The structure of human DNase I bound to magnesium and phosphate ions points to a catalytic mechanism common to members of the DNase I-like superfamily

Biochemistry

Volumn 51, Issue 51, 2012, Pages 10250-10258

  Parsiegla, Goetz ^a,c   Noguere, Christophe ^a   Santell, Lydia ^b   Lazarus, Robert A ^b   Bourne, Yves ^a  

^a AIX MARSEILLE UNIVERSITY   (France)

^b GENENTECH INC   (United States)

^c Centre National de la Recherche Scientifique   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; CRYSTAL STRUCTURE; MAMMALS; METAL IONS; MUTAGENESIS; QUANTUM CHEMISTRY;

CATALYTIC BASE; CATALYTIC MECHANISMS; COORDINATION SPHERE; CYSTIC FIBROSIS; CYSTIC FIBROSIS SPUTUM; LOW MOLECULAR MASS; PHYSIOLOGICAL MECHANISMS; TRANSITION STATE;

MAGNESIUM COMPOUNDS;

CALCIUM ION; DEOXYRIBONUCLEASE I; DNA; MAGNESIUM ION; PHOSPHATE;

ARTICLE; CATALYSIS; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; MUTAGENESIS; PRIORITY JOURNAL;

EID: 84871566762     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi300873f     Document Type: Article

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