Engineering hyperactive variants of human deoxyribonuclease I by altering its functional mechanism

Biochemistry

Volumn 36, Issue 22, 1997, Pages 6624-6632

  Pan, Clark Q ^a   Lazarus, Robert A ^a  

^a GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEOXYRIBONUCLEASE I; DOUBLE STRANDED DNA;

ARTICLE; CYSTIC FIBROSIS; DNA DEGRADATION; DNA STRAND BREAKAGE; DRUG MECHANISM; GENETIC ENGINEERING; HUMAN; HUMAN CELL; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

CALCIUM; DEOXYRIBONUCLEASE I; DNA; DNA LIGASES; DNA POLYMERASE I; DNA REPAIR; DNA, SUPERHELICAL; HUMANS; HYDROLYSIS; KINETICS; MAGNESIUM; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PLASMIDS; PROTEIN ENGINEERING; SODIUM CHLORIDE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0030966960     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi962960x     Document Type: Article

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