메뉴 건너뛰기




Volumn 26, Issue 4, 1996, Pages

The novel anti-inflammatory compound, lisofylline, prevents diabetes in multiple low-dose streptozotocin-treated mice

Author keywords

Cytokine; Diabetes; Lisofylline; Macrophage; Streptozotocin

Indexed keywords

DIFFERENTIATION ANTIGEN; DRUG DERIVATIVE; GAMMA INTERFERON; INSULIN; INTERLEUKIN 10; INTERLEUKIN 4; LISOFYLLINE; MONOCYTE MACROPHAGE DIFFERENTIATION ANTIGEN; MONOCYTE-MACROPHAGE DIFFERENTIATION ANTIGEN; NONSTEROID ANTIINFLAMMATORY AGENT; PENTOXIFYLLINE; STREPTOZOCIN; TUMOR NECROSIS FACTOR ALPHA;

EID: 1642273986     PISSN: 03604039     EISSN: 15388689     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (49)

References (49)
  • 1
    • 0028026652 scopus 로고
    • Insulin-dependent diabetes mellitus as an autoimmune disease
    • Bach JF. Insulin-dependent diabetes mellitus as an autoimmune disease. Endocr Rev. 1994; 15:516-542.
    • (1994) Endocr Rev , vol.15 , pp. 516-542
    • Bach, J.F.1
  • 2
    • 0034089590 scopus 로고    scopus 로고
    • Th1-like dominance in high-risk first-degree relatives of Type I diabetic patients
    • Karlsson MGE, Lawesson SS, Ludvigsson LJ. Th1-like dominance in high-risk first-degree relatives of Type I diabetic patients. Diabetologia. 2000; 43:742-749.
    • (2000) Diabetologia , vol.43 , pp. 742-749
    • Karlsson, M.1    Lawesson, S.S.2    Ludvigsson, L.J.3
  • 3
    • 0029922661 scopus 로고    scopus 로고
    • Cytokine gene expression in pancreatic islet-infiltrating leukocytes of BB rats: Expression of Th1 cytokines correlates with β-cell destructive insulitis and IDDM
    • Rabinovitch A, Suarez-Pinzon W, El-Sheikh A, et al. Cytokine gene expression in pancreatic islet-infiltrating leukocytes of BB rats: expression of Th1 cytokines correlates with β-cell destructive insulitis and IDDM. Diabetes. 1996; 45:749-754.
    • (1996) Diabetes , vol.45 , pp. 749-754
    • Rabinovitch, A.1    Suarez-Pinzon, W.2    El-Sheikh, A.3
  • 4
    • 0037094032 scopus 로고    scopus 로고
    • Molecular mechanisms for gender differences in susceptibility to T cell-mediated autoimmune diabetes in nonobese diabetic mice
    • Bao M, Yang Y, Jun HS, Yoon JW. Molecular mechanisms for gender differences in susceptibility to T cell-mediated autoimmune diabetes in nonobese diabetic mice. J Immunol. 2002; 168:5369-5375.
    • (2002) J Immunol , vol.168 , pp. 5369-5375
    • Bao, M.1    Yang, Y.2    Jun, H.S.3    Yoon, J.W.4
  • 5
    • 0033305236 scopus 로고    scopus 로고
    • Tumor necrosis factor-α-activated cell death pathways in NIT-1 insulinoma cells and primary pancreatic β cells
    • Stephens LA, Thomas HE, Ming L, et al. Tumor necrosis factor-α-activated cell death pathways in NIT-1 insulinoma cells and primary pancreatic β cells. Endocrinology. 1999; 140:3219-3227.
    • (1999) Endocrinology , vol.140 , pp. 3219-3227
    • Stephens, L.A.1    Thomas, H.E.2    Ming, L.3
  • 6
    • 0023779707 scopus 로고
    • Destruction of rat islet cell monolayers by cytokines; synergistic interactions of IFN-γ, tumor necrosis factor, lymphotoxin, and interleukin 1
    • Pukel C, Baquerizo H, Rabinovitch A. Destruction of rat islet cell monolayers by cytokines; synergistic interactions of IFN-γ, tumor necrosis factor, lymphotoxin, and interleukin 1. Diabetes. 1988; 37:133-136.
    • (1988) Diabetes , vol.37 , pp. 133-136
    • Pukel, C.1    Baquerizo, H.2    Rabinovitch, A.3
  • 7
    • 0036095937 scopus 로고    scopus 로고
    • Lisofylline, a novel antiinflammatory agent, protects pancreatic β-cells from proinflammatory cytokine damage by promoting mitochondrial metabolism
    • Chen M, Yang Z, Wu R, Nadler JL. Lisofylline, a novel antiinflammatory agent, protects pancreatic β-cells from proinflammatory cytokine damage by promoting mitochondrial metabolism. Endocrinology. 2002; 143:2341-2348.
    • (2002) Endocrinology , vol.143 , pp. 2341-2348
    • Chen, M.1    Yang, Z.2    Wu, R.3    Nadler, J.L.4
  • 8
    • 0023784346 scopus 로고
    • IFN-γ and tumor necrosis factor-α. Cytotoxicity to murine islets of Langerhans
    • Campbell IL, Iscaro A, Harrison LC. IFN-γ and tumor necrosis factor-α. Cytotoxicity to murine islets of Langerhans. J Immunol. 1988; 141:2325-2329.
    • (1988) J Immunol , vol.141 , pp. 2325-2329
    • Campbell, I.L.1    Iscaro, A.2    Harrison, L.C.3
  • 9
    • 43949152435 scopus 로고
    • Prevention of diabetes in the NOD mouse: Implications for therapeutic intervention in human disease
    • Bowman MA, Leiter EH, Atkinson MA. Prevention of diabetes in the NOD mouse: implications for therapeutic intervention in human disease. Immunol Today. 1994; 15:115-120.
    • (1994) Immunol Today , vol.15 , pp. 115-120
    • Bowman, M.A.1    Leiter, E.H.2    Atkinson, M.A.3
  • 10
    • 0025296156 scopus 로고
    • Prevention of diabetes in BB/Wor rats treated with monoclonal antibodies to interferon-γ [letter]
    • Nicoletti F, Meroni PL, Landolfo S, et al. Prevention of diabetes in BB/Wor rats treated with monoclonal antibodies to interferon-γ [letter]. Lancet. 1990; 36:319.
    • (1990) Lancet , vol.36 , pp. 319
    • Nicoletti, F.1    Meroni, P.L.2    Landolfo, S.3
  • 11
    • 0030995686 scopus 로고    scopus 로고
    • Treatment with neutralizing antibodies specific for IL-1β prevents cyclophosphamide-induced diabetes in nonobese diabetic mice
    • Cailleau C, Diu-Hercend A, Ruuth E, et al. Treatment with neutralizing antibodies specific for IL-1β prevents cyclophosphamide-induced diabetes in nonobese diabetic mice. Diabetes. 1997; 46:937-940.
    • (1997) Diabetes , vol.46 , pp. 937-940
    • Cailleau, C.1    Diu-Hercend, A.2    Ruuth, E.3
  • 12
    • 0030444632 scopus 로고    scopus 로고
    • The effects of a nonimmunogenic form of murine soluble interferon-γ receptor on the development of autoimmune diabetes in the NOD mouse
    • Nicoletti F, Zaccone P, Di Marco R, et al. The effects of a nonimmunogenic form of murine soluble interferon-γ receptor on the development of autoimmune diabetes in the NOD mouse. Endocrinology. 1996; 137:5567-5575.
    • (1996) Endocrinology , vol.137 , pp. 5567-5575
    • Nicoletti, F.1    Zaccone, P.2    Di Marco, R.3
  • 13
    • 0028421286 scopus 로고
    • CT-1501R selectively inhibits induced inflammatory monokines in human whole blood ex vivo
    • Rice GC, Rosen J, Weeks R, et al. CT-1501R selectively inhibits induced inflammatory monokines in human whole blood ex vivo. Shock. 1994; 1:254-266.
    • (1994) Shock , vol.1 , pp. 254-266
    • Rice, G.C.1    Rosen, J.2    Weeks, R.3
  • 14
    • 0033007858 scopus 로고    scopus 로고
    • Effects of lisofylline on hyperoxia-induced lung injury
    • George C, Fantuzzi G, Bursten S, et al. Effects of lisofylline on hyperoxia-induced lung injury. Am J Physol. 1999; 276:L776-L785.
    • (1999) Am J Physol , vol.276
    • George, C.1    Fantuzzi, G.2    Bursten, S.3
  • 15
    • 0029802728 scopus 로고    scopus 로고
    • Lisofylline, an inhibitor of unsaturated phosphatidic acid generation, ameliorates interleukin-1β-induced dysfunction in cultured rat islets
    • Bleich D, Chen S, Bursten SL, Nadler JL. Lisofylline, an inhibitor of unsaturated phosphatidic acid generation, ameliorates interleukin-1β-induced dysfunction in cultured rat islets. Endocrinology. 1996; 137:4871-4877.
    • (1996) Endocrinology , vol.137 , pp. 4871-4877
    • Bleich, D.1    Chen, S.2    Bursten, S.L.3    Nadler, J.L.4
  • 16
    • 0032740616 scopus 로고    scopus 로고
    • Selective pharmacologic inhibition of murine and human IL-12-dependent Th1 differentiation and IL-12 signaling
    • Coon ME, Diegel M, Leshinsky N, Klaus SJ. Selective pharmacologic inhibition of murine and human IL-12-dependent Th1 differentiation and IL-12 signaling. J Immunol. 1999; 163:6567-6574.
    • (1999) J Immunol , vol.163 , pp. 6567-6574
    • Coon, M.E.1    Diegel, M.2    Leshinsky, N.3    Klaus, S.J.4
  • 17
    • 0032534750 scopus 로고    scopus 로고
    • Prevention of experimental allergic encephalomyelitis via inhibition of IL-12 signaling and IL-12-mediated Th1 differentiation: An effect of the novel anti-inflammatory drug Lisofylline
    • Bright JJ, Du C, Coon M, et al. Prevention of experimental allergic encephalomyelitis via inhibition of IL-12 signaling and IL-12-mediated Th1 differentiation: an effect of the novel anti-inflammatory drug Lisofylline. J Immunol. 1998; 161:7015-7022.
    • (1998) J Immunol , vol.161 , pp. 7015-7022
    • Bright, J.J.1    Du, C.2    Coon, M.3
  • 18
    • 0030975513 scopus 로고    scopus 로고
    • Langermans JAM. Effect of Lisofylline and Pentoxifylline on the bacterial-stimulated production of TNF-α, IL-1β and IL-10 by human leukocytes
    • Furth AM, Eerhard-Seijmonsbergen EM, Furth RV, Langermans JAM. Effect of Lisofylline and Pentoxifylline on the bacterial-stimulated production of TNF-α, IL-1β and IL-10 by human leukocytes. Immunology. 1997; 91:193-196.
    • (1997) Immunology , vol.91 , pp. 193-196
    • Furth, A.M.1    Eerhard-Seijmonsbergen, E.M.2    Furth, R.V.3
  • 19
    • 0014572551 scopus 로고
    • Streptozotocin diabetes in the mouse and guinea pig
    • Brosky G, Logothetopoulos J. Streptozotocin diabetes in the mouse and guinea pig. Diabetes. 1969; 18:606-611.
    • (1969) Diabetes , vol.18 , pp. 606-611
    • Brosky, G.1    Logothetopoulos, J.2
  • 20
    • 0017179001 scopus 로고
    • Streptozotocin-induced pancreatic insulitis: New model of diabetes mellitus
    • Like AA, Rossini AA. Streptozotocin-induced pancreatic insulitis: new model of diabetes mellitus. Science. 1976; 193:415-417.
    • (1976) Science , vol.193 , pp. 415-417
    • Like, A.A.1    Rossini, A.A.2
  • 21
    • 0032963182 scopus 로고    scopus 로고
    • Insulin prophylaxis downregulates islet antigen expression and islet autoimmunity in the low-dose STZ mouse model of diabetes
    • Anastasi E, Dotta F, Tiberti C, et al. Insulin prophylaxis downregulates islet antigen expression and islet autoimmunity in the low-dose STZ mouse model of diabetes. Autoimmunity. 1999; 29:249-256.
    • (1999) Autoimmunity , vol.29 , pp. 249-256
    • Anastasi, E.1    Dotta, F.2    Tiberti, C.3
  • 22
    • 0021989345 scopus 로고
    • Low dose streptozotocin induced diabetes in mice. Metabolic, light microscopical, histochemical, immunofluorescence microscopical, electron microscopical and morphometrical findings
    • Cossel L, Schneider E, Kuttler B, et al. Low dose streptozotocin induced diabetes in mice. Metabolic, light microscopical, histochemical, immunofluorescence microscopical, electron microscopical and morphometrical findings. Exp Clin Endocrinol. 1985; 85:7-26.
    • (1985) Exp Clin Endocrinol , vol.85 , pp. 7-26
    • Cossel, L.1    Schneider, E.2    Kuttler, B.3
  • 23
    • 0022408439 scopus 로고
    • Brief communications: An improved method for isolation of mouse pancreatic islets
    • Gotoh M, Maki T, Kiyoizumi T, et al. Brief communications: an improved method for isolation of mouse pancreatic islets. Transplantation. 1985; 40:437-439.
    • (1985) Transplantation , vol.40 , pp. 437-439
    • Gotoh, M.1    Maki, T.2    Kiyoizumi, T.3
  • 24
    • 0030588572 scopus 로고    scopus 로고
    • Acceleration of spontaneous diabetes in TCR beta-transgenic nonobese diabetic mice by β cell-cytotoxic CD8+ T cells expressing identical endogenous TCRα chains
    • +T cells expressing identical endogenous TCRα chains. J Immunol. 1996; 157:4726-4735.
    • (1996) J Immunol , vol.157 , pp. 4726-4735
    • Verdaguer, J.1    Yoon, J.W.2    Erson, B.3
  • 25
    • 0037097550 scopus 로고    scopus 로고
    • Suppression of autoimmune diabetes by viral IL-10 gene transfer
    • Yang Z, Chen M, Wu R, et al. Suppression of autoimmune diabetes by viral IL-10 gene transfer. J Immunol. 2002; 168:6479-6485.
    • (2002) J Immunol , vol.168 , pp. 6479-6485
    • Yang, Z.1    Chen, M.2    Wu, R.3
  • 26
    • 0020594320 scopus 로고
    • Dendritic cell and macrophage staining by monoclonal antibodies in tissue sections and epidermal sheets
    • Flotte TJ, Springer TA, Thorbecke GJ. Dendritic cell and macrophage staining by monoclonal antibodies in tissue sections and epidermal sheets. Am J Pathol. 1983; 111:112-124.
    • (1983) Am J Pathol , vol.111 , pp. 112-124
    • Flotte, T.J.1    Springer, T.A.2    Thorbecke, G.J.3
  • 27
    • 0017648112 scopus 로고
    • Studies of streptozotocin-induced insulitis and diabetes
    • Rossini AA, Like AA, Chick WL, et al. Studies of streptozotocin-induced insulitis and diabetes. Proc Natl Acad Sci USA. 1977; 74:2485-2489.
    • (1977) Proc Natl Acad Sci USA , vol.74 , pp. 2485-2489
    • Rossini, A.A.1    Like, A.A.2    Chick, W.L.3
  • 28
    • 0036386207 scopus 로고    scopus 로고
    • The anti-inflammatory compound lisofylline prevents Type 1 diabetes in non-obese diabetic mice
    • Yang Z, Chen M, Wu R, et al. The anti-inflammatory compound lisofylline prevents Type 1 diabetes in non-obese diabetic mice. Diabetologia. 2002; 45:1307-1314.
    • (2002) Diabetologia , vol.45 , pp. 1307-1314
    • Yang, Z.1    Chen, M.2    Wu, R.3
  • 30
    • 0023837232 scopus 로고
    • IFN-γ induces islet cell MHC antigens and enhances autoimmune streptozotocin-induced diabetes in the mouse
    • Campbell IL, Oxbrow L, Koulmanda M, Harrison LC. IFN-γ induces islet cell MHC antigens and enhances autoimmune streptozotocin-induced diabetes in the mouse. J Immunol. 1988; 140:1111-1116.
    • (1988) J Immunol , vol.140 , pp. 1111-1116
    • Campbell, I.L.1    Oxbrow, L.2    Koulmanda, M.3    Harrison, L.C.4
  • 31
    • 0033041283 scopus 로고    scopus 로고
    • Reduced sensitivity of inducible nitric oxide synthase-deficient mice to multiple low-dose streptozotocin-induced diabetes
    • Flodstrom M, Tyrberg B, Eizirik DL, Sandler S. Reduced sensitivity of inducible nitric oxide synthase-deficient mice to multiple low-dose streptozotocin-induced diabetes. Diabetes. 1999; 48:706-713.
    • (1999) Diabetes , vol.48 , pp. 706-713
    • Flodstrom, M.1    Tyrberg, B.2    Eizirik, D.L.3    Sandler, S.4
  • 32
    • 0023205953 scopus 로고
    • Treatment with anti-T-lymphocyte antibodies prevents induction of insulitis in mice given multiple doses of streptozotocin
    • Herold KC, Montag AG, Fitch FW. Treatment with anti-T-lymphocyte antibodies prevents induction of insulitis in mice given multiple doses of streptozotocin. Diabetes. 1987; 36:796-801.
    • (1987) Diabetes , vol.36 , pp. 796-801
    • Herold, K.C.1    Montag, A.G.2    Fitch, F.W.3
  • 33
    • 0029949222 scopus 로고    scopus 로고
    • Regulation of cytokine production during development of autoimmune diabetes induced with multiple low doses of streptozotocin
    • Herold KC, Vezys V, Sun Q, et al. Regulation of cytokine production during development of autoimmune diabetes induced with multiple low doses of streptozotocin. J Immunol. 1996; 156:3521-3527.
    • (1996) J Immunol , vol.156 , pp. 3521-3527
    • Herold, K.C.1    Vezys, V.2    Sun, Q.3
  • 34
    • 0025944353 scopus 로고
    • Inhibition of nitric oxide generation affects the induction of diabetes by streptozocin in mice
    • Lukic ML, Stosic-Grujicic S, Ostojic N, et al. Inhibition of nitric oxide generation affects the induction of diabetes by streptozocin in mice. Biochem Biophys Res Commun. 1991; 178:913-920.
    • (1991) Biochem Biophys Res Commun , vol.178 , pp. 913-920
    • Lukic, M.L.1    Stosic-Grujicic, S.2    Ostojic, N.3
  • 35
    • 0028354067 scopus 로고
    • Immunoregulatory and cytokine imbalance in the pathogenesis of IDDM: Therapeutic intervention by immunostimulation?
    • Rabinovitch A. Immunoregulatory and cytokine imbalance in the pathogenesis of IDDM: therapeutic intervention by immunostimulation? Diabetes. 1994; 43:613-621.
    • (1994) Diabetes , vol.43 , pp. 613-621
    • Rabinovitch, A.1
  • 36
    • 0023779707 scopus 로고
    • Destruction of rat islet cell monolayers by cytokines. Synergistic interactions of interferon-γ, tumor necrosis factor, lymphotoxin, and interleukin 1
    • Pukel C, Baquerizo H, Rabinovitch A. Destruction of rat islet cell monolayers by cytokines. Synergistic interactions of interferon-γ, tumor necrosis factor, lymphotoxin, and interleukin 1. Diabetes. 1988; 37:133-136.
    • (1988) Diabetes , vol.37 , pp. 133-136
    • Pukel, C.1    Baquerizo, H.2    Rabinovitch, A.3
  • 37
    • 0025108875 scopus 로고
    • Loss of pancreatic islet tolerance induced by β-cell expression of interferon-γ
    • Sarvetnick N, Shizuru J, Liggitt D, et al. Loss of pancreatic islet tolerance induced by β-cell expression of interferon-γ. Nature. 1990; 346:844-847.
    • (1990) Nature , vol.346 , pp. 844-847
    • Sarvetnick, N.1    Shizuru, J.2    Liggitt, D.3
  • 38
    • 0025020303 scopus 로고
    • Prevention of diabetes in nonobese diabetic mice by tumor necrosis factor (TNF): Similarities between TNF-α and interleukin 1
    • Jacob CO, Aiso S, Michie SA, et al. Prevention of diabetes in nonobese diabetic mice by tumor necrosis factor (TNF): similarities between TNF-α and interleukin 1. Proc Natl Acad Sci USA. 1990; 87:968-972.
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 968-972
    • Jacob, C.O.1    Aiso, S.2    Michie, S.A.3
  • 39
    • 0033010281 scopus 로고    scopus 로고
    • Strategies of protection from nitric oxide toxicity in islet inflammation
    • Rothe H, Kolb H. Strategies of protection from nitric oxide toxicity in islet inflammation. J Mol Med. 1999; 77:40-44.
    • (1999) J Mol Med , vol.77 , pp. 40-44
    • Rothe, H.1    Kolb, H.2
  • 40
    • 0027534895 scopus 로고
    • Nitric oxide mediates cytokine-induced inhibition of insulin secretion by human islets of Langerhans
    • Corbett JA, Sweetland MA, Wang JL, et al. Nitric oxide mediates cytokine-induced inhibition of insulin secretion by human islets of Langerhans. Proc Natl Acad Sci USA. 1993; 99:1731-1735.
    • (1993) Proc Natl Acad Sci USA , vol.99 , pp. 1731-1735
    • Corbett, J.A.1    Sweetland, M.A.2    Wang, J.L.3
  • 41
    • 15844396183 scopus 로고    scopus 로고
    • Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells
    • Thierfelder WE, van Deursen JM, Yamamoto K, et al. Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells. Nature. 1996; 382:171-177.
    • (1996) Nature , vol.382 , pp. 171-177
    • Thierfelder, W.E.1    Van Deursen, J.M.2    Yamamoto, K.3
  • 42
    • 0032960249 scopus 로고    scopus 로고
    • Absolute requirement of macrophages for the development and activation of β-cell cytotoxic CD8+ T-cells in T-cell receptor transgenic NOD mice
    • +T-cells in T-cell receptor transgenic NOD mice. Diabetes. 1999; 48:34-42.
    • (1999) Diabetes , vol.48 , pp. 34-42
    • Jun, H.S.1    Santamaria, P.2    Lim, H.W.3
  • 43
    • 0031968921 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms for the initiation and progression of β-cell destruction resulting from the collaboration between macrophages and T cells
    • Yoon JW, Jun HS, Santamaria PS. Cellular and molecular mechanisms for the initiation and progression of β-cell destruction resulting from the collaboration between macrophages and T cells. Autoimmunity. 1998; 127:109-112.
    • (1998) Autoimmunity , vol.127 , pp. 109-112
    • Yoon, J.W.1    Jun, H.S.2    Santamaria, P.S.3
  • 44
    • 0034026665 scopus 로고    scopus 로고
    • Onji M. In situ characterization of dendritic cells occurring in the islets of nonobese diabetic mice during the development of insulitis
    • Shinomiya M, Nadano S, Shinomiya H, Onji M. In situ characterization of dendritic cells occurring in the islets of nonobese diabetic mice during the development of insulitis. Pancreas. 2000; 20:290-296.
    • (2000) Pancreas , vol.20 , pp. 290-296
    • Shinomiya, M.1    Nadano, S.2    Shinomiya, H.3
  • 45
    • 0024211490 scopus 로고
    • Evidence for initial involvement of macrophage in development of insulitis in NOD mice
    • Lee KU, Amano K, Yoon JW. Evidence for initial involvement of macrophage in development of insulitis in NOD mice. Diabetes. 1988; 37:989-991.
    • (1988) Diabetes , vol.37 , pp. 989-991
    • Lee, K.U.1    Amano, K.2    Yoon, J.W.3
  • 46
    • 0033621893 scopus 로고    scopus 로고
    • IL-1α, IL-1β, and IFN-γ mark β cells for Fas-dependent destruction by diabetogenic CD4+ T lymphocytes
    • +T lymphocytes. J Clin Invest 2000; 105:459-468.
    • (2000) J Clin Invest , vol.105 , pp. 459-468
    • Amrani, A.1    Verdaguer, J.2    Thiessen, S.3
  • 47
    • 0028302987 scopus 로고
    • Protection from endotoxic shock in mice by pharmacologic inhibition of phosphatidic acid
    • Rice GC, Brown PA, Nelson RJ, et al. Protection from endotoxic shock in mice by pharmacologic inhibition of phosphatidic acid. Proc Natl Acad Sci USA. 1994; 91:3857-3861.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 3857-3861
    • Rice, G.C.1    Brown, P.A.2    Nelson, R.J.3
  • 48
    • 0033079969 scopus 로고    scopus 로고
    • Selective downregulation of neutrophils by a phosphatidic acid generation inhibitor in a porcine sepsis model
    • Oka Y, Hasegawa N, Nakayama M, et al. Selective downregulation of neutrophils by a phosphatidic acid generation inhibitor in a porcine sepsis model. J Surgical Res. 1999; 81:147-155.
    • (1999) J Surgical Res , vol.81 , pp. 147-155
    • Oka, Y.1    Hasegawa, N.2    Nakayama, M.3
  • 49
    • 1642497152 scopus 로고    scopus 로고
    • Inhibition of STAT4 activation by Lisofylline is associated with the protection of autoimmune diabetes [abstract]
    • Yang Z, Chen M, Fialkow LB, et al. Inhibition of STAT4 activation by Lisofylline is associated with the protection of autoimmune diabetes [abstract]. Diabetes/Metabol Rese and Rev. 2002; 18:31.
    • (2002) Diabetes/Metabol Rese and Rev , vol.18 , pp. 31
    • Yang, Z.1    Chen, M.2    Fialkow, L.B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.