Engineering actin-resistant human DNase I for treatment of cystic fibrosis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 93, Issue 16, 1996, Pages 8225-8229

  Ulmer, Jana S ^a   Herzka, Andrea ^a   Toy, Karen J ^a   Baker, Dana L ^a   Dodge, Anthony H ^a   Sinicropi, Dominick ^a   Shak, Steven ^a   Lazarus, Robert A ^a  

^a GENENTECH INC   (United States)

Author keywords

actin inhibition; DNA enzymology; mutagenesis; protein engineering; sputum viscoelasticity

Indexed keywords

DEOXYRIBONUCLEASE I; ENZYME VARIANT; F ACTIN; G ACTIN; MUTANT PROTEIN;

ARTICLE; CYSTIC FIBROSIS; DNA DEGRADATION; DRUG POTENCY; ENZYME ACTIVITY; ENZYME BINDING; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME MODIFICATION; GENETIC ENGINEERING; NONHUMAN; PRIORITY JOURNAL; PULSED FIELD GEL ELECTROPHORESIS; SITE DIRECTED MUTAGENESIS; SPUTUM ANALYSIS;

ACTINS; CYSTIC FIBROSIS; DEOXYRIBONUCLEASE I; DNA; ENZYME INHIBITORS; HUMANS; MACROMOLECULAR SUBSTANCES; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PROTEIN ENGINEERING; SPUTUM; STRUCTURE-ACTIVITY RELATIONSHIP; VISCOSITY;

EID: 0029758488     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.93.16.8225     Document Type: Article

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