Synthesis and biological evaluation of a new series of 2,3,5-substituted [1,2,4]-thiadiazoles as modulators of adenosine A1 receptors and their molecular mechanism of action

Journal of Medicinal Chemistry

Volumn 48, Issue 4, 2005, Pages 1145-1151

  Göblyös, Anikó ^a   De Vries, Henk ^a   Brussee, Johannes ^a   Ijzerman, Adriaan P ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

1,2,4 THIADIAZOLE DERIVATIVE; 2 CHLORO 6 N CYCLOPENTYLADENOSINE; 2,3 DIPHENYL 5 N (3 HYDROXYPROPYL)IMINO 2H 1,2,4 THIADIAZOLE HYDROBROMIDE; 2,3 DIPHENYL 5 N BENZYLIMINO 2H 1,2,4 THIADIAZOLE HYDROBROMIDE; 2,3 DIPHENYL 5 N BUTYLIMINO 2H 1,2,4 THIADIAZOLE HYDROBROMIDE; 2,3 DIPHENYL 5 N CYCLOPENTYLIMINO 2H 1,2,4 THIADIAZOLE HYDROBROMIDE; 2,3 DIPHENYL 5 N ETHYLIMINO 2H 1,2,4 THIADIAZOLE HYDROBROMIDE; 2,3 DIPHENYL 5 N ISOPROPYLIMINO 2H 1,2,4 THIADIAZOLE HYDROBROMIDE; 2,3 DIPHENYL 5 N METHYLIMINO 2H 1,2,4 THIADIAZOLE HYDROBROMIDE; 2,3 DIPHENYL 5 N PROPYLIMINO 2H 1,2,4 THIADIAZOLE HYDROBROMIDE; 5 N (3 HYDROXYPROPYL)IMINO 2 (3 METHYLPHENYL) 3 PHENYL 2H 1,2,4 THIADIAZOLE HYDROBROMIDE; 5 N BUTYLIMINO 2 (3 METHYLPHENYL) 3 PHENYL 2H 1,2,4 THIADIAZOLE HYDROBROMIDE; 5 N CYCLOPENTYLIMINO 2 (3 METHYLPHENYL) 3 PHENYL 2H 1,2,4 THIADIAZOLE HYDROBROMIDE; 5 N ETHYLIMINO 2 (3 METHYLPHENYL) 3 PHENYL 2H 1,2,4 THIADIAZOLE HYDROBROMIDE; 5 N ISOPROPYLIMINO 2 (3 METHYLPHENYL) 3 PHENYL 2H 1,2,4 THIADIAZOLE HYDROBROMIDE; 5 N METHYLIMINO 2 (3 METHYLPHENYL) 3 PHENYL 2H 1,2,4 THIADIAZOLE HYDROBROMIDE; 5 N PROPYLIMINO 2 (3 METHYLPHENYL) 3 PHENYL 2H 1,2,4 THIADIAZOLE HYDROBROMIDE; 8 CYCLOPENTYL 1,3 DIPROPYLXANTHINE; ADENOSINE A1 RECEPTOR; LUF 5855; N (2,3 DIPHENYL 1,2,4 THIADIAZOL 5(2H) YLIDENE)METHANAMINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CHO CELL; CONTROLLED STUDY; DRUG MECHANISM; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INHIBITION KINETICS; LIGAND BINDING; MASS SPECTROMETRY; NONHUMAN;

ALLOSTERIC REGULATION; ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; HUMANS; KINETICS; RADIOLIGAND ASSAY; RECEPTOR, ADENOSINE A1; STRUCTURE-ACTIVITY RELATIONSHIP; THIADIAZOLES;

EID: 13944279479     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm049337s     Document Type: Article

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