Synthesis and Biological Evaluation of 2,3,5-Substituted [1,2,4]Thiadiazoles as Allosteric Modulators of Adenosine Receptors

Journal of Medicinal Chemistry

Volumn 47, Issue 3, 2004, Pages 663-672

  Van Den Nieuwendijk, Adrianus M C H ^a   Pietra, Daniele ^a   Heitman, Laura ^a   Göblyös, Anikó ^a   IJzerman, Adriaan P ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

1,2,4 THIADIAZOLE DERIVATIVE; 2 CHLORO 6 N CYCLOPENTYLADENOSINE; ADENOSINE A1 RECEPTOR; ADENOSINE A2A RECEPTOR; ADENOSINE A3 RECEPTOR; ADENOSINE RECEPTOR; ALPHA 2A ADRENERGIC RECEPTOR; BETA 1 ADRENERGIC RECEPTOR; DELTA OPIATE RECEPTOR; DOPAMINE 1 RECEPTOR; DOPAMINE 2 RECEPTOR; G PROTEIN COUPLED RECEPTOR; KAPPA OPIATE RECEPTOR; LUF 5789; LUF 5792; LUF 5794; MU OPIATE RECEPTOR; N (2,3 DIPHENYL 1,2,4 THIADIAZOL 5(2H) YLIDENE)METHANAMINE; N [2,3 DIPHENYL 1,2,4 THIADIAZOLE 5(2H) YLIDENE]METHANAMINE; TRITIUM; UNCLASSIFIED DRUG;

ALLOSTERISM; ARTICLE; DISSOCIATION CONSTANT; DRUG BINDING SITE; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; ISOTOPE LABELING; PROTON NUCLEAR MAGNETIC RESONANCE;

ALLOSTERIC REGULATION; ANIMALS; BINDING, COMPETITIVE; CELL LINE; CRICETINAE; HUMANS; KINETICS; RADIOLIGAND ASSAY; RECEPTOR, ADENOSINE A1; RECEPTOR, ADENOSINE A2A; RECEPTOR, ADENOSINE A3; RECEPTORS, PURINERGIC P1; THIADIAZOLES; THIAZOLES;

EID: 1642499664     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm030863d     Document Type: Article

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