메뉴 건너뛰기




Volumn 56, Issue 1, 2013, Pages 126-135

Production and function of IL-12 in islets and beta cells

Author keywords

Diabetes; Human; Interleukin 12; Islets; Pro inflammatory cytokines

Indexed keywords

CASPASE 3; CYTOKINE; GAMMA INTERFERON; GLUCOSE; INSULIN; INTERLEUKIN 12; INTERLEUKIN 12 RECEPTOR; INTERLEUKIN 1BETA; NEUTRALIZING ANTIBODY; TUMOR NECROSIS FACTOR ALPHA;

EID: 84871608983     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-012-2732-9     Document Type: Article
Times cited : (31)

References (50)
  • 1
    • 0029030964 scopus 로고
    • T helper cell subsets in insulin-dependent diabetes
    • 7761837 10.1126/science.7761837 1:CAS:528:DyaK2MXlvVyqsL8%3D
    • Katz JD, Benoist C, Mathis D (1995) T helper cell subsets in insulin-dependent diabetes. Science 268:1185-1188
    • (1995) Science , vol.268 , pp. 1185-1188
    • Katz, J.D.1    Benoist, C.2    Mathis, D.3
  • 2
    • 0029954214 scopus 로고    scopus 로고
    • Insulin-dependent diabetes mellitus
    • DOI 10.1016/S0092-8674(00)81106-X
    • Tisch R, McDevitt H (1996) Insulin-dependent diabetes mellitus. Cell 85:291-297 (Pubitemid 26160699)
    • (1996) Cell , vol.85 , Issue.3 , pp. 291-297
    • Tisch, R.1    McDevitt, H.2
  • 4
    • 0029093933 scopus 로고
    • The role of IL-12 in the induction of organ specific autoimmune diseases
    • 7546194 10.1016/0167-5699(95)80006-9 1:CAS:528:DyaK2MXntleru7k%3D
    • Trembleau S, Germann T, Gately MK, Adorini L (1995) The role of IL-12 in the induction of organ specific autoimmune diseases. Immunol Today 16:383-386
    • (1995) Immunol Today , vol.16 , pp. 383-386
    • Trembleau, S.1    Germann, T.2    Gately, M.K.3    Adorini, L.4
  • 5
    • 0028926524 scopus 로고
    • Interleukin 12 administration induces T helper type i cells and accelerates autoimmune diabetes in NOD mice
    • 7836934 10.1084/jem.181.2.817 1:CAS:528:DyaK2MXjtFygsLs%3D
    • Trembleau S, Penna G, Bosi E, Mortara A, Gately MK, Adorini L (1995) Interleukin 12 administration induces T helper type I cells and accelerates autoimmune diabetes in NOD mice. J Exp Med 181:817-821
    • (1995) J Exp Med , vol.181 , pp. 817-821
    • Trembleau, S.1    Penna, G.2    Bosi, E.3    Mortara, A.4    Gately, M.K.5    Adorini, L.6
  • 6
    • 0034068634 scopus 로고    scopus 로고
    • IL-12 selectively regulates STAT4 via phosphatidylinositol 3-kinase and Ras-independent signal transduction pathways
    • DOI 10.1002/(SICI)1521-4141(200005)30:5<1425::AID-IMMU1425>3.0. CO;2-Q
    • Athie M, Flotow H, Hilyard KL, Cantrell DA (2000) IL-12 selectively regulates STAT4 via phosphatidylinositol 3-kinase and Ras-independent signal transduction pathways. Eur J Immunol 30:1425-1434 (Pubitemid 30311973)
    • (2000) European Journal of Immunology , vol.30 , Issue.5 , pp. 1425-1434
    • Athie, M.V.1    Flotow, H.2    Hilyard, K.L.3    Cantrell, D.A.4
  • 7
    • 0034284088 scopus 로고    scopus 로고
    • Importance of the MKK6/p38 pathway for interleukin-12-induced STAT4 serine phosphorylation and transcriptional activity
    • Visconti R, Gadina M, Chiariello M et al. (2000) Importance of the MKK6/p38 pathway for interleukin-12-induced STAT4 serine phosphorylation and transcriptional activity. Blood 96:1844-1852 (Pubitemid 30662111)
    • (2000) Blood , vol.96 , Issue.5 , pp. 1844-1852
    • Visconti, R.1    Gadina, M.2    Chiariello, M.3    Chen, E.H.4    Stancato, L.F.5    Gutkind, J.S.6    O'Shea, J.J.7
  • 8
    • 0029937270 scopus 로고    scopus 로고
    • Impaired IL-12 responses and enhanced development of Th2 cells in Stat4- deficient mice
    • DOI 10.1038/382174a0
    • Kaplan MH, Sun YI, Hoey T, Grusby MJ (1996) Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice. Nature 382:174-177 (Pubitemid 26242885)
    • (1996) Nature , vol.382 , Issue.6587 , pp. 174-177
    • Kaplan, M.H.1    Sun, Y.-L.2    Hoey, T.3    Grusby, M.J.4
  • 10
    • 0042375986 scopus 로고    scopus 로고
    • The biology of IL-12: Coordinating innate and adaptive immune responses
    • DOI 10.1016/S1359-6101(03)00043-1
    • Watford WT, Moriguchi M, Morinobu A, O'Shea JJ (2003) The biology of IL-12: coordinating innate and adaptive immune responses. Cytokine Growth Factor Rev 14:361-368 (Pubitemid 37099449)
    • (2003) Cytokine and Growth Factor Reviews , vol.14 , Issue.5 , pp. 361-368
    • Watford, W.T.1    Moriguchi, M.2    Morinobu, A.3    O'Shea, J.J.4
  • 11
    • 0037125988 scopus 로고    scopus 로고
    • STAT4 serine phosphorylation is critical for IL-12-induced IFN-gamma production but not for cell proliferation
    • 12213961 10.1073/pnas.182618999 1:CAS:528:DC%2BD38XntlCks7c%3D
    • Morinobu A, Gadina M, Strober W et al. (2002) STAT4 serine phosphorylation is critical for IL-12-induced IFN-gamma production but not for cell proliferation. Proc Natl Acad Sci USA 99:12281-12286
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 12281-12286
    • Morinobu, A.1    Gadina, M.2    Strober, W.3
  • 12
    • 0034022829 scopus 로고    scopus 로고
    • IL-12 enhances IL-2 function by inducing CD25 expression through a p38 mitogen-activated protein kinase pathway
    • DOI 10.1002/(SICI)1521-4141(200005)30:5<1445::AID-IMMU1445>3.0. CO;2-M
    • Nguyen T, Wang R, Russell JH (2000) IL-12 enhances IL-2 function by inducing CD25 expression through a p38 mitogen-activated protein kinase pathway. Eur J Immunol 30:1445-1452 (Pubitemid 30311975)
    • (2000) European Journal of Immunology , vol.30 , Issue.5 , pp. 1445-1452
    • Nguyen, T.1    Wang, R.2    Russell, J.H.3
  • 13
    • 1242263952 scopus 로고    scopus 로고
    • Inhibiting cytokines of the interleukin-12 family: Recent advances and novel challenges
    • DOI 10.1211/0022357022962
    • Vandenbroeck K, Alloza I, Gadina M, Matthys P (2004) Inhibiting cytokines of the interleukin-12 family: recent advances and novel challenges. J Pharm Pharmacol 56:145-160 (Pubitemid 38232744)
    • (2004) Journal of Pharmacy and Pharmacology , vol.56 , Issue.2 , pp. 145-160
    • Vandenbroeck, K.1    Alloza, I.2    Gadina, M.3    Matthys, P.4
  • 15
    • 77957285984 scopus 로고    scopus 로고
    • Association of polymorphisms in the IL-18 and IL-12 genes with susceptibility to Type 1 diabetes in Turkish patients
    • 20061784 1:CAS:528:DC%2BC3cXht1OlsrbJ
    • Altinova AE, Engin D, Akbay E et al. (2010) Association of polymorphisms in the IL-18 and IL-12 genes with susceptibility to Type 1 diabetes in Turkish patients. J Endocrinol Invest 33:451-454
    • (2010) J Endocrinol Invest , vol.33 , pp. 451-454
    • Altinova, A.E.1    Engin, D.2    Akbay, E.3
  • 16
    • 75649112311 scopus 로고    scopus 로고
    • Evaluation of IL12B as a candidate type i diabetes susceptibility gene using data from the Type i Diabetes Genetics Consortium
    • 19956104 10.1038/gene.2009.94 1:CAS:528:DC%2BD1MXhsV2ksLrI
    • Morahan G, McKinnon E, Berry J et al. (2009) Evaluation of IL12B as a candidate type I diabetes susceptibility gene using data from the Type I Diabetes Genetics Consortium. Genes Immun 10(Suppl 1):S64-S68
    • (2009) Genes Immun , vol.10 , Issue.SUPPL. 1
    • Morahan, G.1    McKinnon, E.2    Berry, J.3
  • 17
    • 34250340017 scopus 로고    scopus 로고
    • Glucose, palmitate and pro-inflammatory cytokines modulate production and activity of a phagocyte-like NADPH oxidase in rat pancreatic islets and a clonal beta cell line
    • 17151863 10.1007/s00125-006-0462-6 1:CAS:528:DC%2BD2sXitlSluw%3D%3D
    • Morgan D, Oliveira-Emilio HR, Keane D et al. (2007) Glucose, palmitate and pro-inflammatory cytokines modulate production and activity of a phagocyte-like NADPH oxidase in rat pancreatic islets and a clonal beta cell line. Diabetologia 50:359-369
    • (2007) Diabetologia , vol.50 , pp. 359-369
    • Morgan, D.1    Oliveira-Emilio, H.R.2    Keane, D.3
  • 19
    • 59649115492 scopus 로고    scopus 로고
    • Pancreatic islets are very poor in rectifying oxidative DNA damage
    • 18695629 10.1097/MPA.0b013e318181da4e 1:CAS:528:DC%2BD1cXhsFCmsb3L
    • Modak MA, Parab PB, Ghaskadbi SS (2009) Pancreatic islets are very poor in rectifying oxidative DNA damage. Pancreas 38:23-29
    • (2009) Pancreas , vol.38 , pp. 23-29
    • Modak, M.A.1    Parab, P.B.2    Ghaskadbi, S.S.3
  • 20
    • 0442305381 scopus 로고    scopus 로고
    • Apoptotic signal transduction pathways in diabetes
    • DOI 10.1016/S0006-2952(03)00494-5, PII S0006295203004945
    • Mandrup-Poulsen T (2003) Apoptotic signal transduction pathways in diabetes. Biochem Pharmacol 66:1433-1440 (Pubitemid 38373330)
    • (2003) Biochemical Pharmacology , vol.66 , Issue.8 , pp. 1433-1440
    • Mandrup-Poulsen, T.1
  • 21
    • 48949088649 scopus 로고    scopus 로고
    • Anti-proliferative effect of pro-inflammatory cytokines in cultured beta cells is associated with extracellular signal-regulated kinase 1/2 pathway inhibition: Protective role of glucagon-like peptide-1
    • 18487229 10.1677/JME-07-0154 1:CAS:528:DC%2BD1cXhtVGqurvL
    • Blandino-Rosano M, Perez-Arana G, Mellado-Gil JM, Segundo C, Aguilar-Diosdado M (2008) Anti-proliferative effect of pro-inflammatory cytokines in cultured beta cells is associated with extracellular signal-regulated kinase 1/2 pathway inhibition: protective role of glucagon-like peptide-1. J Mol Endocrinol 41:35-44
    • (2008) J Mol Endocrinol , vol.41 , pp. 35-44
    • Blandino-Rosano, M.1    Perez-Arana, G.2    Mellado-Gil, J.M.3    Segundo, C.4    Aguilar-Diosdado, M.5
  • 22
    • 45449088151 scopus 로고    scopus 로고
    • Glucocorticoids reduce pro-inflammatory cytokines and tissue factor in vitro and improve function of transplanted human islets in vivo
    • DOI 10.1111/j.1432-2277.2008.00664.x
    • Lund T, Fosby B, Korsgren O, Scholz H, Foss A (2008) Glucocorticoids reduce pro-inflammatory cytokines and tissue factor in vitro and improve function of transplanted human islets in vivo. Transpl Int 21:669-678 (Pubitemid 351852766)
    • (2008) Transplant International , vol.21 , Issue.7 , pp. 669-678
    • Lund, T.1    Fosby, B.2    Korsgren, O.3    Scholz, H.4    Foss, A.5
  • 23
    • 79952451443 scopus 로고    scopus 로고
    • Obesity, insulin resistance and free fatty acids
    • 21297467 10.1097/MED.0b013e3283444b09 1:CAS:528:DC%2BC3MXis1egurs%3D
    • Boden G (2011) Obesity, insulin resistance and free fatty acids. Curr Opin Endocrinol Diabetes Obes 18:139-143
    • (2011) Curr Opin Endocrinol Diabetes Obes , vol.18 , pp. 139-143
    • Boden, G.1
  • 24
  • 26
    • 1642273986 scopus 로고    scopus 로고
    • The novel anti-inflammtory compound, lisofylline, prevents diabetes in multiple low-dose streptozotocin-treated mice
    • 12717280 10.1097/00006676-200305000-00021
    • Yang Z, Chen M, Fialkow LB, Ellett JD, Wu R, Nadler JL (2003) The novel anti-inflammtory compound, lisofylline, prevents diabetes in multiple low-dose streptozotocin-treated mice. Pancreas 26:e99-e104
    • (2003) Pancreas , vol.26
    • Yang, Z.1    Chen, M.2    Fialkow, L.B.3    Ellett, J.D.4    Wu, R.5    Nadler, J.L.6
  • 27
    • 21344471092 scopus 로고    scopus 로고
    • Immune cell infiltration, cytokine expression, and β-cell apoptosis during the development of type 1 diabetes in the spontaneously diabetic LEW.1AR1/Ztm-iddm rat
    • DOI 10.2337/diabetes.54.7.2041
    • Jorns A, Gunther A, Hedrich HJ, Wedekind D, Tiedge M, Lenzen S (2005) Immune cell infiltration, cytokine expression, and beta-cell apoptosis during the development of type 1 diabetes in the spontaneously diabetic LEW.1AR1/Ztm-iddm rat. Diabetes 54:2041-2052 (Pubitemid 40911267)
    • (2005) Diabetes , vol.54 , Issue.7 , pp. 2041-2052
    • Jorns, A.1    Gunther, A.2    Hedrich, H.-J.3    Wedekind, D.4    Tiedge, M.5    Lenzen, S.6
  • 28
    • 39749084162 scopus 로고    scopus 로고
    • Proinflammatory cytokines in obesity: Impact of type 2 diabetes mellitus and gastric bypass
    • 18219773 10.1007/s11695-008-9424-z
    • Catalan V, Gomez-Ambrosi J, Ramirez B et al. (2007) Proinflammatory cytokines in obesity: impact of type 2 diabetes mellitus and gastric bypass. Obes Surg 17:1464-1474
    • (2007) Obes Surg , vol.17 , pp. 1464-1474
    • Catalan, V.1    Gomez-Ambrosi, J.2    Ramirez, B.3
  • 29
    • 77955658618 scopus 로고    scopus 로고
    • Palmitate induces a pro-inflammatory response in human pancreatic islets that mimics CCL2 expression by beta cells in type 2 diabetes
    • 20369226 10.1007/s00125-010-1707-y 1:CAS:528:DC%2BC3cXmsFyrs7c%3D
    • Igoillo-Esteve M, Marselli L, Cunha DA et al. (2010) Palmitate induces a pro-inflammatory response in human pancreatic islets that mimics CCL2 expression by beta cells in type 2 diabetes. Diabetologia 53:1395-1405
    • (2010) Diabetologia , vol.53 , pp. 1395-1405
    • Igoillo-Esteve, M.1    Marselli, L.2    Cunha, D.A.3
  • 30
    • 34247489726 scopus 로고    scopus 로고
    • Inflammation in obesity is the common link between defects in fatty acid metabolism and insulin resistance
    • Steinberg GR (2007) Inflammation in obesity is the common link between defects in fatty acid metabolism and insulin resistance. Cell Cycle 6:888-894 (Pubitemid 46658739)
    • (2007) Cell Cycle , vol.6 , Issue.8 , pp. 888-894
    • Steinberg, G.R.1
  • 31
    • 77956951626 scopus 로고    scopus 로고
    • 2-induced mouse islet or clonal pancreatic beta cell dysfunction
    • 20178457 10.1042/BSR20090138 1:CAS:528:DC%2BC3cXht1agsrbP
    • 2-induced mouse islet or clonal pancreatic beta cell dysfunction. Biosci Rep 30:445-453
    • (2010) Biosci Rep , vol.30 , pp. 445-453
    • Michalska, M.1    Wolf, G.2    Walther, R.3    Newsholme, P.4
  • 32
    • 0036386207 scopus 로고    scopus 로고
    • The anti-inflammatory compound lisofylline prevents Type 1 diabetes in non-obese diabetic mice
    • 12242464 10.1007/s00125-002-0901-y 1:CAS:528:DC%2BD38XntFegu7s%3D
    • Yang ZD, Chen M, Wu R, McDuffie M, Nadler JL (2002) The anti-inflammatory compound lisofylline prevents Type 1 diabetes in non-obese diabetic mice. Diabetologia 45:1307-1314
    • (2002) Diabetologia , vol.45 , pp. 1307-1314
    • Yang, Z.D.1    Chen, M.2    Wu, R.3    McDuffie, M.4    Nadler, J.L.5
  • 33
    • 0029984682 scopus 로고    scopus 로고
    • Low antioxidant enzyme gene expression in pancreatic islets compared with various other mouse tissues
    • DOI 10.1016/0891-5849(96)02051-5
    • Lenzen S, Drinkgern J, Tiedge M (1996) Low antioxidant enzyme gene expression in pancreatic islets compared with various other mouse tissues. Free Radic Biol Med 20:463-466 (Pubitemid 26077870)
    • (1996) Free Radical Biology and Medicine , vol.20 , Issue.3 , pp. 463-466
    • Lenzen, S.1    Drinkgern, J.2    Tiedge, M.3
  • 34
    • 45249089262 scopus 로고    scopus 로고
    • Oxidative stress: The vulnerable β-cell
    • DOI 10.1042/BST0360343
    • Lenzen S (2008) Oxidative stress: the vulnerable beta-cell. Biochem Soc Trans 36:343-347 (Pubitemid 351839328)
    • (2008) Biochemical Society Transactions , vol.36 , Issue.3 , pp. 343-347
    • Lenzen, S.1
  • 35
    • 0037219109 scopus 로고    scopus 로고
    • Improvement of the mitochondrial antioxidant defense status prevents cytokine-induced nuclear factor-κB activation in insulin-producing cells
    • DOI 10.2337/diabetes.52.1.93
    • Azevedo-Martins AK, Lortz S, Lenzen S, Curi R, Eizirik DL, Tiedge M (2003) Improvement of the mitochondrial antioxidant defense status prevents cytokine-induced nuclear factor-kappaB activation in insulin-producing cells. Diabetes 52:93-101 (Pubitemid 36042112)
    • (2003) Diabetes , vol.52 , Issue.1 , pp. 93-101
    • Azevedo-Martins, A.K.1    Lortz, S.2    Lenzen, S.3    Curi, R.4    Eizirik, D.L.5    Tiedge, M.6
  • 36
    • 0035079807 scopus 로고    scopus 로고
    • Monocyte chemoattractant protein-1 is expressed in pancreatic islets from prediabetic NOD mice and in interleukin-1β-exposed human and rat islet cells
    • DOI 10.1007/s001250051622
    • Chen MC, Proost P, Gysemans C, Mathieu C, Eizirik DL (2001) Monocyte chemoattractant protein-1 is expressed in pancreatic islets from prediabetic NOD mice and in interleukin-1 beta-exposed human and rat islet cells. Diabetologia 44:325-332 (Pubitemid 32234459)
    • (2001) Diabetologia , vol.44 , Issue.3 , pp. 325-332
    • Chen, M.-C.1    Proost, P.2    Gysemans, C.3    Mathieu, C.4    Eizirik, D.L.5
  • 38
    • 0025316055 scopus 로고
    • Cytotoxic effects of cytokines on human pancreatic islet cells in monolayer culture
    • 2115042 10.1210/jcem-71-1-152 1:CAS:528:DyaK3cXlsFSnsL0%3D
    • Rabinovitch A, Sumoski W, Rajotte RV, Warnock GL (1990) Cytotoxic effects of cytokines on human pancreatic islet cells in monolayer culture. J Clin Endocrinol Metab 71:152-156
    • (1990) J Clin Endocrinol Metab , vol.71 , pp. 152-156
    • Rabinovitch, A.1    Sumoski, W.2    Rajotte, R.V.3    Warnock, G.L.4
  • 40
    • 77649108168 scopus 로고    scopus 로고
    • Blockade of interleukin 1 in type 1 diabetes mellitus
    • 20173777 10.1038/nrendo.2009.271 1:CAS:528:DC%2BC3cXit1Smt7w%3D
    • Mandrup-Poulsen T, Pickersgill L, Donath MY (2010) Blockade of interleukin 1 in type 1 diabetes mellitus. Nat Rev Endocrinol 6:158-166
    • (2010) Nat Rev Endocrinol , vol.6 , pp. 158-166
    • Mandrup-Poulsen, T.1    Pickersgill, L.2    Donath, M.Y.3
  • 41
    • 0033638507 scopus 로고    scopus 로고
    • Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12
    • 11114383 10.1016/S1074-7613(00)00070-4 1:CAS:528:DC%2BD3cXovV2ht7c%3D
    • Oppmann B, Lesley R, Blom B et al. (2000) Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity 13:715-725
    • (2000) Immunity , vol.13 , pp. 715-725
    • Oppmann, B.1    Lesley, R.2    Blom, B.3
  • 42
    • 43449111187 scopus 로고    scopus 로고
    • Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 76-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 1)
    • DOI 10.1016/S0140-6736(08)60725-4, PII S0140673608607254
    • Leonardi CL, Kimball AB, Papp KA et al. (2008) Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 76-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 1). Lancet 371:1665-1674 (Pubitemid 351671883)
    • (2008) The Lancet , vol.371 , Issue.9625 , pp. 1665-1674
    • Leonardi, C.L.1    Kimball, A.B.2    Papp, K.A.3    Yeilding, N.4    Guzzo, C.5    Wang, Y.6    Li, S.7    Dooley, L.T.8    Gordon, K.B.9
  • 43
    • 0030271678 scopus 로고    scopus 로고
    • Interleukin 12 mRNA expression in islets correlates with β-cell destruction in NOD mice
    • DOI 10.1006/jaut.1996.0084
    • Rabinovitch A, Suarez-Pinzon WL, Sorensen O (1996) Interleukin 12 mRNA expression in islets correlates with beta-cell destruction in NOD mice. J Autoimmun 9:645-651 (Pubitemid 26370975)
    • (1996) Journal of Autoimmunity , vol.9 , Issue.5 , pp. 645-651
    • Rabinovitch, A.1    Suarez-Pinzon, W.L.2    Sorensen, O.3
  • 44
    • 0030070207 scopus 로고    scopus 로고
    • Cytokine gene expression in islets and thyroids of BB rats. IFN-gamma and IL-12p40 mRNA increase with age in both diabetic and insulin-treated nondiabetic BB rats
    • 8558012 1:CAS:528:DyaK28Xmtlyhsg%3D%3D
    • Zipris D, Greiner DL, Malkani S, Whalen B, Mordes JP, Rossini AA (1996) Cytokine gene expression in islets and thyroids of BB rats. IFN-gamma and IL-12p40 mRNA increase with age in both diabetic and insulin-treated nondiabetic BB rats. J Immunol 156:1315-1321
    • (1996) J Immunol , vol.156 , pp. 1315-1321
    • Zipris, D.1    Greiner, D.L.2    Malkani, S.3    Whalen, B.4    Mordes, J.P.5    Rossini, A.A.6
  • 46
    • 0030789325 scopus 로고    scopus 로고
    • 2
    • DOI 10.1007/s001250050728
    • Rothe H, O'Hara RM Jr, Martin S, Kolb H (1997) Suppression of cyclophosphamide induced diabetes development and pancreatic Th1 reactivity in NOD mice treated with the interleukin (IL)-12 antagonist IL-12(p40)2. Diabetologia 40:641-646 (Pubitemid 27288108)
    • (1997) Diabetologia , vol.40 , Issue.6 , pp. 641-646
    • Rothe, H.1    O'Hara Jr., R.M.2    Martin, S.3    Kolb, H.4
  • 47
    • 0030858075 scopus 로고    scopus 로고
    • Deviation of pancreas-infiltrating cells to Th2 by interleukin-12 antagonist administration inhibits autoimmune diabetes
    • DOI 10.1002/eji.1830270930
    • Trembleau S, Penna G, Gregori S, Gately MK, Adorini L (1997) Deviation of pancreas-infiltrating cells to Th2 by interleukin-12 antagonist administration inhibits autoimmune diabetes. Eur J Immunol 27:2330-2339 (Pubitemid 27404318)
    • (1997) European Journal of Immunology , vol.27 , Issue.9 , pp. 2330-2339
    • Trembleau, S.1    Penna, G.2    Gregori, S.3    Gately, M.K.4    Adorini, L.5
  • 48
    • 0035660750 scopus 로고    scopus 로고
    • Constitutive β cell expression of IL-12 does not perturb self-tolerance but intensifies established autoimmune diabetes
    • DOI 10.1172/JCI200113915
    • Holz A, Brett K, Oldstone MB (2001) Constitutive beta cell expression of IL-12 does not perturb self-tolerance but intensifies established autoimmune diabetes. J Clin Invest 108:1749-1758 (Pubitemid 34015120)
    • (2001) Journal of Clinical Investigation , vol.108 , Issue.12 , pp. 1749-1758
    • Holz, A.1    Brett, K.2    Oldstone, M.B.A.3
  • 49
    • 81255157815 scopus 로고    scopus 로고
    • Level of serum IL-12 and its correlation with endothelial dysfunction, insulin resistance, proinflammatory cytokines and lipid profile in newly diagnosed T2DM
    • 21855158 10.1016/j.diabres.2011.07.037 1:CAS:528:DC%2BC3MXhsV2ht73K
    • Mishra M, Kumar H, Bajpai S, Singh RK, Tripathi K (2011) Level of serum IL-12 and its correlation with endothelial dysfunction, insulin resistance, proinflammatory cytokines and lipid profile in newly diagnosed T2DM. Diabetes Res Clin Pract 94:255-261
    • (2011) Diabetes Res Clin Pract , vol.94 , pp. 255-261
    • Mishra, M.1    Kumar, H.2    Bajpai, S.3    Singh, R.K.4    Tripathi, K.5
  • 50
    • 24144484765 scopus 로고    scopus 로고
    • Stat4-null non-obese diabetic mice: Protection from diabetes and experimental allergic encephalomyelitis, but with concomitant epitope spread
    • DOI 10.1093/intimm/dxh293
    • Boyton RJ, Davies S, Marden C et al. (2005) Stat4-null non-obese diabetic mice: protection from diabetes and experimental allergic encephalomyelitis, but with concomitant epitope spread. Int Immunol 17:1157-1165 (Pubitemid 41236073)
    • (2005) International Immunology , vol.17 , Issue.9 , pp. 1157-1165
    • Boyton, R.J.1    Davies, S.2    Marden, C.3    Fantino, C.4    Reynolds, C.5    Portugal, K.6    Dewchand, H.7    Altmann, D.M.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.