Improved potency of hyperactive and actin-resistant human DNase I variants for treatment of cystic fibrosis and systemic lupus erythematosus

Journal of Biological Chemistry

Volumn 273, Issue 29, 1998, Pages 18374-18381

  Pan, Clark Q ^a   Dodge, Tony H ^b   Baker, Dana L ^b   Prince, William S ^b   Sinicropi, Dominick V ^b   Lazarus, Robert A ^a,b  

^a Department of Protein Engineering ^*  (United States)

^b GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; DNA; DNA ANTIBODY; DORNASE ALFA; G ACTIN;

ANTIGEN ANTIBODY COMPLEX; ARTICLE; CYSTIC FIBROSIS; DNA DEGRADATION; DRUG ACTIVITY; DRUG POTENCY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; PRIORITY JOURNAL; PULSED FIELD GEL ELECTROPHORESIS; SYSTEMIC LUPUS ERYTHEMATOSUS;

ACTINS; ANTIGEN-ANTIBODY COMPLEX; BINDING SITES; CHROMATIN; CYSTIC FIBROSIS; DEOXYRIBONUCLEASE I; DNA; ENZYME-LINKED IMMUNOSORBENT ASSAY; EXPECTORANTS; HUMANS; LUPUS ERYTHEMATOSUS, SYSTEMIC; MODELS, MOLECULAR; PROTEIN CONFORMATION; PROTEIN ENGINEERING; RECOMBINANT PROTEINS; SPUTUM;

EID: 0032540946     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.273.29.18374     Document Type: Article

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