The effects of alpha lipoic acid on liver cells damages and apoptosis induced by polyunsaturated fatty acids

Food and Chemical Toxicology

Volumn 53, Issue , 2013, Pages 84-93

  Kaya Dagistanli, Fatma ^a   Tanriverdi, Gamze ^b   Altinok, Ayfer ^a   Ozyazgan, Sibel ^a   Ozturk, Melek ^a  

^a ISTANBUL UNIVERSITY   (Turkey)

^b ISTANBUL UNIVERSITY   (Turkey)

Author keywords

Alpha lipoic acid; Apoptosis; Liver; N 6 Diet; Rat; Ultrastructure

Indexed keywords

CASPASE 3; COLLAGEN; GLUTATHIONE; OMEGA 6 FATTY ACID; THIOCTIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL INFILTRATION; CELL VACUOLE; CENTRAL VEIN; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; ENZYME ACTIVITY; FOOD COMPOSITION; LIPID DIET; LIVER CELL; LIVER CELL DAMAGE; LIVER FATTY DEGENERATION; LIVER SINUSOID; NONHUMAN; PROTEIN LOCALIZATION; RAT; STELLATE CELL; TISSUE LEVEL;

ANIMALS; ANTIOXIDANTS; APOPTOSIS; CASPASE 3; FATTY ACIDS, OMEGA-6; FATTY LIVER; FIBROSIS; HEPATIC STELLATE CELLS; HEPATOCYTES; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; MICROSCOPY, ELECTRON; RATS; RATS, WISTAR; REGENERATION; THIOCTIC ACID;

RATTUS; RATTUS NORVEGICUS;

EID: 84871566753     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2012.11.026     Document Type: Article

References (55)

1. Adams L.A., Angulo P., Lindor K.D. Nonalcoholic fatty liver disease. Can. Med. Assoc. J. 2005, 172:899-905.
2. Adiels M., Taskinen M.R., Boren J. Fatty liver, insulin resistance, and dyslipidemia. Curr. Diab. Rep. 2008, 8:60-64.
3. Aguilera C.M., Ramirez-Tortosa C.L., Quiles J.L., Yago M.D., Martínez-Burgos M.A., Martínez-Victoria E., Gil A., Ramirez-Tortosa M.C. Monounsaturated and omega-3 but not omega-6 polyunsaturated fatty acids improve hepatic fibrosis in hypercholesterolemic rabbits. Nutrition 2005, 21:363-371.
4. Araya J., Rodrigo R., Videla L.A., Thielemann L., Orellana M., Pettinelli P., Poniachik J. Increase in long-chain polyunsaturated fatty acid n-6/n-3 ratio in relation to hepatic steatosis in patients with nonalcoholic fatty liver disease. Clin. Sci. 2004, 106:635-643.
5. Atzori L., Poli G., Perra A. Hepatic stellate cell: a star cell in the liver. Int. J. Biochem. Cell Biol. 2009, 41:1639-1642.
6. Barut S., Unlü Y.A., Karaoĝlan A., Tunçdemir M., Daĝistanli F.K., Oztürk M., Colak A. The neuroprotective effects of z-DEVD.fmk, a caspase-3 inhibitor, on traumatic spinal cord injury in rats. Surg. Neurol. 2005, 64:213-220.
7. Beutler E. Glutathione in red blood cell metabolism: a manual of biochemical method 1975, Grune Stratton, New York. second ed.
8. Bitar M.S., Wahid S., Pilcher C.W., Al-Saleh E., Al-Mulla F. Alpha-lipoic acid mitigates insulin resistance in Goto-Kakizaki rats. Horm. Metab. Res. 2004, 36:542-549.
9. Blomhoff R., Wake K. Perisinusoidal stellate cells of the liver: important roles in retinol metabolism and fibrosis. FASEB J. 1991, 5:271-277.
10. Bray T.M., Taylor C.G. Tissue glutathione, nutrition, and oxidative stress. Can. J. Physiol. Pharmacol. 1993, 71:746-751.
11. Bonni A., Brunet A., West A.E., Datta S.R., Takasu M.A., Greenberg M.E. Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms. Science 1999, 286:1358-1362.
12. Bustamante J., Lodge J.K., Marcocci L., Tritschler H.J., Packer L., Rihn B.H. Alpha-lipoic acid in liver metabolism and disease. Free Radic. Biol. Med. 1998, 24:1023-1039.
13. Cortez-Pinto H., Jesus L., Barros H., Lopes C., Moura M.C., Camilo M.E. How different is the dietary pattern in non-alcoholic steatohepatitis patients?. Clin. Nutr. 2006, 25:816-823.
14. Diesel B., Kulhanek-Heinze S., Höltje M., Brandt B., Höltje H.D., Vollmar A.M., Kiemer A.K. Alpha-lipoic acid as a directly binding activator of the insulin receptor: protection from hepatocyte apoptosis. Biochemistry 2007, 46:2146-2155.
15. Duan W.R., Garner D.S., Williams S.D., Funckes-Shippy C.L., Spath I.S., Blomme E.A. Comparison of immunohistochemistry for activated caspase-3 and cleaved cytokeratin 18 with the TUNEL method for quantification of apoptosis in histological sections of PC-3 subcutaneous xenografts. J. Pathol. 2003, 199:221-228.
16. Duenschede F., Erbes K., Kircher A., Westermann S., Schad A., Riegler N., Ewald P., Dutkowski P., Kiemer A.K., Kempski O., Junginger T. Protection from hepatic ischemia/reperfusion injury and improvement of liver regeneration by alpha-lipoic acid. Shock 2007, 27:644-651.
17. Eckle V.S., Buchmann A., Bursch W., Schulte-Hermann R., Schwarz M. Immunohistochemical detection of activated caspases in apoptotic hepatocytes in rat liver. Toxicol. Pathol. 2004, 32:9-15.
18. Elmore S. Apoptosis: a review of programmed cell death. Toxicol. Pathol. 2007, 35:495-516.
19. Friedman S.L. Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. J. Biol. Chem. 2000, 275:2247-2250.
20. Gómez-Candela C., Bermejo-López L.M., Loria-Kohen V. Importance of a balanced omega 6/omega 3 ratio for the maintenance of health: nutritional recommendations. Nutr. Hosp. 2011, 26:323-329.
21. Gora{ogonek}ca A., Huk-Kolega H., Piechota A., Kleniewska P., Ciejka E., Skibska B. Lipoic acid-biological activity and therapeutic potential. Pharmacol. Rep. 2011, 63:849-858.
22. Guzel E., Basar M., Ocak N., Arici A., Kayisli U.A. Bidirectional interaction between unfolded-protein-response key protein HSPA5 and estrogen signaling in human endometrium. Biol. Reprod. 2011, 85:121-127.
23. Gvozdjáková A., Pella D., Kucharská J., Otsuka K., Singh R.B. Omega-3 PUFA, omega-6 PUFA and mitochondria. Mitochondrial Medicine 2008, 343-356. Springerlink, The Netherlands. A. Gvozdjáková (Ed.).
24. Halliwell B., Gutteridge J.M. Role of free radicals and catalytic metal ions in human disease: an overview. Methods Enzymol. 1990, 186:1-85.
25. Han Y.P. Matrix metalloproteinases, the pros and cons, in liver fibrosis. J. Gastroenterol. Hepatol. 2006, 21(Suppl. 3):88-91.
26. Hautekeete M.L., Geerts A. The hepatic stellate (Ito) cell: its role in human liver disease. Virchows Arch. 1997, 430:195-207.
27. Islam M.T. Antioxidant activities of dithiol alpha-lipoic acid. Bangladesh J. Med. Sci. 2009, 8:46-51.
28. Jiang Y., Zhao M., An W. Increased hepatic apoptosis in high-fat diet-induced NASH in rats may be associated with downregulation of hepatic stimulator substance. J. Mol. Med. (Berl) 2011, 89:1207-1217.
29. Kaya-Daĝistanli F., Süsleyici-Duman B., Oztürk M. Protective effects of a calcium channel blocker on apoptosis in thymus of neonatal STZ-diabetic rats. Acta Histochem. 2005, 107:207-214.
30. Kawada N. Evolution of hepatic fibrosis research. Hepatol. Res. 2011, 41:199-208.
31. Kordes C., Sawitza I., Muller-Marbach A., Ale-Agha N., Keitel V., Klonowski-Stumpe H., Haussinger D. CD133(+) hepatic stellate cells are progenitor cells. Biochem. Biophys. Res. Commun. 2007, 352:410-417.
32. Lee U.E., Friedman S.L. Mechanisms of hepatic fibrogenesis. Best Pract. Res. Clin. Gastroenterol. 2011, 25:195-206.
33. Lum H., Roebuck K.A. Oxidant stress and endothelial cell dysfunction. Am. J. Physiol. 2001, 280:719-741.
34. Malhi H., Gores G.J. Molecular mechanisms of lipotoxicity in nonalcoholic fatty liver disease. Semin. Liver Dis. 2008, 28:360-369.
35. Mantovani G., Macciò A., Madeddu C., Mura L., Massa E., Gramignano G., Lusso M.R., Murgia V., Camboni P., Ferreli L. Reactive oxygen species, antioxidant mechanisms, and serum cytokine levels in cancer patients: impact of an antioxidant treatment. J. Environ. Pathol. Toxicol. Oncol. 2003, 22:17-28.
36. Martinez-Hernandez A. The hepatic extracellular matrix. II. Electron immunohistochemical studies in rats with CCl4-induced cirrhosis. Lab. Invest. 1985, 53:166-186.
37. Mei S., Ni H.M., Manley S., Bockus A., Kassel K.M., Luyendyk J.P., Copple B.L., Ding W.X. Differential roles of unsaturated and saturated fatty acids on autophagy and apoptosis in hepatocytes. J. Pharmacol. Exp. Ther. 2011, 339:487-498.
38. Min A.K., Kim M.K., Seo H.Y., Kim H.S., Jang B.K., Hwang J.S., Choi H.S., Lee K.U., Park K.G., Lee I.K. Alpha-lipoic acid inhibits hepatic PAI-1 expression and fibrosis by inhibiting the TGF- signaling pathway. Biochem. Biophys. Res. Commun. 2010, 393:536-541.
39. Moreira R.K. Hepatic stellate cells and liver fibrosis. Arch. Pathol. Lab. Med. 2007 Nov, 131(11):1728-1734.
40. Morini S., Carotti S., Carpino G., Franchitto A., Corradini S.G., Merli M., Gaudio E. GFAP expression in the liver as an early marker of stellate cells activation. Ital J Anat Embryol. 2005, 110:193-207.
41. Park K.G., Min A.K., Koh E.H., Kim H.S., Kim M.O., Park H.S., Kim Y.D., Yoon T.S., Jang B.K., Hwang J.S., Kim J.B., Choi H.S., Park J.Y., Lee I.K., Lee K.U. Alpha-lipoic acid decreases hepatic lipogenesis through adenosine monophosphate-activated protein kinase (AMPK)-dependent and AMPK-independent pathways. Hepatology 2008, 48:1477-1486.
42. Persson H.L., Svensson A.I., Brunk U.T. Alpha-lipoic acid and alpha-lipoamide prevent oxidant-induced lysosomal rupture and apoptosis. Redox Rep. 2001, 6:327-334.
43. Rukkumani R., Aruna K., Varma P.S., Rajasekaran K.N., Menon V.P. Comparative effects of curcumin and an analog of curcumin on alcohol and PUFA induced oxidative stress. J. Pharm. Pharm. Sci. 2004, 7:274-283.
44. Quinn R. Comparing rat's to human's age: how old is my rat in people years?. Nutrition 2005, 21:775-777.
45. Senoo H., Wake K. Suppression of experimental hepatic fibrosis by administration of vitamin A. Lab. Invest. 1985, 52:182-194.
46. Simopoulos A.P. The importance of the ratio of omega-6: omega-3 essential fatty acids. Biomed. Pharmacother. 2002, 56:365-379.
47. Smith M.T., Wills E.D. The effects of dietary lipid and phenobarbitone on the production and utilization of NADPH in the liver. A combined biochemical and quantitative cytochemical study. Biochem. J. 1981, 200:691-699.
48. Smith O. Animal models of human genetic disease. Trends Genet. 1993, 9:112-116.
49. Standish R.A., Cholongitas E., Dhillon A., Burroughs A.K., Dhillon P.A. An appraisal of the histopathological assessment of liver fibrosis. Gut 2006, 55:569-578.
50. Stevens M.J., Obrosova I., Coa X., Huysen C.V., Greene D.A. Effects of DL-a-lipoic acid on peripheral nerve conduction, blood flow, energy metabolism and oxidative stres in experimental diabetic neuropathy. Diabetes 2000, 49:1006-1015.
51. Videla L.A., Rodrigo R., Araya J., Poniachik J. Oxidative stress and depletion of hepatic long-chain polyunsaturated fatty acids may contribute to nonalcoholicfatty liver disease. Free Radic. Biol. Med. 2004, 37:1499-1507.
52. Washington K., Wright K., Shyr Y., Hunter E.B., Olson S., Raidford D.S. Hepatic stellate cell activation in nonalcoholic steatohepatitis and fatty liver. Hum. Pathol. 2000, 31:822-828.
53. Yao J., Zhi M., Minhu C. Effect of silybin on high-fat-induced fatty liver in rats. Braz. J. Med. Biol. Res. 2011, 44:652-659.
54. Yeh M.M., Brunt E.M. Pathology of nonalcoholic fatty liver disease. Am. J. Clin. Pathol. 2007, 128:837-847.
55. Ziegler U., Groscurth P. Morphological features of cell death. News Physiol. Sci. 2004, 19:124-128.