메뉴 건너뛰기




Volumn 19, Issue 3, 2005, Pages 135-144

The use of human deoxyribonuclease (rhDNase) in the management of cystic fibrosis

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; DEOXYRIBONUCLEASE I; DORNASE ALFA; PLACEBO; RECOMBINANT ENZYME; RECOMBINANT HUMAN DEOXYRIBONUCLEASE; SODIUM CHLORIDE; UNCLASSIFIED DRUG;

EID: 22244473009     PISSN: 11738804     EISSN: None     Source Type: Journal    
DOI: 10.2165/00063030-200519030-00001     Document Type: Review
Times cited : (61)

References (79)
  • 1
    • 0024424270 scopus 로고
    • Identification of the cystic fibrosis gene: Cloning and characterization of complementary DNA
    • Riordan JR, Rommens JM, Kerem B, et al. Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA. Science 1989; 245 (4922): 1066-73
    • (1989) Science , vol.245 , Issue.4922 , pp. 1066-1073
    • Riordan, J.R.1    Rommens, J.M.2    Kerem, B.3
  • 2
    • 0024453308 scopus 로고
    • Identification of the cystic fibrosis gene: Chromosome walking and jumping
    • Rommens JM, Iannuzzi MC, Kerem B, et al. Identification of the cystic fibrosis gene: chromosome walking and jumping. Science 1989; 245 (4922): 1059-65
    • (1989) Science , vol.245 , Issue.4922 , pp. 1059-1065
    • Rommens, J.M.1    Iannuzzi, M.C.2    Kerem, B.3
  • 3
    • 0024423668 scopus 로고
    • Identification of the cystic fibrosis gene: Genetic analysis
    • Kerem B, Rommens JM, Buchanan JA, et al. Identification of the cystic fibrosis gene: genetic analysis. Science 1989; 245 (4922): 1073-80
    • (1989) Science , vol.245 , Issue.4922 , pp. 1073-1080
    • Kerem, B.1    Rommens, J.M.2    Buchanan, J.A.3
  • 4
    • 0036258208 scopus 로고    scopus 로고
    • Cystic fibrosis: A worldwide analysis of CFTR mutations. Correlation with incidence data and application to screening
    • Bobadilla JL, Macek M, Fine JP, et al. Cystic fibrosis: a worldwide analysis of CFTR mutations. Correlation with incidence data and application to screening. Hum Mutat 2002; 19 (6): 575-606
    • (2002) Hum Mutat , vol.19 , Issue.6 , pp. 575-606
    • Bobadilla, J.L.1    Macek, M.2    Fine, J.P.3
  • 5
    • 0027395872 scopus 로고
    • The changing epidemiology of cystic fibrosis
    • FitzSimmons SC. The changing epidemiology of cystic fibrosis. J Pediatr 1993; 122 (1): 1-9
    • (1993) J Pediatr , vol.122 , Issue.1 , pp. 1-9
    • FitzSimmons, S.C.1
  • 6
    • 0032934916 scopus 로고    scopus 로고
    • Role of CFTR in airway disease
    • Pilewski JM, Frizzell RA. Role of CFTR in airway disease. Physiol Rev 1999; 79 (1 Suppl.): S215-55
    • (1999) Physiol Rev , vol.79 , Issue.1 SUPPL.
    • Pilewski, J.M.1    Frizzell, R.A.2
  • 7
    • 0014816714 scopus 로고
    • The role of mucus in transport by cilia
    • Eliezer N, Sade J, Silberberg A, et al. The role of mucus in transport by cilia. Am Rev Respir Dis 1970; 102 (1): 48-52
    • (1970) Am Rev Respir Dis , vol.102 , Issue.1 , pp. 48-52
    • Eliezer, N.1    Sade, J.2    Silberberg, A.3
  • 8
    • 0028819164 scopus 로고
    • Regulation of human airway surface liquid
    • Widdicombe JH, Widdicombe JG. Regulation of human airway surface liquid. Respir Physiol 1995; 99 (1): 3-12
    • (1995) Respir Physiol , vol.99 , Issue.1 , pp. 3-12
    • Widdicombe, J.H.1    Widdicombe, J.G.2
  • 10
    • 0021971492 scopus 로고
    • Impaired lung function in patients with IgA deficiency and low levels of IgG2 or IgG3
    • Bjorkander J, Bake B, Oxelius VA, et al. Impaired lung function in patients with IgA deficiency and low levels of IgG2 or IgG3. N Engl J Med 1985; 313 (12): 720-4
    • (1985) N Engl J Med , vol.313 , Issue.12 , pp. 720-724
    • Bjorkander, J.1    Bake, B.2    Oxelius, V.A.3
  • 11
    • 0019353003 scopus 로고
    • Ultrastructural localization of endogenous peroxidase in the lower respiratory tract of the guinea pig
    • Christensen TG, Blanchard GC, Nolley G, et al. Ultrastructural localization of endogenous peroxidase in the lower respiratory tract of the guinea pig. Cell Tissue Res 1981; 214 (2): 407-15
    • (1981) Cell Tissue Res , vol.214 , Issue.2 , pp. 407-415
    • Christensen, T.G.1    Blanchard, G.C.2    Nolley, G.3
  • 12
    • 0026095436 scopus 로고
    • Killing of gram-negative bacteria by lactoferrin and lysozyme
    • Ellison RT, Giehl TJ. Killing of gram-negative bacteria by lactoferrin and lysozyme. J Clin Invest 1991; 88 (4): 1080-91
    • (1991) J Clin Invest , vol.88 , Issue.4 , pp. 1080-1091
    • Ellison, R.T.1    Giehl, T.J.2
  • 13
    • 0001307488 scopus 로고
    • Composition of tracheobronchial secretions in cystic fibrosis of the pancreas and bronchiectasis
    • Chernick WS, Barbero GJ. Composition of tracheobronchial secretions in cystic fibrosis of the pancreas and bronchiectasis. Pediatrics 1959; 24: 739-45
    • (1959) Pediatrics , vol.24 , pp. 739-745
    • Chernick, W.S.1    Barbero, G.J.2
  • 14
    • 0028212809 scopus 로고
    • Reduction in viscosity of cystic fibrosis sputum in vitro by gelsolin
    • Vasconcellos CA, Allen PG, Wohl ME, et al. Reduction in viscosity of cystic fibrosis sputum in vitro by gelsolin. Science 1994; 263 (5149): 969-71
    • (1994) Science , vol.263 , Issue.5149 , pp. 969-971
    • Vasconcellos, C.A.1    Allen, P.G.2    Wohl, M.E.3
  • 15
    • 0032433707 scopus 로고    scopus 로고
    • Evidence for periciliary liquid layer depletion, not abnormal ion composition, in the pathogenesis of cystic fibrosis airways disease
    • Matsui H, Grubb BR, Tarran R, et al. Evidence for periciliary liquid layer depletion, not abnormal ion composition, in the pathogenesis of cystic fibrosis airways disease. Cell 1998; 95 (7): 1005-15
    • (1998) Cell , vol.95 , Issue.7 , pp. 1005-1015
    • Matsui, H.1    Grubb, B.R.2    Tarran, R.3
  • 16
    • 0030881846 scopus 로고    scopus 로고
    • Current understanding of the inflammatory process in cystic fibrosis: Onset and etiology
    • Konstan MW, Berger M. Current understanding of the inflammatory process in cystic fibrosis: onset and etiology. Pediatr Pulmonol 1997; 24 (2): 137-42
    • (1997) Pediatr Pulmonol , vol.24 , Issue.2 , pp. 137-142
    • Konstan, M.W.1    Berger, M.2
  • 17
    • 0001513063 scopus 로고
    • Composition of pulmonary secretions from patients with and without cystic fibrosis
    • Potter J, Matthews LW, Lemm J, et al. Composition of pulmonary secretions from patients with and without cystic fibrosis. Am J Dis Child 1960; 100: 493-5
    • (1960) Am J Dis Child , vol.100 , pp. 493-495
    • Potter, J.1    Matthews, L.W.2    Lemm, J.3
  • 18
    • 0023912397 scopus 로고
    • Sputum changes associated with therapy for endobronchial exacerbation in cystic fibrosis
    • Smith AL, Redding G, Doershuk C, et al. Sputum changes associated with therapy for endobronchial exacerbation in cystic fibrosis. J Pediatr 1988; 112 (4): 547-54
    • (1988) J Pediatr , vol.112 , Issue.4 , pp. 547-554
    • Smith, A.L.1    Redding, G.2    Doershuk, C.3
  • 19
    • 0025647882 scopus 로고
    • Recombinant human DNase I reduces the viscosity of cystic fibrosis sputum
    • Shak S, Capon DJ, Hellmiss R, et al. Recombinant human DNase I reduces the viscosity of cystic fibrosis sputum. Proc Natl Acad Sci U S A 1990; 87 (23): 9188-92
    • (1990) Proc Natl Acad Sci U S A , vol.87 , Issue.23 , pp. 9188-9192
    • Shak, S.1    Capon, D.J.2    Hellmiss, R.3
  • 20
    • 0024990329 scopus 로고
    • The role of mucous glycoproteins in the rheologic properties of cystic fibrosis sputum
    • Lethem MI, James SL, Marriott C. The role of mucous glycoproteins in the rheologic properties of cystic fibrosis sputum. Am Rev Respir Dis 1990; 142 (5): 1053-8
    • (1990) Am Rev Respir Dis , vol.142 , Issue.5 , pp. 1053-1058
    • Lethem, M.I.1    James, S.L.2    Marriott, C.3
  • 21
    • 0018852847 scopus 로고
    • Short-term effects of chest physiotherapy on pulmonary function in children with cystic fibrosis
    • Weller PH, Bush E, Preece MA, et al. Short-term effects of chest physiotherapy on pulmonary function in children with cystic fibrosis. Respiration 1980; 40 (1): 53-6
    • (1980) Respiration , vol.40 , Issue.1 , pp. 53-56
    • Weller, P.H.1    Bush, E.2    Preece, M.A.3
  • 22
    • 0020592607 scopus 로고
    • Immediate and long-term effects of chest physiotherapy in patients with cystic fibrosis
    • Desmond KJ, Schwenk WF, Thomas E, et al. Immediate and long-term effects of chest physiotherapy in patients with cystic fibrosis. J Pediatr 1983; 103 (4): 538-42
    • (1983) J Pediatr , vol.103 , Issue.4 , pp. 538-542
    • Desmond, K.J.1    Schwenk, W.F.2    Thomas, E.3
  • 23
    • 0023705416 scopus 로고
    • Role of conventional physiotherapy in cystic fibrosis
    • Reisman JJ, Rivington-Law B, Corey M, et al. Role of conventional physiotherapy in cystic fibrosis. J Pediatr 1988; 113 (4): 632-6
    • (1988) J Pediatr , vol.113 , Issue.4 , pp. 632-636
    • Reisman, J.J.1    Rivington-Law, B.2    Corey, M.3
  • 24
    • 0028914085 scopus 로고
    • Early pulmonary inflammation in infants with cystic fibrosis
    • Khan TZ, Wagener JS, Bost T, et al. Early pulmonary inflammation in infants with cystic fibrosis. Am J Respir Crit Care Med 1995; 151 (4): 1075-82
    • (1995) Am J Respir Crit Care Med , vol.151 , Issue.4 , pp. 1075-1082
    • Khan, T.Z.1    Wagener, J.S.2    Bost, T.3
  • 25
    • 0029010510 scopus 로고
    • Lower respiratory infection and inflammation in infants with newly diagnosed cystic fibrosis
    • Armstrong DS, Grimwood K, Carzino R, et al. Lower respiratory infection and inflammation in infants with newly diagnosed cystic fibrosis. BMJ 1995; 310 (6994): 1571-2
    • (1995) BMJ , vol.310 , Issue.6994 , pp. 1571-1572
    • Armstrong, D.S.1    Grimwood, K.2    Carzino, R.3
  • 26
    • 0028015883 scopus 로고
    • Bronchoalveolar lavage findings in cystic fibrosis patients with stable, clinically mild lung disease suggest ongoing infection and inflammation
    • Konstan MW, Hilliard KA, Norvell TM, et al. Bronchoalveolar lavage findings in cystic fibrosis patients with stable, clinically mild lung disease suggest ongoing infection and inflammation. Am J Respir Crit Care Med 1994; 150 (2): 448-54
    • (1994) Am J Respir Crit Care Med , vol.150 , Issue.2 , pp. 448-454
    • Konstan, M.W.1    Hilliard, K.A.2    Norvell, T.M.3
  • 27
    • 0028043973 scopus 로고
    • Chest physiotherapy and cystic fibrosis: Why is the most effective form of treatment still unclear?
    • Williams MT. Chest physiotherapy and cystic fibrosis: why is the most effective form of treatment still unclear [abstract]? Chest 1994; 106 (6): 1872-82
    • (1994) Chest , vol.106 , Issue.6 , pp. 1872-1882
    • Williams, M.T.1
  • 28
    • 0028920138 scopus 로고
    • Chest physical therapy management of patients with cystic fibrosis: A meta-analysis
    • Thomas J, Cook DJ, Brooks D. Chest physical therapy management of patients with cystic fibrosis: a meta-analysis. Am J Respir Crit Care Med 1995; 151 (3 Pt 1): 846-50
    • (1995) Am J Respir Crit Care Med , vol.151 , Issue.3 PART 1 , pp. 846-850
    • Thomas, J.1    Cook, D.J.2    Brooks, D.3
  • 29
    • 0031804770 scopus 로고    scopus 로고
    • Finding evidence to support airway clearance techniques in cystic fibrosis
    • Prasad SA, Main E. Finding evidence to support airway clearance techniques in cystic fibrosis. Disabil Rehabil 1998; 20 (6-7): 235-46
    • (1998) Disabil Rehabil , vol.20 , Issue.6-7 , pp. 235-246
    • Prasad, S.A.1    Main, E.2
  • 30
    • 0030276577 scopus 로고    scopus 로고
    • Airway clearance techniques in the treatment of cystic fibrosis
    • McIlwaine MP, Davidson AG. Airway clearance techniques in the treatment of cystic fibrosis. Curr Opin Pulm Med 1996; 2 (6): 447-51
    • (1996) Curr Opin Pulm Med , vol.2 , Issue.6 , pp. 447-451
    • McIlwaine, M.P.1    Davidson, A.G.2
  • 31
    • 0001102999 scopus 로고
    • Liquefaction of viscous purulent exudates by deoxyribonuclease
    • Armstrong JB, White JC. Liquefaction of viscous purulent exudates by deoxyribonuclease. Lancet 1950; II: 739-42
    • (1950) Lancet , vol.2 , pp. 739-742
    • Armstrong, J.B.1    White, J.C.2
  • 32
    • 0004523287 scopus 로고
    • Aerosolized pancreatic dornase and antibiotics in pulmonary infections
    • Spier R, Witebsky E, Paine JR. Aerosolized pancreatic dornase and antibiotics in pulmonary infections. JAMA 1961; 178: 110-8
    • (1961) JAMA , vol.178 , pp. 110-118
    • Spier, R.1    Witebsky, E.2    Paine, J.R.3
  • 33
    • 0014434254 scopus 로고
    • Dornase aerosol effect on sputum viscosity in cases of cystic fibrosis
    • Lieberman J. Dornase aerosol effect on sputum viscosity in cases of cystic fibrosis. JAMA 1968; 205 (5): 312-3
    • (1968) JAMA , vol.205 , Issue.5 , pp. 312-313
    • Lieberman, J.1
  • 34
    • 0014340449 scopus 로고
    • Bronchospasm after inhalation of pancreatic dornase
    • Raskin P. Bronchospasm after inhalation of pancreatic dornase. Am Rev Respir Dis 1968; 98 (4): 597-8
    • (1968) Am Rev Respir Dis , vol.98 , Issue.4 , pp. 597-598
    • Raskin, P.1
  • 35
    • 0026602608 scopus 로고
    • Recombinant human DNase inhalation in normal subjects and patients with cystic fibrosis: A phase 1 study
    • Aitken ML, Burke W, McDonald G, et al. Recombinant human DNase inhalation in normal subjects and patients with cystic fibrosis: a phase 1 study. JAMA 1992; 267 (14): 1947-51
    • (1992) JAMA , vol.267 , Issue.14 , pp. 1947-1951
    • Aitken, M.L.1    Burke, W.2    McDonald, G.3
  • 36
    • 0026548151 scopus 로고
    • A preliminary study of aerosolized recombinant human deoxyribonuclease I in the sputum of cystic fibrosis patients
    • Hubbard RC, McElvaney N, Birrer P, et al. A preliminary study of aerosolized recombinant human deoxyribonuclease I in the sputum of cystic fibrosis patients. N Engl J Med 1992; 326 (12): 812-5
    • (1992) N Engl J Med , vol.326 , Issue.12 , pp. 812-815
    • Hubbard, R.C.1    McElvaney, N.2    Birrer, P.3
  • 37
    • 0027181325 scopus 로고
    • Efficacy and safety of short-term administration of aerosolised recombinant human DNase 1 in adults with stable stage cystic fibrosis
    • Ranasinha C, Assoufi B, Shak S, et al. Efficacy and safety of short-term administration of aerosolised recombinant human DNase 1 in adults with stable stage cystic fibrosis. Lancet 1993; 342 (8865): 199-202
    • (1993) Lancet , vol.342 , Issue.8865 , pp. 199-202
    • Ranasinha, C.1    Assoufi, B.2    Shak, S.3
  • 38
    • 0027278897 scopus 로고
    • Efficacy and safety of short-term administration of aerosolized recombinant human deoxyribonuclease in patients with cystic fibrosis
    • Ramsey BW, Astley SJ, Aitken ML, et al. Efficacy and safety of short-term administration of aerosolized recombinant human deoxyribonuclease in patients with cystic fibrosis. Am Rev Respir Dis 1993; 148 (1): 145-51
    • (1993) Am Rev Respir Dis , vol.148 , Issue.1 , pp. 145-151
    • Ramsey, B.W.1    Astley, S.J.2    Aitken, M.L.3
  • 39
    • 0028129568 scopus 로고
    • Effect of aerosolized recombinant human DNase on exacerbations of respiratory symptoms and on pulmonary function in patients with cystic fibrosis
    • Fuchs H, Borowitz DS, Christiansen DH, et al. Effect of aerosolized recombinant human DNase on exacerbations of respiratory symptoms and on pulmonary function in patients with cystic fibrosis. N Engl J Med 1994; 331 (10): 637-42
    • (1994) N Engl J Med , vol.331 , Issue.10 , pp. 637-642
    • Fuchs, H.1    Borowitz, D.S.2    Christiansen, D.H.3
  • 40
    • 0029067641 scopus 로고
    • Recombinant human DNase 1 in cystic fibrosis patients with severe pulmonary disease: A short-term double-blind study followed by six months open-label treatment
    • Shah PL, Bush A, Canny GJ, et al. Recombinant human DNase 1 in cystic fibrosis patients with severe pulmonary disease: a short-term double-blind study followed by six months open-label treatment. Eur Respir J 1995; 8 (6): 954-8
    • (1995) Eur Respir J , vol.8 , Issue.6 , pp. 954-958
    • Shah, P.L.1    Bush, A.2    Canny, G.J.3
  • 41
    • 0029921953 scopus 로고    scopus 로고
    • Effects of 12-week administration of dornase alfa in patients with advanced cystic fibrosis lung disease
    • McCoy K, Hamilton S, Johnson CAC. Effects of 12-week administration of dornase alfa in patients with advanced cystic fibrosis lung disease. Chest 1996; 110 (4): 889-95
    • (1996) Chest , vol.110 , Issue.4 , pp. 889-895
    • McCoy, K.1    Hamilton, S.2    Johnson, C.A.C.3
  • 42
    • 0035666058 scopus 로고    scopus 로고
    • A two-year randomized, placebo-controlled trial of dornase alfa in young patients with cystic fibrosis with mild lung function abnormalities
    • Quan JM, Tiddens HA, Sy JP, et al. A two-year randomized, placebo-controlled trial of dornase alfa in young patients with cystic fibrosis with mild lung function abnormalities. J Pediatr 2001; 139 (6): 813-20
    • (2001) J Pediatr , vol.139 , Issue.6 , pp. 813-820
    • Quan, J.M.1    Tiddens, H.A.2    Sy, J.P.3
  • 43
    • 0030803202 scopus 로고    scopus 로고
    • Aerosolized dornase alfa in cystic fibrosis: Is there a role in the management in patients with early obstructive lung disease?
    • Geller D. Aerosolized dornase alfa in cystic fibrosis: is there a role in the management in patients with early obstructive lung disease? Pediatr Pulmonol 1997; 24: 155-8
    • (1997) Pediatr Pulmonol , vol.24 , pp. 155-158
    • Geller, D.1
  • 44
    • 0031936645 scopus 로고    scopus 로고
    • Effect of smaller droplet size of dornase alfa on lung function in mild cystic fibrosis: Dornase Alfa Nebulizer Group
    • Geller DE, Eigen H, Fiel SB, et al. Effect of smaller droplet size of dornase alfa on lung function in mild cystic fibrosis: Dornase Alfa Nebulizer Group. Pediatr Pulmonol 1998; 25 (2): 83-7
    • (1998) Pediatr Pulmonol , vol.25 , Issue.2 , pp. 83-87
    • Geller, D.E.1    Eigen, H.2    Fiel, S.B.3
  • 45
    • 0142062982 scopus 로고    scopus 로고
    • Dornase alfa in the treatment of cystic fibrosis in Europe: A report from the Epidemiologic Registry of Cystic Fibrosis
    • Hodson ME, McKenzie S, Harms HK, et al. Dornase alfa in the treatment of cystic fibrosis in Europe: a report from the Epidemiologic Registry of Cystic Fibrosis. Pediatr Pulmonol 2003; 36 (5): 427-32
    • (2003) Pediatr Pulmonol , vol.36 , Issue.5 , pp. 427-432
    • Hodson, M.E.1    McKenzie, S.2    Harms, H.K.3
  • 46
    • 0000536783 scopus 로고    scopus 로고
    • 1 decline in children and adolescents with cystic fibrosis: Effect of predicted equations
    • 1 decline in children and adolescents with cystic fibrosis: effect of predicted equations [abstract]. Am J Respir Crit Care Med 1998; 157 Suppl.: A129
    • (1998) Am J Respir Crit Care Med , vol.157 , Issue.SUPPL.
    • Morgan, W.J.1    Stokes, D.2    Konstan, M.W.3
  • 47
    • 0028452511 scopus 로고
    • Consensus conference: Practical applications of pulmozyme
    • Ramsey BW, Dorkin HL. Consensus conference: practical applications of pulmozyme. Pediatr Pulmonol 1994; 17 (6): 404-8
    • (1994) Pediatr Pulmonol , vol.17 , Issue.6 , pp. 404-408
    • Ramsey, B.W.1    Dorkin, H.L.2
  • 48
    • 0029093124 scopus 로고
    • Two years experience with recombinant human DNase I in the treatment of pulmonary disease in cystic fibrosis
    • Shah PL, Scott SF, Geddes DM, et al. Two years experience with recombinant human DNase I in the treatment of pulmonary disease in cystic fibrosis. Respir Med 1995; 89 (7): 499-502
    • (1995) Respir Med , vol.89 , Issue.7 , pp. 499-502
    • Shah, P.L.1    Scott, S.F.2    Geddes, D.M.3
  • 49
    • 0035094310 scopus 로고    scopus 로고
    • A case-controlled study with dornase alfa to evaluate impact on disease progression over a 4-year period
    • Shah PL, Conway S, Scott SF, et al. A case-controlled study with dornase alfa to evaluate impact on disease progression over a 4-year period. Respiration 2001; 68 (2): 160-4
    • (2001) Respiration , vol.68 , Issue.2 , pp. 160-164
    • Shah, P.L.1    Conway, S.2    Scott, S.F.3
  • 50
    • 0030985609 scopus 로고    scopus 로고
    • Retrospective review of the effects of rhDNase in children with cystic fibrosis
    • Davies J, Trindale MT, Wallis C, et al. Retrospective review of the effects of rhDNase in children with cystic fibrosis. Pediatr Pulmonol 1997; 23 (4): 243-8
    • (1997) Pediatr Pulmonol , vol.23 , Issue.4 , pp. 243-248
    • Davies, J.1    Trindale, M.T.2    Wallis, C.3
  • 51
    • 0031701120 scopus 로고    scopus 로고
    • Long-term effects of aerosolised rhDNase on pulmonary disease progression in patients with cystic fibrosis
    • Milla CE. Long-term effects of aerosolised rhDNase on pulmonary disease progression in patients with cystic fibrosis. Thorax 1998; 53 (12): 1014-7
    • (1998) Thorax , vol.53 , Issue.12 , pp. 1014-1017
    • Milla, C.E.1
  • 52
    • 0028907263 scopus 로고
    • Medium term treatment of stable stage cystic fibrosis with recombinant human DNase I
    • Shah PL, Scott SF, Fuchs HJ, et al. Medium term treatment of stable stage cystic fibrosis with recombinant human DNase I. Thorax 1995; 50 (4): 333-8
    • (1995) Thorax , vol.50 , Issue.4 , pp. 333-338
    • Shah, P.L.1    Scott, S.F.2    Fuchs, H.J.3
  • 53
    • 0029945249 scopus 로고    scopus 로고
    • The role of recombinant human DNase in the treatment of patients with cystic fibrosis: Many promises, many problems
    • Zach MS. The role of recombinant human DNase in the treatment of patients with cystic fibrosis: many promises, many problems. Thorax 1996; 51 (7): 750-5
    • (1996) Thorax , vol.51 , Issue.7 , pp. 750-755
    • Zach, M.S.1
  • 54
    • 0001314891 scopus 로고
    • Proteolytic activity of purulent secretions in patients with CF and bronchitis is increased by DNase
    • Kueppers F, Fiel SB. Proteolytic activity of purulent secretions in patients with CF and bronchitis is increased by DNase [abstract]. Am Rev Respir Dis 1992; 145 Suppl.: A563
    • (1992) Am Rev Respir Dis , vol.145 , Issue.SUPPL.
    • Kueppers, F.1    Fiel, S.B.2
  • 55
    • 0029860628 scopus 로고    scopus 로고
    • Aerosolized rhDNase in cystic fibrosis: Effect on leucocyte proteases in sputum
    • Rochat T, Pastore FD, Schlegel-Haueter SE, et al. Aerosolized rhDNase in cystic fibrosis: effect on leucocyte proteases in sputum. Eur Respir J 1996; 9 (11): 2200-6
    • (1996) Eur Respir J , vol.9 , Issue.11 , pp. 2200-2206
    • Rochat, T.1    Pastore, F.D.2    Schlegel-Haueter, S.E.3
  • 56
    • 0029870027 scopus 로고    scopus 로고
    • The effects of recombinant human DNase on neutrophil elastase activity and interleukin-8 levels in the sputum of patients with cystic fibrosis
    • Shah PL, Scott SF, Knight RA, et al. The effects of recombinant human DNase on neutrophil elastase activity and interleukin-8 levels in the sputum of patients with cystic fibrosis. Eur Respir J 1996; 9 (3): 531-4
    • (1996) Eur Respir J , vol.9 , Issue.3 , pp. 531-534
    • Shah, P.L.1    Scott, S.F.2    Knight, R.A.3
  • 57
    • 0036683406 scopus 로고    scopus 로고
    • Effects of recombinant human DNase and hypertonic saline on airway inflammation in children with cystic fibrosis
    • Suri R, Marshall LJ, Wallis C, et al. Effects of recombinant human DNase and hypertonic saline on airway inflammation in children with cystic fibrosis. Am J Respir Crit Care Med 2002; 166 (3): 352-5
    • (2002) Am J Respir Crit Care Med , vol.166 , Issue.3 , pp. 352-355
    • Suri, R.1    Marshall, L.J.2    Wallis, C.3
  • 58
    • 0029882941 scopus 로고    scopus 로고
    • Effect of nebulised recombinant DNase on neutrophil elastase load in cystic fibrosis
    • Costello CM, O'Connor CM, Finlay GA, et al. Effect of nebulised recombinant DNase on neutrophil elastase load in cystic fibrosis. Thorax 1996; 51 (6): 619-23
    • (1996) Thorax , vol.51 , Issue.6 , pp. 619-623
    • Costello, C.M.1    O'Connor, C.M.2    Finlay, G.A.3
  • 59
    • 10344250594 scopus 로고    scopus 로고
    • Effect of treatment with dornase alpha on airway inflammation in patients with cystic fibrosis
    • Paul K, Rietschel E, Ballmann M, et al. Effect of treatment with dornase alpha on airway inflammation in patients with cystic fibrosis. Am J Respir Crit Care Med 2004; 169 (6): 719-25
    • (2004) Am J Respir Crit Care Med , vol.169 , Issue.6 , pp. 719-725
    • Paul, K.1    Rietschel, E.2    Ballmann, M.3
  • 60
    • 0041373781 scopus 로고    scopus 로고
    • London: BMJ Books
    • British Medical Association and the Royal Pharmaceutical Society of Great Britain. British National Formulary: no. 45. London: BMJ Books, 2003
    • (2003) British National Formulary: No. 45
  • 61
    • 0028964835 scopus 로고
    • Effects of recombinant human DNase therapy on healthcare use and costs in patients with cystic fibrosis
    • Oster G, Huse DM, Lacey MJ, et al. Effects of recombinant human DNase therapy on healthcare use and costs in patients with cystic fibrosis. Ann Pharmacother 1995; 29 (5): 459-64
    • (1995) Ann Pharmacother , vol.29 , Issue.5 , pp. 459-464
    • Oster, G.1    Huse, D.M.2    Lacey, M.J.3
  • 62
    • 13344259313 scopus 로고    scopus 로고
    • A multinational economic evaluation of rhDNase in the treatment of cystic fibrosis
    • Menzin J, Oster G, Davies L, et al. A multinational economic evaluation of rhDNase in the treatment of cystic fibrosis. Int J Technol Assess Health Care 1996; 12 (1): 52-61
    • (1996) Int J Technol Assess Health Care , vol.12 , Issue.1 , pp. 52-61
    • Menzin, J.1    Oster, G.2    Davies, L.3
  • 63
    • 0034055732 scopus 로고    scopus 로고
    • Use of rhDNase therapy and costs of respiratory-related care in patients with cystic fibrosis
    • Ollendorf DA, McGarry LJ, Watrous ML, et al. Use of rhDNase therapy and costs of respiratory-related care in patients with cystic fibrosis. Ann Pharmacother 2000; 34: 304-8
    • (2000) Ann Pharmacother , vol.34 , pp. 304-308
    • Ollendorf, D.A.1    McGarry, L.J.2    Watrous, M.L.3
  • 64
    • 0035021689 scopus 로고    scopus 로고
    • Use of computerized tomography and chest x-rays in evaluating efficacy of aerosolized recombinant human DNase in cystic fibrosis patients younger than age 5 years: A preliminary study
    • Nasr SZ, Kuhns LR, Brown RW, et al. Use of computerized tomography and chest x-rays in evaluating efficacy of aerosolized recombinant human DNase in cystic fibrosis patients younger than age 5 years: a preliminary study. Pediatr Pulmonol 2001; 31 (5): 377-82
    • (2001) Pediatr Pulmonol , vol.31 , Issue.5 , pp. 377-382
    • Nasr, S.Z.1    Kuhns, L.R.2    Brown, R.W.3
  • 65
    • 0000722087 scopus 로고
    • RhDNase therapy in patients with CF: Is it possible to predict lung function improvement?
    • Wojnarowski C, Eichler J, Frischer T, et al. RhDNase therapy in patients with CF: is it possible to predict lung function improvement [abstract]? Pediatr Pulmonol 1995; Suppl. 12: 237
    • (1995) Pediatr Pulmonol , Issue.12 SUPPL. , pp. 237
    • Wojnarowski, C.1    Eichler, J.2    Frischer, T.3
  • 66
    • 0345320389 scopus 로고    scopus 로고
    • Recombinant DNase in cystic fibrosis: A protocol for targeted introduction through n-of-1 trials
    • Bollert FGE, Paton JY, Marshall TG, et al. Recombinant DNase in cystic fibrosis: a protocol for targeted introduction through n-of-1 trials. Eur Respir J 1999; 13 (1): 107-13
    • (1999) Eur Respir J , vol.13 , Issue.1 , pp. 107-113
    • Bollert, F.G.E.1    Paton, J.Y.2    Marshall, T.G.3
  • 67
    • 0035922668 scopus 로고    scopus 로고
    • Comparison of hypertonic saline and alternate-day or daily recombinant human deoxyribonuclease in children with cystic fibrosis: A randomised trial
    • Suri R, Metcalfe C, Lees B, et al. Comparison of hypertonic saline and alternate-day or daily recombinant human deoxyribonuclease in children with cystic fibrosis: a randomised trial. Lancet 2001; 358: 1316-21
    • (2001) Lancet , vol.358 , pp. 1316-1321
    • Suri, R.1    Metcalfe, C.2    Lees, B.3
  • 68
    • 0029974204 scopus 로고    scopus 로고
    • Inhalation of hypertonic saline aerosol enhances mucociliary clearance in asthmatic and healthy subjects
    • Daviskas E, Anderson SD, Gonda I, et al. Inhalation of hypertonic saline aerosol enhances mucociliary clearance in asthmatic and healthy subjects. Eur Respir J 1996; 9 (4): 725-32
    • (1996) Eur Respir J , vol.9 , Issue.4 , pp. 725-732
    • Daviskas, E.1    Anderson, S.D.2    Gonda, I.3
  • 69
    • 0030845454 scopus 로고    scopus 로고
    • Rheology of cystic fibrosis sputum after in vitro treatment with hypertonic saline alone and in combination with recombinant human deoxyribonuclease I
    • King M, Dasgupta B, Tomkiewicz RP, et al. Rheology of cystic fibrosis sputum after in vitro treatment with hypertonic saline alone and in combination with recombinant human deoxyribonuclease I. Am J Respir Crit Care Med 1997; 156 (1): 173-7
    • (1997) Am J Respir Crit Care Med , vol.156 , Issue.1 , pp. 173-177
    • King, M.1    Dasgupta, B.2    Tomkiewicz, R.P.3
  • 70
    • 0027998618 scopus 로고
    • Human airway ion transport: Part two
    • Boucher RC. Human airway ion transport: part two. Am J Respir Crit Care Med 1994; 150 (2): 581-93
    • (1994) Am J Respir Crit Care Med , vol.150 , Issue.2 , pp. 581-593
    • Boucher, R.C.1
  • 71
    • 0026514357 scopus 로고
    • Respiratory mucus from asymptomatic smokers is better hydrated and more easily cleared by mucociliary action
    • Rubin BK, Ramirez O, Zayas G, et al. Respiratory mucus from asymptomatic smokers is better hydrated and more easily cleared by mucociliary action. Am Rev Respir Dis 1992; 145 (3): 545-7
    • (1992) Am Rev Respir Dis , vol.145 , Issue.3 , pp. 545-547
    • Rubin, B.K.1    Ramirez, O.2    Zayas, G.3
  • 73
    • 0029916071 scopus 로고    scopus 로고
    • Effect of hypertonic saline, amiloride, and cough on mucociliary clearance in patients with cystic fibrosis
    • Robinson M, Regnis JA, Bailey DL, et al. Effect of hypertonic saline, amiloride, and cough on mucociliary clearance in patients with cystic fibrosis. Am J Respir Crit Care Med 1996; 153 (5): 1503-9
    • (1996) Am J Respir Crit Care Med , vol.153 , Issue.5 , pp. 1503-1509
    • Robinson, M.1    Regnis, J.A.2    Bailey, D.L.3
  • 74
    • 0030784262 scopus 로고    scopus 로고
    • Effect of increasing doses of hypertonic saline on mucociliary clearance in patients with cystic fibrosis
    • Robinson M, Hemming AL, Regnis JA, et al. Effect of increasing doses of hypertonic saline on mucociliary clearance in patients with cystic fibrosis. Thorax 1997; 52 (10): 900-3
    • (1997) Thorax , vol.52 , Issue.10 , pp. 900-903
    • Robinson, M.1    Hemming, A.L.2    Regnis, J.A.3
  • 75
    • 0027938913 scopus 로고
    • Hypertonic saline challenge in an epidemiological survey of asthma in children
    • Riedler J, Reade T, Dalton M, et al. Hypertonic saline challenge in an epidemiological survey of asthma in children. Am J Respir Crit Care Med 1994; 150 (6 Pt 1): 1632-9
    • (1994) Am J Respir Crit Care Med , vol.150 , Issue.6 PART 1 , pp. 1632-1639
    • Riedler, J.1    Reade, T.2    Dalton, M.3
  • 76
    • 0029921103 scopus 로고    scopus 로고
    • Short-term efficacy of ultrasonically nebulized hypertonic saline in cystic fibrosis
    • Eng PA, Morton J, Douglass JA, et al. Short-term efficacy of ultrasonically nebulized hypertonic saline in cystic fibrosis. Pediatr Pulmonol 1996; 21 (2): 77-83
    • (1996) Pediatr Pulmonol , vol.21 , Issue.2 , pp. 77-83
    • Eng, P.A.1    Morton, J.2    Douglass, J.A.3
  • 77
    • 0000274070 scopus 로고    scopus 로고
    • Hypertonic saline and recombinant human DNase: A randomised cross-over pilot study in patients with cystic fibrosis
    • Ballmann M, von der Hardt H. Hypertonic saline and recombinant human DNase: a randomised cross-over pilot study in patients with cystic fibrosis [abstract]. Pediatr Pulmonol 1998; Suppl. 17: 343
    • (1998) Pediatr Pulmonol , vol.17 , Issue.SUPPL. , pp. 343
    • Ballmann, M.1    Von Der Hardt, H.2
  • 78
    • 0036793667 scopus 로고    scopus 로고
    • Effects of hypertonic saline, alternate day and daily rhDNase on healthcare use, costs and outcomes in children with cystic fibrosis
    • Suri R, Grieve R, Normand C, et al. Effects of hypertonic saline, alternate day and daily rhDNase on healthcare use, costs and outcomes in children with cystic fibrosis. Thorax 2002; 57 (10): 841-6
    • (2002) Thorax , vol.57 , Issue.10 , pp. 841-846
    • Suri, R.1    Grieve, R.2    Normand, C.3
  • 79
    • 0141501501 scopus 로고    scopus 로고
    • Recombinant human deoxyribonuclease for cystic fibrosis
    • Jones AP, Wallis CE. Recombinant human deoxyribonuclease for cystic fibrosis. Cochrane Database Syst Rev 2003; (3): CD001127
    • (2003) Cochrane Database Syst Rev , Issue.3
    • Jones, A.P.1    Wallis, C.E.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.