9-aminoacridines related to quinacrine

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 14, 2008, Pages 6737-6746

  Nguyen Thi, Hanh Thuy ^a   Lee, Chong Yew ^a   Teruya, Kenta ^b   Ong, Wei Yi ^a   Doh ura, Katsumi ^b   Go, Mei Lin ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

6 Chloro 2 methoxy (N9 substituted)acridin 9 amines; Antiprion activity; Murine neuroblastoma cells infected with scrapie prion strains; Quinacrine

Indexed keywords

6 CHLORO 2 METHOXY N [3 (4 METHYLPIPERAZIN 1 YL)PHENYL]ACRIDIN 9 AMINE; 6 CHLORO 2 METHOXY N [4 (4 METHYLPIPERAZIN 1 YL)PHENYL]ACRIDIN 9 AMINE; 6 CHLORO 2 METHOXY N [4 (4 METHYLPIPERAZIN 1 YL)PHENYL]ACRIDINE 9 AMINE; 6 CHLORO 2 METHOXYACRIDIN 9 AMINE DIHYDROCHLORIDE; AMINOACRIDINE DERIVATIVE; MEPACRINE; N 1 (6 CHLORO 2 METHOXYACRIDIN 9 YL) N 2,N 2 DIETHYLETHANE 1,2 DIAMINE DIHYDROCHLORIDE; N 1 (6 CHLORO 2 METHOXYACRIDIN 9 YL) N 3,N 3 DIETHYLBENZENE 1,3 DIAMINE; N 1 (ACRIDIN 9 YL) N 4,N 4 DIETHYLBENZENE 1,4 DIAMINE; N 9 (1 BENZYLPIPERIDIN 4 YL) 6 CHLORO 2 METHOXYACRIDIN 9 AMINE; PRION PROTEIN; QUINPRAMINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; IMMUNOBLOTTING; MOUSE; NEUROBLASTOMA CELL; NONHUMAN; PRION DISEASE; SCRAPIE AGENT; VIRUS STRAIN;

AMINOACRIDINES; CELL LINE; HUMANS; PRION DISEASES; PRIONS; QUINACRINE; STRUCTURE-ACTIVITY RELATIONSHIP;

MURINAE; SCRAPIE PRION;

EID: 47349084838     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.05.060     Document Type: Article

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