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Volumn 134, Issue 51, 2012, Pages 20776-20782

Detection of α-synuclein amyloidogenic aggregates in vitro and in cells using light-switching dipyridophenazine ruthenium(II) complexes

Author keywords

[No Author keywords available]

Indexed keywords

1 ,10-PHENANTHROLINE; FIBRIL FORMATION; FIBRILLIZATION; HUNTINGTON'S DISEASE; IN-VITRO; IN-VIVO; MOLECULAR MECHANISM; MOLECULAR TOOLS; NEUROGLIOMA CELLS; PARKINSON'S DISEASE; PHOTO-STABILITY; PROTEIN AGGREGATION; PROTEIN DEPOSITION; RED-SHIFTED EMISSION; RU(PHEN); RUTHENIUM COMPLEXES; SELF-ASSOCIATIONS; SOLUBLE PROTEINS; STOKES SHIFT; SYNUCLEIN;

EID: 84871595669     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja3100287     Document Type: Article
Times cited : (83)

References (49)
  • 18
    • 0347357617 scopus 로고    scopus 로고
    • Dobson, C. M. Nature 2003, 426, 884-890
    • (2003) Nature , vol.426 , pp. 884-890
    • Dobson, C.M.1
  • 42
    • 0037474250 scopus 로고    scopus 로고
    • Real-time fibrillization assays for α-synuclein with ThT performed by Antony et al. (;) showed lag and saturation times of 2 and 9 h respectively (100 μM spermine, 70 μM α-synuclein). Our experiments, which were conducted under similar conditions (100 μM spermine, 100 μM α-synuclein), show almost identical curves with lag and saturation times of 1.6 and 8.3 h, respectively. The slightly shorter times could be due to experimental variability or, more likely, to the slightly higher concentration of α-synuclein used in our experiments
    • Real-time fibrillization assays for α-synuclein with ThT performed by Antony et al. (Antony, T.; Hoyer, W.; Cherny, D.; Heim, G.; Jovin, T. M.; Subramaniam, V. J. Biol. Chem. 2003, 278, 3235-3240) showed lag and saturation times of 2 and 9 h respectively (100 μM spermine, 70 μM α-synuclein). Our experiments, which were conducted under similar conditions (100 μM spermine, 100 μM α-synuclein), show almost identical curves with lag and saturation times of 1.6 and 8.3 h, respectively. The slightly shorter times could be due to experimental variability or, more likely, to the slightly higher concentration of α-synuclein used in our experiments
    • (2003) J. Biol. Chem. , vol.278 , pp. 3235-3240
    • Antony, T.1    Hoyer, W.2    Cherny, D.3    Heim, G.4    Jovin, T.M.5    Subramaniam, V.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.